SI1664026T1 - Inhibitorji mitotiäśnega kinezina - Google Patents
Inhibitorji mitotiäśnega kinezinaInfo
- Publication number
- SI1664026T1 SI1664026T1 SI200431039T SI200431039T SI1664026T1 SI 1664026 T1 SI1664026 T1 SI 1664026T1 SI 200431039 T SI200431039 T SI 200431039T SI 200431039 T SI200431039 T SI 200431039T SI 1664026 T1 SI1664026 T1 SI 1664026T1
- Authority
- SI
- Slovenia
- Prior art keywords
- mitotic kinesin
- kinesin inhibitors
- compounds
- ksp kinesin
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49563703P | 2003-08-15 | 2003-08-15 | |
| US56358004P | 2004-04-19 | 2004-04-19 | |
| PCT/US2004/026012 WO2005019206A1 (en) | 2003-08-15 | 2004-08-11 | Mitotic kinesin inhibitors |
| EP04780791A EP1664026B1 (en) | 2003-08-15 | 2004-08-11 | Mitotic kinesin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1664026T1 true SI1664026T1 (sl) | 2009-04-30 |
Family
ID=34221386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200431039T SI1664026T1 (sl) | 2003-08-15 | 2004-08-11 | Inhibitorji mitotiäśnega kinezina |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20060234984A1 (sl) |
| EP (1) | EP1664026B1 (sl) |
| JP (1) | JP4773961B2 (sl) |
| AT (1) | ATE421512T1 (sl) |
| AU (1) | AU2004266232B2 (sl) |
| CA (1) | CA2534065A1 (sl) |
| CY (1) | CY1108927T1 (sl) |
| DE (1) | DE602004019229D1 (sl) |
| DK (1) | DK1664026T3 (sl) |
| ES (1) | ES2319429T3 (sl) |
| HR (1) | HRP20090195T1 (sl) |
| PL (1) | PL1664026T3 (sl) |
| PT (1) | PT1664026E (sl) |
| SI (1) | SI1664026T1 (sl) |
| WO (1) | WO2005019206A1 (sl) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL374190A1 (en) | 2002-06-14 | 2005-10-03 | Merck & Co, Inc. | Mitotic kinesin inhibitors |
| AU2003276005B2 (en) | 2002-06-14 | 2009-01-15 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| WO2004103959A2 (en) * | 2003-05-16 | 2004-12-02 | Ambit Biosciences Corporation | Heterocyclic compounds and uses thereof |
| US20050182125A1 (en) * | 2003-05-16 | 2005-08-18 | Ambit Biosciences Corporation | Pyrrole compounds and uses thereof |
| US20040248972A1 (en) * | 2003-05-16 | 2004-12-09 | Ambit Biosciences Corporation | Compounds and uses thereof |
| CA2533889A1 (en) | 2003-08-15 | 2005-03-03 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| ES2319429T3 (es) * | 2003-08-15 | 2009-05-07 | MERCK & CO., INC. | Inhibidores de cinesina mitotica. |
| AU2004264533B2 (en) | 2003-08-15 | 2009-01-22 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| JP2007533762A (ja) * | 2004-04-19 | 2007-11-22 | メルク エンド カムパニー インコーポレーテッド | ２，２−二置換ピロールの調製方法 |
| JP2008505090A (ja) | 2004-07-01 | 2008-02-21 | メルク エンド カムパニー インコーポレーテッド | 有糸***キネシン阻害剤のプロドラッグ |
| WO2006060737A2 (en) * | 2004-12-03 | 2006-06-08 | Takeda San Diego, Inc. | Mitotic kinesin inhibitors |
| CA2599390A1 (en) * | 2005-03-16 | 2006-09-28 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
| BRPI0818605A2 (pt) | 2007-10-19 | 2015-04-22 | Schering Corp | Derivados de 1,3,4-tiadiazl espiro-condensados para inibir a atividade de ksp cinesima |
| HUE039416T2 (hu) | 2008-06-19 | 2018-12-28 | Takeda Pharmaceuticals Co | Heterociklusos vegyület és ennek alkalmazása |
| US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
| UA109417C2 (uk) | 2009-10-14 | 2015-08-25 | Мерк Шарп Енд Доме Корп. | ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ |
| EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
| EP3330377A1 (en) | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
| KR102072631B1 (ko) | 2010-08-17 | 2020-02-03 | 시르나 쎄러퓨틱스 인코퍼레이티드 | 짧은 간섭 핵산 （ｓｉＮＡ）을 사용한 Ｂ형 간염 바이러스 （ＨＢＶ） 유전자 발현의 ＲＮＡ 간섭 매개 억제 |
| EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
