SG90737A1 - A novel crystalline form of 6-hydroxy-3(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo [b] thiophene hydrochloride - Google Patents

A novel crystalline form of 6-hydroxy-3(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo [b] thiophene hydrochloride

Info

Publication number: SG90737A1
Authority: SG; Singapore
Prior art keywords: piperidin; benzo; methoxyphenyl; phenoxy; ethoxy
Prior art date: 1999-07-29

Application number

SG200004287A

Inventor

Kay Bush Julie

Charles Conrad Preston

Gerard Flom Merlyn

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-29

Filing date

2000-07-28

Publication date

2002-08-20

2000-07-28 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2002-08-20 Publication of SG90737A1 publication Critical patent/SG90737A1/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Cell Biology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Cardiology (AREA)
Biotechnology (AREA)
Virology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Developmental Biology & Embryology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)

SG200004287A 1999-07-29 2000-07-28 A novel crystalline form of 6-hydroxy-3(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo [b] thiophene hydrochloride SG90737A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US14618499P	1999-07-29	1999-07-29
US14764299P	1999-08-06	1999-08-06
US14982099P	1999-08-19	1999-08-19

Publications (1)

Publication Number	Publication Date
SG90737A1 true SG90737A1 (en)	2002-08-20

Family

ID=27386367

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200004287A SG90737A1 (en)	1999-07-29	2000-07-28	A novel crystalline form of 6-hydroxy-3(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo [b] thiophene hydrochloride

Country Status (45)

Country	Link
EP (1)	EP1204655B1 (en)
JP (1)	JP2001048880A (en)
KR (1)	KR100733094B1 (en)
CN (1)	CN1138771C (en)
AR (1)	AR029176A1 (en)
AT (2)	ATE251151T1 (en)
AU (2)	AU6335500A (en)
BE (1)	BE1013410A3 (en)
BR (1)	BR0003211A (en)
CA (1)	CA2314685C (en)
CO (1)	CO5180572A1 (en)
CZ (1)	CZ300356B6 (en)
DE (2)	DE60005693T2 (en)
DK (1)	DK176771B1 (en)
EG (1)	EG24196A (en)
ES (1)	ES2208384T3 (en)
FI (1)	FI20001721A (en)
FR (1)	FR2798384B1 (en)
GB (1)	GB2352716A (en)
GR (1)	GR20000100264A (en)
HK (1)	HK1034962A1 (en)
HR (1)	HRP20000502B1 (en)
