SG11202109837SA - Compositions and methods for modulating complement activity - Google Patents
Compositions and methods for modulating complement activityInfo
- Publication number
- SG11202109837SA SG11202109837SA SG11202109837SA SG11202109837SA SG 11202109837S A SG11202109837S A SG 11202109837SA SG 11202109837S A SG11202109837S A SG 11202109837SA SG 11202109837S A SG11202109837S A SG 11202109837SA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- methods
- complement activity
- modulating complement
- modulating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962837978P | 2019-04-24 | 2019-04-24 | |
US201962947188P | 2019-12-12 | 2019-12-12 | |
US201962947183P | 2019-12-12 | 2019-12-12 | |
PCT/US2020/029733 WO2020219822A1 (en) | 2019-04-24 | 2020-04-24 | Compositions and methods for modulating complement activity |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202109837SA true SG11202109837SA (en) | 2021-10-28 |
Family
ID=70977557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202109837S SG11202109837SA (en) | 2019-04-24 | 2020-04-24 | Compositions and methods for modulating complement activity |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220211799A1 (zh) |
EP (1) | EP3958842A1 (zh) |
JP (1) | JP2022530042A (zh) |
KR (1) | KR20220004039A (zh) |
CN (1) | CN113710230A (zh) |
AU (1) | AU2020261059A1 (zh) |
BR (1) | BR112021017820A2 (zh) |
CA (1) | CA3137895A1 (zh) |
IL (1) | IL287079A (zh) |
MX (1) | MX2021013010A (zh) |
SG (1) | SG11202109837SA (zh) |
TW (1) | TW202106290A (zh) |
WO (1) | WO2020219822A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP20211561T8 (hr) | 2014-06-12 | 2022-03-04 | Ra Pharmaceuticals, Inc. | Modulacija aktivnosti komplementa |
PT3250230T (pt) | 2015-01-28 | 2021-12-07 | Ra Pharmaceuticals Inc | Moduladores da atividade do complemento |
WO2017105939A1 (en) | 2015-12-16 | 2017-06-22 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
BR112019011053A2 (pt) | 2016-12-07 | 2019-10-15 | Ra Pharmaceuticals Inc | moduladores da atividade do complemento |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1705100A (en) | 1998-10-09 | 2000-05-01 | Musc Foundation For Research Development | Blocking factor b to treat complement-mediated immune disease |
ES2522525T3 (es) | 2003-05-15 | 2014-11-14 | Genentech, Inc. | Métodos y composiciones para la prevención y el tratamiento de la sepsis |
CN1289066C (zh) * | 2003-09-18 | 2006-12-13 | 中国人民解放军第二军医大学 | 胰高血糖素样肽-1缓释微球制剂及其用途 |
CA2610502A1 (en) | 2005-03-29 | 2006-10-05 | Cardax Pharmaceuticals, Inc. | Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof |
CN101227924A (zh) | 2005-05-26 | 2008-07-23 | 科罗拉多大学评议会 | 用于治疗外伤性脑损伤、脊髓损伤及相关病症的补体旁路抑制 |
JP2009514888A (ja) | 2005-11-04 | 2009-04-09 | ジェネンテック・インコーポレーテッド | 眼疾患を処置するための補体経路の阻害剤の使用 |
HUE026042T2 (en) | 2006-10-10 | 2016-05-30 | Regenesance B V | Complement inhibition for improved nerve regeneration |
US7736860B2 (en) | 2006-11-09 | 2010-06-15 | Univeristy Of Massachusetts | Methods of identifying compounds for the treatment of sterile inflammation |
US20100015139A1 (en) | 2008-07-10 | 2010-01-21 | Rekha Bansal | METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH FACTOR Ba SPECIFIC ANTIBODIES AND USE THEREOF |
BRPI0811007A2 (pt) | 2007-04-30 | 2015-01-27 | Alcon Res Ltd | Tratamento de degeneração macular relacionada à idade usando inibidores de fator de complemento d |
BRPI0812767A2 (pt) | 2007-06-07 | 2014-12-02 | Genentech Inc | Anticorpos para c3b e métodos para prevenção e tratamento de distúrbios associados ao complemento |
US20110142837A1 (en) | 2007-07-20 | 2011-06-16 | Trustees Of The University Of Pennsylvania | Method Of Treating Acute Respiratory Distress Syndrome |
US20110172126A1 (en) | 2008-09-03 | 2011-07-14 | Xenome Ltd | Libraries of peptide conjugates and methods for making them |
US20100086596A1 (en) * | 2008-10-06 | 2010-04-08 | Oakwood Laboratories LLC | Microspheres for releasing an octreotide compound without an initial time lag |
KR20110094029A (ko) | 2008-11-10 | 2011-08-19 | 알렉시온 파마슈티칼스, 인코포레이티드 | 보체-관련된 장애를 치료하는 방법 및 조성물 |
