SG11202006832YA - Gcn2 inhibitors and uses thereof - Google Patents
Gcn2 inhibitors and uses thereofInfo
- Publication number
- SG11202006832YA SG11202006832YA SG11202006832YA SG11202006832YA SG11202006832YA SG 11202006832Y A SG11202006832Y A SG 11202006832YA SG 11202006832Y A SG11202006832Y A SG 11202006832YA SG 11202006832Y A SG11202006832Y A SG 11202006832YA SG 11202006832Y A SG11202006832Y A SG 11202006832YA
- Authority
- SG
- Singapore
- Prior art keywords
- gcn2
- inhibitors
- gcn2 inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862623312P | 2018-01-29 | 2018-01-29 | |
| PCT/US2019/015473 WO2019148136A1 (en) | 2018-01-29 | 2019-01-28 | Gcn2 inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202006832YA true SG11202006832YA (en) | 2020-08-28 |
Family
ID=67392742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202006832YA SG11202006832YA (en) | 2018-01-29 | 2019-01-28 | Gcn2 inhibitors and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10793563B2 (en) |
| EP (1) | EP3746071A4 (en) |
| JP (2) | JP7377207B2 (en) |
| KR (1) | KR20200115620A (en) |
| CN (2) | CN111867581B (en) |
| AR (1) | AR114236A1 (en) |
| AU (1) | AU2019212969A1 (en) |
| BR (1) | BR112020015396A2 (en) |
| CA (1) | CA3089769A1 (en) |
| IL (1) | IL276147A (en) |
| MX (1) | MX2020007797A (en) |
| SG (1) | SG11202006832YA (en) |
| TW (1) | TW201940481A (en) |
| WO (1) | WO2019148136A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6751203B2 (en) | 2016-06-07 | 2020-09-02 | ジャコバイオ ファーマスーティカルズ カンパニー リミテッドＪａｃｏｂｉｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． | Novel heterocyclic derivatives useful as SHP2 inhibitors |
| NZ758458A (en) | 2017-03-23 | 2022-07-29 | Jacobio Pharmaceuticals Co Ltd | Novel heterocyclic derivatives useful as shp2 inhibitors |
| MX2020007799A (en) | 2018-01-29 | 2020-09-18 | Merck Patent Gmbh | Gcn2 inhibitors and uses thereof. |
| AU2019212969A1 (en) | 2018-01-29 | 2020-08-13 | Merck Patent Gmbh | GCN2 inhibitors and uses thereof |
| WO2020010451A1 (en) * | 2018-07-10 | 2020-01-16 | Trillium Therapeutics Inc. | Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists |
| GB202008749D0 (en) | 2020-06-09 | 2020-07-22 | Ip2Ipo Innovations Ltd | Novel compounds |
| GB202104635D0 (en) | 2021-03-31 | 2021-05-12 | Imperial College Innovations Ltd | Methods and compositions for identifying and treating GCN2-dependent cancers |
| WO2023025912A1 (en) | 2021-08-25 | 2023-03-02 | Alesta Therapeutics BV | Use of gcn2 inhibitors in treating cancer |
| AU2022359801A1 (en) | 2021-10-04 | 2024-02-01 | Forx Therapeutics Ag | Parg inhibitory compounds |
| GB202118096D0 (en) | 2021-12-14 | 2022-01-26 | Ip2Ipo Innovations Ltd | Novel compounds |
| WO2023218195A1 (en) | 2022-05-11 | 2023-11-16 | Ip2Ipo Innovations Limited | Gcn2 inhibitorr |
| WO2023239941A1 (en) * | 2022-06-10 | 2023-12-14 | Interline Therapeutics Inc. | Imidazo(1,2-a)pyridine derivatives as ripk2 inhibitors |
| WO2024002284A1 (en) * | 2022-06-29 | 2024-01-04 | 杭州圣域生物医药科技有限公司 | Five-membered and six-membered nitrogen-containing compound, and intermediate, preparation method and use thereof |
| US20240025884A1 (en) * | 2022-07-05 | 2024-01-25 | Dong-A St Co., Ltd. | Compounds as gcn2 inhibitors, pharmaceutical compositions and uses thereof |
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-
2019
- 2019-01-28 AU AU2019212969A patent/AU2019212969A1/en active Pending
- 2019-01-28 CA CA3089769A patent/CA3089769A1/en active Pending
- 2019-01-28 EP EP19743802.1A patent/EP3746071A4/en active Pending
- 2019-01-28 MX MX2020007797A patent/MX2020007797A/en unknown
- 2019-01-28 WO PCT/US2019/015473 patent/WO2019148136A1/en unknown
- 2019-01-28 JP JP2020541375A patent/JP7377207B2/en active Active
- 2019-01-28 SG SG11202006832YA patent/SG11202006832YA/en unknown
- 2019-01-28 CN CN201980019854.5A patent/CN111867581B/en active Active
- 2019-01-28 US US16/260,019 patent/US10793563B2/en active Active
- 2019-01-28 KR KR1020207025021A patent/KR20200115620A/en active Search and Examination
- 2019-01-28 BR BR112020015396-6A patent/BR112020015396A2/en unknown
- 2019-01-28 TW TW108103175A patent/TW201940481A/en unknown
- 2019-01-28 CN CN202311661189.4A patent/CN117659010A/en active Pending
- 2019-01-29 AR ARP190100196A patent/AR114236A1/en unknown
-
2020
- 2020-06-22 US US16/907,622 patent/US20210040083A1/en active Pending
- 2020-07-19 IL IL276147A patent/IL276147A/en unknown
-
2023
- 2023-10-27 JP JP2023184637A patent/JP2023178494A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20190233411A1 (en) | 2019-08-01 |
| KR20200115620A (en) | 2020-10-07 |
| CN111867581B (en) | 2023-12-26 |
| JP2023178494A (en) | 2023-12-14 |
| IL276147A (en) | 2020-09-30 |
| BR112020015396A2 (en) | 2020-12-08 |
| US10793563B2 (en) | 2020-10-06 |
| JP7377207B2 (en) | 2023-11-09 |
| JP2021512078A (en) | 2021-05-13 |
| EP3746071A1 (en) | 2020-12-09 |
| AU2019212969A1 (en) | 2020-08-13 |
| CN117659010A (en) | 2024-03-08 |
| EP3746071A4 (en) | 2021-09-01 |
| AR114236A1 (en) | 2020-08-05 |
| TW201940481A (en) | 2019-10-16 |
| CN111867581A (en) | 2020-10-30 |
| WO2019148136A1 (en) | 2019-08-01 |
| US20210040083A1 (en) | 2021-02-11 |
| CA3089769A1 (en) | 2019-08-01 |
| MX2020007797A (en) | 2020-09-18 |
| RU2020128586A (en) | 2022-03-03 |
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