HU (1)	HUP0003005A2 (en)
ID (1)	ID26679A (en)
IL (1)	IL137552A (en)
IT (1)	IT1318659B1 (en)
LT (1)	LT4789B (en)
LU (1)	LU90616B1 (en)
LV (1)	LV12733B (en)
MD (1)	MD2335G2 (en)
MX (1)	MXPA00007462A (en)
MY (1)	MY120393A (en)
NL (1)	NL1015822C2 (en)
NO (1)	NO325594B1 (en)
NZ (1)	NZ506045A (en)
PE (1)	PE20010383A1 (en)
PL (1)	PL341748A1 (en)
PT (1)	PT102501A (en)
SE (1)	SE0002793L (en)
SG (1)	SG90737A1 (en)
SI (1)	SI20427B (en)
SV (1)	SV2002000134A (en)
TR (1)	TR200002205A2 (en)
TW (1)	TWI271403B (en)
WO (1)	WO2001009115A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7122203B2 (en)	2000-05-08	2006-10-17	Eli Lilly And Company	Stabilized formulations of 6-hydroxy-3-(-4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof
EP1757291A3 (en) *	2000-05-08	2009-07-15	Eli Lilly & Company	Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-YL)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof
AU2005200809B2 (en) *	2000-05-08	2006-05-11	Eli Lilly And Company	Stabilized Formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) Ethoxy]phenoxy)-2-(4-methoxyphenyl) Benzo[b]thiophene and Salts Thereof
CA2408563A1 (en) *	2000-05-08	2001-11-15	Eli Lilly And Company	Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof
EA005116B1 (en) *	2000-10-20	2004-10-28	Эли Лилли Энд Компани	A NOVEL CRYSTALLINE FORM OF 6-HUDROXY-3-(4-[2-PIPERIDIN-1-YL)ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE
AU2002230409A1 (en)	2000-11-27	2002-06-03	Eli Lilly And Company	Process for preparing 3-aryl-benzo(b)thiophenes
DK1773811T3 (en) *	2004-07-22	2010-12-13	Lilly Co Eli	Crystalline variable hydrate of (s) -6- (4- (2 - ((3- (9H-carbazol-4-yloxy) -2-hydroxypropyl) amine) -2-methylpropyl) phenoxy) -3-pyridinecarboxamide hemisuccinate salt
JP2008525439A (en) *	2004-12-23	2008-07-17	ボイジャー・ファーマシューティカル・コーポレーション	Leuprolide acetate and acetylcholinesterase inhibitors or NMDA receptor agonists for the treatment of Alzheimer's disease
EP1853263A1 (en) *	2005-02-11	2007-11-14	Eli Lilly And Company	Compositions and methods for treating dyslipidemia
DE102008057230A1 (en) *	2008-11-11	2010-05-12	Bayer Schering Pharma Aktiengesellschaft	Synergistic pharmaceutical combination with an estrogen receptor antagonist and a progestin
CN113325183B (en) *	2021-06-01	2022-11-15	中国医学科学院北京协和医院	Kit for differential diagnosis of EM/FEM

