SI1539783T1 - Inhibitorji nukleozidnih fosforilaz in nukleozidaz - Google Patents

Inhibitorji nukleozidnih fosforilaz in nukleozidaz

Info

Publication number: SI1539783T1
Authority: SI; Slovenia
Prior art keywords: inhibitors; compounds; phosphorylases; nucleosidases; methylthioadenosine
Prior art date: 2002-08-21

Application number

SI200332011T

Other languages

English (en)

Inventor

Gary Brian Evans

Richard Hubert Furneaux

Dirk Henning Lenz

Vern L Schramm

Peter Charles Tyler

Olga Vladimirovna Zubkova

Original Assignee

Einstein Coll Med

Ind Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-21

Filing date

2003-08-21

Publication date

2011-08-31

2003-08-21 Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med

2011-08-31 Publication of SI1539783T1 publication Critical patent/SI1539783T1/sl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

SI200332011T 2002-08-21 2003-08-21 Inhibitorji nukleozidnih fosforilaz in nukleozidaz SI1539783T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
NZ52091902		2002-08-21
PCT/NZ2003/000186 WO2004018496A1 (en)	2002-08-21	2003-08-21	Inhibitors of nucleoside phosphorylases and nucleosidases
EP03792904A EP1539783B1 (en)	2002-08-21	2003-08-21	Inhibitors of nucleoside phosphorylases and nucleosidases

Publications (1)

Publication Number	Publication Date
SI1539783T1 true SI1539783T1 (sl)	2011-08-31

Family

ID=31944950

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200332011T SI1539783T1 (sl)	2002-08-21	2003-08-21	Inhibitorji nukleozidnih fosforilaz in nukleozidaz

Country Status (18)

Country	Link
US (2)	US7553839B2 (sl)
EP (1)	EP1539783B1 (sl)
JP (1)	JP4682314B2 (sl)
KR (1)	KR101081226B1 (sl)
CN (1)	CN100379750C (sl)
AT (1)	ATE505474T1 (sl)
AU (1)	AU2003258911B2 (sl)
BR (1)	BRPI0313664B8 (sl)
CA (1)	CA2496698C (sl)
CY (1)	CY1111700T1 (sl)
DE (1)	DE60336734D1 (sl)
DK (1)	DK1539783T3 (sl)
ES (1)	ES2363766T3 (sl)
HK (1)	HK1085219A1 (sl)
PT (1)	PT1539783E (sl)
RU (1)	RU2330042C2 (sl)
SI (1)	SI1539783T1 (sl)
WO (1)	WO2004018496A1 (sl)

