SG11202010790XA - Cd73 inhibitors - Google Patents

Cd73 inhibitors

Info

Publication number
SG11202010790XA
SG11202010790XA SG11202010790XA SG11202010790XA SG11202010790XA SG 11202010790X A SG11202010790X A SG 11202010790XA SG 11202010790X A SG11202010790X A SG 11202010790XA SG 11202010790X A SG11202010790X A SG 11202010790XA SG 11202010790X A SG11202010790X A SG 11202010790XA
Authority
SG
Singapore
Prior art keywords
inhibitors
Prior art date
Application number
SG11202010790XA
Inventor
Xiaohui Du
John Eksterowicz
Valeria Fantin
Daqing Sun
Qiuping Ye
Jared Moore
Tatiana Zavorotinskaya
Brian Blank
Yosup Rew
Kejia Wu
Liusheng Zhu
Johnny Pham
Hiroyuki Kawai
Original Assignee
Oric Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oric Pharmaceuticals Inc filed Critical Oric Pharmaceuticals Inc
Publication of SG11202010790XA publication Critical patent/SG11202010790XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10Sulfides; Sulfoxides; Sulfones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14Pyrrolo-pyrimidine radicals
SG11202010790XA 2018-04-30 2019-04-30 Cd73 inhibitors SG11202010790XA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862664841P 2018-04-30 2018-04-30
US201862737647P 2018-09-27 2018-09-27
US201862757714P 2018-11-08 2018-11-08
US201862777697P 2018-12-10 2018-12-10
US201962810790P 2019-02-26 2019-02-26
PCT/US2019/030068 WO2019213174A1 (en) 2018-04-30 2019-04-30 Cd73 inhibitors

Publications (1)

Publication Number Publication Date
SG11202010790XA true SG11202010790XA (en) 2020-11-27

Family

ID=68386646

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202010790XA SG11202010790XA (en) 2018-04-30 2019-04-30 Cd73 inhibitors

Country Status (13)

Country Link
US (3) US11325938B2 (en)
EP (1) EP3787635A4 (en)
JP (1) JP2021522280A (en)
KR (1) KR20210018255A (en)
CN (1) CN112423764A (en)
AU (1) AU2019261976A1 (en)
BR (1) BR112020022068A2 (en)
CA (1) CA3098493A1 (en)
IL (1) IL304348B1 (en)
MX (2) MX2020011542A (en)
SG (1) SG11202010790XA (en)
TW (1) TW202014182A (en)
WO (1) WO2019213174A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018208980A1 (en) 2017-05-10 2018-11-15 Oric Pharmaceuticals, Inc. Cd73 inhibitors
US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
EP3787635A4 (en) 2018-04-30 2022-03-02 Oric Pharmaceuticals, Inc. Cd73 inhibitors
TW202017569A (en) * 2018-05-31 2020-05-16 美商佩樂敦治療公司 Compositions and methods for inhibiting cd73
CN112888696B (en) 2018-06-21 2024-04-16 德琪医疗有限公司 Exonuclease inhibitors and methods of use thereof
US11198699B2 (en) 2019-04-02 2021-12-14 Aligos Therapeutics, Inc. Compounds targeting PRMT5
KR102653726B1 (en) 2019-10-30 2024-04-01 오릭 파마슈티칼스, 인크. CD73 inhibitor
WO2022237747A1 (en) 2021-05-11 2022-11-17 四川海思科制药有限公司 Small molecular cd73 antagonist and use thereof
WO2024076873A1 (en) * 2022-10-03 2024-04-11 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
WO2024076872A1 (en) * 2022-10-03 2024-04-11 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
CN116217644B (en) * 2023-04-24 2023-08-08 南京颐媛生物医学研究院有限公司 Anti-coronavirus ribonucleoside compound, and preparation method and application thereof