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5723474A (en) *	1995-02-28	1998-03-03	Eli Lilly And Company	Benzothiophene compounds, intermediates, compositions, and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2163587T3 (en) *	1995-02-28	2002-02-01	Lilly Co Eli	BENZOTIOPHENE COMPOUNDS, INTERMEDIATE PRODUCTS, COMPOSITIONS AND PROCEDURES.
ZA982877B (en) *	1997-04-09	1999-10-04	Lilly Co Eli	Treatment of central nervous system disorders with selective estrogen receptor modulators.
AU6335600A (en) *	1999-07-29	2001-02-19	Eli Lilly And Company	A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride

2000
- 2000-07-17 AT AT00950222T patent/ATE251151T1/en not_active IP Right Cessation
- 2000-07-17 EP EP00950222A patent/EP1204655B1/en not_active Expired - Lifetime
- 2000-07-17 AU AU63355/00A patent/AU6335500A/en not_active Abandoned
- 2000-07-17 ES ES00950222T patent/ES2208384T3/en not_active Expired - Lifetime
- 2000-07-17 WO PCT/US2000/016332 patent/WO2001009115A2/en active IP Right Grant
- 2000-07-17 DE DE60005693T patent/DE60005693T2/en not_active Expired - Fee Related
- 2000-07-18 LV LVP-00-95A patent/LV12733B/en unknown
- 2000-07-24 ID IDP20000630A patent/ID26679A/en unknown
- 2000-07-24 CZ CZ20002717A patent/CZ300356B6/en not_active IP Right Cessation
- 2000-07-25 HR HR20000502A patent/HRP20000502B1/en not_active IP Right Cessation
- 2000-07-26 EG EG20000954A patent/EG24196A/en active
- 2000-07-27 CO CO00056522A patent/CO5180572A1/en not_active Application Discontinuation
- 2000-07-27 IL IL137552A patent/IL137552A/en not_active IP Right Cessation
- 2000-07-27 NL NL1015822A patent/NL1015822C2/en not_active IP Right Cessation
- 2000-07-27 TR TR2000/02205A patent/TR200002205A2/en unknown
- 2000-07-28 FR FR0009972A patent/FR2798384B1/en not_active Expired - Fee Related
- 2000-07-28 IT IT2000MI001758A patent/IT1318659B1/en active
- 2000-07-28 GB GB0018636A patent/GB2352716A/en not_active Withdrawn
- 2000-07-28 GR GR20000100264A patent/GR20000100264A/en not_active IP Right Cessation
- 2000-07-28 NZ NZ506045A patent/NZ506045A/en unknown
- 2000-07-28 MD MDA20000161A patent/MD2335G2/en not_active IP Right Cessation
- 2000-07-28 DE DE10036855A patent/DE10036855A1/en not_active Withdrawn
- 2000-07-28 FI FI20001721A patent/FI20001721A/en not_active Application Discontinuation
- 2000-07-28 BR BR0003211-5A patent/BR0003211A/en not_active Application Discontinuation
- 2000-07-28 SG SG200004287A patent/SG90737A1/en unknown
- 2000-07-28 DK DK200001150A patent/DK176771B1/en not_active IP Right Cessation
- 2000-07-28 MX MXPA00007462A patent/MXPA00007462A/en active IP Right Grant
- 2000-07-28 AU AU48911/00A patent/AU779559B2/en not_active Ceased
- 2000-07-28 BE BE2000/0477A patent/BE1013410A3/en not_active IP Right Cessation
- 2000-07-28 HU HU0003005A patent/HUP0003005A2/en unknown
- 2000-07-28 SI SI200000173A patent/SI20427B/en not_active IP Right Cessation
- 2000-07-28 AR ARP000103929A patent/AR029176A1/en not_active Application Discontinuation
- 2000-07-28 TW TW089115152A patent/TWI271403B/en not_active IP Right Cessation
- 2000-07-28 JP JP2000228949A patent/JP2001048880A/en active Pending
- 2000-07-28 CN CNB001222406A patent/CN1138771C/en not_active Expired - Fee Related
- 2000-07-28 NO NO20003876A patent/NO325594B1/en not_active IP Right Cessation
- 2000-07-28 CA CA002314685A patent/CA2314685C/en not_active Expired - Fee Related
- 2000-07-28 LT LT2000075A patent/LT4789B/en not_active IP Right Cessation
- 2000-07-28 SV SV2000000134A patent/SV2002000134A/en unknown
- 2000-07-28 PT PT102501A patent/PT102501A/en not_active IP Right Cessation
- 2000-07-28 LU LU90616A patent/LU90616B1/en active
- 2000-07-28 MY MYPI20003448A patent/MY120393A/en unknown
- 2000-07-28 SE SE0002793A patent/SE0002793L/en unknown
- 2000-07-28 KR KR1020000043586A patent/KR100733094B1/en not_active IP Right Cessation
- 2000-07-28 AT AT0132300A patent/AT502317A1/en not_active Application Discontinuation
- 2000-07-28 PL PL00341748A patent/PL341748A1/en not_active Application Discontinuation
- 2000-07-31 PE PE2000000758A patent/PE20010383A1/en not_active Application Discontinuation
2001
- 2001-08-08 HK HK01105511A patent/HK1034962A1/en not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5723474A (en) *	1995-02-28	1998-03-03	Eli Lilly And Company	Benzothiophene compounds, intermediates, compositions, and methods