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CA2634299C (en) *	1999-04-08	2011-05-31	Industrial Research Limited	Process for preparing inhibitors of nucleoside metabolism
EP1539783B1 (en)	2002-08-21	2011-04-13	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside phosphorylases and nucleosidases
NZ523970A (en) *	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
US7557113B2 (en)	2003-08-26	2009-07-07	Teijin Pharma Limited	Substituted pyrrolo[3,2-d]pyrimidine derivatives
EP1661897B1 (en) *	2003-08-26	2013-12-04	Teijin Pharma Limited	Pyrrolopyrimidinone derivative
NZ533360A (en) *	2004-06-04	2007-02-23	Ind Res Ltd	Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
EP1771452A4 (en) *	2004-07-27	2009-07-15	Biocryst Pharm Inc	5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND 5'METHYL THIOADENOSINE / S-ADENOSYLHOMOCYSTEIN NUCLEOSIDASE HEMMER
NZ540160A (en) *	2005-05-20	2008-03-28	Einstein Coll Med	Inhibitors of nucleoside phosphorylases
AU2006275725A1 (en) *	2005-07-27	2007-02-08	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) *	2005-12-15	2008-07-31	Ind Res Ltd	Deazapurine analogs of 1'-aza-l-nucleosides
US20090053221A1 (en) *	2006-01-17	2009-02-26	Cheung Nai-Kong V	Immune response enhancing glucan
WO2007097643A1 (en) *	2006-02-22	2007-08-30	Industrial Research Limited	Analogues of coformycin and their use for treating protozoan parasite infections
WO2007097647A1 (en) *	2006-02-24	2007-08-30	Albert Einstein College Of Medicine Of Yeshiva University	Methods of treating cancer
US20110092521A1 (en) *	2006-02-24	2011-04-21	Richard Hubert Furneaux	Methods of Treating Diseases Using Inhibitors of Nucleoside Phosphorylases and Nucleosidases
AU2006200809B2 (en) *	2006-02-24	2013-11-07	Albert Einstein College Of Medicine Of Yeshiva University	Methods of treating cancer
CN101094080B (zh) *	2006-06-22	2012-06-20	华为技术有限公司	一种即按即通***中的计费方法
WO2008030118A1 (en) *	2006-09-07	2008-03-13	Industrial Research Limited	Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
PL2057165T3 (pl)	2006-09-07	2011-08-31	Victoria Link Ltd	Acykliczne inhibitory aminowe fosforylaz i hydrolaz nukleozydowych
CN101600711A (zh) *	2006-12-22	2009-12-09	工业研究有限公司	核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物
WO2009082247A1 (en) *	2007-12-21	2009-07-02	Industrial Research Limited	Process for preparing immucillins having a methylene link
UA103195C2 (uk)	2008-08-11	2013-09-25	Глаксосмитклайн Ллк	Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
WO2010033236A2 (en)	2008-09-22	2010-03-25	Albert Einstein College Of Medicine Of Yeshiva University	Methods and compositions for treating bacterial infections by inhibiting quorum sensing
JP5766687B2 (ja) *	2009-03-24	2015-08-19	バイオクリストファーマスーティカルズ，インコーポレイテッドＢｉｏｃｒｙｓｔＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	７−［（３ｒ，４ｒ）−３−ヒドロキシ−４−ヒドロキシメチル−ピロリジン−１−イルメチル］−３，５−ジヒドロ−ピロロ［３，２−ｄ］ピリミジン−４−オンの有用な医薬塩
EP2454263B1 (en)	2009-07-17	2018-06-13	Albert Einstein College of Medicine, Inc.	3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
WO2012074912A1 (en) *	2010-11-29	2012-06-07	Albert Einstein College Of Medicine Of Yeshiva University	Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
WO2012122532A2 (en) *	2011-03-09	2012-09-13	Biocryst Pharmaceuticals, Inc.	Compositions and methods for treatment of hyperuricemia
PL2734186T3 (pl)	2011-07-22	2019-01-31	Glaxosmithkline Llc	Kompozycja
WO2014025842A1 (en) *	2012-08-07	2014-02-13	Albert Einstein College Of Medicine Of Yeshiva University	Treatment of helicobacter pylori infections
SG11201500787YA (en)	2012-08-24	2015-03-30	Glaxosmithkline Llc	Pyrazolopyrimidine compounds
US9994574B2 (en)	2012-11-12	2018-06-12	Victoria Link Limited	Salt and polymorphic forms of (3R,4S)-L-((4-amino-5H-pyrrolo[3,2,-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(MTDIA)
US9550785B2 (en)	2012-11-20	2017-01-24	Glaxosmithkline Llc	Pyrrolopyrimidines as therapeutic agents for the treatment of diseases
JP6228223B2 (ja)	2012-11-20	2017-11-08	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅＬＬＣ	新規化合物
ES2625023T3 (es)	2012-11-20	2017-07-18	Glaxosmithkline Llc	Compuestos novedosos
US9616129B2 (en)	2013-06-22	2017-04-11	Nitor Therapeutics	Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency
US10118928B2 (en)	2014-02-12	2018-11-06	Albert Einstein College Of Medicine, Inc.	Treatment of H. pylori infections using MTAN inhibitors
EP2913333A1 (en) *	2014-02-27	2015-09-02	Laboratoire Biodim	3H-thieno[3,4]pyrimidin-4-one and pyrrolopyrimidone as gram-positive antibacterial agents
CN108794628A (zh) *	2018-05-28	2018-11-13	广东工业大学	一种抗幽门螺杆菌的卵黄抗体制备方法及应用
GB202110403D0 (en)	2021-07-20	2021-09-01	Laevoroc Immunology	Ulodesine Salt

