SG11202108552QA - Compounds, compositions and methods - Google Patents

Compounds, compositions and methods

Info

Publication number
SG11202108552QA
SG11202108552QA SG11202108552QA SG11202108552QA SG11202108552QA SG 11202108552Q A SG11202108552Q A SG 11202108552QA SG 11202108552Q A SG11202108552Q A SG 11202108552QA SG 11202108552Q A SG11202108552Q A SG 11202108552QA SG 11202108552Q A SG11202108552Q A SG 11202108552QA
Authority
SG
Singapore
Prior art keywords
compositions
compounds
methods
Prior art date
Application number
SG11202108552QA
Inventor
Robert Craig
Vicente Fidalgo Javier De
Anthony Estrada
Jianwen Feng
Brian Fox
Maksim Osipov
Arun Thottumkara
Original Assignee
Denali Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denali Therapeutics Inc filed Critical Denali Therapeutics Inc
Publication of SG11202108552QA publication Critical patent/SG11202108552QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/101,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/1131,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08Bridged systems
SG11202108552QA 2019-02-13 2020-02-12 Compounds, compositions and methods SG11202108552QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962805263P 2019-02-13 2019-02-13
US201962877232P 2019-07-22 2019-07-22
PCT/US2020/018007 WO2020168011A1 (en) 2019-02-13 2020-02-12 Compounds, compositions and methods

Publications (1)

Publication Number Publication Date
SG11202108552QA true SG11202108552QA (en) 2021-09-29

Family

ID=72043948

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202108552QA SG11202108552QA (en) 2019-02-13 2020-02-12 Compounds, compositions and methods

Country Status (18)

Country Link
US (2) US11306077B2 (en)
EP (1) EP3923935A4 (en)
JP (1) JP2022520236A (en)
KR (1) KR20210126036A (en)
CN (1) CN113518618A (en)
AU (1) AU2020223228A1 (en)
BR (1) BR112021015639A2 (en)
CA (1) CA3129609A1 (en)
CL (1) CL2021002104A1 (en)
CO (1) CO2021010490A2 (en)
CR (1) CR20210426A (en)
IL (1) IL285302A (en)
MA (1) MA54953A (en)
MX (1) MX2021009669A (en)
PE (1) PE20212023A1 (en)
SG (1) SG11202108552QA (en)
TW (1) TW202045164A (en)
WO (1) WO2020168011A1 (en)

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EP3982965A4 (en) 2019-06-12 2023-01-25 Praxis Biotech LLC Modulators of integrated stress response pathway
EP4117780A1 (en) 2020-03-11 2023-01-18 Evotec International GmbH Modulators of the integrated stress response pathway
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Also Published As

Publication number Publication date
CR20210426A (en) 2021-09-30
KR20210126036A (en) 2021-10-19
EP3923935A1 (en) 2021-12-22
MX2021009669A (en) 2021-10-13
US20230114472A1 (en) 2023-04-13
IL285302A (en) 2021-09-30
JP2022520236A (en) 2022-03-29
MA54953A (en) 2021-12-22
CO2021010490A2 (en) 2021-08-30
US20210292311A1 (en) 2021-09-23
TW202045164A (en) 2020-12-16
BR112021015639A2 (en) 2021-10-05
US11958840B2 (en) 2024-04-16
CL2021002104A1 (en) 2022-04-08
AU2020223228A1 (en) 2021-08-26
CA3129609A1 (en) 2020-08-20
PE20212023A1 (en) 2021-10-18
WO2020168011A1 (en) 2020-08-20
US11306077B2 (en) 2022-04-19
CN113518618A (en) 2021-10-19
EP3923935A4 (en) 2022-10-26

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