SI1403277T1 - Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril - Google Patents

Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Info

Publication number
SI1403277T1
SI1403277T1 SI200330092T SI200330092T SI1403277T1 SI 1403277 T1 SI1403277 T1 SI 1403277T1 SI 200330092 T SI200330092 T SI 200330092T SI 200330092 T SI200330092 T SI 200330092T SI 1403277 T1 SI1403277 T1 SI 1403277T1
Authority
SI
Slovenia
Prior art keywords
synthesis
perindopril
alanyl
octahydro
indole
Prior art date
Application number
SI200330092T
Other languages
Slovenian (sl)
Inventor
Thiery Dubuffet
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of SI1403277T1 publication Critical patent/SI1403277T1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
SI200330092T 2003-02-28 2003-02-28 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril SI1403277T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290486A EP1403277B1 (en) 2003-02-28 2003-02-28 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Publications (1)

Publication Number Publication Date
SI1403277T1 true SI1403277T1 (en) 2005-12-31

Family

ID=31970534

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200330092T SI1403277T1 (en) 2003-02-28 2003-02-28 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Country Status (19)

Country Link
US (1) US7157485B2 (en)
EP (1) EP1403277B1 (en)
JP (1) JP4279871B2 (en)
CN (1) CN1331883C (en)
AR (1) AR043410A1 (en)
AT (1) ATE305939T1 (en)
AU (1) AU2004218202B2 (en)
DE (1) DE60301774T2 (en)
DK (1) DK1403277T3 (en)
EA (1) EA009062B1 (en)
ES (1) ES2249691T3 (en)
HK (1) HK1086280A1 (en)
MY (1) MY136851A (en)
NZ (1) NZ541423A (en)
PL (1) PL211506B1 (en)
PT (1) PT1403277E (en)
SI (1) SI1403277T1 (en)
WO (1) WO2004078708A2 (en)
ZA (1) ZA200505780B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1403277T1 (en) * 2003-02-28 2005-12-31 Servier Lab Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril
ES2250847T3 (en) * 2003-02-28 2006-04-16 Les Laboratoires Servier NEW ACID SYNTHESIS PROCEDURE (2S, 3AS, 7AS) -PERHYDROINDOL-2-CARBOXYL AND ITS ETERES AND ITS APPLICATION TO PERINDROPIL SYNTHESIS.
EP2200981B1 (en) 2007-10-17 2011-12-07 DSM IP Assets B.V. Novel carbamoylglycine derivatives
WO2009098251A1 (en) * 2008-02-07 2009-08-13 Dsm Ip Assets B.V. NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES
WO2011133651A1 (en) * 2010-04-20 2011-10-27 Chiral Quest , Inc. An enantioselective process for cycloalkenyl b-substituted alanines
CN106657507B (en) * 2015-11-03 2019-07-02 中移（杭州）信息技术有限公司 A kind of acoustic echo removing method and device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
NL1008302C2 (en) * 1998-02-13 1999-08-16 Dsm Nv Process for the preparation of an optically active indoline-2-carboxylic acid or derivative thereof.
US6433153B1 (en) * 1999-09-02 2002-08-13 Lexicon Genetics Incorporated Human calcium dependent proteases and polynucleotides encoding the same
FR2807431B1 (en) * 2000-04-06 2002-07-19 Adir NOVEL PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
FR2827860B1 (en) * 2001-07-24 2004-12-10 Servier Lab NOVEL PROCESS FOR SYNTHESIS OF ACID DERIVATIVES (2S, 3AS, 7AS) -1 - [(S) -ALANYL] -OCTAHYDRO-1H-INDOLE-2-CARBOXYLINE AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL
SI1403277T1 (en) * 2003-02-28 2005-12-31 Servier Lab Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Also Published As

Publication number Publication date
EP1403277A1 (en) 2004-03-31
DK1403277T3 (en) 2005-11-21
ATE305939T1 (en) 2005-10-15
AR043410A1 (en) 2005-07-27
CN1753907A (en) 2006-03-29
PT1403277E (en) 2005-11-30
US20060149082A1 (en) 2006-07-06
WO2004078708A3 (en) 2004-10-14
ZA200505780B (en) 2006-09-27
EA009062B1 (en) 2007-10-26
JP2006519176A (en) 2006-08-24
AU2004218202A1 (en) 2004-09-16
AU2004218202B2 (en) 2009-07-30
EP1403277B1 (en) 2005-10-05
WO2004078708A2 (en) 2004-09-16
CN1331883C (en) 2007-08-15
US7157485B2 (en) 2007-01-02
HK1086280A1 (en) 2006-09-15
PL211506B1 (en) 2012-05-31
JP4279871B2 (en) 2009-06-17
ES2249691T3 (en) 2006-04-01
MY136851A (en) 2008-11-28
DE60301774D1 (en) 2006-02-16
EA200501257A1 (en) 2006-04-28
PL377220A1 (en) 2006-01-23
DE60301774T2 (en) 2006-07-20
NZ541423A (en) 2008-03-28

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