SG11202011751WA - Chimeric transmembrane proteins and uses thereof - Google Patents
Chimeric transmembrane proteins and uses thereofInfo
- Publication number
- SG11202011751WA SG11202011751WA SG11202011751WA SG11202011751WA SG11202011751WA SG 11202011751W A SG11202011751W A SG 11202011751WA SG 11202011751W A SG11202011751W A SG 11202011751WA SG 11202011751W A SG11202011751W A SG 11202011751WA SG 11202011751W A SG11202011751W A SG 11202011751WA
- Authority
- SG
- Singapore
- Prior art keywords
- transmembrane proteins
- chimeric transmembrane
- chimeric
- proteins
- transmembrane
- Prior art date
Links
- 102000035160 transmembrane proteins Human genes 0.000 title 1
- 108091005703 transmembrane proteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464419—Receptors for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464474—Proteoglycans, e.g. glypican, brevican or CSPG4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862688810P | 2018-06-22 | 2018-06-22 | |
PCT/US2019/038547 WO2019246563A1 (en) | 2018-06-22 | 2019-06-21 | Chimeric transmembrane proteins and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202011751WA true SG11202011751WA (en) | 2021-01-28 |
Family
ID=67352580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202011751WA SG11202011751WA (en) | 2018-06-22 | 2019-06-21 | Chimeric transmembrane proteins and uses thereof |
Country Status (13)
Country | Link |
---|---|
US (2) | US11708401B2 (en) |
EP (1) | EP3810645A1 (en) |
JP (1) | JP2021527689A (en) |
KR (1) | KR20210025525A (en) |
CN (1) | CN112368298A (en) |
AU (2) | AU2019288733C1 (en) |
BR (1) | BR112020025804A2 (en) |
CA (1) | CA3102641A1 (en) |
IL (1) | IL279505A (en) |
MX (1) | MX2020013977A (en) |
SG (1) | SG11202011751WA (en) |
TW (1) | TWI809130B (en) |
WO (1) | WO2019246563A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3034873A1 (en) * | 2016-08-26 | 2018-03-01 | Baylor College Of Medicine | Constitutively active cytokine receptors for cell therapy |
EP3688032A1 (en) | 2017-09-26 | 2020-08-05 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules and methods of use |
US11866494B2 (en) * | 2018-08-31 | 2024-01-09 | Innovative Cellular Therapeutics Holdings, Ltd. | CAR T therapy through uses of co-stimulation |
CA3129862A1 (en) | 2019-03-01 | 2020-09-10 | Allogene Therapeutics, Inc. | Chimeric cytokine receptors bearing a pd-1 ectodomain |
GB201911187D0 (en) | 2019-08-05 | 2019-09-18 | Autolus Ltd | Receptor |
US20210253696A1 (en) * | 2020-01-21 | 2021-08-19 | Cero Therapeutics, Inc. | Bivalent chimeric engulfment receptors and uses thereof |
US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
EP4263600A1 (en) | 2020-12-18 | 2023-10-25 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
CA3212950A1 (en) * | 2021-03-11 | 2022-09-15 | Kite Pharma, Inc. | Improving immune cell function |
CN113736810B (en) * | 2021-09-08 | 2024-05-24 | 苏州因特药物研发有限公司 | Construct, vector, protein, cell, preparation method, product and application |
WO2023197980A1 (en) * | 2022-04-11 | 2023-10-19 | 苏州沙砾生物科技有限公司 | Chimeric antigen receptor and use thereof |
CN117683139A (en) * | 2022-09-09 | 2024-03-12 | 信达细胞制药(苏州)有限公司 | Constitutive chimeric cytokine receptor, immune cell expressing same and application thereof |
CN117402231B (en) * | 2023-12-14 | 2024-04-09 | 南方医科大学南方医院 | Receptor capable of spontaneously transmitting IL-21 signal and application thereof |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0173552B1 (en) | 1984-08-24 | 1991-10-09 | The Upjohn Company | Recombinant dna compounds and the expression of polypeptides such as tpa |
US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
JP4124815B2 (en) | 1991-10-31 | 2008-07-23 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | TGF-β type receptor cDNA and use thereof |
