SG11202103628PA - Method and system of identifying and quantifying a protein - Google Patents

Method and system of identifying and quantifying a protein

Info

Publication number
SG11202103628PA
SG11202103628PA SG11202103628PA SG11202103628PA SG11202103628PA SG 11202103628P A SG11202103628P A SG 11202103628PA SG 11202103628P A SG11202103628P A SG 11202103628PA SG 11202103628P A SG11202103628P A SG 11202103628PA SG 11202103628P A SG11202103628P A SG 11202103628PA
Authority
SG
Singapore
Prior art keywords
quantifying
protein
identifying
Prior art date
Application number
SG11202103628PA
Inventor
Yuetian Yan
Shunhai Wang
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202103628PA publication Critical patent/SG11202103628PA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11202103628PA 2018-10-31 2019-10-30 Method and system of identifying and quantifying a protein SG11202103628PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862753633P 2018-10-31 2018-10-31
PCT/US2019/058759 WO2020092499A1 (en) 2018-10-31 2019-10-30 Method and system of identifying and quantifying a protein

Publications (1)

Publication Number Publication Date
SG11202103628PA true SG11202103628PA (en) 2021-05-28

Family

ID=68582515

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202103628PA SG11202103628PA (en) 2018-10-31 2019-10-30 Method and system of identifying and quantifying a protein

Country Status (10)

Country Link
EP (2) EP3874276B1 (en)
JP (2) JP2022514122A (en)
KR (1) KR20210111243A (en)
CN (1) CN113056676A (en)
AU (1) AU2019369421A1 (en)
CA (1) CA3116717A1 (en)
ES (1) ES2962578T3 (en)
IL (1) IL282778A (en)
SG (1) SG11202103628PA (en)
WO (1) WO2020092499A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240009061A (en) 2022-07-13 2024-01-22 (재)씨젠의료재단 A Method for Direct Quantification of Multiple Apolipoproteins in Serum
KR102629162B1 (en) 2022-11-04 2024-01-29 한국기초과학지원연구원 Method and system of host cell protein quantitative analysis for quality control of biologicla medical product
CN117129591B (en) * 2023-08-16 2024-04-16 北京力邦生物医药科技有限公司 Detection method for determining protein content of CD3/CD20 monoclonal antibody

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005073732A2 (en) * 2004-01-23 2005-08-11 Amgen Inc. Lc/ms method of analyzing high molecular weight proteins
MX2011014008A (en) 2009-06-26 2012-06-01 Regeneron Pharma Readily isolated bispecific antibodies with native immunoglobulin format.
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
JOP20200236A1 (en) 2012-09-21 2017-06-16 Regeneron Pharma Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
AR101262A1 (en) 2014-07-26 2016-12-07 Regeneron Pharma PURIFICATION PLATFORM FOR Bispecific Antibodies
JP2018511300A (en) * 2015-01-16 2018-04-26 アルダー・バイオファーマシューティカルズ・インコーポレーテッド Anti-glycoprotein antibodies and uses thereof
AU2016233557B2 (en) * 2015-03-13 2021-06-24 Bristol-Myers Squibb Company Use of alkaline washes during chromatography to remove impurities
JOP20160154B1 (en) 2015-07-31 2021-08-17 Regeneron Pharma Anti-psma antibodies, bispecific antigen-binding molecules that bind psma and cd3, and uses thereof
EA201891428A1 (en) 2015-12-22 2018-12-28 Регенерон Фармасьютикалз, Инк. COMBINATION OF ANTIBODIES TO PD-1 AND BISPECIFIC ANTIBODIES TO CD20 / CD3 FOR THE TREATMENT OF MALIGNANT TUMOR
CN108602889A (en) 2015-12-22 2018-09-28 瑞泽恩制药公司 Cure the anti-CD20/ anti-cd 3 antibodies of bispecific of acute lymphoblastic leukemia
SG10202102617QA (en) 2016-09-23 2021-04-29 Regeneron Pharma Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof
WO2018067331A1 (en) 2016-09-23 2018-04-12 Regeneron Pharmaceuticals, Inc. Bi specific anti-muc16-cd3 antibodies and nti-muc16 drug conjugates
TWI782930B (en) 2016-11-16 2022-11-11 美商再生元醫藥公司 Anti-met antibodies, bispecific antigen binding molecules that bind met, and methods of use thereof
CN107607642B (en) * 2017-09-06 2020-12-29 上海烟草集团有限责任公司 Multidimensional liquid chromatography-mass spectrometry combined method for identifying protein and proteome in tobacco

Also Published As

Publication number Publication date
CN113056676A (en) 2021-06-29
EP3874276B1 (en) 2023-09-06
EP4270009A2 (en) 2023-11-01
AU2019369421A1 (en) 2021-06-03
CA3116717A1 (en) 2020-05-07
ES2962578T3 (en) 2024-03-19
JP2023052110A (en) 2023-04-11
IL282778A (en) 2021-06-30
WO2020092499A1 (en) 2020-05-07
EP4270009A3 (en) 2024-01-17
KR20210111243A (en) 2021-09-10
EP3874276A1 (en) 2021-09-08
JP2022514122A (en) 2022-02-09

Similar Documents

Publication Publication Date Title
GB201804895D0 (en) System and method for identifying at least one association of entity
IL282778A (en) Method and system of identifying and quantifying a protein
IL277194A (en) Means and methods for glycoprofiling of a protein
ZA202102344B (en) Method and system of identifying and quantifying a protein
IL275840A (en) Method and system for quantifying biomarker of a tissue
IL278958A (en) Method of image-based relationship analysis and system thereof
IL290612A (en) Systems and methods for predicting proteins
GB201807293D0 (en) Biosensor method and system
IL284637A (en) Method and system of identifying and quantifying antibody fragmentation
IL276102A (en) System and method for characterizing protein dimerization
GB2602600B (en) System and method for identifying a disease affected area
EP3948721A4 (en) System and method of identifying equivalents for task completion
SG11202008734WA (en) Method and system of protein extraction
PT3803677T (en) Card-marking system and method for the automated detection of an optimized setting of a card-marking system
IL258250B (en) System and method for identifying associated subjects from location histories
EP3613975C0 (en) Method and system for determining a cause of extra-fuel consumption
SG10201905523TA (en) Data analysis method and data analysis system thereof
HUE053470T2 (en) Method and system for determining a configuration of an interface
EP3991086A4 (en) Method and system for identifying object
SG11202101864WA (en) Information providing system and information providing method
SG10201808304WA (en) System and method for identifying veins
GB2597202B (en) Analysis system and analysis method
AU2018900899A0 (en) System and method for fish identification and analysis
SG11202006629TA (en) Method for identifying proteins
ZA201907057B (en) System and method for providing information