SG11201912281PA - 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof - Google Patents

2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof

Info

Publication number
SG11201912281PA
SG11201912281PA SG11201912281PA SG11201912281PA SG11201912281PA SG 11201912281P A SG11201912281P A SG 11201912281PA SG 11201912281P A SG11201912281P A SG 11201912281PA SG 11201912281P A SG11201912281P A SG 11201912281PA SG 11201912281P A SG11201912281P A SG 11201912281PA
Authority
SG
Singapore
Prior art keywords
methylaminomethyl
benzofuran
fluoro
phenyl
preparation
Prior art date
Application number
SG11201912281PA
Inventor
Chunhao Yang
Zehong Miao
Cun Tan
Xiajuan Huan
Jian Ding
Yi Chen
Original Assignee
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
Fukang Shanghai Health Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institute Of Materia Medica Chinese Academy Of Sciences, Fukang Shanghai Health Technology Co Ltd filed Critical Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
Publication of SG11201912281PA publication Critical patent/SG11201912281PA/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11201912281PA 2017-06-14 2018-05-31 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof SG11201912281PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710449281.2A CN109134409B (en) 2017-06-14 2017-06-14 Mefurazapirone hydrochloride polymorph and preparation method and application thereof
PCT/CN2018/089222 WO2018228205A1 (en) 2017-06-14 2018-05-31 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof

Publications (1)

Publication Number Publication Date
SG11201912281PA true SG11201912281PA (en) 2020-01-30

Family

ID=64660851

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201912281PA SG11201912281PA (en) 2017-06-14 2018-05-31 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof

Country Status (11)

Country Link
US (1) US11174237B2 (en)
EP (1) EP3643708A4 (en)
JP (2) JP7432503B2 (en)
KR (1) KR102458566B1 (en)
CN (1) CN109134409B (en)
AU (1) AU2018286057B2 (en)
CA (1) CA3067336C (en)
SG (1) SG11201912281PA (en)
TW (1) TWI675027B (en)
WO (1) WO2018228205A1 (en)
ZA (1) ZA202000224B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109134409B (en) * 2017-06-14 2023-09-29 中国科学院上海药物研究所 Mefurazapirone hydrochloride polymorph and preparation method and application thereof
CN111320596A (en) * 2018-12-14 2020-06-23 甫康(上海)健康科技有限责任公司 Mefurapine hydrochloride polymorphic substance and preparation method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103242273B (en) * 2012-02-09 2015-06-03 中国科学院上海药物研究所 2-arylbenzofuran-7-methanamide compound, preparation method and application thereof
CN102627620B (en) * 2012-04-10 2015-12-16 江苏先声药物研究有限公司 One class benzofuran derivative and medical applications thereof
CN104003979B (en) * 2013-02-21 2016-08-17 上海汇伦生命科技有限公司 Benzimidazolyl-2 radicals-piperazine compounds, its pharmaceutical composition and its production and use
CN105246875A (en) * 2013-09-03 2016-01-13 四川海思科制药有限公司 Indane derivative, preparation method therefor, and pharmaceutical application thereof
CN104003940B (en) * 2014-06-16 2017-02-15 华东理工大学 2,4-difluoro-5-( phthalazone-1-methyl)-benzoyl piperazine compound and application thereof
CN109134409B (en) * 2017-06-14 2023-09-29 中国科学院上海药物研究所 Mefurazapirone hydrochloride polymorph and preparation method and application thereof
CN111320596A (en) * 2018-12-14 2020-06-23 甫康(上海)健康科技有限责任公司 Mefurapine hydrochloride polymorphic substance and preparation method thereof

Also Published As

Publication number Publication date
JP2022060192A (en) 2022-04-14
AU2018286057A1 (en) 2020-01-30
EP3643708A4 (en) 2021-02-24
TWI675027B (en) 2019-10-21
CA3067336C (en) 2022-11-15
ZA202000224B (en) 2021-08-25
US20200172502A1 (en) 2020-06-04
CN109134409A (en) 2019-01-04
KR102458566B1 (en) 2022-10-24
WO2018228205A1 (en) 2018-12-20
EP3643708A1 (en) 2020-04-29
KR20200014924A (en) 2020-02-11
JP7432503B2 (en) 2024-02-16
CN109134409B (en) 2023-09-29
US11174237B2 (en) 2021-11-16
AU2018286057B2 (en) 2021-03-18
CA3067336A1 (en) 2018-12-20
JP2020524707A (en) 2020-08-20
TW201904952A (en) 2019-02-01

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