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HUT61765A (en) *	1989-10-31	1993-03-01	Biocryst Inc	Process for producing purine nucleoside phosphorylase inhibitors and pharmaceutical compositions comprising same as active ingredient
JPH07242668A (ja) *	1994-03-08	1995-09-19	Nippon Kayaku Co Ltd	新規なアゼチジン誘導体
AU695032B2 (en) *	1994-10-05	1998-08-06	Darwin Discovery Limited	Purine and guanine compounds as inhibitors of PNP
ATE245631T1 (de)	1995-03-29	2003-08-15	Taiho Pharmaceutical Co Ltd	Uracilderivate und diese enthaltende antitumoreffekt-verstärker sowie antitumormittel
US6379911B2 (en)	1996-02-23	2002-04-30	Albert Einstein College Of Medicine Of Yeshiva University	Enzyme detection/assay method and substrates
US5985848A (en)	1997-10-14	1999-11-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside metabolism
CA2634299C (en)	1999-04-08	2011-05-31	Industrial Research Limited	Process for preparing inhibitors of nucleoside metabolism
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JP4110347B2 (ja)	1999-11-05	2008-07-02	大鵬薬品工業株式会社	抗ｈｉｖ剤
JP2004507534A (ja)	2000-08-29	2004-03-11	インダストリアル　リサーチ　リミテッド	ヌクレオシド代謝阻害剤
US6458799B1 (en)	2000-08-31	2002-10-01	Biocryst Pharmaceuticals, Inc.	Deazaguanine analog, preparation thereof and use thereof
US7098334B2 (en)	2002-03-25	2006-08-29	Industrial Research Limited	4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
EP1539783B1 (en)	2002-08-21	2011-04-13	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside phosphorylases and nucleosidases
NZ523970A (en) *	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en)	2004-06-04	2007-02-23	Ind Res Ltd	Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
EP1771452A4 (en)	2004-07-27	2009-07-15	Biocryst Pharm Inc	5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND 5'METHYL THIOADENOSINE / S-ADENOSYLHOMOCYSTEIN NUCLEOSIDASE HEMMER
NZ540160A (en)	2005-05-20	2008-03-28	Einstein Coll Med	Inhibitors of nucleoside phosphorylases
AU2006275725A1 (en)	2005-07-27	2007-02-08	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en)	2005-12-15	2008-07-31	Ind Res Ltd	Deazapurine analogs of 1'-aza-l-nucleosides
US20110092521A1 (en)	2006-02-24	2011-04-21	Richard Hubert Furneaux	Methods of Treating Diseases Using Inhibitors of Nucleoside Phosphorylases and Nucleosidases
WO2007097647A1 (en)	2006-02-24	2007-08-30	Albert Einstein College Of Medicine Of Yeshiva University	Methods of treating cancer
PL2057165T3 (pl)	2006-09-07	2011-08-31	Victoria Link Ltd	Acykliczne inhibitory aminowe fosforylaz i hydrolaz nukleozydowych
WO2008030118A1 (en) *	2006-09-07	2008-03-13	Industrial Research Limited	Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
AU2007300624A1 (en) *	2006-09-26	2008-04-03	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of human 5'-methylthioadenosine phosphorylase
CN101600711A (zh) *	2006-12-22	2009-12-09	工业研究有限公司	核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物
WO2009082247A1 (en)	2007-12-21	2009-07-02	Industrial Research Limited	Process for preparing immucillins having a methylene link
WO2010033236A2 (en)	2008-09-22	2010-03-25	Albert Einstein College Of Medicine Of Yeshiva University	Methods and compositions for treating bacterial infections by inhibiting quorum sensing
EP2454263B1 (en)	2009-07-17	2018-06-13	Albert Einstein College of Medicine, Inc.	3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase

