SG11202000141WA - Powder solid dispersions comprising quercetin, process for their preparation and formulations thereof - Google Patents
Powder solid dispersions comprising quercetin, process for their preparation and formulations thereofInfo
- Publication number
- SG11202000141WA SG11202000141WA SG11202000141WA SG11202000141WA SG11202000141WA SG 11202000141W A SG11202000141W A SG 11202000141WA SG 11202000141W A SG11202000141W A SG 11202000141WA SG 11202000141W A SG11202000141W A SG 11202000141WA SG 11202000141W A SG11202000141W A SG 11202000141WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- milano
- solid dispersions
- viale
- indena
- Prior art date
Links
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 title abstract 6
- 239000007962 solid dispersion Substances 0.000 title abstract 5
- 239000000843 powder Substances 0.000 title abstract 4
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 title abstract 3
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 title abstract 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 229960001285 quercetin Drugs 0.000 title abstract 3
- 235000005875 quercetin Nutrition 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000002417 nutraceutical Substances 0.000 abstract 1
- 235000021436 nutraceutical agent Nutrition 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau omit III m DID Ill Eno oimIE (43) International Publication Date 24 January 2019 (24.01.2019) WIP0 I PCT (10) International Publication Number WO 2019/016146 Al (51) International Patent Classification: A61K 9/00 (2006.01) A61K 9/48 (2006.01) A61K 9/14 (2006.01) A61K 31/352 (2006.01) A61K 9/20 (2006.01) (21) International Application Number: PCT/EP2018/069284 (22) International Filing Date: 16 July 2018 (16.07.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17181634.1 17 July 2017 (17.07.2017) EP (71) Applicant: INDENA S.P.A. [IT/IT]; Viale Ortles, 12, 20139 MILANO (IT). (72) Inventors: RONCHI, Massimo; c/o INDENA S.p.A., Viale Orles, 12, 20139 MILANO (IT). FRATTINI, Elis- abetta; c/o INDENA S.p.A., Viale Orles, 12, 20139 MILANO (IT). RIVA, Antonella; c/o INDENA S.p.A., Viale Ortles, 12, 20139 MILANO (IT). (74) Agent: BERTUCCIO, Silvia; BIANCHETTI BRACCO MINOJA S.r.1., Via Plinio, 63, 20129 MILANO (IT). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 1-1 .•!! Published: with international search report (Art. 21(3)) 71' O 01 (54) Title: POWDER SOLID DISPERSIONS COMPRISING QUERCETIN, PROCESS FOR THEIR PREPARATION AND FOR- MULATIONS THEREOF \" (57) : The present invention relates to powder solid dispersions comprising quercetin, phospholipids and a very to freely C water soluble carrier. The invention also relates to a process for the preparation of the powder solid dispersions and pharmaceutical, nutraceutical and cosmetic compositions comprising said solid dispersions.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17181634 | 2017-07-17 | ||
| PCT/EP2018/069284 WO2019016146A1 (en) | 2017-07-17 | 2018-07-16 | Powder solid dispersions comprising quercetin, process for their preparation and formulations thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202000141WA true SG11202000141WA (en) | 2020-02-27 |
Family
ID=59381081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202000141WA SG11202000141WA (en) | 2017-07-17 | 2018-07-16 | Powder solid dispersions comprising quercetin, process for their preparation and formulations thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11331298B2 (en) |
| EP (1) | EP3654938B1 (en) |
| JP (1) | JP7284743B2 (en) |
| KR (1) | KR20200030076A (en) |
| CN (1) | CN110944624A (en) |
| BR (1) | BR112020000841A2 (en) |
| CA (1) | CA3069055A1 (en) |
