SI1869185T1 - Konjugat ki obsega protein P za zdravljenje raka - Google Patents

Konjugat ki obsega protein P za zdravljenje raka

Info

Publication number: SI1869185T1
Authority: SI; Slovenia
Prior art keywords: protein; cancer; treatment; conjugate; region
Prior art date: 2005-04-14

Application number

SI200630663T

Other languages

English (en)

Inventor

Agamemnon Epenetos

Christina Kousparou

Original Assignee

Trojan Technologies Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-04-14

Filing date

2006-04-18

Publication date

2010-09-30

2006-04-18 Application filed by Trojan Technologies Ltd filed Critical Trojan Technologies Ltd

2010-09-30 Publication of SI1869185T1 publication Critical patent/SI1869185T1/sl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Insects & Arthropods (AREA)
Immunology (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Cell Biology (AREA)
Marine Sciences & Fisheries (AREA)
Inorganic Chemistry (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Communicable Diseases (AREA)
Physics & Mathematics (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SI200630663T 2005-04-14 2006-04-18 Konjugat ki obsega protein P za zdravljenje raka SI1869185T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0507598A GB0507598D0 (en)	2005-04-14	2005-04-14	Composition
PCT/GB2006/001407 WO2006109092A1 (en)	2005-04-14	2006-04-18	Conjugate comprising p21 protein for the treatment of cancer
EP20060726802 EP1869185B1 (en)	2005-04-14	2006-04-18	Conjugate comprising p21 protein for the treatment of cancer

Publications (1)

Publication Number	Publication Date
SI1869185T1 true SI1869185T1 (sl)	2010-09-30

Family

ID=34611144

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200630663T SI1869185T1 (sl)	2005-04-14	2006-04-18	Konjugat ki obsega protein P za zdravljenje raka

Country Status (16)

Country	Link
US (3)	US20080287357A1 (sl)
EP (1)	EP1869185B1 (sl)
JP (1)	JP4955654B2 (sl)
KR (1)	KR20080016798A (sl)
CN (1)	CN101194017B (sl)
AT (1)	ATE458819T1 (sl)
AU (1)	AU2006235742B2 (sl)
CA (1)	CA2604536A1 (sl)
DE (1)	DE602006012463D1 (sl)
DK (1)	DK1869185T3 (sl)
ES (1)	ES2343972T3 (sl)
GB (1)	GB0507598D0 (sl)
PL (1)	PL1869185T3 (sl)
PT (1)	PT1869185E (sl)
SI (1)	SI1869185T1 (sl)
WO (1)	WO2006109092A1 (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK3581207T3 (da)	2013-06-11	2023-02-06	Ppl Bvi Ltd	Fusionsproteiner omfattende hoxd12 og nemo-bindingsdomæne og anvendelse deraf
MA45491A (fr) *	2016-06-27	2019-05-01	Juno Therapeutics Inc	Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
CN110511273B (zh) *	2019-07-12	2021-06-01	福州市皮肤病防治院	一种细胞穿膜多肽的制备方法及其应用
CN111471096B (zh) *	2020-01-15	2022-02-18	上海众启生物科技有限公司	用于阿尔茨海默症自身抗体检测的含有adarb1蛋白片段组合物
GB202019864D0 (en)	2020-12-16	2021-01-27	Anastasis Biotec Ltd	Improved cell-penetrating peptides and fusion proteins
CN112961865B (zh) *	2021-02-22	2023-06-02	广西大学	一种利用基因编辑鸡生物反应器表达的重组曲妥珠单抗及应用
WO2023104874A2 (en) *	2021-12-08	2023-06-15	Ferring B.V.	Method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6372249B1 (en) *	1991-12-16	2002-04-16	Baylor College Of Medicine	Senscent cell-derived inhibitors of DNA synthesis
US6495526B2 (en) *	1996-01-23	2002-12-17	Gpc Biotech, Inc.	Inhibitors of cell-cycle progression and uses related thereto
IL145067A0 (en) *	1999-03-01	2002-06-30	Cell Genesys Inc	Nucleic acid composition containing a first sequence encoding a chimeric cyclin-dependent kinase protein and a second sequence encoding an adenovirus e4 protein
GB0003284D0 (en) *	2000-02-15	2000-04-05	Secr Defence Brit	Anti-viral therapy
EP1272221A2 (en) *	2000-04-12	2003-01-08	Implyx Ltd.	Peptide conjugates for drug delivery

2005
- 2005-04-14 GB GB0507598A patent/GB0507598D0/en not_active Ceased
2006
- 2006-04-18 JP JP2008505969A patent/JP4955654B2/ja not_active Expired - Fee Related
- 2006-04-18 CN CN2006800207462A patent/CN101194017B/zh not_active Expired - Fee Related
- 2006-04-18 US US11/911,427 patent/US20080287357A1/en not_active Abandoned
- 2006-04-18 SI SI200630663T patent/SI1869185T1/sl unknown
- 2006-04-18 CA CA 2604536 patent/CA2604536A1/en not_active Abandoned
- 2006-04-18 ES ES06726802T patent/ES2343972T3/es active Active
- 2006-04-18 EP EP20060726802 patent/EP1869185B1/en not_active Not-in-force
- 2006-04-18 KR KR20077026274A patent/KR20080016798A/ko not_active Application Discontinuation
- 2006-04-18 PT PT06726802T patent/PT1869185E/pt unknown
- 2006-04-18 DK DK06726802T patent/DK1869185T3/da active
- 2006-04-18 WO PCT/GB2006/001407 patent/WO2006109092A1/en active Search and Examination
- 2006-04-18 AT AT06726802T patent/ATE458819T1/de active
- 2006-04-18 AU AU2006235742A patent/AU2006235742B2/en not_active Ceased
- 2006-04-18 DE DE200660012463 patent/DE602006012463D1/de active Active
- 2006-04-18 PL PL06726802T patent/PL1869185T3/pl unknown
2009
- 2009-10-29 US US12/608,718 patent/US9145446B2/en active Active
2015
- 2015-09-22 US US14/861,923 patent/US10259852B2/en active Active

Also Published As

Publication number	Publication date
PT1869185E (pt)	2010-05-28
JP4955654B2 (ja)	2012-06-20
US20110021441A1 (en)	2011-01-27
EP1869185A1 (en)	2007-12-26
DK1869185T3 (da)	2010-06-21
CA2604536A1 (en)	2006-10-19
US20080287357A1 (en)	2008-11-20
US20160068582A1 (en)	2016-03-10
WO2006109092A1 (en)	2006-10-19
ES2343972T3 (es)	2010-08-13
AU2006235742A1 (en)	2006-10-19
DE602006012463D1 (de)	2010-04-08
US9145446B2 (en)	2015-09-29
ATE458819T1 (de)	2010-03-15
JP2008535512A (ja)	2008-09-04
CN101194017A (zh)	2008-06-04
GB0507598D0 (en)	2005-05-18
KR20080016798A (ko)	2008-02-22
US10259852B2 (en)	2019-04-16
AU2006235742B2 (en)	2011-07-14
CN101194017B (zh)	2013-08-28
PL1869185T3 (pl)	2010-10-29
EP1869185B1 (en)	2010-02-24

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