SG11202008225PA - Novel rsv rna molecules and compositions for vaccination - Google Patents
Novel rsv rna molecules and compositions for vaccinationInfo
- Publication number
- SG11202008225PA SG11202008225PA SG11202008225PA SG11202008225PA SG11202008225PA SG 11202008225P A SG11202008225P A SG 11202008225PA SG 11202008225P A SG11202008225P A SG 11202008225PA SG 11202008225P A SG11202008225P A SG 11202008225PA SG 11202008225P A SG11202008225P A SG 11202008225PA
- Authority
- SG
- Singapore
- Prior art keywords
- vaccination
- compositions
- rna molecules
- rsv rna
- novel rsv
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2018059799 | 2018-04-17 | ||
| EP2018060810 | 2018-04-26 | ||
| EP2018061423 | 2018-05-03 | ||
| PCT/EP2019/060000 WO2019202035A1 (en) | 2018-04-17 | 2019-04-17 | Novel rsv rna molecules and compositions for vaccination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202008225PA true SG11202008225PA (en) | 2020-11-27 |
Family
ID=66251773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202008225PA SG11202008225PA (en) | 2018-04-17 | 2019-04-17 | Novel rsv rna molecules and compositions for vaccination |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20210170017A1 (en) |
| EP (2) | EP4227319A1 (en) |
| JP (1) | JP2021519595A (en) |
| KR (1) | KR20210003811A (en) |
| CN (1) | CN112292395A (en) |
| AU (1) | AU2019254591A1 (en) |
| BR (1) | BR112020020933A2 (en) |
| CA (1) | CA3091558A1 (en) |
| MX (1) | MX2020010941A (en) |
| SG (1) | SG11202008225PA (en) |
| WO (1) | WO2019202035A1 (en) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016003361A2 (en) | 2013-08-21 | 2017-11-21 | Curevac Ag | respiratory syncytial virus vaccine (rsv) |
| EP3230458B1 (en) | 2014-12-12 | 2020-02-19 | CureVac AG | Artificial nucleic acid molecules for improved protein expression |
| DK3294885T3 (en) | 2015-05-08 | 2020-08-10 | Curevac Real Estate Gmbh | METHOD OF PREPARING RNA |
| US10760070B2 (en) | 2015-05-29 | 2020-09-01 | Curevac Real Estate Gmbh | Method for producing and purifying RNA, comprising at least one step of tangential flow filtration |
| EP3736261B1 (en) | 2015-09-17 | 2023-10-11 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| MD3718565T2 (en) | 2015-10-22 | 2022-09-30 | Modernatx Inc | Respiratory virus vaccines |
| WO2017081110A1 (en) | 2015-11-09 | 2017-05-18 | Curevac Ag | Rotavirus vaccines |
| EP3701963A1 (en) | 2015-12-22 | 2020-09-02 | CureVac AG | Method for producing rna molecule compositions |
| US11723967B2 (en) | 2016-02-17 | 2023-08-15 | CureVac SE | Zika virus vaccine |
| US11920174B2 (en) | 2016-03-03 | 2024-03-05 | CureVac SE | RNA analysis by total hydrolysis and quantification of released nucleosides |
| WO2018115527A2 (en) | 2016-12-23 | 2018-06-28 | Curevac Ag | Mers coronavirus vaccine |
| JP7332478B2 (en) | 2017-03-15 | 2023-08-23 | モデルナティエックス インコーポレイテッド | Lipid nanoparticle formulation |
| ES2911186T3 (en) | 2017-03-15 | 2022-05-18 | Modernatx Inc | Crystalline forms of aminolipids |
| US11464848B2 (en) | 2017-03-15 | 2022-10-11 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| SG10202110491PA (en) | 2017-03-24 | 2021-11-29 | Curevac Ag | Nucleic acids encoding crispr-associated proteins and uses thereof |
| WO2018232357A1 (en) | 2017-06-15 | 2018-12-20 | Modernatx, Inc. | Rna formulations |
| US11602557B2 (en) | 2017-08-22 | 2023-03-14 | Cure Vac SE | Bunyavirales vaccine |
| WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| RU2020117848A (en) | 2017-11-08 | 2021-12-08 | Куревак Аг | PHK SEQUENCE ADAPTATION |
| US11931406B2 (en) | 2017-12-13 | 2024-03-19 | CureVac SE | Flavivirus vaccine |
| CN111511928A (en) | 2017-12-21 | 2020-08-07 | 库瑞瓦格股份公司 | Linear double-stranded DNA coupled to a single support or tag and method for preparing the same |
