SG11202003524XA - Methods for differentiating mesenchymal stem cells - Google Patents

Methods for differentiating mesenchymal stem cells

Info

Publication number
SG11202003524XA
SG11202003524XA SG11202003524XA SG11202003524XA SG11202003524XA SG 11202003524X A SG11202003524X A SG 11202003524XA SG 11202003524X A SG11202003524X A SG 11202003524XA SG 11202003524X A SG11202003524X A SG 11202003524XA SG 11202003524X A SG11202003524X A SG 11202003524XA
Authority
SG
Singapore
Prior art keywords
methods
stem cells
mesenchymal stem
differentiating mesenchymal
differentiating
Prior art date
Application number
SG11202003524XA
Inventor
Sandra Pietri
Xuan Nguyen
Enrico Bastianelli
Sabrina Ena
Pierre-Yves Laruelle
Isabelle Tytgat
Original Assignee
Bone Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bone Therapeutics Sa filed Critical Bone Therapeutics Sa
Publication of SG11202003524XA publication Critical patent/SG11202003524XA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/15Transforming growth factor beta (TGF-β)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90Polysaccharides
    • C12N2501/91Heparin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
SG11202003524XA 2017-10-20 2018-09-25 Methods for differentiating mesenchymal stem cells SG11202003524XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17197605 2017-10-20
PCT/EP2018/076030 WO2019076591A1 (en) 2017-10-20 2018-09-25 Methods for differentiating mesenchymal stem cells

Publications (1)

Publication Number Publication Date
SG11202003524XA true SG11202003524XA (en) 2020-05-28

Family

ID=60153205

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202003524XA SG11202003524XA (en) 2017-10-20 2018-09-25 Methods for differentiating mesenchymal stem cells

Country Status (13)

Country Link
US (2) US11447749B2 (en)
EP (1) EP3697894A1 (en)
JP (1) JP7039711B2 (en)
KR (1) KR102185697B1 (en)
CN (1) CN111247240A (en)
AU (1) AU2018351804B2 (en)
BE (1) BE1025935A9 (en)
BR (1) BR112020007775A2 (en)
CA (1) CA3079439C (en)
IL (1) IL273987B (en)
RU (1) RU2020113411A (en)
SG (1) SG11202003524XA (en)
WO (1) WO2019076591A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022501053A (en) * 2018-09-25 2022-01-06 ボーン、セラピューティクス、エスアーBone Thrapeutics Sa Methods for Differentiating Mesenchymal Stem Cells
CN113648417A (en) * 2021-03-15 2021-11-16 中国人民解放军军事科学院军事医学研究院 POSTN (polyhedral oligomeric silsesquioxane) as marker for regulating and controlling mesenchymal stem cell differentiation capacity and application thereof
CN113355279A (en) * 2021-06-07 2021-09-07 深圳市中佳生物医疗科技有限公司 Preparation method of human ligament fibroblast

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4764369A (en) 1983-07-14 1988-08-16 New York Blood Center Inc. Undenatured virus-free biologically active protein derivatives
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5972703A (en) 1994-08-12 1999-10-26 The Regents Of The University Of Michigan Bone precursor cells: compositions and methods
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
AU2003202988A1 (en) * 2002-01-14 2003-07-30 The Board Of Trustees Of The University Of Illinois Use of modified pyrimidine compounds to promote stem cell migration and proliferation
ES2830525T3 (en) 2006-02-16 2021-06-03 Univ Bruxelles A method for osteogenic differentiation of bone marrow stem cells (BMSC) and uses thereof
WO2008129563A2 (en) * 2007-04-23 2008-10-30 Stempeutics Research Private Limited, Human mesenchymal stem cells and preparation thereof
US20100278788A1 (en) 2008-01-11 2010-11-04 Bone Therapeutics, S.A. Osteogenic Differentiation Of Bone Marrow Stem Cells And Mesenchymal Stem Cells Using A Combination Of Growth Factors
US10047345B2 (en) * 2012-02-13 2018-08-14 Gamida-Cell Ltd. Culturing of mesenchymal stem cells with FGF4 and nicotinamide
EP2943206A4 (en) 2013-01-12 2017-01-04 Cesca Therapeutics Inc. Rapid infusion of autologous bone marrow derived stem cells
JP2017506511A (en) 2014-02-14 2017-03-09 ナショナル ユニバーシティー オブ アイルランド, ゴールウェイ Serum-free medium
JP6446222B2 (en) * 2014-09-30 2018-12-26 株式会社ジーシー Cartilage differentiation culture medium and method for producing cartilage tissue

Also Published As

Publication number Publication date
US11447749B2 (en) 2022-09-20
CN111247240A (en) 2020-06-05
IL273987A (en) 2020-05-31
JP2020537539A (en) 2020-12-24
AU2018351804B2 (en) 2020-07-09
US20230042822A1 (en) 2023-02-09
RU2020113411A (en) 2021-11-22
KR20200063241A (en) 2020-06-04
AU2018351804A1 (en) 2020-05-14
BE1025935B1 (en) 2019-10-18
CA3079439A1 (en) 2019-04-25
KR102185697B1 (en) 2020-12-03
BE1025935A9 (en) 2019-11-05
EP3697894A1 (en) 2020-08-26
JP7039711B2 (en) 2022-03-22
RU2020113411A3 (en) 2021-11-22
IL273987B (en) 2021-06-30
US20200354682A1 (en) 2020-11-12
BE1025935A1 (en) 2019-08-13
BE1025935B9 (en) 2019-10-29
CA3079439C (en) 2022-08-09
BR112020007775A2 (en) 2020-10-20
WO2019076591A1 (en) 2019-04-25

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