SG11202012567PA - Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields) - Google Patents

Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields)

Info

Publication number
SG11202012567PA
SG11202012567PA SG11202012567PA SG11202012567PA SG11202012567PA SG 11202012567P A SG11202012567P A SG 11202012567PA SG 11202012567P A SG11202012567P A SG 11202012567PA SG 11202012567P A SG11202012567P A SG 11202012567PA SG 11202012567P A SG11202012567P A SG 11202012567PA
Authority
SG
Singapore
Prior art keywords
ttfields
quantify
dose
power loss
loss density
Prior art date
Application number
SG11202012567PA
Inventor
Zeev Bomzon
Hadas Sara Hershkovich
Ariel Naveh
Shay Levi
Noa Urman
Original Assignee
Novocure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocure Gmbh filed Critical Novocure Gmbh
Publication of SG11202012567PA publication Critical patent/SG11202012567PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Social Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Electrotherapy Devices (AREA)
SG11202012567PA 2018-07-18 2019-07-18 Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields) SG11202012567PA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862700080P 2018-07-18 2018-07-18
US201862754901P 2018-11-02 2018-11-02
US201962833983P 2019-04-15 2019-04-15
PCT/IB2019/056181 WO2020016840A1 (en) 2018-07-18 2019-07-18 Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields)

Publications (1)

Publication Number Publication Date
SG11202012567PA true SG11202012567PA (en) 2021-01-28

Family

ID=68051832

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202012567PA SG11202012567PA (en) 2018-07-18 2019-07-18 Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields)

Country Status (12)

Country Link
US (1) US11911612B2 (en)
EP (3) EP3967361A1 (en)
JP (2) JP7267393B2 (en)
KR (2) KR102607603B1 (en)
CN (1) CN112601578A (en)
AU (1) AU2019305159B2 (en)
BR (1) BR112020025269A2 (en)
CA (1) CA3103075A1 (en)
IL (1) IL279253A (en)
MX (1) MX2020013431A (en)
SG (1) SG11202012567PA (en)
WO (1) WO2020016840A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
EP4147747A1 (en) 2016-06-30 2023-03-15 Novocure GmbH Arrays for longitudinal delivery of ttfields to a body
EP3571503A1 (en) 2017-01-19 2019-11-27 Moshe Giladi System for viewing cell cultures under a microscope whilst applying ttfields
CA3103070C (en) 2018-07-10 2024-01-09 Novocure Gmbh Inhibiting viral infection using alternating electric fields
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
CN112770806A (en) 2018-09-07 2021-05-07 诺沃库勒有限责任公司 Treatment of autoimmune diseases using alternating electric fields to reduce proliferation of T cells
US11241577B2 (en) 2018-10-15 2022-02-08 Novocure Gmbh Generating tumor treating fields (TTFields) with high uniformity throughout the brain
EP3870271A1 (en) 2018-10-25 2021-09-01 Zeev Bomzon Delivering alternating electric fields (e.g., ttfields) to a subject's spinal anatomy
EP3922300B1 (en) 2018-11-19 2024-03-06 Novocure GmbH Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements
EP4019081B1 (en) 2018-11-29 2024-04-03 Novocure GmbH Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields)
CN113330485A (en) 2019-01-08 2021-08-31 诺沃库勒有限责任公司 Assessing the quality of segmenting an image into different types of tissue for planning a treatment using a tumor treatment field (TTField)
JP2022522602A (en) 2019-02-26 2022-04-20 ノボキュア ゲーエムベーハー Frequency determination for TT field therapy based on electrical properties of target cancer cells
JP2022522936A (en) 2019-02-27 2022-04-21 ノボキュア ゲーエムベーハー Delivery of Tumor Treatment Electric Field (TTFIELDS) Using Implantable Transducer Array
EP3946322B1 (en) 2019-03-29 2023-09-20 Novocure GmbH Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors
WO2020212824A1 (en) 2019-04-17 2020-10-22 Yoram Wasserman Uploading data from an isolated system without compromising isolation
WO2021019403A1 (en) 2019-07-31 2021-02-04 Yoram Wasserman Applying tumor treating fields (ttfields) via electrodes embedded into skull implants
WO2021038510A1 (en) 2019-08-30 2021-03-04 Novocure Gmbh Delivering tumor treating fields (ttfields) to the neck
CN114901347A (en) 2019-12-31 2022-08-12 诺沃库勒有限责任公司 High voltage, high efficiency sine wave generator to prevent spikes during amplitude adjustment and channel switching
DK4074367T3 (en) 2019-12-31 2023-05-22 Novocure Gmbh ARRAYS FOR DELIVERY OF TUMOR TREATMENT FIELDS (TT FIELDS) WITH INDIVIDUALLY AVAILABLE ELECTRODE ELEMENTS AND TEMPERATURE SENSORS
KR102464313B1 (en) * 2020-05-18 2022-11-08 주식회사 필드큐어 Apparatus and Method for Quality Assurance in Electric Field Therapy
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
EP4271466A2 (en) 2021-03-18 2023-11-08 Novocure Gmbh Constructing a 3d phantom with liquid hydrogel
KR102562095B1 (en) * 2021-06-14 2023-08-02 주식회사 필드큐어 Method and System for Optimizing Electrode Array Structure in Electrotherapy
WO2024052877A1 (en) 2022-09-08 2024-03-14 Novocure Gmbh Constructing a 3d phantom with a matrix material having conductive particles dispersed therein

