SG11202011014VA - Inhibitors of integrated stress response pathway - Google Patents
Inhibitors of integrated stress response pathwayInfo
- Publication number
- SG11202011014VA SG11202011014VA SG11202011014VA SG11202011014VA SG11202011014VA SG 11202011014V A SG11202011014V A SG 11202011014VA SG 11202011014V A SG11202011014V A SG 11202011014VA SG 11202011014V A SG11202011014V A SG 11202011014VA SG 11202011014V A SG11202011014V A SG 11202011014VA
- Authority
- SG
- Singapore
- Prior art keywords
- inhibitors
- stress response
- response pathway
- integrated stress
- integrated
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/58—Nitrogen atoms attached in position 4
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
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CN (1) | CN112912082A (en) |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020011914A2 (en) | 2017-12-13 | 2020-11-24 | Praxis Biotech LLC | integrated voltage response pathway inhibitors |
JP2022536663A (en) | 2019-06-12 | 2022-08-18 | プラクシス バイオテック エルエルシー | Modulators of integrated stress response pathways |
IL296220A (en) | 2020-03-11 | 2022-11-01 | Evotec Int Gmbh | Modulators of the integrated stress response pathway |
KR20230110510A (en) | 2020-10-22 | 2023-07-24 | 에보텍 인터내셔널 게엠베하 | Modulators of the integrated stress response pathway |
JP2023546224A (en) | 2020-10-22 | 2023-11-01 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Modulators of integrated stress response pathways |
WO2022084448A1 (en) | 2020-10-22 | 2022-04-28 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
EP4001917A1 (en) | 2020-11-12 | 2022-05-25 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Inhibitors for use in treating liver disorders |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8917687D0 (en) * | 1989-08-02 | 1989-09-20 | Fujisawa Pharmaceutical Co | Aminopiperazine derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
US5250528A (en) * | 1989-08-02 | 1993-10-05 | Fujisawa Pharmaceutical Co., Ltd. | New aminopiperazine derivatives |
GB2236751B (en) | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
WO1998035951A2 (en) * | 1997-02-17 | 1998-08-20 | Fujisawa Pharmaceutical Co., Ltd. | New aminopiperazine derivatives |
JP3241711B2 (en) * | 1997-07-31 | 2001-12-25 | エフ.ホフマン−ラ ロシュ アーゲー | O-substituted hydroxycoumaranone derivatives as antitumor and antimetastatic agents |
EP1362265A1 (en) | 2001-01-10 | 2003-11-19 | Adtex Inc. | New automatic control system |
EP1464335A3 (en) | 2003-03-31 | 2007-05-09 | Taisho Pharmaceutical Co. Ltd. | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist |
ME02970B (en) | 2004-06-24 | 2018-07-20 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
JP4868731B2 (en) | 2004-11-17 | 2012-02-01 | 独立行政法人理化学研究所 | Cell-free protein synthesis system derived from cultured mammalian cells |
FR2918984B1 (en) * | 2007-07-16 | 2012-09-21 | Sanofi Aventis | 3.5-CARBOXYLATE PYRAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
US20110039860A1 (en) | 2008-05-07 | 2011-02-17 | Cangming Yang | Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment |
US8273900B2 (en) | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
JP5748777B2 (en) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Cyclohexylamide derivatives as CRF receptor antagonists |
JP6353846B2 (en) | 2012-11-09 | 2018-07-04 | バイオエヌテック アーゲーBioNTech AG | Cell RNA expression method |
JP6806562B2 (en) * | 2013-03-15 | 2021-01-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Regulator of the eIF2α pathway |
TW201808888A (en) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | Modulators of the integrated stress pathway |
TW202304851A (en) | 2016-05-05 | 2023-02-01 | 美商嘉來克生命科學有限責任公司 | Modulators of the integrated stress pathway |
TW201808914A (en) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | Modulators of the integrated stress pathway |
TW201808903A (en) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | Modulators of the integrated stress pathway |
CN109563034A (en) | 2016-06-08 | 2019-04-02 | 葛兰素史密斯克莱知识产权发展有限公司 | Chemical compound |
ES2913929T3 (en) | 2016-06-08 | 2022-06-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds as inhibitors of the ATF4 pathway |
