SG11202106700WA - Polypeptides comprising modified il-2 polypeptides and uses thereof - Google Patents

Polypeptides comprising modified il-2 polypeptides and uses thereof

Info

Publication number
SG11202106700WA
SG11202106700WA SG11202106700WA SG11202106700WA SG11202106700WA SG 11202106700W A SG11202106700W A SG 11202106700WA SG 11202106700W A SG11202106700W A SG 11202106700WA SG 11202106700W A SG11202106700W A SG 11202106700WA SG 11202106700W A SG11202106700W A SG 11202106700WA
Authority
SG
Singapore
Prior art keywords
polypeptides
modified
Prior art date
Application number
SG11202106700WA
Inventor
John C Timmer
Brendan P Eckelman
Katelyn Mckabe Willis
Florian J Sulzmaier
Bryan R Becklund
Original Assignee
Inhibrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibrx Inc filed Critical Inhibrx Inc
Publication of SG11202106700WA publication Critical patent/SG11202106700WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11202106700WA 2019-01-07 2020-01-06 Polypeptides comprising modified il-2 polypeptides and uses thereof SG11202106700WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962789075P 2019-01-07 2019-01-07
PCT/US2020/012296 WO2020146221A1 (en) 2019-01-07 2020-01-06 Polypeptides comprising modified il-2 polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
SG11202106700WA true SG11202106700WA (en) 2021-07-29

Family

ID=69374426

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202106700WA SG11202106700WA (en) 2019-01-07 2020-01-06 Polypeptides comprising modified il-2 polypeptides and uses thereof

Country Status (15)

Country Link
US (1) US20220089667A1 (en)
EP (1) EP3908596A1 (en)
JP (1) JP2022516557A (en)
KR (1) KR20210113265A (en)
CN (1) CN113924311A (en)
AR (1) AR117770A1 (en)
AU (1) AU2020206672A1 (en)
BR (1) BR112021012294A2 (en)
CA (1) CA3125529A1 (en)
CL (1) CL2021001779A1 (en)
IL (1) IL284633A (en)
MX (1) MX2021008147A (en)
SG (1) SG11202106700WA (en)
TW (1) TW202043259A (en)
WO (1) WO2020146221A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI757528B (en) 2017-08-03 2022-03-11 美商欣爍克斯公司 Cytokine conjugates for the treatment of proliferative and infectious diseases
EP3746095A4 (en) 2018-02-01 2021-04-21 Nkmax Co., Ltd. Method of producing natural killer cells and composition for treating cancer
CN115916831A (en) * 2020-06-30 2023-04-04 Gi 医诺微新 Fusion proteins comprising anti-LAG-3 antibodies and IL-2 and uses thereof
WO2022006380A2 (en) * 2020-07-02 2022-01-06 Inhibrx, Inc. Polypeptides comprising modified il-2 polypeptides and uses thereof
CN112979782B (en) * 2021-03-08 2023-07-18 深圳市乐土生物医药有限公司 Polypeptide and application thereof
US20240174753A1 (en) * 2021-03-31 2024-05-30 Anwita Biosciences, Inc. Fusion proteins, pharmaceutical compositions, and therapeutic applications
TW202309102A (en) * 2021-07-20 2023-03-01 美商英伊布里克斯公司 Cd8-targeted modified il-2 polypeptides and uses thereof
CA3225092A1 (en) * 2021-07-20 2023-01-26 John C. Timmer Cd8-binding polypeptides and uses thereof
TW202319397A (en) * 2021-08-30 2023-05-16 美商英伊布里克斯公司 Nkp46-binding polypeptides and uses thereof
WO2023034741A1 (en) * 2021-08-30 2023-03-09 Inhibrx, Inc. Nkp46-targeted modified il-2 polypeptides and uses thereof
CN118019849A (en) * 2021-09-26 2024-05-10 上海药明生物技术有限公司 IL-2 variants and fusion proteins thereof
TW202334193A (en) * 2022-01-05 2023-09-01 美商英伊布里克斯公司 Gamma delta t-cell-targeted modified il-2 polypeptides and uses thereof
WO2024026449A2 (en) * 2022-07-28 2024-02-01 Proviva Therapeutics (Hong Kong) Limited Il-2 procytokine antibody fusion proteins