Also Published As

Publication number	Publication date
FR2798384B1 (en)	2004-09-24
PT102501A (en)	2001-01-31
WO2001009115A3 (en)	2001-08-16
AT502317A1 (en)	2007-02-15
CA2314685A1 (en)	2001-01-29
FI20001721A (en)	2001-01-30
LU90616B1 (en)	2007-06-08
DK176771B1 (en)	2009-08-03
ES2208384T3 (en)	2004-06-16
CN1138771C (en)	2004-02-18
SE0002793L (en)	2001-01-30
DE60005693T2 (en)	2004-07-29
SI20427B (en)	2009-04-30
CZ300356B6 (en)	2009-04-29
NO325594B1 (en)	2008-06-23
NL1015822A1 (en)	2001-01-30
SV2002000134A (en)	2002-06-07
IT1318659B1 (en)	2003-08-27
ID26679A (en)	2001-02-01
HU0003005D0 (en)	2000-10-28
DK200001150A (en)	2001-01-30
IL137552A0 (en)	2001-07-24
WO2001009115A2 (en)	2001-02-08
HK1034962A1 (en)	2001-11-09
ITMI20001758A0 (en)	2000-07-28
SI20427A (en)	2001-06-30
ATE251151T1 (en)	2003-10-15
EP1204655B1 (en)	2003-10-01
MD2335F2 (en)	2003-12-31
LV12733A (en)	2001-10-20
JP2001048880A (en)	2001-02-20
AU6335500A (en)	2001-02-19
NO20003876D0 (en)	2000-07-28
CA2314685C (en)	2009-10-20
HUP0003005A2 (en)	2002-04-29
BR0003211A (en)	2001-03-13
PL341748A1 (en)	2001-02-12
FI20001721A0 (en)	2000-07-28
IE20000604A1 (en)	2001-04-04
FR2798384A1 (en)	2001-03-16
DE60005693D1 (en)	2003-11-06
AU779559B2 (en)	2005-01-27
EG24196A (en)	2008-10-14
AU4891100A (en)	2001-02-01
MXPA00007462A (en)	2002-06-04
SE0002793D0 (en)	2000-07-28
NO20003876L (en)	2001-01-30
CN1283622A (en)	2001-02-14
GB2352716A (en)	2001-02-07
GR20000100264A (en)	2001-03-30
CO5180572A1 (en)	2002-07-30
MD20000161A (en)	2001-04-30
AR029176A1 (en)	2003-06-18
ITMI20001758A1 (en)	2002-01-28
MD2335G2 (en)	2004-06-30
KR100733094B1 (en)	2007-06-27
PE20010383A1 (en)	2001-04-05
TR200002205A2 (en)	2001-03-21
LT2000075A (en)	2001-02-26
NZ506045A (en)	2002-02-01
EP1204655A2 (en)	2002-05-15
MY120393A (en)	2005-10-31
LV12733B (en)	2002-02-20
HRP20000502B1 (en)	2008-04-30
TWI271403B (en)	2007-01-21
LT4789B (en)	2001-05-25
KR20010049911A (en)	2001-06-15
DE10036855A1 (en)	2001-03-22
GB0018636D0 (en)	2000-09-13
HRP20000502A2 (en)	2001-06-30
IL137552A (en)	2009-06-15
BE1013410A3 (en)	2001-12-04
NL1015822C2 (en)	2004-08-04
CZ20002717A3 (en)	2001-05-16

Publication	Publication Date	Title
SG90737A1 (en)	2002-08-20	A novel crystalline form of 6-hydroxy-3(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo [b] thiophene hydrochloride
IL137553A0 (en)	2001-07-24	A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3-(4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE
IL155487A0 (en)	2003-11-23	A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3-(4-[2- (PIPERIDIN-1-YL) ETHOXY] PHENOXY)-2-(4-METHOXYPHENYL) BENZO[b]THIOPHENE HYDROCHLORIDE
CY2344B1 (en)	2004-06-04	A novel crystalline form of 6-hydroxy-3-(4-(2-(piperidin-1-yl) ethoxy) phenoxy)-2-(4-methoxyphenyl) benzo (b) thiphene hydrochloride.
ZA200003838B (en)	2002-01-28	A novel chrystalline form of 6-hydroxy-3-(4-[2-)piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride.
HUP0302190A3 (en)	2009-03-30	Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof
TJ20000620A (en)	2002-07-01	A novel crystalline form of 6-hydroxy-3-(4-Ä2-(piperidin-1-yl) ethoxy Ü phenoxy) - 2 - (4-methanoxyphenyl) benzo ÄbÜ thiophene hidrochloride
TJ398B (en)	2004-12-29	A novel crystalline form of 6-hydroxy -3-(4-Ä2-(piperidin-1-yl) ethoxyÜ-phenoxy) -2-(4-methoxyphenyl) benzo ÄbÜ thiophene hydrochloride.