ES2174868T3 (en) | 1992-10-29 | 2002-11-16 | Celtrix Pharma | FRAGMENT OF THE FIXING RECEIVER TO TGF-BETA TIPOII AS A THERAPEUTIC AGENT. |
DE19608753C1 (en) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduction system based on rep-negative adeno-associated virus vector |
US20030125251A1 (en) | 2001-06-21 | 2003-07-03 | Wakefield Lalage M. | Transforming growth factor beta (TGF-beta) antagonist selectively neutralizes "pathological" TGF-beta |
CN1314803C (en) | 2001-06-22 | 2007-05-09 | 中外制药株式会社 | Cell proliferation inhibitors containing anti-glypican 3 antibody |
WO2004022597A1 (en) | 2002-09-04 | 2004-03-18 | Chugai Seiyaku Kabushiki Kaisha | Antibody against blood-solubilized n-terminal peptide in gpc3 |
WO2006012414A2 (en) | 2004-07-20 | 2006-02-02 | Critical Therapeutics, Inc. | Novel polyadenylation signal for use in expression vectors |
EP3798237A1 (en) | 2010-03-05 | 2021-03-31 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
JP6251570B2 (en) | 2010-09-21 | 2017-12-20 | アルター・バイオサイエンス・コーポレーション | Multimeric IL-15 soluble fusion molecule and methods for its production and use |
CN105968209B (en) | 2011-04-19 | 2021-08-03 | 美国政府(由卫生和人类服务部的部长所代表) | Human monoclonal antibodies specific for glypican 3 and uses thereof |
US20140322216A1 (en) | 2011-11-08 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
CN104334573A (en) | 2012-04-30 | 2015-02-04 | 比奥孔有限公司 | Targeted/immunomodulatory fusion proteins and methods for making same |
WO2013181543A1 (en) | 2012-06-01 | 2013-12-05 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | High-affinity monoclonal antibodies to glypican-3 and use thereof |
JP6359019B2 (en) | 2012-10-24 | 2018-07-18 | ノバルティス アーゲー | IL-15Rα type, cells expressing IL-15Rα type, and therapeutic use of IL-15Rα and IL-15 / IL-15Rα complex |
CN110423282B (en) | 2013-02-15 | 2023-09-08 | 加利福尼亚大学董事会 | Chimeric antigen receptor and methods of use thereof |
CN105874061B (en) | 2013-02-26 | 2021-08-10 | 纪念斯隆-凯特琳癌症中心 | Compositions and methods for immunotherapy |
CN104140974B (en) | 2013-05-08 | 2017-09-29 | 科济生物医药(上海)有限公司 | Encode the nucleic acid of the Chimeric antigen receptor albumen of GPC 3 and express the T lymphocytes of the Chimeric antigen receptor albumen of GPC 3 |
AU2014308751B2 (en) | 2013-08-22 | 2020-03-05 | Acceleron Pharma, Inc. | TGF-beta receptor type II variants and uses thereof |
US20170335281A1 (en) | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
CN106795221B (en) | 2014-04-03 | 2022-06-07 | 塞勒克提斯公司 | CD 33-specific chimeric antigen receptor for cancer immunotherapy |
US9926377B2 (en) | 2014-05-22 | 2018-03-27 | Genentech, Inc. | Anti-GPC3 antibodies and immunoconjugates |
WO2016036973A1 (en) | 2014-09-04 | 2016-03-10 | The Trustees Of The University Of Pennsylvania | Glypican-3 antibody and uses thereof |
JP2017529851A (en) | 2014-09-26 | 2017-10-12 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | Glypican-3 specific chimeric antigen receptor for adoptive immunotherapy |
MA40035A (en) | 2014-10-14 | 2016-04-21 | Dana Farber Cancer Inst Inc | PD-L1 ANTIBODY MOLECULES AND THEIR USES |
WO2016113203A1 (en) | 2015-01-12 | 2016-07-21 | Pieris Ag | Engineered t cells and uses therefor |
WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
CN109414512A (en) | 2016-04-22 | 2019-03-01 | 科济生物医药(上海)有限公司 | Composition and method for cellular immunotherapy |
CN105949324B (en) | 2016-06-30 | 2019-08-27 | 上海恒润达生生物科技有限公司 | Target the Chimeric antigen receptor and application thereof of GPC3 |
CA3034873A1 (en) * | 2016-08-26 | 2018-03-01 | Baylor College Of Medicine | Constitutively active cytokine receptors for cell therapy |
EP3507361A1 (en) | 2016-08-30 | 2019-07-10 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use for treating viral and other infections |
EP3551197B1 (en) | 2016-12-12 | 2023-11-22 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
