SG11202101613XA - Inhibitors of keap1-nrf2 protein-protein interaction - Google Patents
Inhibitors of keap1-nrf2 protein-protein interactionInfo
- Publication number
- SG11202101613XA SG11202101613XA SG11202101613XA SG11202101613XA SG11202101613XA SG 11202101613X A SG11202101613X A SG 11202101613XA SG 11202101613X A SG11202101613X A SG 11202101613XA SG 11202101613X A SG11202101613X A SG 11202101613XA SG 11202101613X A SG11202101613X A SG 11202101613XA
- Authority
- SG
- Singapore
- Prior art keywords
- protein
- keap1
- inhibitors
- nrf2
- interaction
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000004850 protein–protein interaction Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862719978P | 2018-08-20 | 2018-08-20 | |
US201962801433P | 2019-02-05 | 2019-02-05 | |
US201962823450P | 2019-03-25 | 2019-03-25 | |
US201962875737P | 2019-07-18 | 2019-07-18 | |
US201962881639P | 2019-08-01 | 2019-08-01 | |
PCT/US2019/047015 WO2020041169A2 (en) | 2018-08-20 | 2019-08-19 | Inhibitors of keap1-nrf2 protein-protein interaction |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202101613XA true SG11202101613XA (en) | 2021-03-30 |
Family
ID=69523716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202101613XA SG11202101613XA (en) | 2018-08-20 | 2019-08-19 | Inhibitors of keap1-nrf2 protein-protein interaction |
Country Status (26)
Country | Link |
---|---|
US (3) | US10947252B2 (en) |
EP (2) | EP4364804A2 (en) |
JP (2) | JP7212763B2 (en) |
KR (2) | KR20230146136A (en) |
CN (1) | CN112930347A (en) |
AU (3) | AU2019326368B2 (en) |
BR (1) | BR112021002979A2 (en) |
CA (1) | CA3108534A1 (en) |
CL (1) | CL2021000426A1 (en) |
CO (1) | CO2021002670A2 (en) |
CR (1) | CR20210087A (en) |
DK (1) | DK3833662T3 (en) |
EC (1) | ECSP21016032A (en) |
FI (1) | FI3833662T3 (en) |
IL (2) | IL280950B2 (en) |
JO (1) | JOP20210030A1 (en) |
MX (1) | MX2021002060A (en) |
PE (1) | PE20211205A1 (en) |
PH (1) | PH12021500012A1 (en) |
PL (1) | PL3833662T3 (en) |
PT (1) | PT3833662T (en) |
SG (1) | SG11202101613XA (en) |
TW (2) | TW202309020A (en) |
UA (1) | UA126950C2 (en) |
UY (1) | UY38338A (en) |
WO (1) | WO2020041169A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2019326368B2 (en) | 2018-08-20 | 2021-11-11 | Janssen Pharmaceutica Nv | Inhibitors of KEAP1-Nrf2 protein-protein interaction |
EP3978073A4 (en) | 2019-05-31 | 2023-07-12 | UBE Corporation | Benzotriazole derivative |
US20230107927A1 (en) | 2020-02-28 | 2023-04-06 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
CA3206893A1 (en) * | 2020-12-28 | 2022-07-07 | Senju Pharmaceutical Co., Ltd. | Nrf2-activating compound |
CN112661655B (en) * | 2020-12-29 | 2022-02-18 | 江苏云朴医药新材料科技有限公司 | 1-aminomethyl-1-cyclopropanol compound and synthetic method thereof |
TW202404984A (en) * | 2022-04-28 | 2024-02-01 | 日商第一三共股份有限公司 | Benzotriazole compound |
CN115925606B (en) * | 2023-01-05 | 2023-10-13 | 宁夏医科大学 | 5- (3- (sulfonamide) phenyl) -1H-pyrrole-2-carboxylic acid derivative and preparation method and application thereof |
CN116003397B (en) * | 2023-03-24 | 2023-06-16 | 凯思凯旭(上海)医药科技有限公司 | Benzo-polycyclic thiazoline amide compound and application thereof |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007005879A2 (en) | 2005-07-01 | 2007-01-11 | The Johns Hopkins University | Compositions and methods for the treatment or prevention of disorders relating to oxidative stress |
