SI2068909T1 - Modified fgf-21 polypeptides and their uses - Google Patents

Modified fgf-21 polypeptides and their uses

Info

Publication number
SI2068909T1
SI2068909T1 SI200830701T SI200830701T SI2068909T1 SI 2068909 T1 SI2068909 T1 SI 2068909T1 SI 200830701 T SI200830701 T SI 200830701T SI 200830701 T SI200830701 T SI 200830701T SI 2068909 T1 SI2068909 T1 SI 2068909T1
Authority
SI
Slovenia
Prior art keywords
polypeptides
modified fgf
fgf
modified
Prior art date
Application number
SI200830701T
Other languages
Slovenian (sl)
Inventor
Thomas P Cujec
Roberto Mariani
Putnam Anna-Maria A Hays
William M Keefe
Nick Knudsen
Lillian Ho
Jason Pinkstaff
Vadim Kraynov
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Priority claimed from PCT/US2008/057563 external-priority patent/WO2008121563A2/en
Publication of SI2068909T1 publication Critical patent/SI2068909T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200830701T 2007-03-30 2008-03-19 Modified fgf-21 polypeptides and their uses SI2068909T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92129707P 2007-03-30 2007-03-30
US98806007P 2007-11-14 2007-11-14
PCT/US2008/057563 WO2008121563A2 (en) 2007-03-30 2008-03-19 Modified fgf-21 polypeptides and their uses
EP08732507A EP2068909B1 (en) 2007-03-30 2008-03-19 Modified fgf-21 polypeptides and their uses

Publications (1)

Publication Number Publication Date
SI2068909T1 true SI2068909T1 (en) 2012-09-28

Family

ID=41790591

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200830701T SI2068909T1 (en) 2007-03-30 2008-03-19 Modified fgf-21 polypeptides and their uses

Country Status (2)

Country Link
CN (1) CN101663046B (en)
SI (1) SI2068909T1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6069198B2 (en) * 2010-07-20 2017-02-01 ノヴォ ノルディスク アー／エス FGF21 compound modified at the N-terminus
CN102464712A (en) * 2010-11-11 2012-05-23 重庆富进生物医药有限公司 Deletion human fibroblast growth factor 21 variant and conjugate thereof
TWI527590B (en) * 2011-06-17 2016-04-01 艾瑞斯貿易公司 Freeze-dried formulations of fgf-18
CN102603886B (en) * 2012-02-14 2013-08-07 东北农业大学 Mutant fibroblast growth factor and use thereof in treating endocrine diseases
AU2013370404B2 (en) * 2012-12-27 2017-11-02 Ngm Biopharmaceuticals, Inc. Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
CN103882015B (en) * 2013-12-17 2015-12-02 吉林省奇健生物技术有限公司 A kind of recombinant bacterial strain of high expression human growth hormone and construction process and application
MX2017007458A (en) 2014-12-23 2017-08-10 Novo Nordisk As Fgf21 derivatives and uses thereof.
US20220017570A1 (en) * 2018-11-05 2022-01-20 Bristol-Meyers Squibb Company Method for purifying pegylated protein
CN111187845B (en) * 2020-02-05 2023-03-31 内蒙古农业大学 Application of FGF21 gene in breeding of wool-producing animals and/or regulating hair length
CN115804847B (en) * 2022-07-26 2023-08-15 四川省医学科学院·四川省人民医院 PH/hydrogen peroxide/MMP 9 time sequence response microsphere, exosome-carrying biological carrier and application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459540B1 (en) * 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
AU1922101A (en) * 1999-11-18 2001-05-30 Chiron Corporation Human fgf-21 gene and gene expression products
CN101001866A (en) * 2004-02-02 2007-07-18 Ambrx公司 Modified human interferon polypeptides and their uses
US20070265200A1 (en) * 2004-03-17 2007-11-15 Eli Lilly And Company Glycol Linked Fgf-21 Compounds
JP5948627B2 (en) * 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー Fibroblast growth factor (FGF) remodeling and carbohydrate pegylation

Also Published As

Publication number Publication date
CN101663046B (en) 2017-07-28
CN101663046A (en) 2010-03-03

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