SG11202101283WA - Microorganisms with improved 1,3-propanediol and butyric acid production - Google Patents

Microorganisms with improved 1,3-propanediol and butyric acid production

Info

Publication number
SG11202101283WA
SG11202101283WA SG11202101283WA SG11202101283WA SG11202101283WA SG 11202101283W A SG11202101283W A SG 11202101283WA SG 11202101283W A SG11202101283W A SG 11202101283WA SG 11202101283W A SG11202101283W A SG 11202101283WA SG 11202101283W A SG11202101283W A SG 11202101283WA
Authority
SG
Singapore
Prior art keywords
propanediol
microorganisms
improved
butyric acid
acid production
Prior art date
Application number
SG11202101283WA
Inventor
Wanda Dischert
Céline Raynaud
Laurence Dumon-Seignovert
Nadège Dumoulin
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of SG11202101283WA publication Critical patent/SG11202101283WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0067—Oxidoreductases (1.) acting on hydrogen as donor (1.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y112/00—Oxidoreductases acting on hydrogen as donor (1.12)
    • C12Y112/07—Oxidoreductases acting on hydrogen as donor (1.12) with an iron-sulfur protein as acceptor (1.12.7)
    • C12Y112/07002—Ferredoxin hydrogenase (1.12.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/0103—Glycerol kinase (2.7.1.30)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11202101283WA 2018-08-10 2019-08-09 Microorganisms with improved 1,3-propanediol and butyric acid production SG11202101283WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18306099 2018-08-10
PCT/EP2019/071392 WO2020030775A1 (en) 2018-08-10 2019-08-09 Microorganisms with improved 1,3-propanediol and butyric acid production

Publications (1)

Publication Number Publication Date
SG11202101283WA true SG11202101283WA (en) 2021-03-30

Family

ID=63449410

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202101283WA SG11202101283WA (en) 2018-08-10 2019-08-09 Microorganisms with improved 1,3-propanediol and butyric acid production

Country Status (13)

Country Link
US (1) US11814663B2 (en)
EP (1) EP3833770A1 (en)
JP (1) JP2021533764A (en)
KR (1) KR20210043606A (en)
CN (1) CN112567044A (en)
AR (1) AR114547A1 (en)
AU (1) AU2019319045A1 (en)
BR (1) BR112021002573A2 (en)
CA (1) CA3107573A1 (en)
IL (1) IL280749A (en)
MX (1) MX2021001619A (en)
SG (1) SG11202101283WA (en)
WO (1) WO2020030775A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000031979A1 (en) 2020-12-22 2022-06-22 Novamont Spa PURIFICATION PROCESS OF A MIXTURE INCLUDING DIOLS AND ACETALS
IT202100006419A1 (en) 2021-03-17 2022-09-17 Novamont Spa RECOVERY OF DIOLS FROM A MIXTURE

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2633939B1 (en) 1988-07-06 1991-05-31 Inst Francais Du Petrole PROCESS FOR THE PRODUCTION OF NORMAL BUTYRIC ACID BY FERMENTATION FROM A SUGAR SUBSTRATE IN THE PRESENCE OF AT LEAST ONE STRAIN OF THE SPECIES CLOSTRIDIUM
FR2796081B1 (en) 1999-07-09 2003-09-26 Agronomique Inst Nat Rech PROCESS FOR THE PREPARATION OF 1,3-PROPANEDIOL BY A MICROORGANISM RECOMBINANT IN THE ABSENCE OF COENZYME B12 OR ONE OF ITS PRECURSORS
WO2002077183A2 (en) * 2001-03-21 2002-10-03 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
ES2356526T3 (en) 2002-10-04 2011-04-08 E.I. Du Pont De Nemours And Company PROCEDURE FOR THE BIOLOGICAL PRODUCTION OF 1,3-PROPANODIOL WITH HIGH PERFORMANCE.
CN1327001C (en) 2005-06-03 2007-07-18 清华大学 Method for producing 1,3-propylene glycol through using glycerin of by-product from biologic diesel oil
JP5203375B2 (en) 2006-10-03 2013-06-05 メタボリック エクスプローラー Chromosome uptake and DNA sequence replacement in Clostridium bacteria
EP2400027A1 (en) * 2006-10-31 2011-12-28 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
BRPI0814640A2 (en) 2007-07-23 2014-10-14 Dsm Ip Assets Bv BUTANOL AND ETHANOL PREPARATION PROCESS
CN101925567B (en) 2007-11-30 2014-04-23 代谢探索者公司 Method for purifying alcohol from fermentation broth
MX2011003558A (en) 2008-10-03 2011-05-02 Metabolic Explorer Sa Method for purifying an alcohol from a fermentation broth using a falling film, a wiped film, a thin film or a short path evaporator.
EP2248904A1 (en) 2009-05-05 2010-11-10 Metabolic Explorer Continuous culture for 1,3-propanediol production using high glycerine concentration
WO2011042434A1 (en) 2009-10-05 2011-04-14 Metabolic Explorer 1,3-propanediol production with immobilised cells reactors
AR083799A1 (en) * 2010-11-10 2013-03-20 Metabolic Explorer Sa MICROORGANISMS FOR THE PRODUCTION OF 1,3-PROPANODIOL USING CONCENTRATION OF HIGH GLYCERINE
GB201116971D0 (en) * 2011-10-03 2011-11-16 Isis Innovation Cofactor regeneration system
KR20140032057A (en) * 2012-09-05 2014-03-14 삼성전자주식회사 Recombinant microorganism having improved productivity of glycerol dehydration product and use thereof
WO2016042160A1 (en) * 2014-09-18 2016-03-24 Institut National Des Sciences Appliquees Clostridium acetobutylicum strains unable to produce hydrogen and useful for the continuous production of chemicals and fuels
FR3039167B1 (en) 2015-07-23 2023-11-10 Afyren METHOD FOR EXTRACTION OF FERMENTARY METABOLITES PRODUCED BY ANAEROBIC FERMENTATION FROM FERMENTESCIBLE BIOMASS
DK3583221T3 (en) * 2017-02-20 2021-09-06 Metabolic Explorer Sa Microbial consortium comprising clostridia for the production of 1,3-propanediol from glycerol

Also Published As

Publication number Publication date
AU2019319045A1 (en) 2021-02-18
US20210254108A1 (en) 2021-08-19
US11814663B2 (en) 2023-11-14
WO2020030775A1 (en) 2020-02-13
JP2021533764A (en) 2021-12-09
KR20210043606A (en) 2021-04-21
IL280749A (en) 2021-04-29
CA3107573A1 (en) 2020-02-13
CN112567044A (en) 2021-03-26
AR114547A1 (en) 2020-09-16
BR112021002573A2 (en) 2021-05-11
EP3833770A1 (en) 2021-06-16
MX2021001619A (en) 2021-05-12

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