SG11202105469YA - 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors - Google Patents

2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors

Info

Publication number
SG11202105469YA
SG11202105469YA SG11202105469YA SG11202105469YA SG11202105469YA SG 11202105469Y A SG11202105469Y A SG 11202105469YA SG 11202105469Y A SG11202105469Y A SG 11202105469YA SG 11202105469Y A SG11202105469Y A SG 11202105469YA SG 11202105469Y A SG11202105469Y A SG 11202105469YA
Authority
SG
Singapore
Prior art keywords
inhibitors
methionine adenosyltransferase
oxoquinazoline derivatives
oxoquinazoline
derivatives
Prior art date
Application number
SG11202105469YA
Inventor
Muzaffar Alam
Leah Cleary
Melissa Fleury
Zhonghua Pei
Richard Steel
James Sutton
John Knox
Zachary Newby
Original Assignee
Ideaya Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ideaya Biosciences Inc filed Critical Ideaya Biosciences Inc
Publication of SG11202105469YA publication Critical patent/SG11202105469YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG11202105469YA 2018-12-10 2019-12-09 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors SG11202105469YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862777715P 2018-12-10 2018-12-10
US201962835853P 2019-04-18 2019-04-18
US201962883945P 2019-08-07 2019-08-07
PCT/US2019/065260 WO2020123395A1 (en) 2018-12-10 2019-12-09 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors

Publications (1)

Publication Number Publication Date
SG11202105469YA true SG11202105469YA (en) 2021-06-29

Family

ID=69138003

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202105469YA SG11202105469YA (en) 2018-12-10 2019-12-09 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors

Country Status (17)

Country Link
US (4) US20220106276A1 (en)
EP (1) EP3894396A1 (en)
JP (1) JP2022512156A (en)
KR (1) KR20210103498A (en)
CN (1) CN113166078A (en)
AU (1) AU2019395338A1 (en)
BR (1) BR112021010842A2 (en)
CA (1) CA3121236A1 (en)
CL (1) CL2021001508A1 (en)
CO (1) CO2021008895A2 (en)
IL (1) IL283743A (en)
MA (1) MA54452A (en)
MX (1) MX2021006841A (en)
PH (1) PH12021551274A1 (en)
SG (1) SG11202105469YA (en)
TW (1) TW202039487A (en)
WO (1) WO2020123395A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4165035A1 (en) * 2020-06-10 2023-04-19 Ideaya Biosciences, Inc. Heteroaryl alkylene substituted 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors
BR112022026105A2 (en) * 2020-06-22 2023-01-17 Hoffmann La Roche COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, METHOD FOR THE TREATMENT OR PREVENTION OF PULMONARY ADENOCARCINOMA, USE OF COMPOUNDS AND INVENTION
JP2023531021A (en) * 2020-06-22 2023-07-20 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト amidopyrimidone derivative
CN116406271A (en) * 2020-07-14 2023-07-07 江苏先声药业有限公司 Bicyclic compounds
WO2022063128A1 (en) * 2020-09-24 2022-03-31 上海凌达生物医药有限公司 Aromatic ring or arylheterocyclic pyridone compound, pharmaceutical compositions, and use thereof
US20230072276A1 (en) * 2020-12-15 2023-03-09 Mirati Therapeutics, Inc. Azaquinazoline pan-KRas inhibitors
TW202227443A (en) 2020-12-31 2022-07-16 中國商江蘇先聲藥業有限公司 Tricyclic compound and use thereof
WO2022206730A1 (en) * 2021-03-29 2022-10-06 武汉人福创新药物研发中心有限公司 Pyrimidopyrazine compound and use thereof
WO2022222911A1 (en) * 2021-04-19 2022-10-27 武汉人福创新药物研发中心有限公司 Pyrimidone compound and use thereof
WO2022228515A1 (en) * 2021-04-30 2022-11-03 赛诺哈勃药业（成都）有限公司 Methionine adenosyltransferase inhibitor, preparation method therefor and application thereof
KR20240019172A (en) * 2021-06-02 2024-02-14 아이디어야 바이오사이언시스 인코포레이티드 Combination therapy involving a MAT2A inhibitor and a type II PRMT inhibitor
WO2022256808A1 (en) * 2021-06-02 2022-12-08 Ideaya Biosciences Inc. Combination therapy comprising a mat2a inhibitor and type i prmt inhibitor
CN117412967A (en) * 2021-06-02 2024-01-16 南京正大天晴制药有限公司 Methionine adenosine transferase 2A inhibitors
TW202327600A (en) * 2021-10-20 2023-07-16 香港商英科智能有限公司 Methionine adenosyltransferase 2a (mat2a) inhibitors and uses thereof
WO2023083210A1 (en) * 2021-11-09 2023-05-19 上海海雁医药科技有限公司 Substituted naphthyridinone derivative, and pharmaceutical composition thereof and use thereof
WO2023086934A1 (en) * 2021-11-12 2023-05-19 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a taxane
WO2023116696A1 (en) * 2021-12-21 2023-06-29 南京正大天晴制药有限公司 Methionine adenosyltransferase 2a heterocyclic inhibitor
WO2023143356A1 (en) * 2022-01-26 2023-08-03 勤浩医药（苏州）有限公司 Methionine adenosyltransferase 2a inhibitor for treating mtap deletion-type cancer
WO2023177894A1 (en) 2022-03-18 2023-09-21 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and an antimetabolite agent
GB202204913D0 (en) 2022-04-04 2022-05-18 Cambridge Entpr Ltd antiviral therapy
WO2023201338A1 (en) 2022-04-15 2023-10-19 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a parp inhibitor
WO2024080788A1 (en) 2022-10-13 2024-04-18 한미약품 주식회사 Novel tricyclic derivative compound and uses thereof
CN117777134A (en) * 2022-12-19 2024-03-29 艾立康药业股份有限公司 Polycyclic compounds as MAT2A inhibitors
CN116283800B (en) * 2023-05-16 2023-07-18 英矽智能科技(上海)有限公司 Oxo quinazoline compound and application thereof
CN116478172B (en) * 2023-06-20 2023-09-05 英矽智能科技(上海)有限公司 Pyrrolo [3,2-d ] pyrimidine compound and application thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5761758B2 (en) 1974-01-11 1982-12-25 Hisamitsu Pharmaceutical Co
EP0759454B1 (en) 1994-05-11 2002-03-06 Asahi Kasei Kabushiki Kaisha para-ORIENTED AROMATIC POLYAMIDE MOLDING AND PROCESS FOR PRODUCING THE SAME
US5525711A (en) * 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
EP2266984A1 (en) 2009-06-26 2010-12-29 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis
ES2612472T3 (en) * 2010-08-31 2017-05-17 Hanmi Science Co., Ltd. Quinoline or quinazoline derivatives with apoptosis inducing activity on cells
EP2748169A4 (en) 2011-09-30 2015-06-17 Kineta Inc Anti-viral compounds
KR20140103972A (en) * 2011-12-22 2014-08-27 에프. 호프만-라 로슈 아게 2,4-diamine-pyrimidine derivatives as serine/threonine kinase inhibitors
MX2018006781A (en) 2015-12-03 2018-11-09 Agios Pharmaceuticals Inc Mat2a inhibitors for treating mtap null cancer.
CA3034705C (en) 2016-08-31 2021-08-03 Agios Pharmaceuticals, Inc. Inhibitors of cellular metabolic processes
HUE056777T2 (en) 2016-12-22 2022-03-28 Amgen Inc Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
JOP20190272A1 (en) 2017-05-22 2019-11-21 Amgen Inc Kras g12c inhibitors and methods of using the same
WO2018221433A1 (en) 2017-05-29 2018-12-06 第一三共株式会社 Heteroaryl amine derivative
JP7150823B2 (en) * 2017-09-08 2022-10-11 アムジエン・インコーポレーテツド Inhibitors of KRas G12C and methods of using same
PL3774805T3 (en) 2018-03-30 2024-05-06 Les Laboratoires Servier Heterobicyclic inhibitors of mat2a and methods of use for treating cancer
US11090304B2 (en) 2018-05-04 2021-08-17 Amgen Inc. KRAS G12C inhibitors and methods of using the same
AU2019336588B2 (en) 2018-06-12 2022-07-28 Amgen Inc. KRAS G12C inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
US11376256B2 (en) 2018-07-19 2022-07-05 Agency For Science, Technology And Research Method of treating a methionine-dependent cancer
AU2019388998A1 (en) 2018-11-29 2021-06-03 Araxes Pharma Llc Compounds and methods of use thereof for treatment of cancer
BR112021012599A2 (en) 2018-12-27 2021-09-08 Les Laboratoires Servier Sas AZA-HETEROBICYCLIC MAT2A INHIBITORS AND METHODS OF USE FOR TREATMENT OF CANCER
BR112021012595A2 (en) 2018-12-27 2021-09-08 Les Laboratoires Servier Sas AZA-HETEROBICYCLIC MAT2A INHIBITORS AND METHODS OF USE FOR TREATMENT OF CANCER