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
USRE43618E1 (en) 2000-02-17 2012-08-28 Novocure Ltd Method and apparatus for destroying dividing cells
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US7805201B2 (en) 2000-02-17 2010-09-28 Standen Ltd. Treating a tumor or the like with an electric field
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US8447395B2 (en) 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US6546290B1 (en) 2000-04-12 2003-04-08 Roamitron Holding S.A. Method and apparatus for electromedical therapy
JP5260056B2 (en) 2004-12-07 2013-08-14 スタンデン・リミテッド Electrodes for applying an electric field to a living body over a long period of time
CN101124011B (en) 2004-12-27 2011-08-31 斯坦顿有限公司 Treating a tumor or the like with electric fields at different orientations
US20160055304A1 (en) * 2005-06-16 2016-02-25 Aaken Laboratories Targeted electrical stimulation
CA2624624C (en) 2005-10-03 2016-07-19 Novocure Limited Optimizing characteristics of an electric field to increase the field's effect on proliferating cells
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
WO2009044289A1 (en) 2007-03-06 2009-04-09 Novocure Ltd. Treating cancer using electromagnetic fields in combination with photodynamic therapy
CN101820947A (en) 2007-08-14 2010-09-01 诺沃库勒有限公司 Use treating parasites with electric fields
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode
WO2011047387A2 (en) * 2009-10-16 2011-04-21 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
WO2016181316A1 (en) * 2015-05-12 2016-11-17 Navix International Limited Systems and methods for tracking an intrabody catheter
US9910453B2 (en) 2015-09-25 2018-03-06 Novocure Limited High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
EP4147747A1 (en) 2016-06-30 2023-03-15 Novocure GmbH Arrays for longitudinal delivery of ttfields to a body
US20180008708A1 (en) 2016-07-10 2018-01-11 Novocure Limited Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents
FI3500334T3 (en) 2016-08-18 2023-10-30 Novocure Gmbh Temperature measurement in arrays for delivering ttfields
EP3974024A1 (en) 2016-12-13 2022-03-30 Novocure GmbH Treating patients with ttfields with the electrode positions optimized using deformable templates
EP3571503A1 (en) 2017-01-19 2019-11-27 Moshe Giladi System for viewing cell cultures under a microscope whilst applying ttfields
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
EP3773726A1 (en) 2018-04-09 2021-02-17 Moshe Giladi Treating tumors with ttfields and an aurora kinase inhibitor
WO2019197999A1 (en) 2018-04-10 2019-10-17 Zeev Bomzon Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times
EP3900775B1 (en) 2018-07-03 2022-10-05 The Board of Trustees of the Leland Stanford Junior University Using alternating electric fields to increase cell membrane permeability
CA3103070C (en) 2018-07-10 2024-01-09 Novocure Gmbh Inhibiting viral infection using alternating electric fields
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib

Also Published As

Publication number Publication date
JP2023100700A (en) 2023-07-19
EP3967361A1 (en) 2022-03-16
EP3823715A1 (en) 2021-05-26
WO2020016840A1 (en) 2020-01-23
JP7448709B2 (en) 2024-03-12
JP2022511225A (en) 2022-01-31
AU2019305159B2 (en) 2022-07-14
IL279253A (en) 2021-01-31
MX2020013431A (en) 2021-05-27
US11911612B2 (en) 2024-02-27
JP7267393B2 (en) 2023-05-01
KR20230161546A (en) 2023-11-27
NZ770869A (en) 2023-11-24
AU2019305159A1 (en) 2021-01-07
KR102607603B1 (en) 2023-11-29
US20200023179A1 (en) 2020-01-23
EP3967362A1 (en) 2022-03-16
CN112601578A (en) 2021-04-02
KR20210034620A (en) 2021-03-30
CA3103075A1 (en) 2020-01-23
BR112020025269A2 (en) 2021-03-09

Similar Documents

Publication Publication Date Title
IL279253A (en) Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields)
HUE048646T2 (en) Reducing motility of cancer cells using tumor treating fields (ttfields)
EP4066887C0 (en) Devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
IL268138A (en) Combinations of cabozantinib and atezolizumab to treat cancer
HK1216991A1 (en) Cancer vaccines and methods of treatment using the same
EP4021559C0 (en) Delivering tumor treating fields (ttfields) to the neck
EP3060680A4 (en) Methods relating to circulating tumor cell clusters and the treatment of cancer
IL282836A (en) 5-halouracil-modified micrornas and their use in the treatment of cancer
HK1231560A1 (en) Predictive method of characterizing the radiosensitivity and tissular reaction of a patient to therapeutic ionizing radiation
IL247859B (en) Methods of identifiying a tumor that is sensetive to treatment with axitinib, and axitinib for use for treating cancer
IL254842A0 (en) Therapeutic compositions and methods of use for treating cancer
MX2019008233A (en) Targeted doxorubicin-gold nanoconjugates for tumor therapy.
IL286334A (en) Modified micrornas and their use in the treatment of cancer
IL280060A (en) Methods of treating cancer with tnf expressing myxoma virus
SG11201707134WA (en) Cell therapeutic agent for cancer treatment and combination therapy with same
IL279591A (en) Methods of treating cancer using combination therapy
IL280726A (en) Treatment of b cell malignancies
IL280000A (en) Tumor reduction formulations and methods of use thereof
IL290321A (en) Use of sepiapterin and metabolites thereof to treat radiation exposure
IL288898A (en) Activated lymphocytic cells and methods of using the same to treat cancer and infectious conditions
IL275517A (en) Methods and combination therapy to treat cancer
FR3017624B1 (en) PREDICTIVE METHOD FOR CHARACTERIZING THE RADIOSENSITIVITY AND TISSUE REACTION OF A PATIENT TO THERAPEUTIC IONIZING RADIATION
IL275913A (en) Methods and combination therapy to treat cancer
EP4126014A4 (en) Combination therapeutics using tumor treating fields (ttfields)
IL277158A (en) Compounds and uses thereof to treat tumors in a subject