WO2007008652A2 (en) | 2005-07-08 | 2007-01-18 | The University Of North Carolina At Chapel Hill | Methods and compositions directed to dj-1 as regulator of the anti-oxidant transcription factor nrf2 |
US8022246B2 (en) | 2006-10-10 | 2011-09-20 | The Burnham Institute For Medical Research | Neuroprotective compositions and methods |
WO2011156889A1 (en) | 2010-06-14 | 2011-12-22 | Trt Pharma Inc. | Novel modulators of nrf2 and uses thereof |
EP2666857B1 (en) | 2011-01-21 | 2016-08-31 | Riken | Nucleic acid construct for expressing oxidative stress indicator and use thereof |
US9075070B2 (en) | 2011-02-09 | 2015-07-07 | Rutgers, The State University Of New Jersey | HTS fluorescence polarization assay for inhibitors of Keap1-Nrf2 interaction |
CA2827990A1 (en) | 2011-02-25 | 2012-08-30 | The Johns Hopkins University | Chalcone derivatives as nrf2 activators |
JP2013028575A (en) | 2011-07-29 | 2013-02-07 | Toray Ind Inc | Keap1 protein binding compound, crystal of complex between the same and keap1 protein, and method for producing the same |
WO2013067036A1 (en) | 2011-10-31 | 2013-05-10 | Rutgers, The State University Of New Jersey | Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators |
RS61544B1 (en) | 2012-04-27 | 2021-04-29 | Reata Pharmaceuticals Inc | 2,2-difluoropropionamide derivative of bardoxolone methyl, pharmaceutical compositions and polymorphs thereof for use in treating certain conditions |
WO2014058982A2 (en) | 2012-10-10 | 2014-04-17 | Temple University Of The Commonwealth System Of Higher Education | Nuclear factor-erythroid 2 related factor 2 (nrf2) biosensors and modulators of nrf2 |
US9796752B2 (en) | 2013-03-19 | 2017-10-24 | Daiichi Sankyo Company, Limited | Terpenoid derivatives |
UY39092A (en) | 2013-04-24 | 2021-03-26 | Abbvie Inc | DERIVATIVES OF 2,2-DIFLUOROPROPANAMIDE AND METHYL BARDOXOLONE, POLYMORPHIC FORMS AND METHODS OF USE |
WO2014197818A2 (en) | 2013-06-07 | 2014-12-11 | The General Hospital Corporation | Small molecule activators of nrf2 pathway |
US10980896B2 (en) | 2013-10-29 | 2021-04-20 | President And Fellows Of Harvard College | Methods and compositions for inhibiting oxidative stress |
WO2015092713A1 (en) * | 2013-12-18 | 2015-06-25 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
EP3107939B1 (en) | 2014-02-19 | 2020-06-17 | University of Florida Research Foundation, Inc. | Delivery of nrf2 as therapy for protection against reactive oxygen species |
KR20170055482A (en) | 2014-09-10 | 2017-05-19 | 다이이찌 산쿄 가부시키가이샤 | Sustained-release pharmaceutical composition for treating and preventing ophthalmic diseases |
ES2570452B1 (en) | 2014-10-15 | 2017-04-19 | Fundación Para La Investigación Biomédida Del Hospital Universitario De La Princesa | Compounds derived from 3-Alkylamino-1H-Indolyl acrylate and its use in the treatment of neurodegenerative diseases |
US20160120158A1 (en) | 2014-11-03 | 2016-05-05 | The Johns Hopkins University | Compositions and methods for the study and treatment of acute kidney injury |
