SG11202010790XA - Cd73 inhibitors - Google Patents
Cd73 inhibitorsInfo
- Publication number
- SG11202010790XA SG11202010790XA SG11202010790XA SG11202010790XA SG11202010790XA SG 11202010790X A SG11202010790X A SG 11202010790XA SG 11202010790X A SG11202010790X A SG 11202010790XA SG 11202010790X A SG11202010790X A SG 11202010790XA SG 11202010790X A SG11202010790X A SG 11202010790XA
- Authority
- SG
- Singapore
- Prior art keywords
- inhibitors
- Prior art date
Links
- 229940127272 CD73 inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862664841P | 2018-04-30 | 2018-04-30 | |
US201862737647P | 2018-09-27 | 2018-09-27 | |
US201862757714P | 2018-11-08 | 2018-11-08 | |
US201862777697P | 2018-12-10 | 2018-12-10 | |
US201962810790P | 2019-02-26 | 2019-02-26 | |
PCT/US2019/030068 WO2019213174A1 (en) | 2018-04-30 | 2019-04-30 | Cd73 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202010790XA true SG11202010790XA (en) | 2020-11-27 |
Family
ID=68386646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202010790XA SG11202010790XA (en) | 2018-04-30 | 2019-04-30 | Cd73 inhibitors |
Country Status (13)
Country | Link |
---|---|
US (3) | US11325938B2 (en) |
EP (1) | EP3787635A4 (en) |
JP (1) | JP2021522280A (en) |
KR (1) | KR20210018255A (en) |
CN (1) | CN112423764A (en) |
AU (1) | AU2019261976A1 (en) |
BR (1) | BR112020022068A2 (en) |
CA (1) | CA3098493A1 (en) |
IL (1) | IL304348B1 (en) |
MX (2) | MX2020011542A (en) |
SG (1) | SG11202010790XA (en) |
TW (1) | TW202014182A (en) |
WO (1) | WO2019213174A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018208980A1 (en) | 2017-05-10 | 2018-11-15 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
US11377469B2 (en) | 2017-11-03 | 2022-07-05 | Oric Pharmaceuticals, Inc. | CD73 inhibitors |
EP3787635A4 (en) | 2018-04-30 | 2022-03-02 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
TW202017569A (en) * | 2018-05-31 | 2020-05-16 | 美商佩樂敦治療公司 | Compositions and methods for inhibiting cd73 |
CN112888696B (en) | 2018-06-21 | 2024-04-16 | 德琪医疗有限公司 | Exonuclease inhibitors and methods of use thereof |
US11198699B2 (en) | 2019-04-02 | 2021-12-14 | Aligos Therapeutics, Inc. | Compounds targeting PRMT5 |
KR102653726B1 (en) | 2019-10-30 | 2024-04-01 | 오릭 파마슈티칼스, 인크. | CD73 inhibitor |
WO2022237747A1 (en) | 2021-05-11 | 2022-11-17 | 四川海思科制药有限公司 | Small molecular cd73 antagonist and use thereof |
WO2024076873A1 (en) * | 2022-10-03 | 2024-04-11 | Teon Therapeutics, Inc. | Heterocyclic inhibitors of cd73 for treatment of disease |
WO2024076872A1 (en) * | 2022-10-03 | 2024-04-11 | Teon Therapeutics, Inc. | Heterocyclic inhibitors of cd73 for treatment of disease |
CN116217644B (en) * | 2023-04-24 | 2023-08-08 | 南京颐媛生物医学研究院有限公司 | Anti-coronavirus ribonucleoside compound, and preparation method and application thereof |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0477454A1 (en) * | 1990-09-28 | 1992-04-01 | Merrell Dow Pharmaceuticals Inc. | Novel phosphonate derivatives of certain nucleosides |
KR20030081343A (en) | 2000-12-15 | 2003-10-17 | 파마셋, 리미티드 | Antiviral agents for treatment of flaviviridae infections |
US20040229839A1 (en) * | 2003-05-14 | 2004-11-18 | Biocryst Pharmaceuticals, Inc. | Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
WO2005020885A2 (en) | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
WO2007139946A2 (en) | 2006-05-25 | 2007-12-06 | University Of Tennessee Research Foundation | Gpcr ligands identified by computational modeling |
DE102007001370A1 (en) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-encoded antibodies |
WO2009127230A1 (en) | 2008-04-16 | 2009-10-22 | Curevac Gmbh | MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION |
US20090274686A1 (en) * | 2008-05-02 | 2009-11-05 | Yat Sun Or | Nucleoside phosphonate derivatives |
