SG11202005595YA - Antibodies and variants thereof against tigit - Google Patents
Antibodies and variants thereof against tigitInfo
- Publication number
- SG11202005595YA SG11202005595YA SG11202005595YA SG11202005595YA SG11202005595YA SG 11202005595Y A SG11202005595Y A SG 11202005595YA SG 11202005595Y A SG11202005595Y A SG 11202005595YA SG 11202005595Y A SG11202005595Y A SG 11202005595YA SG 11202005595Y A SG11202005595Y A SG 11202005595YA
- Authority
- SG
- Singapore
- Prior art keywords
- antibodies
- variants
- against tigit
- tigit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018072607 | 2018-01-15 | ||
| PCT/CN2019/071711 WO2019137548A1 (en) | 2018-01-15 | 2019-01-15 | Antibodies and variants thereof against tigit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202005595YA true SG11202005595YA (en) | 2020-07-29 |
Family
ID=67219401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202005595YA SG11202005595YA (en) | 2018-01-15 | 2019-01-15 | Antibodies and variants thereof against tigit |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11708410B2 (en) |
| EP (1) | EP3740508A4 (en) |
| JP (1) | JP7316284B2 (en) |
| KR (1) | KR20200109313A (en) |
| CN (1) | CN111601826B (en) |
| AU (1) | AU2019207296A1 (en) |
| CA (1) | CA3088332A1 (en) |
| IL (1) | IL275737A (en) |
| SG (1) | SG11202005595YA (en) |
| TW (1) | TW201932489A (en) |
| WO (1) | WO2019137548A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3618863B1 (en) | 2017-05-01 | 2023-07-26 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
| US20230071889A1 (en) | 2018-12-21 | 2023-03-09 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| AU2020406083A1 (en) | 2019-12-17 | 2022-06-16 | Ose Immunotherapeutics | Bifunctional molecules comprising an IL-7 variant |
| JP2023525082A (en) | 2020-05-07 | 2023-06-14 | アンスティテュ・クリー | ANTXR1 as a biomarker of immunosuppressive fibroblast populations and its use to predict response to immunotherapy |
| CN114507284B (en) * | 2020-05-09 | 2023-05-26 | 华博生物医药技术（上海）有限公司 | Antibodies against TIGIT, methods of preparation and uses thereof |
| IL298946A (en) | 2020-06-18 | 2023-02-01 | Genentech Inc | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
| TW202216778A (en) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Tigit and cd112r blockade |
| EP4238991A4 (en) * | 2020-11-23 | 2024-05-15 | Guangdong Fapon Biopharma Inc | Anti-tigit antibody or antigen-binding fragment thereof |
| WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
| WO2022148781A1 (en) | 2021-01-05 | 2022-07-14 | Institut Curie | Combination of mcoln activators and immune checkpoint inhibitors |
| WO2022214652A1 (en) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
| JP2024515263A (en) | 2021-04-09 | 2024-04-08 | オーエスイー・イミュノセラピューティクス | Novel scaffolds for bifunctional molecules with improved properties |
| AR125753A1 (en) | 2021-05-04 | 2023-08-09 | Agenus Inc | ANTI-TIGIT ANTIBODIES, ANTI-CD96 ANTIBODIES AND METHODS OF USE OF THESE |
| CN115466327A (en) * | 2021-06-10 | 2022-12-13 | 北京天广实生物技术股份有限公司 | Antibodies that bind to TIGIT and uses thereof |
| EP4377350A2 (en) | 2021-07-28 | 2024-06-05 | Genentech, Inc. | Methods and compositions for treating cancer |
| WO2023056403A1 (en) | 2021-09-30 | 2023-04-06 | Genentech, Inc. | Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists |
| WO2023138639A1 (en) * | 2022-01-24 | 2023-07-27 | 原启生物科技(上海)有限责任公司 | Antigen-binding protein targeting tigit and use thereof |
| WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
| WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
| WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
| WO2024041639A1 (en) * | 2022-08-26 | 2024-02-29 | Nanjing Legend Biotech Co., Ltd. | Antibodies targeting tigit and uses thereof |
| CN116444653B (en) * | 2023-03-09 | 2024-03-15 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | Preparation and application of blocking African swine fever virus monoclonal antibody hybridoma cell strain |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103073644B (en) * | 2012-12-31 | 2014-03-12 | 中国科学技术大学 | Specific anti-mouse TIGIT monoclonal antibody and preparation method, identification and application thereof |
| KR20170023081A (en) * | 2014-07-16 | 2017-03-02 | 제넨테크, 인크. | Methods of treating cancer using tigit inhibitors and anti-cancer agents |
| JP6920194B2 (en) | 2014-08-19 | 2021-08-18 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Anti-TIGIT antibody |
| AU2015369831B2 (en) * | 2014-12-22 | 2019-07-11 | Systimmune, Inc. | Bispecific tetravalent antibodies and methods of making and using thereof |
| MA40662B1 (en) * | 2014-12-23 | 2020-12-31 | Bristol Myers Squibb Co | Antibodies against tigit |
| TWI715587B (en) * | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit-binding agents and uses thereof |
| US20180243435A1 (en) * | 2015-08-20 | 2018-08-30 | Abbvie Stemcentrx Llc | Anti-dll3 antibody drug conjugates and methods of use |
| RU2732591C2 (en) * | 2015-09-25 | 2020-09-21 | Дженентек, Инк. | Anti-tigit antibodies and methods of using |
| CN108368176B (en) | 2015-10-01 | 2022-06-07 | 波滕扎治疗公司 | anti-TIGIT antigen binding proteins and methods of use thereof |
| WO2018128939A1 (en) * | 2017-01-05 | 2018-07-12 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
-
2019
- 2019-01-15 KR KR1020207020419A patent/KR20200109313A/en active Search and Examination
- 2019-01-15 US US15/733,364 patent/US11708410B2/en active Active
- 2019-01-15 JP JP2020539000A patent/JP7316284B2/en active Active
- 2019-01-15 CA CA3088332A patent/CA3088332A1/en active Pending
- 2019-01-15 SG SG11202005595YA patent/SG11202005595YA/en unknown
- 2019-01-15 WO PCT/CN2019/071711 patent/WO2019137548A1/en unknown
- 2019-01-15 TW TW108101551A patent/TW201932489A/en unknown
- 2019-01-15 CN CN201980008439.XA patent/CN111601826B/en active Active
- 2019-01-15 EP EP19738954.7A patent/EP3740508A4/en active Pending
- 2019-01-15 AU AU2019207296A patent/AU2019207296A1/en active Pending
-
2020
- 2020-06-29 IL IL275737A patent/IL275737A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20210095028A1 (en) | 2021-04-01 |
| WO2019137548A1 (en) | 2019-07-18 |
| EP3740508A4 (en) | 2022-03-23 |
| TW201932489A (en) | 2019-08-16 |
| IL275737A (en) | 2020-08-31 |
| CN111601826B (en) | 2023-12-15 |
| JP2021510710A (en) | 2021-04-30 |
| KR20200109313A (en) | 2020-09-22 |
| US11708410B2 (en) | 2023-07-25 |
| CA3088332A1 (en) | 2019-07-18 |
| EP3740508A1 (en) | 2020-11-25 |
| AU2019207296A1 (en) | 2020-07-16 |
| CN111601826A (en) | 2020-08-28 |
| JP7316284B2 (en) | 2023-07-27 |
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