SG11202011961YA - Dosing and effect of c5a antagonist with anca-associated vasculitis - Google Patents

Dosing and effect of c5a antagonist with anca-associated vasculitis

Info

Publication number
SG11202011961YA
SG11202011961YA SG11202011961YA SG11202011961YA SG11202011961YA SG 11202011961Y A SG11202011961Y A SG 11202011961YA SG 11202011961Y A SG11202011961Y A SG 11202011961YA SG 11202011961Y A SG11202011961Y A SG 11202011961YA SG 11202011961Y A SG11202011961Y A SG 11202011961YA
Authority
SG
Singapore
Prior art keywords
anca
antagonist
dosing
effect
associated vasculitis
Prior art date
Application number
SG11202011961YA
Inventor
Jun Deng
Petrus Bekker
Jan Hillson
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of SG11202011961YA publication Critical patent/SG11202011961YA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
SG11202011961YA 2018-06-07 2019-06-06 Dosing and effect of c5a antagonist with anca-associated vasculitis SG11202011961YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862682013P 2018-06-07 2018-06-07
PCT/US2019/035758 WO2019236820A1 (en) 2018-06-07 2019-06-06 Dosing and effect of c5a antagonist with anca-associated vasculitis

Publications (1)

Publication Number Publication Date
SG11202011961YA true SG11202011961YA (en) 2020-12-30

Family

ID=68764799

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011961YA SG11202011961YA (en) 2018-06-07 2019-06-06 Dosing and effect of c5a antagonist with anca-associated vasculitis

Country Status (14)

Country Link
US (2) US11191756B2 (en)
EP (1) EP3801519A4 (en)
JP (1) JP2021527062A (en)
KR (1) KR20210018906A (en)
CN (1) CN112423752A (en)
AU (1) AU2019282327A1 (en)
BR (1) BR112020024842A2 (en)
CA (1) CA3102403A1 (en)
CL (1) CL2020003171A1 (en)
IL (1) IL279188A (en)
MA (1) MA52808A (en)
MX (1) MX2020013166A (en)
SG (1) SG11202011961YA (en)
WO (1) WO2019236820A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020112961A1 (en) 2018-11-30 2020-06-04 Chemocentryx, Inc. Capsule formulations
JP2023501789A (en) 2019-11-08 2023-01-19 ケモセントリックス,インコーポレイティド Amorphous Form of Complement Component C5a Receptor
CA3235574A1 (en) 2019-11-08 2021-05-14 Chemocentryx, Inc. Salt forms of a complement component c5a receptor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1739078A1 (en) * 2005-05-30 2007-01-03 Jerini AG Antagonists of C5a-receptor
JP2010513530A (en) 2006-12-22 2010-04-30 エンサイシブ・ファーマシューティカルズ・インコーポレイテッド C3A receptor modulator and method of use thereof
US8268972B2 (en) * 2008-02-20 2012-09-18 G2 Inflammation Pty Ltd Humanized anti-C5aR antibodies
US20110275639A1 (en) 2008-12-22 2011-11-10 Chemocentryx, Inc. C5aR ANTAGONISTS
WO2010075257A1 (en) * 2008-12-22 2010-07-01 Chemocentryx, Inc. C5ar antagonists
PL2585064T3 (en) 2010-06-24 2017-09-29 Chemocentryx, Inc. C5ar antagonists
CN113121415A (en) 2014-09-29 2021-07-16 凯莫森特里克斯股份有限公司 Processes and intermediates for preparing C5aR antagonists
ES2781980T3 (en) 2015-04-17 2020-09-09 Euroimmun Medizinische Labordiagnostika Ag Procedure and diagnostic test for rapidly progressive glomerulonephritis in a subject
MX2018011831A (en) 2016-04-04 2019-02-13 Chemocentryx Inc SOLUBLE C5aR ANTAGONISTS.
WO2019089534A1 (en) 2017-10-31 2019-05-09 Chemocentryx, Inc. C5aR INHIBITOR REDUCTION OF URINARY sCD163

Also Published As

Publication number Publication date
MA52808A (en) 2021-04-14
US11191756B2 (en) 2021-12-07
KR20210018906A (en) 2021-02-18
US20190374524A1 (en) 2019-12-12
US20220296576A1 (en) 2022-09-22
BR112020024842A2 (en) 2021-03-02
CA3102403A1 (en) 2019-12-12
AU2019282327A1 (en) 2021-01-07
WO2019236820A1 (en) 2019-12-12
EP3801519A1 (en) 2021-04-14
IL279188A (en) 2021-01-31
JP2021527062A (en) 2021-10-11
CL2020003171A1 (en) 2021-06-04
MX2020013166A (en) 2021-03-29
CN112423752A (en) 2021-02-26
EP3801519A4 (en) 2022-03-30

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