SG182136A1 - Formulation and chemical composition of a high efficacy disinfectant against avian influenza h5n1 virus. - Google Patents
Formulation and chemical composition of a high efficacy disinfectant against avian influenza h5n1 virus. Download PDFInfo
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- SG182136A1 SG182136A1 SG2012028106A SG2012028106A SG182136A1 SG 182136 A1 SG182136 A1 SG 182136A1 SG 2012028106 A SG2012028106 A SG 2012028106A SG 2012028106 A SG2012028106 A SG 2012028106A SG 182136 A1 SG182136 A1 SG 182136A1
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- Singapore
- Prior art keywords
- formulation
- virus
- chemical composition
- efficacy against
- highly pathogenic
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- 239000000203 mixture Substances 0.000 title claims abstract description 69
- 239000000126 substance Substances 0.000 title claims abstract description 33
- 238000009472 formulation Methods 0.000 title claims abstract description 31
- 241000700605 Viruses Species 0.000 title claims description 25
- 239000000645 desinfectant Substances 0.000 title abstract description 24
- 208000002979 Influenza in Birds Diseases 0.000 title abstract description 13
- 206010064097 avian influenza Diseases 0.000 title abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 230000001717 pathogenic effect Effects 0.000 claims description 22
- 235000019441 ethanol Nutrition 0.000 claims description 19
- 101000823955 Homo sapiens Serine palmitoyltransferase 1 Proteins 0.000 claims description 11
- 102100022068 Serine palmitoyltransferase 1 Human genes 0.000 claims description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000000341 volatile oil Substances 0.000 claims description 9
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 7
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 5
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 5
- 235000001050 hortel pimenta Nutrition 0.000 claims description 5
- 244000246386 Mentha pulegium Species 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 230000002195 synergetic effect Effects 0.000 claims description 4
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 3
- 235000014435 Mentha Nutrition 0.000 claims description 2
- 241001072983 Mentha Species 0.000 claims description 2
- 241000305182 Peperita Species 0.000 claims description 2
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims 8
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
- IEORSVTYLWZQJQ-UHFFFAOYSA-N 2-(2-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=CC=C1OCCO IEORSVTYLWZQJQ-UHFFFAOYSA-N 0.000 claims 1
- 241001479543 Mentha x piperita Species 0.000 claims 1
- 150000003868 ammonium compounds Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229920000847 nonoxynol Polymers 0.000 claims 1
- 241000271566 Aves Species 0.000 description 14
- 241000282412 Homo Species 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 244000144977 poultry Species 0.000 description 5
- 235000013594 poultry meat Nutrition 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- 241000712461 unidentified influenza virus Species 0.000 description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
- 230000029142 excretion Effects 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 241000272517 Anseriformes Species 0.000 description 3
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- 239000003814 drug Substances 0.000 description 3
- 210000002257 embryonic structure Anatomy 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 210000001161 mammalian embryo Anatomy 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 2
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 2
- 241000286209 Phasianidae Species 0.000 description 2
- 235000019270 ammonium chloride Nutrition 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
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- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
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- 241000712431 Influenza A virus Species 0.000 description 1
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- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- ZWRUINPWMLAQRD-UHFFFAOYSA-N n-Nonyl alcohol Natural products CCCCCCCCCO ZWRUINPWMLAQRD-UHFFFAOYSA-N 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Formulation and Chemical Composition of a High Efficacy Disinfectant against Avian Influenza H5N1 Virus.AbstractThe invention relates to the formulation and chemical composition of a disinfectant cleaner with 100% killing efficacy against avian influenza H5N1 Virus. Figure:
Description
So ___ sis0150%
SS Title _ *Go000I* . Formulation and Chemical Composition of a High Efficacy Disinfectant against
Avian Influenza H5N1 Virus.
Description oo This invention relates to the formulation and chemical composition of a fast acting disinfectant cleaner that has a 100% killing efficacy against the highly pathogenic H5N1 Virus by specifically and synergistically blending alcohol with twin-chain quaternary ammonium compound, essential oil, non-ionic surfactant, : and solvent.
The use of synergistic combination of twin-chain quaternary ammonium compound, ethyl alcohol or methyl alcohol, non-ionic surfactant, essential oil and oo water as a fast acting disinfectant cleaner to combat the current high lethality and virulence H5N1 Virus has been an area of considerable research and investigation of the patentee.