MA39986A (en) | 2014-04-25 | 2017-03-01 | Vitae Pharmaceuticals Inc | Purine derivatives as cd73 inhibitors for the treatment of cancer |
CN104530166B (en) | 2014-12-04 | 2016-08-24 | 陕西汉江药业集团股份有限公司 | The method of selective reduction 4,6-conjugated diene-3-ketosteroid compound |
LT3399984T (en) | 2016-01-08 | 2023-11-10 | Arcus Biosciences, Inc. | Modulators of 5'-nucleotidase, ecto and the use thereof |
JP7125144B2 (en) * | 2016-09-09 | 2022-08-24 | キャリセラ バイオサイエンシーズ, インコーポレイテッド | Ectonucleotidase inhibitors and methods of use thereof |
US11058704B2 (en) * | 2016-10-03 | 2021-07-13 | Arcus Biosciences, Inc. | Inhibitors of adenosine 5′-nucleotidase |
US11267845B2 (en) | 2016-11-18 | 2022-03-08 | Arcus Biosciences, Inc. | Inhibitors of CD73-mediated immunosuppression |
BR112019012327A2 (en) | 2016-12-22 | 2019-11-19 | Calithera Biosciences Inc | ectonucleotidase inhibitors and methods of use thereof |
WO2018183635A1 (en) * | 2017-03-31 | 2018-10-04 | Peloton Therapeutics, Inc. | Cd73 inhibitors and uses thereof |
WO2018208727A1 (en) | 2017-05-08 | 2018-11-15 | Eternity Bioscience Inc. | Nucleoside and nucleotide analogues as cd73 inhibitors and therapeutic uses thereof |
WO2018208980A1 (en) | 2017-05-10 | 2018-11-15 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
US11377469B2 (en) | 2017-11-03 | 2022-07-05 | Oric Pharmaceuticals, Inc. | CD73 inhibitors |
EP3787635A4 (en) | 2018-04-30 | 2022-03-02 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
TW202017569A (en) | 2018-05-31 | 2020-05-16 | 美商佩樂敦治療公司 | Compositions and methods for inhibiting cd73 |
CN112888696B (en) | 2018-06-21 | 2024-04-16 | 德琪医疗有限公司 | Exonuclease inhibitors and methods of use thereof |
EP3843714A4 (en) | 2018-08-27 | 2022-04-20 | Arcus Biosciences, Inc. | Cd73 inhibitors |
KR20220024629A (en) | 2019-06-20 | 2022-03-03 | 칼리테라 바이오사이언시즈, 인코포레이티드 | Ectonucleotidase inhibitors and methods of use thereof |
JP2022540890A (en) | 2019-07-16 | 2022-09-20 | オリック ファーマシューティカルズ,インク. | CD73 inhibitor |
KR102653726B1 (en) | 2019-10-30 | 2024-04-01 | 오릭 파마슈티칼스, 인크. | CD73 inhibitor |
-
2019
- 2019-04-30 EP EP19796584.1A patent/EP3787635A4/en active Pending
- 2019-04-30 WO PCT/US2019/030068 patent/WO2019213174A1/en unknown
- 2019-04-30 MX MX2020011542A patent/MX2020011542A/en unknown
- 2019-04-30 JP JP2020560361A patent/JP2021522280A/en active Pending
- 2019-04-30 IL IL304348A patent/IL304348B1/en unknown
- 2019-04-30 KR KR1020207034512A patent/KR20210018255A/en not_active Application Discontinuation
- 2019-04-30 CA CA3098493A patent/CA3098493A1/en active Pending
- 2019-04-30 SG SG11202010790XA patent/SG11202010790XA/en unknown
- 2019-04-30 BR BR112020022068-0A patent/BR112020022068A2/en unknown
- 2019-04-30 AU AU2019261976A patent/AU2019261976A1/en active Pending
- 2019-04-30 CN CN201980044455.4A patent/CN112423764A/en active Pending
- 2019-04-30 TW TW108115143A patent/TW202014182A/en unknown
-
2020
- 2020-10-23 US US17/078,567 patent/US11325938B2/en active Active
- 2020-10-29 MX MX2023002507A patent/MX2023002507A/en unknown
-
2022
- 2022-03-17 US US17/697,318 patent/US11807658B2/en active Active
-
2023
- 2023-09-28 US US18/476,763 patent/US20240124512A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3098493A1 (en) | 2019-11-07 |
CN112423764A (en) | 2021-02-26 |
WO2019213174A1 (en) | 2019-11-07 |
US20210047359A1 (en) | 2021-02-18 |
IL304348B1 (en) | 2024-04-01 |
US20240124512A1 (en) | 2024-04-18 |
US20220220147A1 (en) | 2022-07-14 |
EP3787635A4 (en) | 2022-03-02 |
AU2019261976A1 (en) | 2020-12-03 |
US11807658B2 (en) | 2023-11-07 |
TW202014182A (en) | 2020-04-16 |
MX2023002507A (en) | 2023-03-13 |
MX2020011542A (en) | 2020-11-24 |
IL304348A (en) | 2023-09-01 |
BR112020022068A2 (en) | 2021-04-20 |
US11325938B2 (en) | 2022-05-10 |
JP2021522280A (en) | 2021-08-30 |
KR20210018255A (en) | 2021-02-17 |
EP3787635A1 (en) | 2021-03-10 |
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