CA2971474C (en) | 2009-10-16 | 2022-11-22 | Omeros Corporation | Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation |
US9358266B2 (en) | 2010-02-25 | 2016-06-07 | The Trustees Of The University Of Pennsylvania | Treatment of sepsis using complement inhibitors |
EP2563359A1 (en) | 2010-04-30 | 2013-03-06 | Allergan, Inc. | Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase |
TW201241008A (en) * | 2010-10-01 | 2012-10-16 | Alexion Pharma Inc | Polypeptides that bind to human complement component C5 |
ES2894342T3 (es) | 2011-04-08 | 2022-02-14 | Univ Leicester | Métodos para tratar afecciones asociadas con la activación de complemento dependiente de MASP-2 |
WO2012162215A1 (en) | 2011-05-20 | 2012-11-29 | The Trustees Of The University Of Pennsylvania | Promotion of fracture healing using complement inhibitors |
WO2012174055A1 (en) | 2011-06-13 | 2012-12-20 | The Trustees Of The University Of Pennsylvania | Wound healing using complement inhibitors |
US20130246083A1 (en) | 2012-03-16 | 2013-09-19 | Alexion Pharmaceuticals, Inc. | Methods of distributing complement-inhibiting drugs to patients receiving a complement inhibitor |
US9579360B2 (en) | 2012-06-20 | 2017-02-28 | The Trustees Of The University Of Pennsylvania | Methods of treating or preventing periodontitis and diseases associated with periodontitis |
US20130345257A1 (en) | 2012-06-26 | 2013-12-26 | The Regents Of The University Of California | Composition for lupus nephritis and methods of making and using the same |
WO2014078622A1 (en) | 2012-11-15 | 2014-05-22 | The Brigham And Women's Hospital, Inc. | Method and system for diagnosing and treating preeclampsia |
US20140234275A1 (en) | 2013-02-15 | 2014-08-21 | Jason Williams | Method for treating als via the increased production of factor h |
US20160324798A1 (en) * | 2013-12-31 | 2016-11-10 | Heron Therapeutics, Inc. | Polymer-based compositions for extended release of proteins |
HRP20211561T8 (hr) | 2014-06-12 | 2022-03-04 | Ra Pharmaceuticals, Inc. | Modulacija aktivnosti komplementa |
WO2016138520A1 (en) | 2015-02-27 | 2016-09-01 | The Johns Hopkins University | Assay to diagnose and treat disorders of the alternative pathway of complement activation |
WO2017105939A1 (en) * | 2015-12-16 | 2017-06-22 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
BR112019011053A2 (pt) | 2016-12-07 | 2019-10-15 | Ra Pharmaceuticals Inc | moduladores da atividade do complemento |
EP4272821A3 (en) * | 2017-04-03 | 2024-01-03 | InflaRx GmbH | Treatment of inflammatory diseases with inhibitors of c5a activity |
-
2020
- 2020-04-24 JP JP2021562971A patent/JP2022530042A/ja active Pending
- 2020-04-24 KR KR1020217034548A patent/KR20220004039A/ko unknown
- 2020-04-24 CA CA3137895A patent/CA3137895A1/en active Pending
- 2020-04-24 SG SG11202109837S patent/SG11202109837SA/en unknown
- 2020-04-24 AU AU2020261059A patent/AU2020261059A1/en not_active Abandoned
- 2020-04-24 WO PCT/US2020/029733 patent/WO2020219822A1/en active Application Filing
- 2020-04-24 CN CN202080030772.3A patent/CN113710230A/zh active Pending
- 2020-04-24 US US17/605,495 patent/US20220211799A1/en active Pending
- 2020-04-24 BR BR112021017820A patent/BR112021017820A2/pt not_active Application Discontinuation
- 2020-04-24 TW TW109113822A patent/TW202106290A/zh unknown
- 2020-04-24 MX MX2021013010A patent/MX2021013010A/es unknown
- 2020-04-24 EP EP20730497.3A patent/EP3958842A1/en active Pending
-
2021
- 2021-10-07 IL IL287079A patent/IL287079A/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2022530042A (ja) | 2022-06-27 |
BR112021017820A2 (pt) | 2022-02-08 |
IL287079A (en) | 2021-12-01 |
CA3137895A1 (en) | 2020-10-29 |
MX2021013010A (es) | 2022-01-18 |
TW202106290A (zh) | 2021-02-16 |
AU2020261059A1 (en) | 2021-10-14 |
US20220211799A1 (en) | 2022-07-07 |
KR20220004039A (ko) | 2022-01-11 |
EP3958842A1 (en) | 2022-03-02 |
CN113710230A (zh) | 2021-11-26 |
WO2020219822A1 (en) | 2020-10-29 |
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