WO2018225093A1 (en) | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
BR112020000086A2 (en) | 2017-07-03 | 2020-07-07 | Glaxosmithkline Intellectual Property Development Limited | 2- (4-chlorophenoxy) -n - ((1- (2- (4-chlorophenoxy) ethinazetidin-3-yl) methyl) acetamide derivatives and related compounds as inhibitors of atf4 for the treatment of cancer and other diseases |
BR112020000122A2 (en) | 2017-07-03 | 2020-07-07 | Glaxosmithkline Intellectual Property Development Limited | derivatives of n- (3- (2- (4-chlorophenoxy) acetamido) bicyclo [1.1.1] pentan-1-yl) -2-cyclobutane-1-carboxamide and related compounds as inhibitors of atf4 for treatment against cancer and other diseases |
MX2020001352A (en) | 2017-08-09 | 2020-03-20 | Denali Therapeutics Inc | Compounds, compositions and methods. |
SI3676297T1 (en) | 2017-09-01 | 2023-12-29 | Denali Therapeutics Inc. | Compounds, compositions and methods |
CN112204012B (en) | 2017-11-02 | 2023-12-26 | 卡里科生命科学有限责任公司 | Modulators of integrated stress pathways |
CN112218869A (en) | 2017-11-02 | 2021-01-12 | 卡里科生命科学有限责任公司 | Modulators of integrated stress pathways |
UY37958A (en) | 2017-11-02 | 2019-05-31 | Abbvie Inc | INTEGRATED STRESS ROAD MODULATORS |
UY37956A (en) | 2017-11-02 | 2019-05-31 | Abbvie Inc | INTEGRATED STRESS ROAD MODULATORS |
EP3704091A1 (en) | 2017-11-02 | 2020-09-09 | Calico Life Sciences LLC | Modulators of the integrated stress pathway |
CN112204006B (en) | 2017-11-02 | 2023-11-28 | 卡里科生命科学有限责任公司 | Modulators of integrated stress pathways |
MX2020004557A (en) | 2017-11-02 | 2020-10-05 | Calico Life Sciences Llc | Modulators of the integrated stress pathway. |
UY37957A (en) | 2017-11-02 | 2019-05-31 | Abbvie Inc | INTEGRATED STRESS ROAD MODULATORS |
JP7184889B2 (en) | 2017-11-02 | 2022-12-06 | カリコ ライフ サイエンシーズ エルエルシー | Modulators of integrated stress pathways |
BR112020011914A2 (en) | 2017-12-13 | 2020-11-24 | Praxis Biotech LLC | integrated voltage response pathway inhibitors |
EP3768660A1 (en) | 2018-03-23 | 2021-01-27 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
WO2019193541A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
WO2019193540A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Heteroaryl derivatives of formula (i) as atf4 inhibitors |
EP3820843A1 (en) | 2018-07-09 | 2021-05-19 | GlaxoSmithKline Intellectual Property Development Limited | Chemical compounds |
WO2020031107A1 (en) | 2018-08-08 | 2020-02-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds |
TWI832295B (en) | 2018-10-11 | 2024-02-11 | 美商嘉來克生命科學有限責任公司 | Prodrug modulators of the integrated stress pathway |
US20220177438A1 (en) | 2019-02-13 | 2022-06-09 | Denali Therapeutics Inc. | Compounds, compositions and methods |
CR20210426A (en) | 2019-02-13 | 2021-09-30 | Denali Therapeutics Inc | Compounds, compositions and methods |
JP2022521605A (en) | 2019-02-25 | 2022-04-11 | プラクシス バイオテック エルエルシー | Inhibitors of integrated stress response pathways |
WO2020181247A1 (en) | 2019-03-06 | 2020-09-10 | Denali Therapeutics Inc. | Compounds, compositions and methods |
BR112021020402A2 (en) | 2019-04-23 | 2021-12-07 | Evotec Int Gmbh | Modulators of the integrated stress response pathway |
EP3959210A1 (en) | 2019-04-23 | 2022-03-02 | Evotec International GmbH | Modulators of the integrated stress response pathway |
KR20220016468A (en) | 2019-04-30 | 2022-02-09 | 칼리코 라이프 사이언시스 엘엘씨 | Substituted cycloalkyls as modulators of the integrative stress pathway |
AU2020266592A1 (en) | 2019-04-30 | 2021-12-02 | Abbvie Inc. | Substituted cyclolakyls as modulators of the integrated stress pathway |
MX2021015210A (en) | 2019-06-12 | 2022-01-18 | Praxis Biotech LLC | Inhibitors of integrated stress response pathway. |
JP2022536663A (en) | 2019-06-12 | 2022-08-18 | プラクシス バイオテック エルエルシー | Modulators of integrated stress response pathways |
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AU2019282253A1 (en) | 2020-11-26 |
US20220071966A1 (en) | 2022-03-10 |
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CA3100715A1 (en) | 2019-12-12 |
IL279151A (en) | 2021-01-31 |
CL2020003074A1 (en) | 2021-04-16 |
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