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EP0477454A1 (en) * 1990-09-28 1992-04-01 Merrell Dow Pharmaceuticals Inc. Novel phosphonate derivatives of certain nucleosides
KR20030081343A (en) 2000-12-15 2003-10-17 파마셋, 리미티드 Antiviral agents for treatment of flaviviridae infections
US20040229839A1 (en) * 2003-05-14 2004-11-18 Biocryst Pharmaceuticals, Inc. Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
WO2005020885A2 (en) 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
WO2007139946A2 (en) 2006-05-25 2007-12-06 University Of Tennessee Research Foundation Gpcr ligands identified by computational modeling
DE102007001370A1 (en) 2007-01-09 2008-07-10 Curevac Gmbh RNA-encoded antibodies
WO2009127230A1 (en) 2008-04-16 2009-10-22 Curevac Gmbh MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION
US20090274686A1 (en) * 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
MA39986A (en) 2014-04-25 2017-03-01 Vitae Pharmaceuticals Inc Purine derivatives as cd73 inhibitors for the treatment of cancer
CN104530166B (en) 2014-12-04 2016-08-24 陕西汉江药业集团股份有限公司 The method of selective reduction 4,6-conjugated diene-3-ketosteroid compound
LT3399984T (en) 2016-01-08 2023-11-10 Arcus Biosciences, Inc. Modulators of 5'-nucleotidase, ecto and the use thereof
JP7125144B2 (en) * 2016-09-09 2022-08-24 キャリセラ バイオサイエンシーズ, インコーポレイテッド Ectonucleotidase inhibitors and methods of use thereof
US11058704B2 (en) * 2016-10-03 2021-07-13 Arcus Biosciences, Inc. Inhibitors of adenosine 5′-nucleotidase
US11267845B2 (en) 2016-11-18 2022-03-08 Arcus Biosciences, Inc. Inhibitors of CD73-mediated immunosuppression
BR112019012327A2 (en) 2016-12-22 2019-11-19 Calithera Biosciences Inc ectonucleotidase inhibitors and methods of use thereof
WO2018183635A1 (en) * 2017-03-31 2018-10-04 Peloton Therapeutics, Inc. Cd73 inhibitors and uses thereof
WO2018208727A1 (en) 2017-05-08 2018-11-15 Eternity Bioscience Inc. Nucleoside and nucleotide analogues as cd73 inhibitors and therapeutic uses thereof
WO2018208980A1 (en) 2017-05-10 2018-11-15 Oric Pharmaceuticals, Inc. Cd73 inhibitors
US11377469B2 (en) 2017-11-03 2022-07-05 Oric Pharmaceuticals, Inc. CD73 inhibitors
EP3787635A4 (en) 2018-04-30 2022-03-02 Oric Pharmaceuticals, Inc. Cd73 inhibitors
TW202017569A (en) 2018-05-31 2020-05-16 美商佩樂敦治療公司 Compositions and methods for inhibiting cd73
CN112888696B (en) 2018-06-21 2024-04-16 德琪医疗有限公司 Exonuclease inhibitors and methods of use thereof
EP3843714A4 (en) 2018-08-27 2022-04-20 Arcus Biosciences, Inc. Cd73 inhibitors
KR20220024629A (en) 2019-06-20 2022-03-03 칼리테라 바이오사이언시즈, 인코포레이티드 Ectonucleotidase inhibitors and methods of use thereof
JP2022540890A (en) 2019-07-16 2022-09-20 オリック ファーマシューティカルズ,インク. CD73 inhibitor
KR102653726B1 (en) 2019-10-30 2024-04-01 오릭 파마슈티칼스, 인크. CD73 inhibitor

Also Published As

Publication number Publication date
CA3098493A1 (en) 2019-11-07
CN112423764A (en) 2021-02-26
WO2019213174A1 (en) 2019-11-07
US20210047359A1 (en) 2021-02-18
IL304348B1 (en) 2024-04-01
US20240124512A1 (en) 2024-04-18
US20220220147A1 (en) 2022-07-14
EP3787635A4 (en) 2022-03-02
AU2019261976A1 (en) 2020-12-03
US11807658B2 (en) 2023-11-07
TW202014182A (en) 2020-04-16
MX2023002507A (en) 2023-03-13
MX2020011542A (en) 2020-11-24
IL304348A (en) 2023-09-01
BR112020022068A2 (en) 2021-04-20
US11325938B2 (en) 2022-05-10
JP2021522280A (en) 2021-08-30
KR20210018255A (en) 2021-02-17
EP3787635A1 (en) 2021-03-10

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