| US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
| WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| GEP20156285B (en) * | 2011-02-25 | 2015-05-11 | Aierem Elelsi | Compounds and compositions as trk inhibitors |
| US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
| EP3358013B1 (en) | 2012-05-02 | 2020-06-24 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| US9233979B2 (en) | 2012-09-28 | 2016-01-12 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
| CA2892361A1 (en) | 2012-11-28 | 2014-06-05 | Merck Sharp & Dohme Corp. | Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels |
| WO2014100065A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
| US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| CN104370939B (zh) * | 2014-10-14 | 2016-10-26 | 上海交通大学 | 一种手性二氢吡咯类化合物的制备方法 |
| JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
| KR20190140454A (ko) | 2017-04-13 | 2019-12-19 | 아두로 바이오테크 홀딩스, 유럽 비.브이. | 항-sirp 알파 항체 |
| EP3706742B1 (en) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| WO2019148412A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
| EP3833668A4 (en) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | PRMT5 INHIBITORS |
| US20210309688A1 (en) | 2018-08-07 | 2021-10-07 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| BR112022012032A2 (pt) | 2019-12-17 | 2022-09-06 | Merck Sharp & Dohme Llc | Inibidores de prmt5 |
| EP4301744A1 (en) | 2021-08-10 | 2024-01-10 | AbbVie Inc. | Nicotinamide ripk1 inhibitors |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3142699A (en) * | 1958-04-24 | 1964-07-28 | Bayer Ag | Urethane compounds and process therefor |
| US3635982A (en) * | 1969-04-08 | 1972-01-18 | American Home Prod | Amino-substituted-quinoxalinyloxazolidines and -oxazines |
| US4477389A (en) * | 1982-10-25 | 1984-10-16 | The United States Of America As Represented By The Secretary Of Agriculture | Polyhalogenated phenyl isocyanate synthesis with excess phosgene and either triethylamine or tetramethylurea |
| GB9206757D0 (en) | 1992-03-27 | 1992-05-13 | Ferring Bv | Novel peptide receptor ligands |
| EP0934265B1 (en) | 1996-08-16 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof |
| US6057342A (en) | 1996-08-16 | 2000-05-02 | Dupont Pharmaceutical Co. | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof |
| US6440686B1 (en) | 2000-06-15 | 2002-08-27 | Cytokinetics, Inc. | Methods for screening and therapeutic applications of kinesin modulators |
| AU2002363960B2 (en) | 2001-12-06 | 2008-07-10 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| JP2003177052A (ja) * | 2001-12-13 | 2003-06-27 | Takata Corp | シート重量計測装置 |
| ATE448207T1 (de) * | 2002-03-08 | 2009-11-15 | Merck & Co Inc | Mitotische kinesin-hemmer |
| AU2003231799A1 (en) * | 2002-05-23 | 2003-12-12 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| EP1517904A4 (en) * | 2002-05-23 | 2007-02-21 | Merck & Co Inc | INHIBITORS OF MITOTIC KINESIN |
| PL374190A1 (en) * | 2002-06-14 | 2005-10-03 | Merck & Co, Inc. | Mitotic kinesin inhibitors |
| AU2003276005B2 (en) | 2002-06-14 | 2009-01-15 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| US6835899B2 (en) * | 2002-08-21 | 2004-12-28 | Trw Inc. | Load sensing assembly for a vehicle seat |
| WO2004037171A2 (en) * | 2002-10-18 | 2004-05-06 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| EP1636182A4 (en) * | 2003-06-12 | 2008-09-03 | Merck & Co Inc | PRODRUGS OF INHIBITORS FROM MITOTIC KINESINE |
| CN100403900C (zh) * | 2003-06-12 | 2008-07-23 | 麦克公司 | 有丝***驱动蛋白抑制剂 |