WO2016089648A1 (en) | 2014-12-01 | 2016-06-09 | Vtv Therapeutics Llc | Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof |
CN104825443B (en) | 2015-04-27 | 2017-10-24 | 广东省中医院 | The anti-oxidant application of sweet wormwood alkene |
LT3307739T (en) | 2015-06-15 | 2021-03-10 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
WO2016203400A1 (en) | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
WO2017031223A1 (en) | 2015-08-18 | 2017-02-23 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Activators of nrf2-dependent photoprotection and related uses thereof |
EP3359532A1 (en) | 2015-10-06 | 2018-08-15 | GlaxoSmithKline Intellectual Property Development Limited | Biaryl pyrazoles as nrf2 regulators |
WO2017060855A1 (en) | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Arylcyclohexyl pyrazoles as nrf2 regulators |
CN105566241B (en) | 2016-01-18 | 2018-05-25 | 中国药科大学 | 1- sulfoamido -4- aryloxy group classes compound, preparation method and its medical usage |
EP3429690A4 (en) | 2016-03-16 | 2019-10-23 | Ionis Pharmaceuticals, Inc. | Methods of modulating keap1 |
CN105753795B (en) * | 2016-04-29 | 2018-04-13 | 济南大学 | A kind of alkaloid compound with 1,2,3 triazole structure fragments and application thereof |
EP3471733A4 (en) | 2016-06-15 | 2020-02-05 | Der Sarkissian, Shant | Reagents, compositions and methods for improving viability and function of cells, tissues and organs |
WO2018089386A1 (en) | 2016-11-11 | 2018-05-17 | The Broad Institute, Inc. | Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action |
WO2018104766A1 (en) | 2016-12-06 | 2018-06-14 | Glaxosmithkline Intellectual Property Development Limited | 3-(2,3-dihydro-1h-inden-5-yl)propanoic acid derivatives and their use as nrf2 regulators |
EP3551621A1 (en) | 2016-12-12 | 2019-10-16 | GlaxoSmithKline Intellectual Property Development Limited | N-aryl pyrazoles as nrf2 regulators |
JP2020500919A (en) | 2016-12-12 | 2020-01-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Pyrrole 3-carboxylate as NRF2 regulator |
ES2901617T3 (en) * | 2016-12-14 | 2022-03-23 | Glaxosmithkline Ip Dev Ltd | Bisarylamides as regulators of NRF2 |
JP2020502123A (en) | 2016-12-14 | 2020-01-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Bisaryl heterocycles as NRF2 activators |
WO2018109648A1 (en) | 2016-12-14 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | 3-oxo-1,4-diazepinyle compounds as nrf2 activators |
US11059816B2 (en) | 2016-12-15 | 2021-07-13 | Glaxosmithkline Intellectual Property Development Limited | Ether linked triazoles as NRF2 activators |
EP3555104B1 (en) | 2016-12-15 | 2021-11-24 | GlaxoSmithKline Intellectual Property Development Limited | Nrf2 compounds |
EP3573968A1 (en) | 2017-01-30 | 2019-12-04 | Biogen MA Inc. | Nrf2 activator |
US10786471B2 (en) * | 2017-02-06 | 2020-09-29 | Massachusetts Institute Of Technology | Methods and products related to glutaminase inhibitors |
JP2020097526A (en) | 2017-03-28 | 2020-06-25 | 武田薬品工業株式会社 | Heterocyclic compound |
CN107033100B (en) | 2017-05-24 | 2019-03-01 | 济南大学 | A kind of benzothiazole derivant, preparation method and its medical usage |
CN107236813A (en) | 2017-07-02 | 2017-10-10 | 东北林业大学 | A kind of intracellular detection methods of BiFC and system of instruction Nrf2 Keap1 interactions |