CA3049189A1 (en) | 2017-01-10 | 2018-07-19 | Yamaguchi University | Anti-gpc3 antibody |
EP3615574A4 (en) | 2017-04-26 | 2021-02-24 | Eureka Therapeutics, Inc. | Constructs specifically recognizing glypican 3 and uses thereof |
PL3628049T3 (en) | 2017-05-04 | 2023-09-25 | Acceleron Pharma Inc. | Tgf-beta receptor type ii fusion proteins and uses thereof |
CN111683962A (en) | 2017-11-10 | 2020-09-18 | 美国政府(由卫生和人类服务部的部长所代表) | Chimeric antigen receptors targeting tumor antigens |
WO2019109980A1 (en) | 2017-12-06 | 2019-06-13 | 科济生物医药(上海)有限公司 | Chimeric protein, and immune effector cell expressing same and application thereof |
-
2019
- 2019-06-21 BR BR112020025804-0A patent/BR112020025804A2/en unknown
- 2019-06-21 SG SG11202011751WA patent/SG11202011751WA/en unknown
- 2019-06-21 US US16/449,089 patent/US11708401B2/en active Active
- 2019-06-21 EP EP19742108.4A patent/EP3810645A1/en active Pending
- 2019-06-21 MX MX2020013977A patent/MX2020013977A/en unknown
- 2019-06-21 CN CN201980042055.XA patent/CN112368298A/en active Pending
- 2019-06-21 WO PCT/US2019/038547 patent/WO2019246563A1/en active Application Filing
- 2019-06-21 KR KR1020207036743A patent/KR20210025525A/en unknown
- 2019-06-21 CA CA3102641A patent/CA3102641A1/en active Pending
- 2019-06-21 TW TW108121854A patent/TWI809130B/en active
- 2019-06-21 AU AU2019288733A patent/AU2019288733C1/en active Active
- 2019-06-21 JP JP2020570911A patent/JP2021527689A/en active Pending
-
2020
- 2020-12-16 IL IL279505A patent/IL279505A/en unknown
-
2023
- 2023-02-28 AU AU2023201197A patent/AU2023201197A1/en active Pending
- 2023-06-01 US US18/327,651 patent/US20230416339A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2019246563A1 (en) | 2019-12-26 |
US20200002402A1 (en) | 2020-01-02 |
JP2021527689A (en) | 2021-10-14 |
CN112368298A (en) | 2021-02-12 |
AU2023201197A1 (en) | 2023-03-30 |
US20230416339A1 (en) | 2023-12-28 |
IL279505A (en) | 2021-01-31 |
EP3810645A1 (en) | 2021-04-28 |
TWI809130B (en) | 2023-07-21 |
MX2020013977A (en) | 2021-06-15 |
KR20210025525A (en) | 2021-03-09 |
AU2019288733B2 (en) | 2022-12-01 |
BR112020025804A2 (en) | 2021-03-23 |
AU2019288733C1 (en) | 2023-08-03 |
CA3102641A1 (en) | 2019-12-26 |
AU2019288733A1 (en) | 2020-12-24 |
US11708401B2 (en) | 2023-07-25 |
TW202000691A (en) | 2020-01-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL279505A (en) | Chimeric transmembrane proteins and uses thereof | |
IL276950A (en) | Anti-cd73 antibodies and uses thereof | |
IL268346A (en) | Targeted chimeric proteins and uses thereof | |
IL282968A (en) | Anti-nkg2a antibodies and uses thereof | |
SG11202012004SA (en) | Rna-targeting fusion protein compositions and methods for use | |
EP3833391A4 (en) | SIRP1alpha TARGETED CHIMERIC PROTEINS AND USES THEREOF | |
IL275826A (en) | Anti-mct1 antibodies and uses thereof | |
IL281297A (en) | Anti-npr1 antibodies and uses thereof | |
SG11202009772PA (en) | Anti-dll3 antibodies and uses thereof | |
DK3737402T3 (en) | Modificeret protein | |
EP3722305A4 (en) | Hm-3 fusion protein and use thereof | |
SG11202009625WA (en) | Anti-trem-1 antibodies and uses thereof | |
ZA201906235B (en) | Csf1r-based chimeric proteins | |
IL280321A (en) | Anti-cxcr2 antibodies and uses thereof | |
IL277330A (en) | Anti-il-27 antibodies and uses thereof | |
SG11202101904UA (en) | Spd-1 variant - fc fusion proteins | |
ZA202003845B (en) | Fusion proteins | |
IL283875A (en) | Anti-il-27 antibodies and uses thereof | |
IL281202A (en) | Anti-tnfrsf9 antibodies and uses thereof | |
IL277075A (en) | Anti-phf-tau antibodies and uses thereof | |
IL276548A (en) | Bcma-binding antibodies and uses thereof | |
IL281088A (en) | Flt3l-based chimeric proteins | |
SG11202012680TA (en) | Anti-l1cam antibodies and uses thereof | |
IL283926A (en) | Anti-alpha-synuclein antibodies and uses thereof | |
IL273626A (en) | Immunomodulatory fusion proteins |