The patentee has discovered the formulation and chemical composition of a fast ) i. acting disinfectant that has 100% killing efficacy against the virulent H5N1 virus oo by synergistically formulating and combining twin-chain quaternary ammonium, alcohol, non-ionic surfactant, essential oil, and water.
The invention includes the use of anti-viral agent using Dideycl Methyl
Ammonium Chloride, Ethyl Alcohol or Methyl Alcohol as a synergistic anti-viral and antimicrobial agent, Nonyl Phenol or Alcohol Ehtoxylate as the cleaning and emulsifying agent, peppermint essential oil to further enhance the synergistic effect of the anti-viral properties, water as a carrier and to enhance the solubility a of above said chemicals.
Co Avian influenza is an infection caused by avian (bird) influenza (flu) viruses.
Co These influenza viruses occur naturally among birds. Wild birds worldwide carry the viruses in their intestines, but usually do not get sick from them. However, avian influenza is very contagious among birds and can make some © ~ domesticated birds, including chickens, ducks, and turkeys, very sick and kill - ~ them.
: Infected birds shed influenza virus in their saliva, nasal secretions, and feces. . Susceptible birds become infected when they have contact with contaminated secretions or excretions or with surfaces that are contaminated with secretions or . excretions from infected birds. Domesticated birds may become infected with : avian influenza virus through direct contact with infected waterfowl or other infected poultry, or through contact with surfaces (such as dirt or cages) or materials (such as water or feed) that have been contaminated with the virus. - Usually, “avian influenza virus” refers to influenza A viruses found chiefly in birds, : but infections with these viruses can occur in humans. The risk from avian influenza is generally low to most people, because the viruses do not usuaily : infect humans. However, confirmed cases of human infection from several subtypes of avian influenza infection have been reported since 1997. Most cases of avian influenza infection in humans have resulted from contact with infected poultry (e.g., domesticated chicken, ducks, and turkeys) or surfaces : : contaminated with secretion/excretions from infected birds.
During an outbreak of avian influenza among poultry, there is a possible risk to people who have contact with infected birds or surfaces that have been : : contaminated with secretions or excretions from infected birds.
Of the human cases associated with the ongoing H5N1 outbreaks in poultry and wild birds in Asia and parts of Europe, the Near East and Africa, more than half of those people reported infected with the virus have died. Most cases have : occurred in previously healthy children and young adults and have resulted from
So direct or close contact with H5N1-infected poultry or HSN1-contaminated surfaces. In general, HSN1 remains a very rare disease in people. The H5N1 - virus does not infect humans easily, and if a person is infected, it is very difficult for the virus to spread to another person. oo ~ Nonetheless, because all influenza viruses have the ability to change, scientists are concerned that H5N1 virus one day could be able to infect humans and spread easily from one person to another. Because these viruses do not
Co commonly infect humans, there is little or no immune protection against them in the human population. If HSN1 virus were to gain the capacity to spread easily : from person to person, an influenza pandemic (worldwide outbreak of disease) could begin
No one can predict when a pandemic might occur. However, experts from around : the world are watching the H5N1 situation in Asia and Europe very closely and are preparing for the possibility that the virus may begin to spread more easily : and widely from person to person.
Due to the high lethality and virulence of H5N1 Virus, its endemic presence, its increasingly large host reservoir, and its significant ongoing mutations, the H5N1 virus is the world's largest current pandemic threat. The world is teetering on the x edge of a pandemic that could kill a large fraction of the human population. in view of the above, the patentee has invented a highly effective disinfectant to .. protect those who are exposed to the pathogenic H5NI virus through direct or oo direct contact with the said virus. i : SUMMARY OF THE INVENTION
Se Patentee has discovered the formulation and chemical composition of a fast oo acting disinfectant cleaner that has 100% killing efficacy against HSN1 Virus by synergistically blending alcohol, twin-chain quaternary ammonium compound, essential oil and non-ionic surfactant with water.
In an embodiment of the invention, the ethyl alcohol (Co,HsOH) is used as it is a less toxic than methyl alcohol and as a co-disinfectant in the said formulation and chemical composition.
In another embodiment of the invention Didecyl Dimethyl Ammonium Chloride is used as the main disinfecting agent against HSN 1 in the said formulation and chemical composition because of its high potency properties against H5N1 virus. a In yet another embodiment of the invention Alcohol Ethoxyiate non-ionic surfactant is used as a cleaning agent in said formulation and chemical
SL composition because of its lower toxicity properties than Nonyl Phenol.