| MA54676A (en) | 2018-01-29 | 2021-11-17 | Modernatx Inc | RSV RNA VACCINES |
| CN113166783A (en) | 2018-10-09 | 2021-07-23 | 不列颠哥伦比亚大学 | Compositions and systems comprising transfection-active vesicles free of organic solvents and detergents and methods related thereto |
| US11058725B2 (en) | 2019-09-10 | 2021-07-13 | Obsidian Therapeutics, Inc. | CA2 compositions and methods for tunable regulation |
| CN114728887A (en) | 2019-09-19 | 2022-07-08 | 摩登纳特斯有限公司 | Branched tail end lipid compounds and compositions for intracellular delivery of therapeutic agents |
| JP2023507465A (en) * | 2019-12-20 | 2023-02-22 | キュアバック エスイー | Lipid nanoparticles for nucleic acid delivery |
| EP4096683A4 (en) * | 2020-01-30 | 2024-04-10 | Modernatx Inc | Respiratory virus immunizing compositions |
| US11241493B2 (en) | 2020-02-04 | 2022-02-08 | Curevac Ag | Coronavirus vaccine |
| US11576966B2 (en) | 2020-02-04 | 2023-02-14 | CureVac SE | Coronavirus vaccine |
| US20230201327A1 (en) * | 2020-05-13 | 2023-06-29 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Rsv vaccine bearing one or more p gene mutations |
| IL298084A (en) | 2020-05-29 | 2023-01-01 | CureVac SE | Nucleic acid based combination vaccines |
| EP4175967A2 (en) | 2020-07-02 | 2023-05-10 | Life Technologies Corporation | Trinucleotide cap analogs, preparation and uses thereof |
| KR20230124927A (en) | 2020-11-25 | 2023-08-28 | 아카제라 메디신즈, 인크. | Lipid Nanoparticles for Delivery of Nucleic Acids, and Related Methods of Use |
| MX2023007574A (en) | 2020-12-22 | 2023-09-29 | CureVac SE | Rna vaccine against sars-cov-2 variants. |
| CN114763324A (en) * | 2021-01-15 | 2022-07-19 | 纳肽得(青岛)生物医药有限公司 | Lipid compound, liposome and pharmaceutical composition |
| WO2022175479A1 (en) * | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Vaccine combinations against respiratory syncytial virus strain a and b infections |
| CN115197078B (en) * | 2021-04-08 | 2024-06-04 | 厦门赛诺邦格生物科技股份有限公司 | Pegylated lipid and modified liposome thereof, pharmaceutical composition containing liposome and preparation and application of pharmaceutical composition |
| WO2022221336A1 (en) * | 2021-04-13 | 2022-10-20 | Modernatx, Inc. | Respiratory syncytial virus mrna vaccines |
| CN115385820A (en) * | 2021-05-09 | 2022-11-25 | 英维沃生物科技(苏州)有限公司 | Cationic lipids and uses thereof |
| WO2023004307A1 (en) * | 2021-07-19 | 2023-01-26 | Epivax, Inc. | T cell epitopes and related compositions useful in the prevention and treatment of respiratory syncytial virus infection |
| CN114044741B (en) * | 2022-01-13 | 2022-04-15 | 北京悦康科创医药科技股份有限公司 | Cationic lipid compound, composition containing same and application |
| CN114989182B (en) * | 2022-06-23 | 2023-06-23 | 尧唐(上海)生物科技有限公司 | Lipid compound, composition containing lipid compound and application of lipid compound |
| WO2024041772A1 (en) * | 2022-08-22 | 2024-02-29 | Glaxosmithkline Biologicals Sa | Rsv-f proteins |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001813A1 (en) | 1990-07-25 | 1992-02-06 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| US5773244A (en) | 1993-05-19 | 1998-06-30 | Regents Of The University Of California | Methods of making circular RNA |
| US6019980A (en) | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
| US6210931B1 (en) | 1998-11-30 | 2001-04-03 | The United States Of America As Represented By The Secretary Of Agriculture | Ribozyme-mediated synthesis of circular RNA |
| ES2356934T3 (en) | 2001-06-05 | 2011-04-14 | Curevac Gmbh | MRNA STABILIZED WITH AN INCREASED G / C CONTENT THAT CODIFIES FOR A VIRAL ANTIGEN. |
| DE102005023170A1 (en) | 2005-05-19 | 2006-11-23 | Curevac Gmbh | Optimized formulation for mRNA |
