SG11202006837XA - Dihydroindolizinone derivative - Google Patents
Dihydroindolizinone derivativeInfo
- Publication number
- SG11202006837XA SG11202006837XA SG11202006837XA SG11202006837XA SG11202006837XA SG 11202006837X A SG11202006837X A SG 11202006837XA SG 11202006837X A SG11202006837X A SG 11202006837XA SG 11202006837X A SG11202006837X A SG 11202006837XA SG 11202006837X A SG11202006837X A SG 11202006837XA
- Authority
- SG
- Singapore
- Prior art keywords
- dihydroindolizinone
- derivative
- dihydroindolizinone derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/73—Hydrolases (EC 3.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018006269 | 2018-01-18 | ||
PCT/JP2019/001364 WO2019142883A1 (en) | 2018-01-18 | 2019-01-18 | Dihydroindolizinone derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202006837XA true SG11202006837XA (en) | 2020-08-28 |
Family
ID=67302218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202006837XA SG11202006837XA (en) | 2018-01-18 | 2019-01-18 | Dihydroindolizinone derivative |
Country Status (12)
Country | Link |
---|---|
US (1) | US11530211B2 (en) |
EP (1) | EP3741757B1 (en) |
JP (1) | JP7359697B2 (en) |
KR (1) | KR20200110338A (en) |
CN (1) | CN111630052B (en) |
AU (1) | AU2019208634A1 (en) |
CA (1) | CA3088968C (en) |
ES (1) | ES2958118T3 (en) |
IL (1) | IL276125A (en) |
SG (1) | SG11202006837XA (en) |
TW (1) | TWI818948B (en) |
WO (1) | WO2019142883A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2020309946A1 (en) * | 2019-07-08 | 2022-03-03 | Daiichi Sankyo Company, Limited | Method for producing insulin-producing cell using dihydroindolizinone derivatives |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR039059A1 (en) | 2001-08-06 | 2005-02-09 | Sanofi Aventis | COMPOUND DERIVED FROM ACILAMINOTIAZOL, ITS USE, PROCEDURES TO PREPARE IT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, AND INTERMEDIARY COMPOUNDS |
JP2003128551A (en) * | 2001-08-15 | 2003-05-08 | Sankyo Co Ltd | New antidiabetic pharmaceutical composition |
WO2007022506A2 (en) | 2005-08-18 | 2007-02-22 | University Of Massachusetts | Methods and compositions for treating neurological disease |
EP2650359B1 (en) | 2006-03-02 | 2022-05-04 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
CN102307871A (en) * | 2008-12-08 | 2012-01-04 | 西特里斯药业公司 | Isoindolinone and related analogs as sirtuin modulators |
JP5938726B2 (en) | 2010-10-28 | 2016-06-22 | 国立大学法人 熊本大学 | Method and medium for improving differentiation induction efficiency of pluripotent stem cells |
JPWO2012121168A1 (en) * | 2011-03-04 | 2014-07-17 | 国立大学法人京都大学 | Kinase inhibitor |
WO2013163739A1 (en) | 2012-04-30 | 2013-11-07 | University Health Network | METHODS AND COMPOSITIONS FOR GENERATING PANCREATIC PROGENITORS AND FUNCTIONAL BETA CELLS FROM hPSCs |
JP2014161257A (en) | 2013-02-22 | 2014-09-08 | Univ Of Tokyo | Method for preparing pancreatic langerhans islet from pluripotent stem cell |
US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
US9796962B2 (en) | 2013-08-07 | 2017-10-24 | Kyoto University | Method for generating pancreatic hormone-producing cells |
DK3039122T3 (en) | 2013-08-30 | 2019-09-30 | Novo Nordisk As | GENERATION OF ENDOCRINE PROGENITOR CELLS FROM HUMAN PLURIPOTENT STEM CELLS USING SMALL MOLECULES |
JP6351018B2 (en) | 2014-02-21 | 2018-07-04 | 国立大学法人 熊本大学 | Stem cell differentiation induction method using amino acid composition modified medium, and medium kit containing the medium |
JP6094516B2 (en) | 2014-03-19 | 2017-03-15 | 三菱電機株式会社 | Elevator equipment |
EP3143127B1 (en) | 2014-05-16 | 2021-07-14 | Janssen Biotech, Inc. | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
JP6596708B2 (en) | 2014-05-20 | 2019-10-30 | 国立大学法人東京工業大学 | Method for inducing differentiation of insulin producing cells |
RU2017105133A (en) * | 2014-07-31 | 2018-08-28 | Мерк Патент Гмбх | INDOLYSINE DERIVATIVES THAT USE FOR NEURODEGENERATIVE DISEASES |
US20160175363A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived beta cells and uses thereof |
WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
WO2016100925A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING AUGMENTED STEM CELL-DERIVED β CELLS AND USES THEREOF |
WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
CN113234661A (en) | 2014-12-18 | 2021-08-10 | 哈佛学院校长同事会 | Method for producing stem cell-derived beta cells and method for using same |
AU2016228894B2 (en) | 2015-03-11 | 2021-03-04 | Ccs Ventures Limited | Pancreatic endocrine progenitor cell therapies for the treatment of obesity and Type 2 diabetes (T2D) |
-
2019
- 2019-01-18 SG SG11202006837XA patent/SG11202006837XA/en unknown
- 2019-01-18 CN CN201980008987.2A patent/CN111630052B/en active Active
- 2019-01-18 TW TW108101951A patent/TWI818948B/en active
- 2019-01-18 EP EP19741238.0A patent/EP3741757B1/en active Active
- 2019-01-18 KR KR1020207020768A patent/KR20200110338A/en not_active Application Discontinuation
- 2019-01-18 WO PCT/JP2019/001364 patent/WO2019142883A1/en unknown
- 2019-01-18 US US16/960,308 patent/US11530211B2/en active Active
- 2019-01-18 AU AU2019208634A patent/AU2019208634A1/en active Pending
- 2019-01-18 CA CA3088968A patent/CA3088968C/en active Active
- 2019-01-18 JP JP2019566511A patent/JP7359697B2/en active Active
- 2019-01-18 ES ES19741238T patent/ES2958118T3/en active Active
-
2020
- 2020-07-16 IL IL276125A patent/IL276125A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20210053965A1 (en) | 2021-02-25 |
ES2958118T3 (en) | 2024-02-01 |
AU2019208634A1 (en) | 2020-08-06 |
KR20200110338A (en) | 2020-09-23 |
AU2019208634A2 (en) | 2020-09-24 |
CN111630052B (en) | 2023-04-18 |
CA3088968C (en) | 2023-10-17 |
EP3741757A4 (en) | 2021-11-03 |
EP3741757B1 (en) | 2023-07-26 |
TWI818948B (en) | 2023-10-21 |
EP3741757A1 (en) | 2020-11-25 |
CA3088968A1 (en) | 2019-07-25 |
TW201938156A (en) | 2019-10-01 |
JPWO2019142883A1 (en) | 2021-01-14 |
US11530211B2 (en) | 2022-12-20 |
JP7359697B2 (en) | 2023-10-11 |
CN111630052A (en) | 2020-09-04 |
IL276125A (en) | 2020-08-31 |
WO2019142883A1 (en) | 2019-07-25 |
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