In yet another embodiment of the invention the peppermint essential oil used is } a Mentha Peperita as a synergistic co-disinfectant in the said formulation and chemical composition because of its excellent compatibility with Didecyl Dimethyl oo Ammonium Chloride and its good residual anti-microbial activity. ) In yet another embodiment of the invention water is used a co-carrier of the synergistically blended chemical raw materials.
The foregoing embodiments are susceptible to considerable variation in its oo practice. : Accordingly, the embodiments are not intended to be limited to the specific exemplifications set forth hereinabove. Rather, the foregoing embodiments are not within the spirit and scope of the appended claims, including the equivalents
Co thereof available as matter of law.
INVENTION. } In accordance with this discovery, it is an object of the invention to provide the test procedures to ascertain the disinfectant efficacy of said invention against
I Avian Influenza HSN1 Virus. : A The method and test procedures are herein described. 1.0 Purpose : The purpose of the test is to ascertain the efficacy of said invention/disinfectant against Avian Influenza H5N1 virus. - 1.1 Observation Parameter
The test parameter is based on the observation of the percentage of death virus : after the introduction of said invention/disinfectant. 2.0 Test Method } Using Isolated Al H5N1 virus from Tasikmalaya 2005, collected from : oo Microbiology Department of Faculty of Veterinary, Bogor Institute of oo - Agriculture (IPB). The test was done in the unit of the Integrated Services of
Medicine of Microbiology, Faculty of Veterinary IPB. Five live egg embryos ~~ Specific Pathogen Free (SPF) were used as medium for the test.
Co ‘2.1 Test Procedure - - ~ Three components were used; Al H5N1 Virus, Live Egg Embryos and said : disinfectant 100% concentration. : The preparation of the disinfectant solution was done by diluting 1 part of said : disinfectant to 1 part distilled water by weight.
Subsequently, 2 ml of Al H5N1 Virus (10 ° EID sp) was introduced in to the said
Co disinfectant solution and then the mixture was incubated for 15 minutes at : 37°C. : 0.2 ml of said mixture was then injected into 11 days old live embryo via allantois and kept in the incubator at 37°C, observation was then carried out daily till the death of embryo. : . The liquid of the allantois was taken out for rapid test, HA/HI using Al standard ~ serum. .
Co 3.0 Results a Based on observation all the embryos died two days after the introduction of the oo mixture of said disinfectant and H5NI Virus. The liquid from the allantois of the
Lo death embryo was then taken for rapid test HA/HI using Al standard serum. The results as tabulated below: oo Table1. The Efficacy Result of said invention/disinfectant against Al H5NI
Virus
Concentration | Dilution | Percentage of Inactive Virus Al H5N1 (% . Based on Table 1, the said invention/disinfectant has the ability to inactivate ~~ 100% of Al H5NI virus. oo 4.0 Conclusion
Based on the said efficacy test, the said invention/disinfectant is highly effective } against Avian Influenza H5N1 Virus. - 50. Reference
Co Adams, R.H. 1995. Veterinary Pharmacology and Therapeutics. 7" Ed. lowa
State University Press/ Ames, lowa. oo | Boot, N.H. 1988. Veterinary Pharmacology and Therapeutics.lowa University : Press Ames. lowa.USA
Clarke, M.L.Harvey,D.G and Humphrys, D.J. 1981. Veterinary Toxicology. 2"
Lo ED. English Language Book Society and Bailliere Tindal.Longdon.
Brander, G.C. Pugh, D.M. Bywater, R.J and Jenkins,W.L. 1991. Drug and
Therapeutics. 6” Ed. Bailliere Tindal, London.
Lo Katzung, B.G 1992. Basic and Clinical Pharmacology. 5" Ed. Appleton & Lange oo Norwalk, Connecticut.
