SG11202000298VA - Antibodies to madcam - Google Patents

Antibodies to madcam

Info

Publication number
SG11202000298VA
SG11202000298VA SG11202000298VA SG11202000298VA SG11202000298VA SG 11202000298V A SG11202000298V A SG 11202000298VA SG 11202000298V A SG11202000298V A SG 11202000298VA SG 11202000298V A SG11202000298V A SG 11202000298VA SG 11202000298V A SG11202000298V A SG 11202000298VA
Authority
SG
Singapore
Prior art keywords
antibodies
madcam
international
disclosure
relates
Prior art date
Application number
SG11202000298VA
Inventor
Karin Anderson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SG11202000298VA publication Critical patent/SG11202000298VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII oviolo Ho VIII Inv n (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/014572 Al (43) International Publication Date 17 January 2019 (17.01.2019) WIPO I PCT (51) International Patent Classification: CO7K 16/28 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: PCT/US2018/042052 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 13 July 2018 (13.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/532,809 14 July 2017 (14.07.2017) US (71) Applicant: PFIZER, INC. [US/US]; 235 East 42nd Street, New York, NY 10017 (US). (72) Inventor: ANDERSON, Karin; c/o Pfizer, Inc., 235 East 42nd Street, New York, NY 10017 (US). (74) Agent: MENDEZ, Julio, J. et al.; Proskauer Rose LLP, One International Place, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (54) Title: ANTIBODIES TO MADCAM (57) : The present disclosure relates to antibodies including human antibodies and antigen- binding portions thereof that specifi- cally bind to MAdCAM, preferably human MAdCAM and that func- tion to inhibit MAdCAM. The disclosure also relates to human an- ti-MAdCAM antibodies and antigen-binding portions thereof. The disclosure also relates to antibodies that are chimeric, bispecific, de- rivatized, single chain antibodies or portions of fusion proteins. The disclosure also relates to isolated heavy and light chain immunoglob- ulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present disclo- sure also relates to methods of making human anti- MAdCAM an- tibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The disclosure also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The disclosure also relates to transgenic animals or plants comprising nu- clpeic acid molecules of the disclosure. Figure IA Figure 1J r Figure IL Figure IB Figure C [MI Figure 10 Figure IF Figure IC A rir.rr. _w,rerrrrri Figure IR Figure IH
SG11202000298VA 2017-07-14 2018-07-13 Antibodies to madcam SG11202000298VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762532809P 2017-07-14 2017-07-14
PCT/US2018/042052 WO2019014572A1 (en) 2017-07-14 2018-07-13 Antibodies to madcam

Publications (1)

Publication Number Publication Date
SG11202000298VA true SG11202000298VA (en) 2020-02-27

Family

ID=63209653

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202000298VA SG11202000298VA (en) 2017-07-14 2018-07-13 Antibodies to madcam

Country Status (24)

Country Link
US (2) US20190169291A1 (en)
EP (1) EP3652211A1 (en)
JP (1) JP7160491B2 (en)
KR (1) KR20200028006A (en)
CN (1) CN111032694B (en)
AR (1) AR112336A1 (en)
AU (1) AU2018300189A1 (en)
BR (1) BR112020000698A2 (en)
CA (1) CA3069914A1 (en)
CL (1) CL2020000102A1 (en)
CO (1) CO2020000352A2 (en)
CR (1) CR20200076A (en)
CU (1) CU20200002A7 (en)
DO (1) DOP2020000005A (en)
EA (1) EA202090286A1 (en)
EC (1) ECSP20011317A (en)
IL (1) IL272015A (en)
MA (1) MA48241A1 (en)
NI (1) NI202000004A (en)
PE (1) PE20200616A1 (en)
PH (1) PH12020500100A1 (en)
SG (1) SG11202000298VA (en)
TW (1) TW201920266A (en)
WO (1) WO2019014572A1 (en)

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Also Published As

Publication number Publication date
CO2020000352A2 (en) 2020-04-13
CU20200002A7 (en) 2020-11-30
CL2020000102A1 (en) 2020-10-09
TW201920266A (en) 2019-06-01
ECSP20011317A (en) 2020-12-31
JP7160491B2 (en) 2022-10-25
EA202090286A1 (en) 2020-05-12
WO2019014572A1 (en) 2019-01-17
US11802156B2 (en) 2023-10-31
PH12020500100A1 (en) 2020-09-14
BR112020000698A2 (en) 2020-07-14
NI202000004A (en) 2020-03-30
CR20200076A (en) 2020-06-10
KR20200028006A (en) 2020-03-13
DOP2020000005A (en) 2021-02-15
CA3069914A1 (en) 2019-01-17
US20220119521A1 (en) 2022-04-21
US20190169291A1 (en) 2019-06-06
EP3652211A1 (en) 2020-05-20
CN111032694B (en) 2024-03-08
PE20200616A1 (en) 2020-03-11
IL272015A (en) 2020-02-27
MA48241A1 (en) 2021-03-31
CN111032694A (en) 2020-04-17
AR112336A1 (en) 2019-10-16
AU2018300189A1 (en) 2020-01-30
JP2020533953A (en) 2020-11-26

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