SG11202009136RA - Oxadiazole transient receptor potential channel inhibitors - Google Patents
Oxadiazole transient receptor potential channel inhibitorsInfo
- Publication number
- SG11202009136RA SG11202009136RA SG11202009136RA SG11202009136RA SG11202009136RA SG 11202009136R A SG11202009136R A SG 11202009136RA SG 11202009136R A SG11202009136R A SG 11202009136RA SG 11202009136R A SG11202009136R A SG 11202009136RA SG 11202009136R A SG11202009136R A SG 11202009136RA
- Authority
- SG
- Singapore
- Prior art keywords
- oxadiazole
- transient receptor
- receptor potential
- channel inhibitors
- potential channel
- Prior art date
Links
- 108010037150 Transient Receptor Potential Channels Proteins 0.000 title 1
- 102000011753 Transient Receptor Potential Channels Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862644987P | 2018-03-19 | 2018-03-19 | |
US201862676057P | 2018-05-24 | 2018-05-24 | |
US201862725488P | 2018-08-31 | 2018-08-31 | |
US201962812806P | 2019-03-01 | 2019-03-01 | |
PCT/US2019/022659 WO2019182925A1 (en) | 2018-03-19 | 2019-03-18 | Oxadiazole transient receptor potential channel inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202009136RA true SG11202009136RA (en) | 2020-10-29 |
Family
ID=65952221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202009136RA SG11202009136RA (en) | 2018-03-19 | 2019-03-18 | Oxadiazole transient receptor potential channel inhibitors |
Country Status (19)
Country | Link |
---|---|
US (3) | US10710994B2 (en) |
EP (1) | EP3768260A1 (en) |
JP (2) | JP7095106B2 (en) |
KR (2) | KR102533094B1 (en) |
CN (1) | CN111867585A (en) |
AU (1) | AU2019237992A1 (en) |
BR (1) | BR112020018983A2 (en) |
CA (1) | CA3091486A1 (en) |
CL (1) | CL2020002399A1 (en) |
CO (1) | CO2020011852A2 (en) |
CR (1) | CR20200413A (en) |
IL (2) | IL276654B2 (en) |
MA (1) | MA52077A (en) |
MX (1) | MX2020009657A (en) |
PE (1) | PE20210660A1 (en) |
PH (1) | PH12020551501A1 (en) |
SG (1) | SG11202009136RA (en) |
TW (1) | TWI829676B (en) |
WO (1) | WO2019182925A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10710994B2 (en) * | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
US11964967B2 (en) | 2018-06-26 | 2024-04-23 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
EP3843842A1 (en) | 2018-08-31 | 2021-07-07 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
PE20211066A1 (en) | 2018-08-31 | 2021-06-09 | Xenon Pharmaceuticals Inc | SULFONAMIDE COMPOUNDS SUBSTITUTED WITH HETEROARYL AND THEIR USE AS THERAPEUTIC AGENTS |
WO2021233752A1 (en) | 2020-05-19 | 2021-11-25 | Bayer Aktiengesellschaft | Trpa1 antagonists for the treatment of diseases associated with pain and inflammation |
FR3114235A1 (en) | 2020-09-18 | 2022-03-25 | Université Grenoble Alpes | INHIBITION OF ASTROCYTIC TRPA1 CHANNEL AS A NEW NEUROPROTECTIVE THERAPEUTIC TARGET IN THE PRODROMAL PHASES OF ALZHEIMER'S DISEASE |
US11919909B2 (en) | 2021-03-04 | 2024-03-05 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
IT202100015098A1 (en) | 2021-06-09 | 2022-12-09 | Flonext S R L | TRPA1 CHANNEL ANTAGONIST COMPOUND FOR USE IN DEGENERATIVE DISEASES OF THE RETINA |
WO2023164679A1 (en) | 2022-02-28 | 2023-08-31 | Genentech, Inc. | Processes for the preparation of phenyltetrahydrofuran compounds |
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US10710994B2 (en) * | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
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2019
- 2019-03-15 US US16/355,352 patent/US10710994B2/en active Active
- 2019-03-18 SG SG11202009136RA patent/SG11202009136RA/en unknown
- 2019-03-18 EP EP19714073.4A patent/EP3768260A1/en active Pending
- 2019-03-18 KR KR1020207029785A patent/KR102533094B1/en active IP Right Grant
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- 2019-03-18 BR BR112020018983-9A patent/BR112020018983A2/en unknown
- 2019-03-18 MX MX2020009657A patent/MX2020009657A/en unknown
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- 2019-03-18 MA MA052077A patent/MA52077A/en unknown
- 2019-03-18 CR CR20200413A patent/CR20200413A/en unknown
- 2019-03-18 WO PCT/US2019/022659 patent/WO2019182925A1/en unknown
- 2019-03-18 KR KR1020237015886A patent/KR20230070333A/en not_active Application Discontinuation
- 2019-03-18 PE PE2020001418A patent/PE20210660A1/en unknown
- 2019-03-18 TW TW108109093A patent/TWI829676B/en active
- 2019-03-18 CN CN201980020491.7A patent/CN111867585A/en active Pending
- 2019-03-18 AU AU2019237992A patent/AU2019237992A1/en active Pending
- 2019-03-18 JP JP2020550612A patent/JP7095106B2/en active Active
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2020
- 2020-06-16 US US16/903,020 patent/US11655245B2/en active Active
- 2020-09-16 CL CL2020002399A patent/CL2020002399A1/en unknown
- 2020-09-18 PH PH12020551501A patent/PH12020551501A1/en unknown
- 2020-09-24 CO CONC2020/0011852A patent/CO2020011852A2/en unknown
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2022
- 2022-06-22 JP JP2022100252A patent/JP2022126779A/en active Pending
- 2022-08-02 US US17/816,855 patent/US20230121700A1/en active Pending
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2023
- 2023-07-30 IL IL304835A patent/IL304835A/en unknown
Also Published As
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IL276654B2 (en) | 2024-01-01 |
CR20200413A (en) | 2020-11-23 |
TWI829676B (en) | 2024-01-21 |
JP2022126779A (en) | 2022-08-30 |
PH12020551501A1 (en) | 2021-09-06 |
US20190284179A1 (en) | 2019-09-19 |
CO2020011852A2 (en) | 2020-10-20 |
MX2020009657A (en) | 2020-10-08 |
CN111867585A (en) | 2020-10-30 |
RU2020133430A (en) | 2022-04-19 |
CA3091486A1 (en) | 2019-09-26 |
US20200308161A1 (en) | 2020-10-01 |
TW202003510A (en) | 2020-01-16 |
IL304835A (en) | 2023-09-01 |
EP3768260A1 (en) | 2021-01-27 |
US10710994B2 (en) | 2020-07-14 |
IL276654A (en) | 2020-09-30 |
MA52077A (en) | 2021-01-27 |
JP7095106B2 (en) | 2022-07-04 |
WO2019182925A1 (en) | 2019-09-26 |
KR20200133358A (en) | 2020-11-27 |
KR102533094B1 (en) | 2023-05-16 |
US20230121700A1 (en) | 2023-04-20 |
KR20230070333A (en) | 2023-05-22 |
CL2020002399A1 (en) | 2020-12-18 |
BR112020018983A2 (en) | 2020-12-29 |
JP2021518388A (en) | 2021-08-02 |
US11655245B2 (en) | 2023-05-23 |
IL276654B1 (en) | 2023-09-01 |
PE20210660A1 (en) | 2021-03-31 |
AU2019237992A1 (en) | 2020-09-03 |
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