SI1527188T1 - Postopek za pripravo povečanih količin pravilnozvitega heterolognega proteina v inkluzijskih telesih - Google Patents

Postopek za pripravo povečanih količin pravilnozvitega heterolognega proteina v inkluzijskih telesih

Info

Publication number
SI1527188T1
SI1527188T1 SI200331784T SI200331784T SI1527188T1 SI 1527188 T1 SI1527188 T1 SI 1527188T1 SI 200331784 T SI200331784 T SI 200331784T SI 200331784 T SI200331784 T SI 200331784T SI 1527188 T1 SI1527188 T1 SI 1527188T1
Authority
SI
Slovenia
Prior art keywords
production
heterologous protein
inclusion bodies
increased amounts
correctly folded
Prior art date
Application number
SI200331784T
Other languages
English (en)
Inventor
MENART@Viktor
GABERC@POREKAR@Vladka
JEVSEVAR@Simona
Original Assignee
LEK@Pharmaceuticals@d@d
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEK@Pharmaceuticals@d@d filed Critical LEK@Pharmaceuticals@d@d
Publication of SI1527188T1 publication Critical patent/SI1527188T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
SI200331784T 2002-07-31 2003-06-11 Postopek za pripravo povečanih količin pravilnozvitega heterolognega proteina v inkluzijskih telesih SI1527188T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200200187A SI21273A (sl) 2002-07-31 2002-07-31 Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
PCT/EP2003/006134 WO2004015124A1 (en) 2002-07-31 2003-06-11 Process for the production of a heterologous protein
EP03783975A EP1527188B1 (en) 2002-07-31 2003-06-11 Process for the production of increased amounts of correctly folded heterologous protein in inclusion bodies

Publications (1)

Publication Number Publication Date
SI1527188T1 true SI1527188T1 (sl) 2010-05-31

Family

ID=31713326

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200200187A SI21273A (sl) 2002-07-31 2002-07-31 Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
SI200331784T SI1527188T1 (sl) 2002-07-31 2003-06-11 Postopek za pripravo povečanih količin pravilnozvitega heterolognega proteina v inkluzijskih telesih

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200200187A SI21273A (sl) 2002-07-31 2002-07-31 Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina

Country Status (9)

Country Link
US (1) US20050283000A1 (sl)
EP (1) EP1527188B1 (sl)
JP (2) JP4703186B2 (sl)
AR (1) AR040719A1 (sl)
AT (1) ATE456665T1 (sl)
AU (1) AU2003250347A1 (sl)
DE (1) DE60331149D1 (sl)
SI (2) SI21273A (sl)
WO (1) WO2004015124A1 (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21639A (sl) * 2003-12-23 2005-06-30 LEK farmacevtska dru�ba d.d. Farmacevtski pripravek, ki vsebuje nemicelarne sulfobetaine
EP1939212A1 (en) * 2006-12-20 2008-07-02 LEK Pharmaceuticals D.D. Organic compounds
WO2008096370A2 (en) * 2007-02-05 2008-08-14 Natco Pharma Limited An efficient and novel purification method of recombinant hg-csf
WO2008133141A1 (ja) * 2007-04-24 2008-11-06 Toyo Boseki Kabushiki Kaisha オスモチン組換えタンパク質およびその製造方法、並びにその利用
RS53404B (en) 2007-08-27 2014-10-31 Ratiopharm Gmbh LIQUID FORMULATION OF G-CSF CONJUGATES
US20090294362A1 (en) * 2008-05-30 2009-12-03 Persson Jonas Par Stationary phase for hydrophilic interaction chromatography
WO2011109556A2 (en) 2010-03-04 2011-09-09 Pfenex Inc. Method for producing soluble recombinant interferon protein without denaturing
WO2011123570A2 (en) 2010-04-01 2011-10-06 Pfenex Inc. Methods for g-csf production in a pseudomonas host cell
JP5836621B2 (ja) 2011-03-31 2015-12-24 株式会社マキタ 動力工具
HUP1200171A1 (hu) 2012-03-19 2013-09-30 Richter Gedeon Nyrt Módszerek polipeptidek elõállítására
HUP1200172A2 (en) * 2012-03-19 2013-10-28 Richter Gedeon Nyrt Methods for refolding g-csf from inclusion bodies
US10065987B2 (en) 2013-02-12 2018-09-04 Bristol-Myers Squibb Company High pH protein refolding methods
EP3744728A1 (en) 2013-02-12 2020-12-02 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
JP2016535770A (ja) * 2013-11-01 2016-11-17 スフェリウム バイオメッド エス．エル． 治療用及び美容用物質を経皮送達するための封入体
CN104152515B (zh) * 2014-08-14 2019-12-31 江苏奥赛康药业有限公司 一种制备重组人粒细胞集落刺激因子的培养基及发酵方法
JP2020080727A (ja) * 2018-11-26 2020-06-04 Ｓｐｉｂｅｒ株式会社 目的タンパク質の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPH0618778B2 (ja) * 1985-10-04 1994-03-16 中外製薬株式会社 白血球減少症治療剤
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
DE4037196A1 (de) * 1990-11-22 1992-05-27 Boehringer Mannheim Gmbh Verfahren zur reaktivierung von denaturiertem protein
AU6028396A (en) * 1995-06-07 1996-12-30 Amgen, Inc. Ob protein compositions and method
US5912327A (en) * 1996-09-30 1999-06-15 Human Genome Sciences, Inc. Method of purifying chemokines from inclusion bodies
JP3535525B2 (ja) * 1996-12-27 2004-06-07 日本たばこ産業株式会社 花器特異的遺伝子およびそのプロモーター配列
US20020052026A1 (en) * 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6677139B1 (en) * 1999-12-23 2004-01-13 Genecor International, Inc. Methods for production of proteins in host cells
US6936437B2 (en) * 2001-02-23 2005-08-30 Lucia Irene Gonzalez-Villasenor Methods and compositions for production of recombinant peptides
SI21102A (sl) * 2001-12-19 2003-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika

Also Published As

Publication number Publication date
SI21273A (sl) 2004-02-29
AU2003250347A1 (en) 2004-02-25
WO2004015124A1 (en) 2004-02-19
US20050283000A1 (en) 2005-12-22
AR040719A1 (es) 2005-04-20
DE60331149D1 (de) 2010-03-18
JP2006502708A (ja) 2006-01-26
EP1527188B1 (en) 2010-01-27
JP2011078421A (ja) 2011-04-21
ATE456665T1 (de) 2010-02-15
JP4703186B2 (ja) 2011-06-15
EP1527188A1 (en) 2005-05-04

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