| CA2659301A1 (en) | 2006-07-28 | 2008-02-07 | Applera Corporation | Dinucleotide mrna cap analogs |
| DE102006061015A1 (en) | 2006-12-22 | 2008-06-26 | Curevac Gmbh | Process for the purification of RNA on a preparative scale by HPLC |
| FR2911325B1 (en) | 2007-01-12 | 2012-01-06 | Jean Jacques Fidelis | ART RETRIEVAL CHILDREN'S CASE, INTEGRATING AN INTERCHANGEABLE ROLLER WITH ELECTROSTATIC PRE-CUTTING SHEETS |
| WO2008157688A2 (en) | 2007-06-19 | 2008-12-24 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap |
| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| EP2224912B1 (en) | 2008-01-02 | 2016-05-11 | TEKMIRA Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| JP5475753B2 (en) | 2008-04-15 | 2014-04-16 | プロチバ バイオセラピューティクス インコーポレイティッド | Lipid formulations for nucleic acid delivery |
| PL215513B1 (en) | 2008-06-06 | 2013-12-31 | Univ Warszawski | New borane phosphate analogs of dinucleotides, their application, RNA particle, method of obtaining RNA and method of obtaining peptides or protein |
| WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
| US9139554B2 (en) | 2008-10-09 | 2015-09-22 | Tekmira Pharmaceuticals Corporation | Amino lipids and methods for the delivery of nucleic acids |
| WO2010048536A2 (en) | 2008-10-23 | 2010-04-29 | Alnylam Pharmaceuticals, Inc. | Processes for preparing lipids |
| WO2010053572A2 (en) | 2008-11-07 | 2010-05-14 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| NO2355851T3 (en) | 2008-11-10 | 2018-09-01 | ||
| AU2010208035B2 (en) | 2009-01-29 | 2016-06-23 | Arbutus Biopharma Corporation | Improved lipid formulation for the delivery of nucleic acids |
| SG10201911942UA (en) | 2009-05-05 | 2020-02-27 | Muthiah Manoharan | Lipid compositions |
| CN102625696B (en) | 2009-06-10 | 2015-06-03 | 阿尔尼拉姆医药品有限公司 | Improved lipid formulation |
| EP2281579A1 (en) | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
| US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| WO2011069529A1 (en) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
| CA2800401C (en) | 2010-06-03 | 2020-09-15 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
| US8968746B2 (en) | 2010-07-30 | 2015-03-03 | Curevac Gmbh | Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation |
| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2012113413A1 (en) | 2011-02-21 | 2012-08-30 | Curevac Gmbh | Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates |
| US8969545B2 (en) | 2011-10-18 | 2015-03-03 | Life Technologies Corporation | Alkynyl-derivatized cap analogs, preparation and uses thereof |
| US20130156849A1 (en) * | 2011-12-16 | 2013-06-20 | modeRNA Therapeutics | Modified nucleoside, nucleotide, and nucleic acid compositions |
| KR20140139101A (en) | 2012-03-27 | 2014-12-04 | 큐어백 게엠바하 | Artificial nucleic acid molecules comprising a 5'top utr |
| MX2015013065A (en) * | 2013-03-13 | 2016-06-06 | Us Health | Prefusion rsv f proteins and their use. |
| BR112016003361A2 (en) * | 2013-08-21 | 2017-11-21 | Curevac Ag | respiratory syncytial virus vaccine (rsv) |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| CA2925021A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Ag | Modified rna with decreased immunostimulatory properties |
| JP6486955B2 (en) | 2013-11-18 | 2019-03-20 | アークトゥルス セラピューティクス， インコーポレイテッド | Ionizable cationic lipids for RNA delivery |
| KR102459599B1 (en) | 2014-06-10 | 2022-10-26 | 큐어백 리얼 이스테이트 게엠베하 | Methods and Means for enhancing RNA production |
| HUE060907T2 (en) | 2014-06-25 | 2023-04-28 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| EP3169335B8 (en) | 2014-07-16 | 2019-10-09 | ModernaTX, Inc. | Circular polynucleotides |
| EP3230458B1 (en) | 2014-12-12 | 2020-02-19 | CureVac AG | Artificial nucleic acid molecules for improved protein expression |
