SG11202106081YA - Bicyclic peptide ligands specific for mt1-mmp - Google Patents

Bicyclic peptide ligands specific for mt1-mmp

Info

Publication number
SG11202106081YA
SG11202106081YA SG11202106081YA SG11202106081YA SG11202106081YA SG 11202106081Y A SG11202106081Y A SG 11202106081YA SG 11202106081Y A SG11202106081Y A SG 11202106081YA SG 11202106081Y A SG11202106081Y A SG 11202106081YA SG 11202106081Y A SG11202106081Y A SG 11202106081YA
Authority
SG
Singapore
Prior art keywords
mmp
peptide ligands
ligands specific
bicyclic peptide
bicyclic
Prior art date
Application number
SG11202106081YA
Inventor
Liuhong Chen
Euan Richards
Rachid Lani
Gemma Mudd
Catherine Stace
Daniel Teufel
Edward Walker
Original Assignee
Bicycletx Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1820286.1A external-priority patent/GB201820286D0/en
Priority claimed from GBGB1906534.1A external-priority patent/GB201906534D0/en
Application filed by Bicycletx Ltd filed Critical Bicycletx Ltd
Publication of SG11202106081YA publication Critical patent/SG11202106081YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489Metalloendopeptidases (3.4.24)
    • C12N9/6491Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
SG11202106081YA 2018-12-13 2019-12-13 Bicyclic peptide ligands specific for mt1-mmp SG11202106081YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1820286.1A GB201820286D0 (en) 2018-12-13 2018-12-13 Bicyclic peptide ligands specific for mt1-mmp
GBGB1906534.1A GB201906534D0 (en) 2019-05-09 2019-05-09 Bicycle peptide ligands specific for MT1-MMP
PCT/GB2019/053540 WO2020120984A1 (en) 2018-12-13 2019-12-13 Bicyclic peptide ligands specific for mt1-mmp

Publications (1)

Publication Number Publication Date
SG11202106081YA true SG11202106081YA (en) 2021-07-29

Family

ID=68988066

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202106081YA SG11202106081YA (en) 2018-12-13 2019-12-13 Bicyclic peptide ligands specific for mt1-mmp

Country Status (12)

Country Link
US (1) US20220024982A1 (en)
EP (1) EP3894010A1 (en)
JP (1) JP2022513806A (en)
KR (1) KR20210123295A (en)
CN (1) CN113507962A (en)
AU (1) AU2019398516A1 (en)
BR (1) BR112021011340A2 (en)
CA (1) CA3122669A1 (en)
IL (1) IL283873A (en)
MX (1) MX2021006991A (en)
SG (1) SG11202106081YA (en)
WO (1) WO2020120984A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018115203A1 (en) 2016-12-23 2018-06-28 Bicyclerd Limited Peptide derivatives having novel linkage structures
TWI825046B (en) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Bicyclic peptide ligands specific for epha2
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
TW202110485A (en) 2019-07-30 2021-03-16 英商拜西可泰克斯有限公司 Heterotandem bicyclic peptide complex
WO2022148975A1 (en) * 2021-01-08 2022-07-14 Bicycletx Limited Heterotandem bicyclic peptide complexes
CA3233035A1 (en) * 2021-09-29 2023-04-06 Huining LI Tricyclic polypeptide conjugated drug and use thereof
WO2023088236A1 (en) * 2021-11-16 2023-05-25 海思科医药集团股份有限公司 Bicyclic peptide ligand of mt1-mmp and conjugate thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
WO2006078161A1 (en) 2005-01-24 2006-07-27 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics
EP2653545A1 (en) 2008-02-05 2013-10-23 Bicycle Therapeutics Limited Methods and compositions
GB0913775D0 (en) * 2009-08-06 2009-09-16 Medical Res Council Multispecific peptides
WO2013142229A1 (en) * 2012-03-19 2013-09-26 President And Fellows Of Harvard College Designing novel peptides for inducing fibronectin matrix assembly
SG11201702845QA (en) * 2014-10-29 2017-05-30 Bicycle Therapeutics Ltd Bicyclic peptide ligands specific for mt1-mmp
GB201713560D0 (en) * 2017-08-23 2017-10-04 Bicycle Therapeutics Ltd Peptide ligands for binding to Mt1-Mmp
US10624968B2 (en) * 2017-01-06 2020-04-21 Bicyclerd Limited Compounds for treating cancer
WO2018197893A1 (en) * 2017-04-27 2018-11-01 Bicycletx Limited Bicyclic peptide ligands and uses thereof

Also Published As

Publication number Publication date
IL283873A (en) 2021-07-29
AU2019398516A1 (en) 2021-08-05
US20220024982A1 (en) 2022-01-27
BR112021011340A2 (en) 2021-09-08
JP2022513806A (en) 2022-02-09
MX2021006991A (en) 2021-10-13
CN113507962A (en) 2021-10-15
WO2020120984A1 (en) 2020-06-18
EP3894010A1 (en) 2021-10-20
KR20210123295A (en) 2021-10-13
CA3122669A1 (en) 2020-06-18

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