Also Published As

Publication number Publication date
MA54452A (en) 2022-03-16
PH12021551274A1 (en) 2021-12-06
CL2021001508A1 (en) 2022-01-21
US11046691B1 (en) 2021-06-29
KR20210103498A (en) 2021-08-23
CA3121236A1 (en) 2020-06-18
BR112021010842A2 (en) 2021-08-24
CO2021008895A2 (en) 2021-07-30
IL283743A (en) 2021-07-29
US20220106276A1 (en) 2022-04-07
CN113166078A (en) 2021-07-23
MX2021006841A (en) 2021-07-02
WO2020123395A1 (en) 2020-06-18
EP3894396A1 (en) 2021-10-20
JP2022512156A (en) 2022-02-02
US11130759B1 (en) 2021-09-28
TW202039487A (en) 2020-11-01
US11084798B1 (en) 2021-08-10
AU2019395338A1 (en) 2021-07-29

Similar Documents

Publication Publication Date Title
IL283743A (en) 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors
IL277455A (en) Aminopyrimidine derivatives as ctps1 inhibitors
IL282386A (en) Aminopyrimidine/pyrazine derivatives as ctps1 inhibitors
ZA202204675B (en) New methylquinazolinone derivatives
IL283990A (en) Substituted oxopyridine derivatives
IL279453B (en) Pyrazole derivatives as malt1 inhibitors
IL289197A (en) 2-hydroxycycloalkane-1-carbamoyl derivatives
IL276592A (en) Derivatives of sobetirome
IL279452B (en) Pyrazole derivatives as malt1 inhibitors
IL279938A (en) Spirochromane derivatives
IL290815A (en) Alpha-d-galactopyranoside derivatives
SI3796975T1 (en) Sulfonylaminobenzamide derivatives
HK1252767A1 (en) Pyrazol-pyridine derivatives as eaat3 inhibitors
EP3526216C0 (en) Benzothiazole derivatives as dyrk1 inhibitors
HUE062256T2 (en) Dihydrochromene derivatives
EP3618837A4 (en) Multitargeted nucleoside derivatives
HUE054792T2 (en) Pyridoquinazoline derivatives useful as protein kinase inhibitors
IL304189A (en) Pyrazoleamide derivatives
GB201919210D0 (en) Dihydro-cyclopenta-isoquinoline derivatives
GB201806948D0 (en) Derivatives