SG11202110667PA - Method of sialylating a protein - Google Patents

Method of sialylating a protein

Info

Publication number
SG11202110667PA
SG11202110667PA SG11202110667PA SG11202110667PA SG11202110667PA SG 11202110667P A SG11202110667P A SG 11202110667PA SG 11202110667P A SG11202110667P A SG 11202110667PA SG 11202110667P A SG11202110667P A SG 11202110667PA SG 11202110667P A SG11202110667P A SG 11202110667PA
Authority
SG
Singapore
Prior art keywords
sialylating
protein
Prior art date
Application number
SG11202110667PA
Inventor
Sern Farh Matthew Choo
Terry Nguyen-Khuong
Edward George Pallister
Say Kong Ng
Sabine Lahja Flitsch
Original Assignee
Agency Science Tech & Res
Univ Manchester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res, Univ Manchester filed Critical Agency Science Tech & Res
Publication of SG11202110667PA publication Critical patent/SG11202110667PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121Serpins
    • C07K14/8125Alpha-1-antitrypsin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/99Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99001Beta-galactoside alpha-2,6-sialyltransferase (2.4.99.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/99Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99004Beta-galactoside alpha-2,3-sialyltransferase (2.4.99.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1081Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
SG11202110667PA 2019-03-29 2020-03-23 Method of sialylating a protein SG11202110667PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201902822V 2019-03-29
PCT/SG2020/050154 WO2020204814A1 (en) 2019-03-29 2020-03-23 Method of sialylating a protein

Publications (1)

Publication Number Publication Date
SG11202110667PA true SG11202110667PA (en) 2021-10-28

Family

ID=72667479

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202110667PA SG11202110667PA (en) 2019-03-29 2020-03-23 Method of sialylating a protein

Country Status (5)

Country Link
US (1) US20220251619A1 (en)
EP (1) EP3947707A4 (en)
CN (1) CN113785071A (en)
SG (1) SG11202110667PA (en)
WO (1) WO2020204814A1 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69823046T2 (en) * 1997-01-16 2005-03-31 Neose Technologies, Inc. PRACTICAL IN VITRO SIALYLATION OF RECOMBINANT GLYCLE PROTEINS
JP4003093B2 (en) * 1997-07-29 2007-11-07 東洋紡績株式会社 Method for producing saccharides
BR112015019348A2 (en) * 2013-02-13 2017-08-22 Lab Francais Du Fractionnement METHODS FOR PRODUCING GLYCOSYLATION MODIFIED AND SIALYLATION ENHANCED PROTEIN, TO ENHANCE SIALYL TRANSFERASE ACTIVITY IN THE MAMMARY GLAND AND TO PRODUCE SIALYL TRANSFERASE, GLYCOSYLATION MODIFIED PROTEIN OR SIALYLATION ENHANCED PROTEIN, COMPOSITION, SIALYL TRANSFERASE, MAMMALIAN, AND TRANSGENE MAMMARY EPITHELIAL
CN105324487B (en) * 2013-05-29 2020-01-17 豪夫迈·罗氏有限公司 Quantitative control of sialylation
WO2015001033A1 (en) * 2013-07-05 2015-01-08 F. Hoffmann-La Roche Ag Process for the mono- and bi-sialylation of glycoproteins employing n-terminally truncated beta-galactoside alpha-2,6-sialyltransferase mutants
EP3382014A1 (en) * 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation

Also Published As

Publication number Publication date
CN113785071A (en) 2021-12-10
US20220251619A1 (en) 2022-08-11
EP3947707A4 (en) 2023-01-11
WO2020204814A1 (en) 2020-10-08
EP3947707A1 (en) 2022-02-09

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