| BR112017009835A2 (en) | 2014-12-30 | 2017-12-26 | Curevac Ag | artificial nucleic acid molecules |
| WO2016118724A1 (en) | 2015-01-21 | 2016-07-28 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| WO2016118725A1 (en) | 2015-01-23 | 2016-07-28 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| CN107567497A (en) | 2015-04-17 | 2018-01-09 | 库瑞瓦格股份公司 | RNA's is lyophilized |
| ES2897823T3 (en) | 2015-04-30 | 2022-03-02 | Curevac Ag | Immobilized poly(N)polymerase |
| DK3294885T3 (en) | 2015-05-08 | 2020-08-10 | Curevac Real Estate Gmbh | METHOD OF PREPARING RNA |
| CN107530448A (en) | 2015-05-20 | 2018-01-02 | 库瑞瓦格股份公司 | Include long-chain RNA dry powder composite |
| SG11201708540VA (en) | 2015-05-20 | 2017-12-28 | Curevac Ag | Dry powder composition comprising long-chain rna |
| EP4098743A1 (en) | 2015-05-29 | 2022-12-07 | CureVac AG | Method for adding cap structures to rna using immobilized enzymes |
| US10760070B2 (en) | 2015-05-29 | 2020-09-01 | Curevac Real Estate Gmbh | Method for producing and purifying RNA, comprising at least one step of tangential flow filtration |
| US20180296663A1 (en) | 2015-06-17 | 2018-10-18 | Curevac Ag | Vaccine composition |
| IL283545B2 (en) | 2015-06-29 | 2023-09-01 | Acuitas Therapeutics Inc | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| US20180237786A1 (en) * | 2015-08-28 | 2018-08-23 | Curevac Ag | Artificial nucleic acid molecules |
| CN116590285A (en) | 2015-09-21 | 2023-08-15 | 垂林克生物技术有限公司 | Compositions and methods for synthesizing 5' -capped RNA |
| AU2016336344A1 (en) * | 2015-10-05 | 2018-04-19 | Modernatx, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| WO2017066791A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Sugar substituted mrna cap analogs |
| WO2017066789A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Mrna cap analogs with modified sugar |
| DK3362461T3 (en) | 2015-10-16 | 2022-05-09 | Modernatx Inc | MRNA-CAP ANALOGS WITH MODIFIED PHOSPHAT BINDING |
| WO2017066782A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Hydrophobic mrna cap analogs |
| EP3362460A1 (en) | 2015-10-16 | 2018-08-22 | Modernatx, Inc. | Mrna cap analogs and methods of mrna capping |
| WO2017066797A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Trinucleotide mrna cap analogs |
| JP6921833B2 (en) | 2015-10-22 | 2021-08-18 | モデルナティーエックス， インコーポレイテッド | Human cytomegalovirus vaccine |
| SG10201914006UA (en) | 2015-10-22 | 2020-03-30 | Modernatx Inc | Respiratory syncytial virus vaccine |
| EP3365007A4 (en) | 2015-10-22 | 2019-07-03 | ModernaTX, Inc. | Broad spectrum influenza virus vaccine |
| PT3368507T (en) | 2015-10-28 | 2023-02-07 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| WO2017081082A2 (en) | 2015-11-09 | 2017-05-18 | Curevac Ag | Optimized nucleic acid molecules |
| WO2017090134A1 (en) | 2015-11-25 | 2017-06-01 | 神栄テクノロジー株式会社 | Particle sensor |
| MD3386484T2 (en) | 2015-12-10 | 2022-11-30 | Modernatx Inc | Compositions and methods for delivery of therapeutic agents |
| ES2913626T3 (en) | 2015-12-22 | 2022-06-03 | Modernatx Inc | Compounds and compositions for the intracellular delivery of agents |
| EP3701963A1 (en) | 2015-12-22 | 2020-09-02 | CureVac AG | Method for producing rna molecule compositions |
| US11248223B2 (en) | 2015-12-23 | 2022-02-15 | Curevac Ag | Method of RNA in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof |
| US9834510B2 (en) | 2015-12-30 | 2017-12-05 | Arcturus Therapeutics, Inc. | Aromatic ionizable cationic lipid |
| EP3436064A1 (en) | 2016-03-29 | 2019-02-06 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Substitutions-modified prefusion rsv f proteins and their use |
| EP3468612A1 (en) | 2016-06-09 | 2019-04-17 | CureVac AG | Hybrid carriers for nucleic acid cargo |
