SI1526856T1 - Farmacevtski sestavek, ki obsega estetrolne derivate za uporabo pri zdravljenju raka - Google Patents
Farmacevtski sestavek, ki obsega estetrolne derivate za uporabo pri zdravljenju rakaInfo
- Publication number
- SI1526856T1 SI1526856T1 SI200331093T SI200331093T SI1526856T1 SI 1526856 T1 SI1526856 T1 SI 1526856T1 SI 200331093 T SI200331093 T SI 200331093T SI 200331093 T SI200331093 T SI 200331093T SI 1526856 T1 SI1526856 T1 SI 1526856T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pharmaceutical composition
- cancer therapy
- estetrol
- derivatives
- estetrol derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02077812 | 2002-07-12 | ||
EP03075435 | 2003-02-14 | ||
PCT/NL2003/000513 WO2004006936A1 (en) | 2002-07-12 | 2003-07-11 | Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy |
EP03764245A EP1526856B1 (en) | 2002-07-12 | 2003-07-11 | Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1526856T1 true SI1526856T1 (sl) | 2008-04-30 |
Family
ID=30116907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200331093T SI1526856T1 (sl) | 2002-07-12 | 2003-07-11 | Farmacevtski sestavek, ki obsega estetrolne derivate za uporabo pri zdravljenju raka |
Country Status (13)
Country | Link |
---|---|
US (2) | US9034854B2 (sl) |
EP (1) | EP1526856B1 (sl) |
CN (1) | CN100374116C (sl) |
AT (1) | ATE382356T1 (sl) |
AU (1) | AU2003253506A1 (sl) |
CA (1) | CA2492287C (sl) |
CY (1) | CY1107906T1 (sl) |
DE (1) | DE60318447T2 (sl) |
DK (1) | DK1526856T3 (sl) |
ES (1) | ES2299730T3 (sl) |
PT (1) | PT1526856E (sl) |
SI (1) | SI1526856T1 (sl) |
WO (1) | WO2004006936A1 (sl) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003253506A1 (en) * | 2002-07-12 | 2004-02-02 | Pantarhei Biosciences B.V. | Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy |
DE102007032468A1 (de) * | 2007-07-10 | 2009-01-15 | Brätter, Christian, Dr. | Transdermale Therapeutische Systeme, welche den Wirkstoff Anastrozol enthalten |
KR101994805B1 (ko) | 2011-06-01 | 2019-07-01 | 에스테트라 에스.피.알.엘. | 에스테트롤 중간체의 제조 방법 |
CN103619867B (zh) | 2011-06-01 | 2015-12-23 | 埃斯特拉公司 | 用于产生雌四醇中间体的方法 |
EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
WO2013034780A2 (en) | 2012-12-20 | 2013-03-14 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol and related compounds |
CA2924255C (en) | 2013-09-18 | 2022-11-22 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol |
MD3310345T2 (ro) * | 2015-06-18 | 2021-07-31 | Estetra Sprl | Comprimată orodispersabilă ce conține estetrol |
NO3106148T3 (sl) | 2015-06-18 | 2018-08-11 | ||
MD3310346T2 (ro) | 2015-06-18 | 2021-06-30 | Estetra Sprl | Comprimată orodispersabilă ce conține estetrol |
EP3701944B1 (en) | 2015-06-18 | 2021-12-08 | Estetra SRL | Orodispersible dosage unit containing an estetrol component |
CA3178291A1 (en) | 2016-08-05 | 2018-04-12 | Estetra Srl | Method for the management of dysmenorrhea and menstrual pain |
TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
ES2919626T3 (es) * | 2018-05-02 | 2022-07-27 | Estetra Sprl | Régimen de tratamiento para el tratamiento de cáncer de mama avanzado positivo para el receptor de estrógenos |
HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3440320A (en) | 1964-06-18 | 1969-04-22 | Mortimer D Sackler | Chelated suppository and method of using same |
US3797494A (en) | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
DE2426779A1 (de) | 1974-05-31 | 1975-12-18 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
DE2336433A1 (de) | 1973-07-13 | 1975-04-03 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
DE2336434A1 (de) | 1973-07-13 | 1975-04-17 | Schering Ag | 1.3-oxygenierte 8 alpha-oestratriene |
US4722941A (en) | 1978-06-07 | 1988-02-02 | Kali-Chemie Pharma Gmbh | Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof |
US4460372A (en) | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
US4573996A (en) | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
US4624665A (en) | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
US4937238A (en) | 1986-03-04 | 1990-06-26 | The Board Of Regents Of The University Of Nebraska | Prevention of mammary carcinoma |
US4762717A (en) | 1986-03-21 | 1988-08-09 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive |
US5223261A (en) | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
US5043331A (en) | 1989-06-15 | 1991-08-27 | Orion-Yhtyma Oy | Treatment of postmenopausal disorders |
US5130137A (en) | 1989-08-09 | 1992-07-14 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use in treating benign ovarian secretory disorders |
JPH04235171A (ja) | 1990-07-26 | 1992-08-24 | Sumitomo Chem Co Ltd | スルホヒドロキサム酸誘導体、その製造法およびそれを有効成分とする除草剤 |
US5063507A (en) | 1990-09-14 | 1991-11-05 | Plains Cotton Cooperative Association | Goods database employing electronic title or documentary-type title |
US5340585A (en) * | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
US5340586A (en) | 1991-04-12 | 1994-08-23 | University Of Southern California | Methods and formulations for use in treating oophorectomized women |
US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
