SG11202003111SA - Antibodies targeting cd137 and methods of use thereof - Google Patents

Antibodies targeting cd137 and methods of use thereof

Info

Publication number
SG11202003111SA
SG11202003111SA SG11202003111SA SG11202003111SA SG11202003111SA SG 11202003111S A SG11202003111S A SG 11202003111SA SG 11202003111S A SG11202003111S A SG 11202003111SA SG 11202003111S A SG11202003111S A SG 11202003111SA SG 11202003111S A SG11202003111S A SG 11202003111SA
Authority
SG
Singapore
Prior art keywords
methods
antibodies targeting
targeting
antibodies
Prior art date
Application number
SG11202003111SA
Inventor
Tea Gunde
Matthias Brock
Christian Hess
Alexandre Simonin
Original Assignee
Numab Therapeutics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP17195780.6A external-priority patent/EP3470428A1/en
Application filed by Numab Therapeutics AG filed Critical Numab Therapeutics AG
Publication of SG11202003111SA publication Critical patent/SG11202003111SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
SG11202003111SA 2017-10-10 2018-10-09 Antibodies targeting cd137 and methods of use thereof SG11202003111SA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17195780.6A EP3470428A1 (en) 2017-10-10 2017-10-10 Antibodies targeting cd137 and methods of use thereof
EP18167092 2018-04-12
EP18180815 2018-06-29
PCT/EP2018/077514 WO2019072870A1 (en) 2017-10-10 2018-10-09 Antibodies targeting cd137 and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11202003111SA true SG11202003111SA (en) 2020-05-28

Family

ID=63834023

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202003111SA SG11202003111SA (en) 2017-10-10 2018-10-09 Antibodies targeting cd137 and methods of use thereof

Country Status (11)

Country Link
US (1) US11578133B2 (en)
EP (1) EP3694880A1 (en)
JP (1) JP7438939B2 (en)
KR (1) KR20200063153A (en)
CN (1) CN111183159A (en)
AU (1) AU2018348431A1 (en)
CA (1) CA3075337A1 (en)
IL (1) IL273841A (en)
MA (1) MA50354A (en)
SG (1) SG11202003111SA (en)
WO (1) WO2019072870A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018224094A1 (en) 2017-02-24 2019-09-19 Macrogenics, Inc. Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof
CA3075969A1 (en) * 2017-10-10 2019-04-18 Numab Therapeutics AG Multispecific antibody
WO2021013142A1 (en) * 2019-07-22 2021-01-28 江苏恒瑞医药股份有限公司 Anti-4-1bb antibody, antigen-binding fragment thereof, and bispecific antibody
CN112898426A (en) * 2019-11-19 2021-06-04 非同（成都）生物科技有限公司 Humanized 4-1BB monoclonal antibody and pharmaceutical composition thereof
TW202144395A (en) * 2020-02-12 2021-12-01 日商中外製藥股份有限公司 Anti-CD137 antigen-binding molecule for use in cancer treatment
JP2024509915A (en) * 2021-03-09 2024-03-05 ジェンマブ エー／エス Multispecific binding agents for CD40 and CD137 in therapy
KR102647506B1 (en) 2022-02-22 2024-03-13 방윤배 Frame reinforcement panel for fixing the interior wall

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPH02500329A (en) 1987-05-21 1990-02-08 クリエイテイブ・バイオマリキユールズ・インコーポレーテツド Targeted multifunctional protein
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
ES2202310T3 (en) 1991-12-13 2004-04-01 Xoma Corporation METHODS AND MATERIALS FOR THE PREPARATION OF VARIABLE DOMAINS OF MODIFIED ANTIBODIES AND THEIR THERAPEUTIC USES.
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
EP0985039B1 (en) 1997-06-12 2008-02-20 Novartis International Pharmaceutical Ltd. Artificial antibody polypeptides
DE19819846B4 (en) 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalent antibody constructs
KR20000034847A (en) 1998-11-17 2000-06-26 성재갑 Humanized Antibody Specific for Human 4-1BB Molecule and Pharmaceutical Composition Comprising Same
PL375144A1 (en) 2002-07-30 2005-11-28 Bristol-Myers Squibb Company Humanized antibodies against human 4-1bb
CN104356236B (en) 2005-07-01 2020-07-03 E.R.施贵宝&圣斯有限责任公司 Human monoclonal antibodies to programmed death ligand 1(PD-L1)
US8921279B2 (en) 2007-06-26 2014-12-30 F-Star Biotechnologische Forschungs—und Entwicklungsges. m.b.H Display of binding agents
PE20120341A1 (en) 2008-12-09 2012-04-24 Genentech Inc ANTI-PD-L1 ANTIBODIES AND ITS USE TO IMPROVE T-CELL FUNCTION
KR101573109B1 (en) 2009-11-24 2015-12-01 메디뮨 리미티드 Targeted binding agents against b7-h1
SG10201506906VA (en) 2010-09-09 2015-10-29 Pfizer 4-1bb binding molecules
LT2785375T (en) 2011-11-28 2020-11-10 Merck Patent Gmbh Anti-pd-l1 antibodies and uses thereof
JP2016539632A (en) * 2013-10-25 2016-12-22 ヌマブ アクチェンゲゼルシャフト Bispecific constructs and their use in the treatment of various diseases
EA201890041A1 (en) 2015-06-15 2018-07-31 Нумаб Инновейшн Аг HETERODIMERNY POLYSPECIFIC ANTIBODY FORMAT
CA3075969A1 (en) * 2017-10-10 2019-04-18 Numab Therapeutics AG Multispecific antibody

Also Published As

Publication number Publication date
JP7438939B2 (en) 2024-02-27
CA3075337A1 (en) 2019-04-18
MA50354A (en) 2020-08-19
US11578133B2 (en) 2023-02-14
IL273841A (en) 2020-05-31
CN111183159A (en) 2020-05-19
AU2018348431A1 (en) 2020-03-12
JP2020537520A (en) 2020-12-24
EP3694880A1 (en) 2020-08-19
KR20200063153A (en) 2020-06-04
US20200332015A1 (en) 2020-10-22
WO2019072870A1 (en) 2019-04-18

Similar Documents

Publication Publication Date Title
IL290809B1 (en) Tau-protein targeting protacs and associated methods of use
PT3618863T (en) Anti-tigit antibodies and methods of use thereof
ZA201906730B (en) Anti-trem2 antibodies and methods of use thereof
HK1249445A1 (en) Anti-sortilin antibodies and methods of use thereof
IL259495A (en) Antibodies and methods of use thereof
HK1252698A1 (en) Anti-siglec-9 antibodies and methods of use thereof
HK1252696A1 (en) Anti-siglec-7 antibodies and methods of use thereof
SG10201912150TA (en) Anti-trem2 antibodies and methods of use thereof
IL273841A (en) Antibodies targeting cd137 and methods of use thereof
HK1258204A1 (en) Antibodies targeting cd32b and methods of use thereof
IL270793A (en) Anti-htra1 antibodies and methods of use thereof
IL274221A (en) Anti-apoc3 antibodies and methods of use thereof
ZA202002144B (en) Antibodies and methods of use
IL273578A (en) Antibodies targeting pdl1 and methods of use thereof
IL281767A (en) Antibodies targeting cd137 and methods of use thereof