SG11202000086PA - Mpo inhibitors for use in medicine - Google Patents

Abstract

FigureAverage MDA staining by flow cytometric analysis MDA staining total andrology N=29 P<0.01 r (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII oviolo nonnit Env Hs (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/016074 Al (43) International Publication Date 24 January 2019 (24.01.2019) WIP0 I PCT (51) International Patent Classification: A61K 31/505 (2006.01) A61P 15/10 (2006.01) (21) International Application Number: PCT/EP2018/068992 (22) International Filing Date: 12 July 2018 (12.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/533,448 17 July 2017 (17.07.2017) US (71) Applicant: ASTRAZENECA AB [SE/SE]; 151 85 Sodertalje (SE). (72) Inventors: WHITTAKER, Andrew; 1 Francis Crick Av- enue, Cambridge Biomedical Campus, Cambridge Cam- bridgeshire CB2 OAA (GB). SANGANEE, Hitesh, Jayan- tilal; 1 Francis Crick Avenue, Cambridge Biomedical Cam- pus, Cambridge Cambridgeshire CB2 OAA (GB). 1-1 N 1-1 C (74) Agent: LEESE, Mathew, Paul; Milstein Building, Granta Park, Cambridge Cambridgeshire CB21 6GH (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) (54) Title: MPO INHIBITORS FOR USE IN MEDICINE Pdg Sp'? rm a Sit= N euro b SO' ,10 +Ai) C SpErm 4r4.1 1-1 (57) : The present disclosure relates to new therapeutic uses of MPO inhibitors and methods of treatment involving the same. C [Continued on next page] WO 2019/016074 Al IMIOHOMMIDERIDIEDIUMMIEDIRMIEMMOVOIMIE Published: — with international search report (Art. 21(3))