US5468736A (en) | 1993-02-25 | 1995-11-21 | The Medical College Of Hampton Road | Hormone replacement therapy |
US5895783A (en) | 1993-07-16 | 1999-04-20 | Schering Aktiengesellschaft | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor |
NL9301562A (nl) | 1993-09-09 | 1995-04-03 | Saturnus Ag | Preparaat voor substitutietherapie. |
DE4344405C2 (de) | 1993-12-24 | 1995-12-07 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption |
AU2103495A (en) | 1994-08-04 | 1996-03-04 | Biex, Inc. | Method for prediction of premature delivery using estetrol (e4) as an indicator |
DE4429374C1 (de) | 1994-08-12 | 1996-02-01 | Jenapharm Gmbh | Pharmazeutische Präparate zur Kontrazeption/Hormonsubstitution mit biogener Estrogenkomponente |
AU8727798A (en) | 1997-06-20 | 1999-01-04 | Akzo Nobel N.V. | Gonadotropin releasing hormone antagonist |
DE19739916C2 (de) | 1997-09-11 | 2001-09-13 | Hesch Rolf Dieter | Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen |
US6214815B1 (en) | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
DE19917930A1 (de) | 1999-04-15 | 2000-10-19 | Schering Ag | Ent-Steroide als selektiv wirksame Estrogene |
WO2000062753A1 (de) | 1999-04-16 | 2000-10-26 | Jenapharm Gmbh & Co. Kg | Pharmazeutische oder kosmetische zusammensetzungen zur lokalen, intradermalen applikation von hormonen |
AU5137900A (en) | 1999-05-28 | 2000-12-18 | University Of Cincinnati, The | Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use |
WO2001030356A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
US20020012710A1 (en) * | 1999-11-29 | 2002-01-31 | Rimonest Ltd. | Pomegranate products useful in improving health and methods of use thereof |
EP1286664B1 (en) | 2000-05-12 | 2007-07-25 | Oregon Health and Science University | Combination of low dose estrogen and immunotherapeutic agent for treating immune diseases |
US20040192598A1 (en) * | 2000-10-11 | 2004-09-30 | Laura Kragie | Composition and method of alleviating adverse side effects and/or enhancing efficacy of agents that inhibit aromatase |
AU2002240949A1 (en) * | 2001-03-21 | 2002-10-03 | Schering Aktiengesellschaft | Pharmaceutical combined preparations containing aromatase inhibitors and substances having an estrogen effect in addition to the use thereof for producing a medicament for estrogen-replacement-therapy |
US6936599B2 (en) | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
EP1260225A1 (en) | 2001-05-18 | 2002-11-27 | Pantarhei Bioscience B.V. | A pharmaceutical composition for use in hormone replacement therapy |
DK1390040T3 (da) | 2001-05-18 | 2007-04-23 | Pantarhei Bioscience Bv | Farmaceutisk præparat til anvendelse i hormonerstatningsterapi |
US6593321B2 (en) * | 2001-06-11 | 2003-07-15 | Southwest Foundation For Biomedical Research | 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity |
AU2003253506A1 (en) * | 2002-07-12 | 2004-02-02 | Pantarhei Biosciences B.V. | Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy |
PT1556058E (pt) * | 2002-10-23 | 2008-03-20 | Pantarhei Bioscience Bv | Composições farmacêuticas que compreendem derivados do estretol para serem utilizadas no tratamento do cancro |
EP1624878B1 (en) * | 2003-05-22 | 2006-09-27 | Pantarhei Bioscience B.V. | Use of compositions comprising an estrogenic component for the treatment and prevention of musculoskeletal pain |
-
2003
- 2003-07-11 AU AU2003253506A patent/AU2003253506A1/en not_active Abandoned
- 2003-07-11 CA CA2492287A patent/CA2492287C/en not_active Expired - Lifetime
- 2003-07-11 DK DK03764245T patent/DK1526856T3/da active
- 2003-07-11 EP EP03764245A patent/EP1526856B1/en not_active Expired - Lifetime
- 2003-07-11 US US10/521,040 patent/US9034854B2/en active Active
- 2003-07-11 CN CNB038217449A patent/CN100374116C/zh not_active Expired - Lifetime
- 2003-07-11 WO PCT/NL2003/000513 patent/WO2004006936A1/en active IP Right Grant
- 2003-07-11 DE DE60318447T patent/DE60318447T2/de not_active Expired - Lifetime
- 2003-07-11 SI SI200331093T patent/SI1526856T1/sl unknown
- 2003-07-11 AT AT03764245T patent/ATE382356T1/de not_active IP Right Cessation
- 2003-07-11 PT PT03764245T patent/PT1526856E/pt unknown
- 2003-07-11 ES ES03764245T patent/ES2299730T3/es not_active Expired - Lifetime
-
2008
- 2008-03-13 CY CY20081100284T patent/CY1107906T1/el unknown
-
2015
- 2015-01-20 US US14/600,795 patent/US10201611B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
DE60318447D1 (de) | 2008-02-14 |
CA2492287C (en) | 2011-12-13 |
ES2299730T3 (es) | 2008-06-01 |
AU2003253506A1 (en) | 2004-02-02 |
CY1107906T1 (el) | 2013-09-04 |
CA2492287A1 (en) | 2004-01-22 |
WO2004006936A1 (en) | 2004-01-22 |
EP1526856A1 (en) | 2005-05-04 |
DE60318447T2 (de) | 2009-01-02 |
EP1526856B1 (en) | 2008-01-02 |
CN1681513A (zh) | 2005-10-12 |
US10201611B2 (en) | 2019-02-12 |
CN100374116C (zh) | 2008-03-12 |
WO2004006936A8 (en) | 2005-03-03 |
PT1526856E (pt) | 2008-04-11 |
US20150133413A1 (en) | 2015-05-14 |
US9034854B2 (en) | 2015-05-19 |
DK1526856T3 (da) | 2008-03-10 |
US20060063723A1 (en) | 2006-03-23 |
ATE382356T1 (de) | 2008-01-15 |
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