CN107881195B (en) | 2017-10-26 | 2021-08-27 | 深圳市第三人民医院 | Double-gene co-expression plasmid pIRES2-Nrf2-DKK1 and preparation method and application thereof |
KR20200104335A (en) | 2017-12-22 | 2020-09-03 | 메디뮨 리미티드 | Small molecule regulator of the BTB domain of Keap1 |
JP7378156B2 (en) | 2018-04-06 | 2023-11-13 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction |
US11643407B2 (en) | 2018-05-23 | 2023-05-09 | Glaxosmithkline Intellectual Property Development Limited | Indanes as NRF2 activators |
CN110724669A (en) | 2018-06-29 | 2020-01-24 | 李陶 | Umbilical cord mesenchymal stem cell modified by Nrf2 gene, and preparation method and application thereof |
CN108752245A (en) | 2018-07-16 | 2018-11-06 | 宁夏医科大学 | Naphthalene sulfonylamide acetamides and its application and pharmaceutical composition |
AU2019326368B2 (en) * | 2018-08-20 | 2021-11-11 | Janssen Pharmaceutica Nv | Inhibitors of KEAP1-Nrf2 protein-protein interaction |
EP3866779A4 (en) | 2018-10-19 | 2022-07-06 | Aclipse One, Inc. | Treatment of neurological diseases |
CN112996785A (en) | 2018-10-22 | 2021-06-18 | 希四克斯探索有限公司 | Therapeutic compounds |
AR117251A1 (en) | 2018-12-05 | 2021-07-21 | Scohia Pharma Inc | MACROCYCLIC COMPOUND AS ACTIVATOR OF NRF2 |
WO2020132040A1 (en) | 2018-12-20 | 2020-06-25 | President And Fellows Of Harvard College | Compositions and methods for the treatment of degenerative ocular diseases |
US20220112160A1 (en) | 2019-01-18 | 2022-04-14 | Rutgers, The State University Of New Jersey | Small molecule direct inhibitors of keap1-nrf2 protein-protein interaction |
WO2020165776A1 (en) | 2019-02-15 | 2020-08-20 | Glaxosmithkline Intellectual Property Development Limited | Hydroxypyridoxazepines as nrf2 activators |
US20220265595A1 (en) | 2019-04-30 | 2022-08-25 | Sitryx Therapeutics Limited | Itaconic acid derivatives and uses thereof intreating an inflammatory disease or a disease associated with an undesirable immune response |
EP3978073A4 (en) | 2019-05-31 | 2023-07-12 | UBE Corporation | Benzotriazole derivative |
CN110256305B (en) | 2019-07-24 | 2020-05-26 | 中国药科大学 | Naphthalene sulfonamide compound, preparation method and application |
CN110845435B (en) | 2019-11-28 | 2021-06-08 | 中国药科大学 | Hydrogen peroxide response type Keap1-Nrf2 PPI inhibitor prodrug, preparation method and medical application thereof |
CN111362857B (en) | 2020-04-23 | 2023-02-28 | 中国药科大学 | Compound with indoline skeleton, preparation method and medical application thereof |
CN112321620B (en) | 2020-11-10 | 2022-03-29 | 中国药科大学 | Keap1-Nrf2 PPI inhibitor prodrug, preparation method and application |
-
2019
- 2019-08-19 AU AU2019326368A patent/AU2019326368B2/en active Active
- 2019-08-19 SG SG11202101613XA patent/SG11202101613XA/en unknown
- 2019-08-19 US US16/544,462 patent/US10947252B2/en active Active
- 2019-08-19 KR KR1020237034899A patent/KR20230146136A/en not_active Application Discontinuation
- 2019-08-19 JO JOP/2021/0030A patent/JOP20210030A1/en unknown
- 2019-08-19 PE PE2021000224A patent/PE20211205A1/en unknown
- 2019-08-19 KR KR1020217008105A patent/KR102590310B1/en active IP Right Grant
- 2019-08-19 CR CR20210087A patent/CR20210087A/en unknown