| DK (1) | DK3654938T3 (en) |
| ES (1) | ES2929981T3 (en) |
| FI (1) | FI3654938T3 (en) |
| HU (1) | HUE060387T2 (en) |
| IL (1) | IL271852B1 (en) |
| PL (1) | PL3654938T3 (en) |
| PT (1) | PT3654938T (en) |
| SG (1) | SG11202000141WA (en) |
| SI (1) | SI3654938T1 (en) |
| WO (1) | WO2019016146A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210393579A1 (en) * | 2020-06-23 | 2021-12-23 | Zestt Wellness Limited | Anthocyanin and Quercetin Based Formulations for Improved Respiratory Health |
| JP7123434B1 (en) | 2021-03-17 | 2022-08-23 | 株式会社アイビー化粧品 | Osteoclast differentiation inhibitor |
| CN113712988A (en) * | 2021-08-17 | 2021-11-30 | 塔里木大学 | Quercetin-tilmicosin polymer nanoparticles as well as preparation method and application thereof |
| IT202200002108A1 (en) | 2022-02-07 | 2023-08-07 | Indena Spa | QUERCETIN-BASED COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF EYE DISEASES |
| KR102653457B1 (en) * | 2023-12-20 | 2024-04-02 | 서울대학교산학협력단 | Method for preparing Quercetin powder composition improving mucosal adhesive capacity and Quercetin powder composition prepared by the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100370968C (en) * | 2005-12-06 | 2008-02-27 | 四川大学 | Quercetin long-acting liposome powder for injection and its preparing method |
| CN100367953C (en) * | 2006-03-06 | 2008-02-13 | 山东大学 | Quercetin solid liposome nano particle preparation and its preparing method |
| CN101904821A (en) | 2009-06-02 | 2010-12-08 | 姜玲敏 | Quercetin nano freeze-dried powder and preparation method thereof |
| CN102058536A (en) | 2011-01-14 | 2011-05-18 | 四川大学 | Quercetin hydroxypropyl Beta-cyclodextrin inclusion liposome, preparation method and application thereof |
-
2018
- 2018-07-16 SI SI201830771T patent/SI3654938T1/en unknown
- 2018-07-16 DK DK18743743.9T patent/DK3654938T3/en active
- 2018-07-16 PL PL18743743.9T patent/PL3654938T3/en unknown
- 2018-07-16 IL IL271852A patent/IL271852B1/en unknown
- 2018-07-16 BR BR112020000841-9A patent/BR112020000841A2/en unknown
- 2018-07-16 CA CA3069055A patent/CA3069055A1/en active Pending
- 2018-07-16 EP EP18743743.9A patent/EP3654938B1/en active Active
- 2018-07-16 US US16/631,285 patent/US11331298B2/en active Active
- 2018-07-16 JP JP2020500740A patent/JP7284743B2/en active Active
- 2018-07-16 FI FIEP18743743.9T patent/FI3654938T3/en active
- 2018-07-16 WO PCT/EP2018/069284 patent/WO2019016146A1/en unknown
- 2018-07-16 KR KR1020207003402A patent/KR20200030076A/en not_active Application Discontinuation
- 2018-07-16 PT PT187437439T patent/PT3654938T/en unknown
- 2018-07-16 ES ES18743743T patent/ES2929981T3/en active Active
- 2018-07-16 HU HUE18743743A patent/HUE060387T2/en unknown
- 2018-07-16 CN CN201880048118.8A patent/CN110944624A/en active Pending
- 2018-07-16 SG SG11202000141WA patent/SG11202000141WA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020527549A (en) | 2020-09-10 |
| IL271852B1 (en) | 2024-03-01 |
| IL271852A (en) | 2020-02-27 |
| KR20200030076A (en) | 2020-03-19 |
| RU2020106924A3 (en) | 2021-11-17 |
| EP3654938B1 (en) | 2022-08-31 |
| FI3654938T3 (en) | 2022-12-15 |
| SI3654938T1 (en) | 2022-11-30 |
| US20200206186A1 (en) | 2020-07-02 |
| DK3654938T3 (en) | 2022-10-03 |
| US11331298B2 (en) | 2022-05-17 |
| WO2019016146A1 (en) | 2019-01-24 |
| BR112020000841A2 (en) | 2020-07-21 |
| EP3654938A1 (en) | 2020-05-27 |
| CA3069055A1 (en) | 2019-01-24 |
| AU2018304534A1 (en) | 2020-02-06 |
| PL3654938T3 (en) | 2022-12-27 |
| HUE060387T2 (en) | 2023-02-28 |
| CN110944624A (en) | 2020-03-31 |
| ES2929981T3 (en) | 2022-12-05 |
| RU2020106924A (en) | 2021-08-17 |
| PT3654938T (en) | 2022-11-03 |
| JP7284743B2 (en) | 2023-05-31 |
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