| US20190336611A1 (en) * | 2016-06-09 | 2019-11-07 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
| AU2017277731B2 (en) | 2016-06-09 | 2021-02-18 | CureVac SE | Hybrid carriers for nucleic acid cargo |
| WO2017212007A1 (en) | 2016-06-09 | 2017-12-14 | Curevac Ag | Cationic carriers for nucleic acid delivery |
| SG11201811432WA (en) * | 2016-08-19 | 2019-03-28 | Curevac Ag | Rna for cancer therapy |
| EP3529255A1 (en) | 2016-10-19 | 2019-08-28 | Arcturus Therapeutics, Inc. | Trinucleotide mrna cap analogs |
| KR20190093816A (en) * | 2016-10-26 | 2019-08-26 | 큐어백 아게 | Lipid nanoparticle mRNA vaccine |
| US20220233568A1 (en) * | 2017-10-19 | 2022-07-28 | Curevac Ag | Novel artificial nucleic acid molecules |
-
2019
- 2019-04-17 EP EP23164447.7A patent/EP4227319A1/en active Pending
- 2019-04-17 US US17/047,947 patent/US20210170017A1/en active Pending
- 2019-04-17 CN CN201980026206.2A patent/CN112292395A/en active Pending
- 2019-04-17 AU AU2019254591A patent/AU2019254591A1/en active Pending
- 2019-04-17 BR BR112020020933-3A patent/BR112020020933A2/en unknown
- 2019-04-17 WO PCT/EP2019/060000 patent/WO2019202035A1/en unknown
- 2019-04-17 CA CA3091558A patent/CA3091558A1/en active Pending
- 2019-04-17 KR KR1020207033015A patent/KR20210003811A/en not_active Application Discontinuation
- 2019-04-17 JP JP2020553650A patent/JP2021519595A/en active Pending
- 2019-04-17 SG SG11202008225PA patent/SG11202008225PA/en unknown
- 2019-04-17 MX MX2020010941A patent/MX2020010941A/en unknown
- 2019-04-17 EP EP19719234.7A patent/EP3781591A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019202035A1 (en) | 2019-10-24 |
| CA3091558A1 (en) | 2019-10-24 |
| EP4227319A1 (en) | 2023-08-16 |
| BR112020020933A2 (en) | 2021-04-06 |
| MX2020010941A (en) | 2021-01-29 |
| US20210170017A1 (en) | 2021-06-10 |
| EP3781591A1 (en) | 2021-02-24 |
| AU2019254591A1 (en) | 2020-09-10 |
| JP2021519595A (en) | 2021-08-12 |
| CN112292395A (en) | 2021-01-29 |
| KR20210003811A (en) | 2021-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11202008225PA (en) | Novel rsv rna molecules and compositions for vaccination | |
| EP3746090A4 (en) | Rsv rna vaccines | |
| IL272850A (en) | Novel artificial nucleic acid molecules | |
| EP3638215A4 (en) | Rna formulations | |
| EP3876947A4 (en) | Rna cancer vaccines | |
| SG11202001208XA (en) | Rna targeting methods and compositions | |
| SG11201911430PA (en) | Novel nucleic acid molecules | |
| IL288461A (en) | Targeted nucleic acid conjugate compositions | |
| EP3576751A4 (en) | Rna cancer vaccines | |
| ES2972098T3 (en) | Compositions and methods for synthesizing 5'-capped RNA | |
| EP3386550A4 (en) | Methods and compositions for the making and using of guide nucleic acids | |
| EP3707257A4 (en) | Methods and compositions for circular rna molecules | |
| WO2016065349A8 (en) | Short non-coding protein regulatory rnas (sprrnas) and methods of use | |
| IL281930A (en) | Rna particles comprising polysarcosin | |
| IL277921A (en) | Novel small activating rna | |
| SG11202006396SA (en) | Immunomodulatory small hairpin rna molecules | |
| IL277472A (en) | Nucleic acid molecules for pseudouridylation | |
| SG11202009774XA (en) | Compositions and methods for preparing nucleic acid libraries | |
| ZA202001649B (en) | Rna molecules | |
| EP3897671A4 (en) | Compositions and methods related to site-specific identification of rna modifications | |
| ZA202007174B (en) | Novel gunshot-simulating bird-repelling dummy | |
| EP3402883A4 (en) | Compositions and methods for sequencing nucleic acids | |
| IL284333A (en) | Oligomeric nucleic acid molecule and use thereof | |
| EP3583112A4 (en) | Compositions and methods for sequencing nucleic acids | |
| SG11202100713VA (en) | Depleting unwanted rna species |