- 2019-08-19 UA UAA202101384A patent/UA126950C2/en unknown
- 2019-08-19 JP JP2021509891A patent/JP7212763B2/en active Active
- 2019-08-19 DK DK19773579.8T patent/DK3833662T3/en active
- 2019-08-19 EP EP24151840.6A patent/EP4364804A2/en active Pending
- 2019-08-19 CA CA3108534A patent/CA3108534A1/en active Pending
- 2019-08-19 PT PT197735798T patent/PT3833662T/en unknown
- 2019-08-19 WO PCT/US2019/047015 patent/WO2020041169A2/en active Application Filing
- 2019-08-19 MX MX2021002060A patent/MX2021002060A/en unknown
- 2019-08-19 TW TW111142540A patent/TW202309020A/en unknown
- 2019-08-19 IL IL280950A patent/IL280950B2/en unknown
- 2019-08-19 PL PL19773579.8T patent/PL3833662T3/en unknown
- 2019-08-19 UY UY0001038338A patent/UY38338A/en unknown
- 2019-08-19 BR BR112021002979-6A patent/BR112021002979A2/en unknown
- 2019-08-19 TW TW108129422A patent/TWI781342B/en active
- 2019-08-19 EP EP19773579.8A patent/EP3833662B1/en active Active
- 2019-08-19 CN CN201980069221.5A patent/CN112930347A/en active Pending
- 2019-08-19 FI FIEP19773579.8T patent/FI3833662T3/en active
-
2020
- 2020-12-18 US US17/127,569 patent/US11897900B2/en active Active
-
2021
- 2021-02-11 PH PH12021500012A patent/PH12021500012A1/en unknown
- 2021-02-18 CL CL2021000426A patent/CL2021000426A1/en unknown
- 2021-02-26 CO CONC2021/0002670A patent/CO2021002670A2/en unknown
- 2021-03-05 EC ECSENADI202116032A patent/ECSP21016032A/en unknown
- 2021-08-30 US US17/460,775 patent/US11427601B1/en active Active
-
2022
- 2022-01-25 AU AU2022200478A patent/AU2022200478B2/en active Active
-
2023
- 2023-01-13 JP JP2023003696A patent/JP2023038270A/en active Pending
- 2023-06-28 IL IL304110A patent/IL304110A/en unknown
- 2023-09-29 AU AU2023237198A patent/AU2023237198A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL283639A (en) | Kif18a inhibitors | |
ZA201805879B (en) | Inhibitors of wdr5 protein-protein binding | |
IL291430A (en) | Mcl-1 inhibitors | |
IL304110A (en) | Inhibitors of keap1-nrf2 protein-protein interaction | |
IL284508A (en) | Irreversible inhibitors of menin-mll interaction | |
EP4069212A4 (en) | Inhibitors of hif-2alpha | |
EP3423437A4 (en) | Inhibitors of wdr5 protein-protein binding | |
EP3801503A4 (en) | Inhibitors of sarm1 | |
IL279949A (en) | Heterocyclic inhibitors of mct4 | |
EP3679031A4 (en) | Inhibitors of wdr5 protein-protein binding | |
EP3906029A4 (en) | Inhibitors of menin-mll interaction | |
ZA202006092B (en) | Imidazopiperazine inhibitors of transcription activating proteins | |
IL276013A (en) | Pi4kiiibeta inhibitors | |
GB201708457D0 (en) | Inhibitors of metallo-beta-lactamases | |
EP3801499A4 (en) | Inhibitors of sarm1 | |
SG11202000621VA (en) | Inhibitors of ror? | |
EP3801500A4 (en) | Inhibitors of sarm1 | |
IL281514A (en) | O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors | |
EP3801525A4 (en) | Inhibitors of prolyl-trna-synthetase | |
IL261265A (en) | Peptide inhibitors of calcium channels | |
GB201708451D0 (en) | Inhibitors of metallo-beta-lactamases | |
IL277578A (en) | Novel salt forms of urat-1 inhibitors | |
SG11202105136WA (en) | Application of chidamide | |
GB201812462D0 (en) | Inhibitors | |
GB201804439D0 (en) | Dopamin-b-hydroxylase inhibitors |