| US7307085B2 (en) * | 2003-08-13 | 2007-12-11 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| AU2004264533B2 (en) * | 2003-08-15 | 2009-01-22 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| PE20050730A1 (es) * | 2003-08-15 | 2005-09-20 | Merck & Co Inc | Derivados de 2,5-dihidropirrol 2,2-disustituidos como inhibidores de quinesinas mitoticas |
| ES2319429T3 (es) * | 2003-08-15 | 2009-05-07 | MERCK & CO., INC. | Inhibidores de cinesina mitotica. |
| US7294640B2 (en) * | 2004-02-06 | 2007-11-13 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
-
2004
- 2004-08-11 ES ES04780791T patent/ES2319429T3/es active Active
- 2004-08-11 AU AU2004266232A patent/AU2004266232B2/en not_active Ceased
- 2004-08-11 PT PT04780791T patent/PT1664026E/pt unknown
- 2004-08-11 US US10/567,676 patent/US20060234984A1/en not_active Abandoned
- 2004-08-11 DE DE602004019229T patent/DE602004019229D1/de active Active
- 2004-08-11 DK DK04780791T patent/DK1664026T3/da active
- 2004-08-11 SI SI200431039T patent/SI1664026T1/sl unknown
- 2004-08-11 AT AT04780791T patent/ATE421512T1/de active
- 2004-08-11 JP JP2006523332A patent/JP4773961B2/ja not_active Expired - Fee Related
- 2004-08-11 WO PCT/US2004/026012 patent/WO2005019206A1/en active Application Filing
- 2004-08-11 PL PL04780791T patent/PL1664026T3/pl unknown
- 2004-08-11 EP EP04780791A patent/EP1664026B1/en active Active
- 2004-08-11 US US10/915,743 patent/US7465746B2/en not_active Expired - Fee Related
- 2004-08-11 CA CA002534065A patent/CA2534065A1/en not_active Abandoned
-
2009
- 2009-03-30 CY CY20091100367T patent/CY1108927T1/el unknown
- 2009-04-03 HR HR20090195T patent/HRP20090195T1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1664026A1 (en) | 2006-06-07 |
| ES2319429T3 (es) | 2009-05-07 |
| CY1108927T1 (el) | 2014-07-02 |
| DE602004019229D1 (de) | 2009-03-12 |
| WO2005019206A1 (en) | 2005-03-03 |
| PL1664026T3 (pl) | 2009-06-30 |
| US20050043357A1 (en) | 2005-02-24 |
| AU2004266232A1 (en) | 2005-03-03 |
| JP4773961B2 (ja) | 2011-09-14 |
| US7465746B2 (en) | 2008-12-16 |
| AU2004266232B2 (en) | 2008-07-03 |
| CA2534065A1 (en) | 2005-03-03 |
| US20060234984A1 (en) | 2006-10-19 |
| ATE421512T1 (de) | 2009-02-15 |
| EP1664026B1 (en) | 2009-01-21 |
| HRP20090195T1 (en) | 2009-05-31 |
| JP2007502774A (ja) | 2007-02-15 |
| DK1664026T3 (da) | 2009-05-04 |
| PT1664026E (pt) | 2009-04-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20090195T1 (en) | Mitotic kinesin inhibitors | |
| IL165624A0 (en) | Mitotic kinesin inhibitors | |
| EP1492487A4 (en) | INHIBITORS OF MITOTIC KINESIN | |
| EP1515949A4 (en) | INHIBITORS OF MITOTIC KINESIN | |
| WO2004037171A3 (en) | Mitotic kinesin inhibitors | |
| WO2005017190A3 (en) | Mitotic kinesin inhibitors | |
| EP1551812A4 (en) | MITOTIC KINESINE HEMMER | |
| EP1463733A4 (en) | INHIBITORS OF MITOTIC KINESIN | |
| EP1481077A4 (en) | MITOTIC KINESINE HEMMER | |
| WO2005018547A3 (en) | Mitotic kinesin inhibitors | |
| WO2004039774A3 (en) | Mitotic kinesin inhibitors | |
| WO2003099211A3 (en) | Mitotic kinesin inhibitors | |
| WO2006068933A3 (en) | Mitotic kinesin inhibitors | |
| WO2004058148A3 (en) | Mitotic kinesin inhibitors | |
| WO2004058700A3 (en) | Mitotic kinesin inhibitors | |
| WO2006031348A3 (en) | Mitotic kinesin inhibitors | |
| WO2005065183A3 (en) | Mitotic kinesin inhibitors | |
| WO2006007496A3 (en) | Mitotic kinesin inhibitors | |
| WO2006007501A3 (en) | Mitotic kinesin inhibitors | |
| IL180328A0 (en) | Mitotic kinesin inhibitors | |
| WO2006023440A3 (en) | Mitotic kinesin inhibitors | |
| EP1635641A4 (en) | INHIBITORS OF MITOTIC KINESINE | |
| WO2005060654A3 (en) | Mitotic kinesin inhibitors | |
| WO2004087050A3 (en) | Mitotic kinesin inhibitors |