SG11202009199YA - Rimegepant for cgrp related disorders - Google Patents

Rimegepant for cgrp related disorders

Info

Publication number
SG11202009199YA
SG11202009199YA SG11202009199YA SG11202009199YA SG11202009199YA SG 11202009199Y A SG11202009199Y A SG 11202009199YA SG 11202009199Y A SG11202009199Y A SG 11202009199YA SG 11202009199Y A SG11202009199Y A SG 11202009199YA SG 11202009199Y A SG11202009199Y A SG 11202009199YA
Authority
SG
Singapore
Prior art keywords
rimegepant
related disorders
cgrp related
cgrp
disorders
Prior art date
Application number
SG11202009199YA
Inventor
Vladimir Coric
Robert Croop
Original Assignee
Biohaven Pharm Holding Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohaven Pharm Holding Co Ltd filed Critical Biohaven Pharm Holding Co Ltd
Publication of SG11202009199YA publication Critical patent/SG11202009199YA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2063Proteins, e.g. gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
SG11202009199YA 2018-03-25 2019-03-25 Rimegepant for cgrp related disorders SG11202009199YA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862647794P 2018-03-25 2018-03-25
US201862664761P 2018-04-30 2018-04-30
US201862774285P 2018-12-02 2018-12-02
US201862777180P 2018-12-09 2018-12-09
US201862777625P 2018-12-10 2018-12-10
PCT/US2019/023940 WO2019191008A1 (en) 2018-03-25 2019-03-25 Rimegepant for cgrp related disorders

Publications (1)

Publication Number Publication Date
SG11202009199YA true SG11202009199YA (en) 2020-10-29

Family

ID=68060723

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202009199YA SG11202009199YA (en) 2018-03-25 2019-03-25 Rimegepant for cgrp related disorders

Country Status (13)

Country Link
US (3) US20210000814A1 (en)
EP (2) EP3773572A4 (en)
JP (2) JP2021519288A (en)
KR (1) KR20200135465A (en)
CN (1) CN112153969A (en)
AU (1) AU2019242604A1 (en)
BR (1) BR112020019396A2 (en)
CA (1) CA3094693A1 (en)
IL (1) IL277272A (en)
MX (1) MX2020009856A (en)
PH (1) PH12020551425A1 (en)
SG (1) SG11202009199YA (en)
WO (1) WO2019191008A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202009199YA (en) * 2018-03-25 2020-10-29 Biohaven Pharm Holding Co Ltd Rimegepant for cgrp related disorders
AU2020210024A1 (en) * 2019-01-20 2021-07-01 Biohaven Pharmaceutical Holding Company Ltd. CGRP antagonists for treating migraine breakthrough
US20220401439A1 (en) * 2019-12-17 2022-12-22 Biohaven Pharmaceutical Holding Company Ltd. Intranasal pharmaceutical compositions of cgrp inhibitors
BR112022016790A2 (en) * 2020-02-27 2022-11-08 Biohaven Pharm Holding Co Ltd RIMEGEPANT FAST DISPERSION ORAL DOSAGE FORM
US20230285390A1 (en) * 2020-03-23 2023-09-14 Biohaven Pharmaceutical Holding Company Ltd. Methods of treating pulmonary injury with cgrp inhibitors
JP2023533634A (en) * 2020-03-29 2023-08-04 バイオヘイブン・ファーマシューティカル・アイルランド・デジグネイテッド・アクティビティ・カンパニー Prophylactic treatment of migraine
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans
US20230285380A1 (en) * 2021-05-25 2023-09-14 Biohaven Pharmaceutical Ireland Dac Dual treatment of migraine
WO2023055758A1 (en) * 2021-09-29 2023-04-06 Pfizer Ireland Pharmaceuticals Preventative treatment of migraine
CN114010608A (en) * 2021-11-23 2022-02-08 莱默(北京)药业科技有限公司 Ruimeiping freeze-dried orally disintegrating tablet and preparation method thereof
CN115154469A (en) * 2022-07-22 2022-10-11 中国科学院广州生物医药与健康研究院 Application of rimazepam or pharmaceutically acceptable salt thereof in preparation of medicament for preventing or treating obesity
WO2024062504A1 (en) * 2022-09-22 2024-03-28 Quisitive Therapeutics Pharmaceutical composition comprising ubrogepant and administration thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
GB9817793D0 (en) 1998-08-14 1998-10-14 Scherer Corp R P The formation of indicia in the base of a blister pack for transference to a body cast therein
US7704583B2 (en) 1998-08-14 2010-04-27 R.P.Scherer Technologies, Inc. Embossed blister pack
GB9908014D0 (en) * 1999-04-08 1999-06-02 Scherer Corp R P Pharmaceutical compositions
CA2615463A1 (en) * 2005-07-29 2007-02-08 Merck & Co., Inc. Heterocyclic benzodiazepine cgrp receptor antagonists
US8715715B2 (en) * 2008-11-03 2014-05-06 Nal Pharmaceuticals Ltd. Dosage form for insertion into the mouth
US8314117B2 (en) 2009-10-14 2012-11-20 Bristol-Myers Squibb Company CGRP receptor antagonists
US8669368B2 (en) 2010-10-12 2014-03-11 Bristol-Myers Squibb Company Process for the preparation of cycloheptapyridine CGRP receptor antagonists
SI2820016T1 (en) 2012-02-27 2017-11-30 Bristol-Myers Squibb Company N- (5s, 6s, 9r) - 5 -amino- 6 - (2, 3 - difluorophenyl) -6, 7, 8, 9 - tetrahydro - 5h - cyclohepta (b)pyridin-9 -yl- 4 - (2 - oxo-2, 3 - dihydro - 1h- imidazo (4, 5 -b)pyridin - 1 - yl) piperidine - 1 - carboxylate, hemisulfate salt
EP2815749A1 (en) * 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
AU2015214502B2 (en) * 2014-02-05 2019-06-06 Merck Sharp & Dohme Llc Tablet formulation for CGRP-active compounds
CA2921336A1 (en) * 2015-06-30 2016-12-30 Gilead Sciences, Inc. Pharmaceutical formulations
GB201519196D0 (en) * 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
SG11202009199YA (en) * 2018-03-25 2020-10-29 Biohaven Pharm Holding Co Ltd Rimegepant for cgrp related disorders
AU2020210024A1 (en) * 2019-01-20 2021-07-01 Biohaven Pharmaceutical Holding Company Ltd. CGRP antagonists for treating migraine breakthrough

Also Published As

Publication number Publication date
JP2023134690A (en) 2023-09-27
CN112153969A (en) 2020-12-29
KR20200135465A (en) 2020-12-02
PH12020551425A1 (en) 2021-12-13
AU2019242604A1 (en) 2020-10-22
US20200383969A1 (en) 2020-12-10
BR112020019396A2 (en) 2021-01-05
EP4088720A1 (en) 2022-11-16
WO2019191008A1 (en) 2019-10-03
US11083724B2 (en) 2021-08-10
US20220168295A1 (en) 2022-06-02
EP3773572A4 (en) 2022-01-05
JP2021519288A (en) 2021-08-10
US20210000814A1 (en) 2021-01-07
CA3094693A1 (en) 2019-10-03
IL277272A (en) 2020-10-29
MX2020009856A (en) 2020-10-08
EP3773572A1 (en) 2021-02-17

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