Bh Tjay, T.H. Raharja, K.2000. Obat-Obat Pentin1g. Depkes R.l. Gramedia.Jakarta. oo 5
Claims (1)
- CT Claims: What is claimed is:: . 1) The formulation and chemical composition for 100% killing efficacy against E highly pathogenic HSN1 comprising all of the synergistic following chemicals: : Alcohol, Quaternary Ammonium Compound, Essential Oil, Non-lonic Surfactant oo and Water. 2) The formulation and chemical composition for 100% killing efficacy against highly pathogenic H5N1 Virus as in claim 1 wherein the Alcohol used is either Methyl or Ethyl Alcohol. - 3) The formulation chemical composition for 100% killing efficacy against highly pathogenic H5N1 Virus as in claim 1 wherein the Quaternary Ammonium . Compound is a Twin Chain Quaternary Ammonium Compound. BN 4) The formulation and chemical composition for 100% killing efficacy against : : highly pathogenic H5N1 Virus as in claim 3 wherein the Twin-Chain Quaternary Co Ammonium Compound consists of Didecyl Dimethyl Ammonium Chloride. ER 5) The formulation and chemical composition for 100% killing efficacy against : highly pathogenic H5N1 Virus as in claim 1 wherein the Essential Qil is Peppermint. oo 6) The formulation and chemical composition for 100% killing efficacy against highly pathogenic H5N1 Virus as in claim 1 wherein the Non lonic Surfactant used is either Alcohol Ethoxylate or Nonyl Phenol Ethoxylate. Co 7) The formulation and chemical composition for 100% killing efficacy against oo highly pathogenic HSN1 as in claim 6 wherein the said surfactants consist of either 9 or 10 moles of ethylene oxide. 8) The formulation and chemical composition for 100% killing efficacy against highly pathogenic H5N1 as in claim 7 wherein said surfactant used is Secondary ~~ + Alcohol Ethoxylates. Cr 9) The formulation and chemical composition for 100% killing efficacy against oo highly pathogenic H5N1 virus as in claim 8 wherein the Alcohol Ethoxylate : surfactant consists of 10 moles of ethylene oxide. oo 10) The formulation and chemical composition for 100% killing efficacy against Co highly pathogenic H5N1 virus as in claim 9 wherein the content of said surfactant ranges from 0.5 to 5 wt %. a 611) The formulation and chemical composition for 100% killing efficacy against highly pathogenic H5N1 virus as in claim 1 wherein the solvent used is water. : 12) The formulation and chemical composition for 100% killing efficacy against : highly pathogenic H5N1 virus as in claim 11 wherein the water content ranges from 1% to 60 % wt/wt oo 13) The formulation and chemical composition for 100% Killing efficacy against SE highly pathogenic H5N1 virus as in claim 2 wherein the alcohol is ethyl alcohol. 14) The formulation and chemical composition for 100% killing efficacy against highly pathogenic HSN1 as in claim 13 wherein the composition content of said alcohol ranges from 10 % to 90 % wt/wt. 15) The formulation and chemical composition for 100% killing efficacy against highly pathogenic HSN1 virus as in claim 4 wherein the composition content of ; Didecyl Dimetyl Ammonium Chloride ranges from 0.5% to 10% wt/wt. 17) The formulation and chemical composition for 100% killing efficacy against highly pathogenic HSN1 virus as in claim 5 wherein the botanical name of the peppermint used is Mentha Peperita. 18) The formulation and chemical composition for 100% killing efficacy against ~ highly pathogenic HSN1 virus as in claim 17 wherein the content composition of peppermint ranges from 0.1% to 5 % wt/wt. 19) The formulation and chemical composition for 100% killing efficacy against C highly pathogenic H5SN1 virus wherein the. composition prepared in accordance Nn with claim 1, comprising: a) 10- 90 wt % of Ethyl Alcohol ~ b) 0.5- 10 wt % of Quaternary Ammonium Compound Co c) 0.1- 5 wt % of Essential Oil d) 0.5- 5 wt % Non-lonic Surfactant e) 1- 60 wt % Solvent20) The formulation and chemical composition for 100% killing efficacy against Bh : highly pathogenic HSN1 wherein the formulation and composition prepared in B accordance with claim 19, comprising of: - a) 60 wt % of Ethyl Alcohol b) 1.5 wt % of Quaternary Ammonium Compound oo c) 3 Wt% of Essential Oil - d) 3 wt % of Non-lonic Surfactant© .- e) 32.5wt% of solvent
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG2012028106A SG182136A1 (en) | 2008-03-31 | 2008-03-31 | Formulation and chemical composition of a high efficacy disinfectant against avian influenza h5n1 virus. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG2012028106A SG182136A1 (en) | 2008-03-31 | 2008-03-31 | Formulation and chemical composition of a high efficacy disinfectant against avian influenza h5n1 virus. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG182136A1 true SG182136A1 (en) | 2012-07-30 |
Family
ID=46964839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012028106A SG182136A1 (en) | 2008-03-31 | 2008-03-31 | Formulation and chemical composition of a high efficacy disinfectant against avian influenza h5n1 virus. |
Country Status (1)
| Country | Link |
|---|---|
| SG (1) | SG182136A1 (en) |
-
2008
- 2008-03-31 SG SG2012028106A patent/SG182136A1/en unknown
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