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
LU91067I2 (en) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab and its variants and immunochemical derivatives including immotoxins
DK1034298T3 (en) 1997-12-05 2012-01-30 Scripps Research Inst Humanization of murine antibody
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
CN101979650B (en) 2003-10-22 2015-09-16 凯克研究生院 Use monoploid mating strategy in yeast, synthesize the method for different poly-many subunit polypeptides
CN1930300A (en) * 2004-03-05 2007-03-14 希龙公司 In vitro test system for predicting patient tolerability of therapeutic agents
WO2005091956A2 (en) * 2004-03-05 2005-10-06 Chiron Corporation In vitro test system for predicting patient tolerability of therapeutic agents
BRPI0508761A (en) 2004-03-31 2007-08-14 Genentech Inc humanized antibody, composition comprising a humanized antibody, isolated nucleic acid, vector, host cell, humanized antibody production process, tgf-beta dysfunction treatment method, tgf-beta detection method, manufactured article and method of treating cancer
CN102101885B (en) * 2010-09-01 2013-06-05 南京发士达生物科技有限公司 Human interleukin-II mutant of low-inductivity suppressor T cells and use thereof
SG10201604160WA (en) * 2011-02-10 2016-07-28 Roche Glycart Ag Mutant Interleukin-2 Polypeptides
CA2931114A1 (en) * 2014-02-06 2015-08-13 F. Hoffmann-La Roche Ag Interleukin-2 fusion proteins and uses thereof
CN109071623B (en) * 2016-05-04 2022-05-27 美国安进公司 Interleukin-2 muteins for expansion of T regulatory cells
AU2018273914A1 (en) * 2017-05-24 2019-11-14 Pandion Operations, Inc. Targeted immunotolerance

Also Published As

Publication number Publication date
BR112021012294A2 (en) 2021-09-08
AU2020206672A1 (en) 2021-07-15
EP3908596A1 (en) 2021-11-17
KR20210113265A (en) 2021-09-15
WO2020146221A1 (en) 2020-07-16
CN113924311A (en) 2022-01-11
CA3125529A1 (en) 2020-07-16
AR117770A1 (en) 2021-08-25
JP2022516557A (en) 2022-02-28
TW202043259A (en) 2020-12-01
MX2021008147A (en) 2021-08-11
US20220089667A1 (en) 2022-03-24
IL284633A (en) 2021-08-31
CL2021001779A1 (en) 2022-03-04

Similar Documents

Publication Publication Date Title
IL284633A (en) Polypeptides comprising modified il-2 polypeptides and uses thereof
IL281192A (en) Interleukin-2 polypeptide conjugates and their uses
IL274844A (en) Il-2 muteins and uses thereof
IL287781A (en) Clec12a-binding polypeptides and uses thereof
IL279458A (en) Neoantigens and uses thereof
IL287782A (en) Cd33-binding polypeptides and uses thereof
IL280808A (en) Ox40-binding polypeptides and uses thereof
EP3813861A4 (en) Heparin-associated polypeptides and uses thereof
GB201819200D0 (en) Polypeptide and uses thereof
SG11202006669RA (en) Peptides and uses thereof
EP3816186A4 (en) Pd-l1-binding polypeptide and use thereof
GB2603645B (en) Polypeptides having anti-senescent effects and uses thereof
GB202201001D0 (en) Polypeptide and use thereof
EP3630795C0 (en) Engineered aldolase polypeptides and uses thereof
EP3684796A4 (en) Succinate-regulating polypeptides and use thereof
GB201803363D0 (en) New materials and uses thereof
EP3947418C0 (en) Peptides and use thereof
GB202109082D0 (en) Polypeptides and uses thereof
GB202018733D0 (en) Polypeptides and uses thereof
GB201812328D0 (en) Polypeptides and uses thereof
AU2019903255A0 (en) Polypeptides and uses thereof
AU2018904117A0 (en) Polypeptides and uses thereof
IL309885A (en) Alpha-sheet polypeptides and their use
EP3880713A4 (en) Anti-b7s1 polypeptides and their use
IL287503A (en) Thiosemicarbazates and uses thereof