SG11202007240QA - Combination of sting agonist and il-15/il15-ra for the treatment of cancer - Google Patents

Combination of sting agonist and il-15/il15-ra for the treatment of cancer

Info

Publication number
SG11202007240QA
SG11202007240QA SG11202007240QA SG11202007240QA SG11202007240QA SG 11202007240Q A SG11202007240Q A SG 11202007240QA SG 11202007240Q A SG11202007240Q A SG 11202007240QA SG 11202007240Q A SG11202007240Q A SG 11202007240QA SG 11202007240Q A SG11202007240Q A SG 11202007240QA
Authority
SG
Singapore
Prior art keywords
cancer
treatment
combination
sting agonist
sting
Prior art date
Application number
SG11202007240QA
Inventor
Nadja Kopp
Justin Leong
Jeffrey Mckenna
Chudi Obioma Ndubaku
Maria Pinzon-Ortiz
Xianhui Rong
Ryan Sullivan
Original Assignee
Novartis Ag
Aduro Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Aduro Biotech Inc filed Critical Novartis Ag
Publication of SG11202007240QA publication Critical patent/SG11202007240QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
SG11202007240QA 2018-02-02 2019-02-01 Combination of sting agonist and il-15/il15-ra for the treatment of cancer SG11202007240QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862625671P 2018-02-02 2018-02-02
PCT/IB2019/050806 WO2019150310A1 (en) 2018-02-02 2019-02-01 Combination of sting agonist and il-15/il15-ra for the treatment of cancer

Publications (1)

Publication Number Publication Date
SG11202007240QA true SG11202007240QA (en) 2020-08-28

Family

ID=65433703

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202007240QA SG11202007240QA (en) 2018-02-02 2019-02-01 Combination of sting agonist and il-15/il15-ra for the treatment of cancer

Country Status (11)

Country Link
US (1) US20220211815A1 (en)
EP (1) EP3746104A1 (en)
JP (1) JP2021512104A (en)
KR (1) KR20200118082A (en)
CN (1) CN111936156A (en)
AU (1) AU2019213843A1 (en)
CA (1) CA3090171A1 (en)
IL (1) IL276363A (en)
RU (1) RU2020128830A (en)
SG (1) SG11202007240QA (en)
WO (1) WO2019150310A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210309692A1 (en) 2018-07-10 2021-10-07 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease
BR112022014493A2 (en) * 2020-02-05 2022-09-20 Novartis Ag CHO CELL EXPRESSING IL-15 HETERODIMERS
CN111592570B (en) * 2020-05-15 2022-04-29 清华大学 Novel STING agonists, methods of preparation and uses thereof
EP4228681A1 (en) * 2020-10-14 2023-08-23 Boehringer Ingelheim International GmbH Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist
WO2024091794A1 (en) * 2022-10-28 2024-05-02 Nant Holdings IP, LLP Vaccine composition for stimulation of broad-spectrum memory of b cell expansion

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL71691A (en) 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
US6174666B1 (en) 1992-03-27 2001-01-16 The United States Of America As Represented By The Department Of Health And Human Services Method of eliminating inhibitory/instability regions from mRNA
MX2007014474A (en) 2005-05-17 2008-02-07 Univ Connecticut Compositions and methods for immunomodulation in an organism.
US8021668B2 (en) 2005-12-12 2011-09-20 Immune Disease Institute, Inc. Integrin alpha L I domain mutants with increased binding affinity
NZ569541A (en) 2006-01-13 2012-05-25 Us Gov Health & Human Serv Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells
CA2690825C (en) 2007-05-11 2019-02-12 Altor Bioscience Corporation Fusion molecules and il-15 variants
EP2326531B2 (en) 2008-08-22 2021-01-13 Magna Seating Inc. Disc recliner with reduced backlash
KR20140020228A (en) 2010-09-21 2014-02-18 알토 바이오사이언스 코포레이션 Multimeric il-15 soluble fusion molecules and methods of making and using same
JP6453855B2 (en) 2013-05-18 2019-01-16 アドゥロ バイオテック，インク． Compositions and methods for activating "interferon gene stimulator" dependent signaling
ES2811974T3 (en) * 2014-07-29 2021-03-15 Novartis Ag Dose escalation regimens of il-15 and il-15ralpha heterodimer for treating conditions
EP3506884B1 (en) * 2016-08-30 2021-05-05 Dana-Farber Cancer Institute, Inc. Drug delivery compositions and uses thereof

Also Published As

Publication number Publication date
KR20200118082A (en) 2020-10-14
WO2019150310A1 (en) 2019-08-08
JP2021512104A (en) 2021-05-13
IL276363A (en) 2020-09-30
CN111936156A (en) 2020-11-13
RU2020128830A (en) 2022-03-03
AU2019213843A1 (en) 2020-08-20
EP3746104A1 (en) 2020-12-09
CA3090171A1 (en) 2019-08-08
US20220211815A1 (en) 2022-07-07

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