SG11202006255UA - Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability - Google Patents

Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability

Info

Publication number
SG11202006255UA
SG11202006255UA SG11202006255UA SG11202006255UA SG11202006255UA SG 11202006255U A SG11202006255U A SG 11202006255UA SG 11202006255U A SG11202006255U A SG 11202006255UA SG 11202006255U A SG11202006255U A SG 11202006255UA SG 11202006255U A SG11202006255U A SG 11202006255UA
Authority
SG
Singapore
Prior art keywords
intraocular
medicine
preventing
disease associated
vascular permeability
Prior art date
Application number
SG11202006255UA
Inventor
Hideaki Hara
Shuh Narumiya
Tomohiro Aoki
Ichiro Aramori
Rie Yamamoto
Original Assignee
Univ Kyoto
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kyoto, Astellas Pharma Inc filed Critical Univ Kyoto
Publication of SG11202006255UA publication Critical patent/SG11202006255UA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
SG11202006255UA 2018-02-02 2019-02-01 Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability SG11202006255UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018016911 2018-02-02
PCT/JP2019/003573 WO2019151470A1 (en) 2018-02-02 2019-02-01 Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability

Publications (1)

Publication Number Publication Date
SG11202006255UA true SG11202006255UA (en) 2020-07-29

Family

ID=67479734

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202006255UA SG11202006255UA (en) 2018-02-02 2019-02-01 Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability

Country Status (17)

Country Link
US (1) US20210113529A1 (en)
EP (1) EP3747471A4 (en)
JP (1) JPWO2019151470A1 (en)
KR (1) KR20200116953A (en)
CN (1) CN111683682A (en)
AU (1) AU2019214265A1 (en)
BR (1) BR112020015567A2 (en)
CA (1) CA3089952A1 (en)
IL (1) IL275603A (en)
JO (1) JOP20200186A1 (en)
MA (1) MA53098A (en)
MX (1) MX2020007948A (en)
PH (1) PH12020551015A1 (en)
RU (1) RU2020128700A (en)
SG (1) SG11202006255UA (en)
WO (1) WO2019151470A1 (en)
ZA (1) ZA202004327B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021148439A1 (en) * 2020-01-21 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for stimulating cerebrovascular function
WO2021163355A1 (en) * 2020-02-11 2021-08-19 Arena Pharmaceuticals, Inc. Formulations and methods of treating conditions related to the s1p1 receptor
CN113082031A (en) * 2021-03-09 2021-07-09 温州医科大学附属眼视光医院 Application of dopamine D1 and D2 receptor nonselective agonist in preparation of drugs for treating pathological angiogenesis of eyes

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1643983T3 (en) 2003-06-24 2010-10-29 Univ Connecticut Methods of inhibiting vascular permeability and apoptosis
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
CN1993333B (en) 2004-08-04 2012-08-01 大正制药株式会社 Triazole derivative
GB0504544D0 (en) * 2005-03-04 2005-04-13 Novartis Ag Organic compounds
US8022091B2 (en) 2006-02-03 2011-09-20 Taisho Pharmaceutical Co., Ltd. Triazole derivative
EP1988081B1 (en) 2006-02-06 2012-10-17 Taisho Pharmaceutical Co., Ltd Binding inhibitor of sphingosine-1-phosphate
ES2453372T3 (en) 2006-04-03 2014-04-07 Astellas Pharma Inc. Oxadiazole derivatives as S1P1 agonists
WO2008055072A2 (en) 2006-10-27 2008-05-08 Lpath, Inc. Compositions and methods for treating ocular diseases and conditions
WO2008063932A2 (en) 2006-11-10 2008-05-29 Genentech, Inc. Method for treating age-related macular degeneration
EP2014653A1 (en) * 2007-06-15 2009-01-14 Bioprojet Novel dicarboxylic acid derivatives as S1P1 receptor agonists
WO2009017219A1 (en) 2007-08-01 2009-02-05 Taisho Pharmaceutical Co., Ltd. Inhibitor of binding of s1p1
BRPI0922135B1 (en) 2008-12-05 2021-07-13 Astellas Pharma Inc 2H-CROMENE COMPOUND OR A SALT THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SUCH COMPOUND AND USE OF THE SAME TO PREVENT OR TREAT A DISEASE INDUCED BY UNDESIRABLE LYMPHOCYTE INFILTRATION ASSOCIATED WITH S1P1
CN102686574A (en) 2009-10-23 2012-09-19 阿勒根公司 Coumarin compounds as receptor modulators with therapeutic utility
CA2780908A1 (en) 2009-11-24 2011-06-03 Allergan, Inc. Novel compounds as receptor modulators with therapeutic utility
BR112012017071A2 (en) 2010-01-14 2016-04-12 Univ Nagoya City pharmaceutical product to prevent or treat disorders accompanied by ocular agiogenesis and / or increased ocular vascular permeability
US8273776B2 (en) 2010-04-16 2012-09-25 Allergan, Inc Biphenyl oxadiazole derivatives as sphingosine-1-phosphate receptors modulators
CN103380112A (en) 2010-11-24 2013-10-30 阿勒根公司 Indole derivatives as modulators of S1P receptors
CN103402986A (en) 2010-11-24 2013-11-20 阿勒根公司 Modulators of S1P receptors
RU2013129484A (en) 2010-12-03 2015-01-10 Аллерган, Инк. ALKINIC AND ALKENE DERIVATIVES AS MODULATORS OF THE RECEPTOR OF SINGINGIN-1-PHOSPHATE-1
CN103391782A (en) 2011-02-02 2013-11-13 公立大学法人名古屋市立大学 Medicinal agent for prevention or treatment of diseases associated with intraocular neovascularization and/or intraocular vascular hyperpermeability
AU2012242807A1 (en) 2011-04-14 2013-11-07 Allergan, Inc. Phenyl bicyclic methyl azetidine derivatives as sphingosine-1 phosphate receptors modulators
CN103781766A (en) 2011-04-18 2014-05-07 阿勒根公司 Substituted bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators
US9000016B2 (en) 2012-11-05 2015-04-07 Allergan, Inc. 1,3,4-Oxadiazoles-2-thio derivatives as sphingosine-1 phosphate receptors modulators
US8735433B1 (en) 2012-11-14 2014-05-27 Allergan, Inc. Aryl oxadiazole derivatives as sphingosine 1-phosphate (S1P) receptor modulators
WO2014130565A1 (en) 2013-02-20 2014-08-28 Allergan, Inc. Substituted diaryl azetidine derivatives as sphingosine receptor modulators
EP2990055B1 (en) * 2013-04-26 2019-06-05 Kyoto University Composition comprising a sphingosine-1-phosphate receptor 1 agonist for inhibiting formation and/or enlargement of cerebral aneurysm or for shrinking it
JP2018016911A (en) 2016-07-28 2018-02-01 村田機械株式会社 Analyzer