2003
- 2003-08-21 EP EP03792904A patent/EP1539783B1/en not_active Expired - Lifetime
- 2003-08-21 WO PCT/NZ2003/000186 patent/WO2004018496A1/en active Application Filing
- 2003-08-21 SI SI200332011T patent/SI1539783T1/sl unknown
- 2003-08-21 KR KR1020057002959A patent/KR101081226B1/ko active IP Right Grant
- 2003-08-21 JP JP2004530687A patent/JP4682314B2/ja not_active Expired - Lifetime
- 2003-08-21 CN CNB038243547A patent/CN100379750C/zh not_active Expired - Lifetime
- 2003-08-21 DK DK03792904.9T patent/DK1539783T3/da active
- 2003-08-21 ES ES03792904T patent/ES2363766T3/es not_active Expired - Lifetime
- 2003-08-21 BR BRPI0313664A patent/BRPI0313664B8/pt active IP Right Grant
- 2003-08-21 CA CA2496698A patent/CA2496698C/en not_active Expired - Lifetime
- 2003-08-21 AU AU2003258911A patent/AU2003258911B2/en not_active Expired
- 2003-08-21 PT PT03792904T patent/PT1539783E/pt unknown
- 2003-08-21 RU RU2005107714/04A patent/RU2330042C2/ru active
- 2003-08-21 DE DE60336734T patent/DE60336734D1/de not_active Expired - Lifetime
- 2003-08-21 AT AT03792904T patent/ATE505474T1/de active
- 2003-08-21 US US10/524,995 patent/US7553839B2/en not_active Expired - Lifetime
2006
- 2006-05-02 HK HK06105174A patent/HK1085219A1/xx not_active IP Right Cessation
2009
- 2009-06-03 US US12/455,537 patent/US8173662B2/en active Active
2011
- 2011-07-12 CY CY20111100673T patent/CY1111700T1/el unknown

Also Published As

Publication number	Publication date
EP1539783A1 (en)	2005-06-15
JP2006501239A (ja)	2006-01-12
KR20050093756A (ko)	2005-09-23
RU2330042C2 (ru)	2008-07-27
RU2005107714A (ru)	2006-01-20
CA2496698C (en)	2012-01-24
US20060160765A1 (en)	2006-07-20
ES2363766T3 (es)	2011-08-16
AU2003258911B2 (en)	2009-11-19
BRPI0313664B8 (pt)	2021-05-25
DK1539783T3 (da)	2011-06-20
EP1539783A4 (en)	2010-05-19
CA2496698A1 (en)	2004-03-04
BRPI0313664B1 (pt)	2021-03-23
CY1111700T1 (el)	2015-10-07
HK1085219A1 (en)	2006-08-18
ATE505474T1 (de)	2011-04-15
PT1539783E (pt)	2011-06-01
JP4682314B2 (ja)	2011-05-11
WO2004018496A1 (en)	2004-03-04
US7553839B2 (en)	2009-06-30
CN100379750C (zh)	2008-04-09
EP1539783B1 (en)	2011-04-13
AU2003258911A1 (en)	2004-03-11
DE60336734D1 (de)	2011-05-26
US20090239885A1 (en)	2009-09-24
KR101081226B1 (ko)	2011-11-07
US8173662B2 (en)	2012-05-08
BR0313664A (pt)	2005-07-12
CN1692120A (zh)	2005-11-02

Publication	Publication Date	Title
HK1085219A1 (en)	2006-08-18	Inhibitors of nucleoside phosphorylases and nucleosidases
EP1881984A4 (en)	2010-03-03	INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES
HK1131612A1 (en)	2010-01-29	Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
MXPA04003668A (es)	2004-07-22	Inhibidores de fosfodiesteresa de tipo 4 y usos de los mismos.
MY132106A (en)	2007-09-28	New pyridazin-3(2h)-one derivatives
ATE245648T1 (de)	2003-08-15	1h-pyrazolo(3,4-d)pyrimidine-4,6-dione als inhibitoren für die vermehrung von t-zellen
HUP0004211A2 (hu)	2001-11-28	PDE-5 inhibitorok alkalmazása tüdõ magas vérnyomás kezelésére szolgáló gyógyszerkészítmények elõállítására
EP1624874A4 (en)	2006-11-22	3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IN THE TREATMENT OR PREVENTION OF DIABETES
IL169897A0 (en)	2007-07-04	Sustituted heterocycles
PL376822A1 (pl)	2006-01-09	Pochodne fenyloalaniny jako inhibitory dipeptydylopeptydazy do leczenia lub zapobiegania cukrzycy
MY144616A (en)	2011-10-14	Substituted dihydroquinazolines
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