SG11201912827TA - 7-substituted pyrrolotriazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereof - Google Patents

7-substituted pyrrolotriazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereof

Info

Publication number
SG11201912827TA
SG11201912827TA SG11201912827TA SG11201912827TA SG11201912827TA SG 11201912827T A SG11201912827T A SG 11201912827TA SG 11201912827T A SG11201912827T A SG 11201912827TA SG 11201912827T A SG11201912827T A SG 11201912827TA SG 11201912827T A SG11201912827T A SG 11201912827TA
Authority
SG
Singapore
Prior art keywords
pharmaceutically acceptable
acceptable salts
preparation methods
pyrrolotriazine compounds
substituted pyrrolotriazine
Prior art date
Application number
SG11201912827TA
Inventor
Chunhao Yang
Linghua Meng
Haoyue Xiang
Jing Li
Xi Zhang
Xiang Wang
Cun Tan
Qian He
Jian Ding
Yi Chen
Original Assignee
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institute Of Materia Medica Chinese Academy Of Sciences filed Critical Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
Publication of SG11201912827TA publication Critical patent/SG11201912827TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG11201912827TA 2017-06-23 2018-06-22 7-substituted pyrrolotriazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereof SG11201912827TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710493411.2A CN109111447A (en) 2017-06-23 2017-06-23 7- substituted azole triazin compounds or its pharmaceutically available salt, and its preparation method and application
PCT/CN2018/092419 WO2018233684A1 (en) 2017-06-23 2018-06-22 7-site substituted pyrrole triazine compounds or pharmaceutically acceptable salts thereof, and preparation method therefor and uses thereof

Publications (1)

Publication Number Publication Date
SG11201912827TA true SG11201912827TA (en) 2020-01-30

Family

ID=64733772

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201912827TA SG11201912827TA (en) 2017-06-23 2018-06-22 7-substituted pyrrolotriazine compounds or pharmaceutically acceptable salts thereof, and preparation methods and uses thereof

Country Status (13)

Country Link
US (1) US11214572B2 (en)
EP (1) EP3643717B1 (en)
JP (1) JP6852199B2 (en)
KR (1) KR102413943B1 (en)
CN (2) CN109111447A (en)
AU (1) AU2018287971B9 (en)
BR (1) BR112019027545A2 (en)
CA (1) CA3068114C (en)
ES (1) ES2887629T3 (en)
PT (1) PT3643717T (en)
RU (1) RU2745548C1 (en)
SG (1) SG11201912827TA (en)
WO (1) WO2018233684A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220079866A (en) * 2019-09-19 2022-06-14 토투스 메디신스 아이엔씨. therapeutic conjugate
CN111909153B (en) * 2020-04-16 2021-11-19 山东鲁西药业有限公司 Synthesis process of 7-iodopyrrolo [2,1-F ] [1,2,4] triazin-4-amine
CN117126164A (en) * 2023-08-30 2023-11-28 山东轩硕医药科技有限公司 Pyrrolotriazines compound, preparation method and application thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1761540B1 (en) 2004-05-13 2016-09-28 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
EP2435438A1 (en) 2009-05-27 2012-04-04 Genentech, Inc. Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
CA2840518A1 (en) 2011-07-01 2013-01-10 Bayer Intellectual Property Gmbh Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors
AR091315A1 (en) 2012-03-06 2015-01-28 Boehringer Ingelheim Int BENZODIOXAN INHIBITORS OF LEUCOTRENE PRODUCTION
CN103450204B (en) 2012-05-31 2016-08-17 中国科学院上海药物研究所 Pyrroles [2,1-f] [1,2,4] triazin compound, Preparation Method And The Use
CN102675323B (en) * 2012-06-01 2014-04-09 南京药石药物研发有限公司 Pyrrole-[2, 1-f] [1, 2 and 4] triazine derivative and antitumor effect thereof
JOP20130273B1 (en) 2012-09-11 2021-08-17 Genzyme Corp Glucosylceramide synthase inhibitors
EP3053926B1 (en) 2013-09-30 2018-08-08 Shanghai Yingli Pharmaceutical Co. Ltd. Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof
AU2017280293B2 (en) 2016-06-25 2020-02-06 Suzhou Kintor Pharmaceuticals, Inc. Mechanistic target of rapamycin signaling pathway inhibitors and therapeutic applications thereof

Also Published As

Publication number Publication date
AU2018287971B8 (en) 2021-02-04
CN110869371B (en) 2022-04-15
AU2018287971A8 (en) 2021-02-04
AU2018287971B9 (en) 2021-02-11
US11214572B2 (en) 2022-01-04
EP3643717B1 (en) 2021-06-02
KR102413943B1 (en) 2022-06-27
WO2018233684A1 (en) 2018-12-27
AU2018287971B2 (en) 2020-12-24
US20200157110A1 (en) 2020-05-21
PT3643717T (en) 2021-08-31
JP2020527541A (en) 2020-09-10
ES2887629T3 (en) 2021-12-23
EP3643717A4 (en) 2020-04-29
KR20200015786A (en) 2020-02-12
CN110869371A (en) 2020-03-06
RU2745548C1 (en) 2021-03-26
JP6852199B2 (en) 2021-03-31
BR112019027545A2 (en) 2020-07-07
CN109111447A (en) 2019-01-01
EP3643717A1 (en) 2020-04-29
CA3068114A1 (en) 2018-12-27
CA3068114C (en) 2022-05-10
AU2018287971A1 (en) 2020-02-13

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