Also Published As

Publication number Publication date
BR112020015567A2 (en) 2021-02-02
JOP20200186A1 (en) 2020-07-29
EP3747471A4 (en) 2021-10-27
WO2019151470A1 (en) 2019-08-08
US20210113529A1 (en) 2021-04-22
RU2020128700A (en) 2022-03-02
RU2020128700A3 (en) 2022-03-02
KR20200116953A (en) 2020-10-13
CN111683682A (en) 2020-09-18
JPWO2019151470A1 (en) 2021-02-25
ZA202004327B (en) 2022-01-26
CA3089952A1 (en) 2019-08-08
MX2020007948A (en) 2020-12-10
EP3747471A1 (en) 2020-12-09
IL275603A (en) 2020-08-31
MA53098A (en) 2021-05-12
PH12020551015A1 (en) 2021-09-06
AU2019214265A1 (en) 2020-07-23

Similar Documents

Publication Publication Date Title
ZA202004327B (en) Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability
EP3749264C0 (en) Laser therapy for treatment and prevention of eye diseases
IL268327A (en) A pharmaceutical composition for use in the treatment or prevention of a c5-related disease and a method for treating or preventing a c5-related disease
EP3823569C0 (en) Integrated surgical system for treatment in the irido-corneal angle of the eye
HUE055873T2 (en) Use of gold cluster or gold cluster-containing substance in preparation of drug for preventing and/or treating glaucoma
SG11202104501UA (en) Systems and methods for the treatment of eye conditions
IL287758A (en) Anti-sema3a antibodies and their uses for treating eye or ocular diseases
IL277557A (en) Sap and peptidomimetics for treatment of eye disease
EP3405159A4 (en) Treatment and prevention of retinal vascular disease by photocoagulation
EP3481411A4 (en) Treatment for glaucoma and other eye diseases
SG11202102820VA (en) Ophthalmic composition for treatment of dry eye disease
IL284344A (en) Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease
IL282504A (en) Ocular formulations for drug-delivery and protection of the anterior segment of the eye
IL289405A (en) Personalized treatment of ophthalmologic diseases
SG11202104178TA (en) Peptides and pharmaceutical compositions for treating eye diseases
GB2559756B (en) Implantable medical device with differentiated luminal and abluminal characteristics
EP3691654A4 (en) Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease
SG11202012473UA (en) Ophthalmic compositions and methods for the treatment of eye disorders
EP3639854A4 (en) Mtor-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof
IL282898A (en) Ophthalmic compositions and methods for the treatment of skin diseases and eye diseases
IL280588A (en) Ophthalmic compositions and methods for the treatment of eye disorders and skin diseases
EP4072486A4 (en) Near eye reflective devices for diagnostic and therapeutic ophthalmic procedures
SI3897595T1 (en) Nutraceutical ophthalmic composition for treating diseases of the retina with neovascular component
GB201914516D0 (en) Treatment of eye disease
SG11202102411WA (en) Simulated sclera and simulated eyeball