SG11201911164WA - Method for preparing intermediate of 4-methoxypyrrole derivative - Google Patents

Method for preparing intermediate of 4-methoxypyrrole derivative

Info

Publication number
SG11201911164WA
SG11201911164WA SG11201911164WA SG11201911164WA SG11201911164WA SG 11201911164W A SG11201911164W A SG 11201911164WA SG 11201911164W A SG11201911164W A SG 11201911164WA SG 11201911164W A SG11201911164W A SG 11201911164WA SG 11201911164W A SG11201911164W A SG 11201911164WA
Authority
SG
Singapore
Prior art keywords
preparing intermediate
methoxypyrrole derivative
methoxypyrrole
derivative
preparing
Prior art date
Application number
SG11201911164WA
Inventor
Jeong-Taek Shin
Jeong Hyun Son
Seung Chul Lee
Original Assignee
Daewoong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daewoong Pharmaceutical Co Ltd filed Critical Daewoong Pharmaceutical Co Ltd
Publication of SG11201911164WA publication Critical patent/SG11201911164WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/402,5-Pyrrolidine-diones
    • C07D207/4162,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201911164WA 2017-06-21 2018-06-21 Method for preparing intermediate of 4-methoxypyrrole derivative SG11201911164WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170078745A KR102233455B1 (en) 2017-06-21 2017-06-21 Method for preparation of intermediate of 4-methoxypyrrole derivative
PCT/KR2018/006989 WO2018236153A1 (en) 2017-06-21 2018-06-21 Method for preparing intermediate of 4-methoxypyrrole derivative

Publications (1)

Publication Number Publication Date
SG11201911164WA true SG11201911164WA (en) 2020-01-30

Family

ID=64735783

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201911164WA SG11201911164WA (en) 2017-06-21 2018-06-21 Method for preparing intermediate of 4-methoxypyrrole derivative

Country Status (30)

Country Link
US (2) US11345660B2 (en)
EP (1) EP3642181B1 (en)
JP (1) JP6799178B2 (en)
KR (1) KR102233455B1 (en)
CN (1) CN110582482B (en)
AU (1) AU2018288933B2 (en)
BR (1) BR112019027323A2 (en)
CA (1) CA3061713C (en)
CL (1) CL2019003450A1 (en)
CO (1) CO2019012689A2 (en)
DO (1) DOP2019000291A (en)
EC (1) ECSP19081847A (en)
ES (1) ES2901701T3 (en)
HR (1) HRP20211819T1 (en)
HU (1) HUE057666T2 (en)
JO (1) JOP20190265B1 (en)
MA (1) MA49472B1 (en)
MY (1) MY188800A (en)
NZ (1) NZ758770A (en)
PE (1) PE20210151A1 (en)
PH (1) PH12019502865A1 (en)
PL (1) PL3642181T3 (en)
PT (1) PT3642181T (en)
RS (1) RS62564B1 (en)
RU (1) RU2737470C1 (en)
SA (1) SA519410407B1 (en)
SG (1) SG11201911164WA (en)
SI (1) SI3642181T1 (en)
TN (1) TN2019000301A1 (en)
WO (1) WO2018236153A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102081920B1 (en) 2016-03-25 2020-02-26 주식회사 대웅제약 Novel crystalline form of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine salt
KR102233455B1 (en) * 2017-06-21 2021-03-29 주식회사 대웅제약 Method for preparation of intermediate of 4-methoxypyrrole derivative
US10789690B2 (en) * 2018-03-07 2020-09-29 Adobe Inc. Masking non-public content
CN109867617A (en) * 2019-04-03 2019-06-11 南京格亚医药科技有限公司 A kind of preparation method of 4- methoxypyrrole intermediate
CN112094219B (en) * 2020-09-10 2022-08-05 广东莱佛士制药技术有限公司 Method for preparing intermediate of potassium ion competitive retarder
CN117326961B (en) * 2023-09-27 2024-05-03 安徽峆一药业股份有限公司 Green synthesis method of non-surafaxin intermediate

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622948A (en) 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
EP2336107B1 (en) 2004-09-30 2015-09-23 Takeda Pharmaceutical Company Limited Proton pump inhibitors
PL1919865T3 (en) 2005-08-30 2011-09-30 Takeda Pharmaceuticals Co 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors
KR101174191B1 (en) 2007-02-02 2012-08-14 에프. 호프만-라 로슈 아게 Novel 2-aminooxazolines as taar1 ligands for cns disorders
CN102088855A (en) * 2008-05-08 2011-06-08 百时美施贵宝公司 2-aryl glycinamide derivatives
US8895558B2 (en) * 2008-10-02 2014-11-25 Green Cross Corporation Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders
KR101613245B1 (en) * 2015-04-27 2016-04-18 주식회사 대웅제약 Novel 4-methoxy pyrrole derivatives or salts thereof and pharmaceutical composition comprising the same
WO2017164575A1 (en) 2016-03-25 2017-09-28 Daewoong Pharmaceutical Co.,Ltd. Novel acid addition salt of 1-(5-(2,4-difluorophenyl)-1-((3- fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n- methylmethanamine
KR20170113040A (en) * 2016-03-25 2017-10-12 주식회사 대웅제약 Novel acid addition salt of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine
KR102081920B1 (en) 2016-03-25 2020-02-26 주식회사 대웅제약 Novel crystalline form of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine salt
KR102233456B1 (en) * 2017-05-31 2021-03-29 주식회사 대웅제약 Method for preparation of intermediate of 4-methoxypyrrole derivative
KR102233455B1 (en) * 2017-06-21 2021-03-29 주식회사 대웅제약 Method for preparation of intermediate of 4-methoxypyrrole derivative
KR102126576B1 (en) * 2018-09-19 2020-06-24 주식회사 대웅제약 Manufacturing method for 4-methoxypyrrole derivatives

Also Published As

Publication number Publication date
US11345660B2 (en) 2022-05-31
NZ758770A (en) 2022-01-28
KR102233455B1 (en) 2021-03-29
CN110582482A (en) 2019-12-17
JP2020519680A (en) 2020-07-02
WO2018236153A1 (en) 2018-12-27
PH12019502865A1 (en) 2020-12-07
EP3642181A4 (en) 2020-12-09
JOP20190265A1 (en) 2019-11-12
CA3061713C (en) 2021-10-12
DOP2019000291A (en) 2019-12-15
SI3642181T1 (en) 2022-04-29
CL2019003450A1 (en) 2020-03-27
RU2737470C1 (en) 2020-11-30
SA519410407B1 (en) 2022-06-14
US20200181080A1 (en) 2020-06-11
PT3642181T (en) 2021-12-20
TN2019000301A1 (en) 2021-05-07
CO2019012689A2 (en) 2020-01-17
ECSP19081847A (en) 2019-11-30
AU2018288933A1 (en) 2019-11-21
KR20180138476A (en) 2018-12-31
EP3642181B1 (en) 2021-11-03
RS62564B1 (en) 2021-12-31
AU2018288933B2 (en) 2020-12-10
EP3642181A1 (en) 2020-04-29
CA3061713A1 (en) 2018-12-27
MA49472A (en) 2020-04-29
PL3642181T3 (en) 2022-02-14
US20220259146A1 (en) 2022-08-18
JOP20190265B1 (en) 2023-03-28
MY188800A (en) 2022-01-04
CN110582482B (en) 2022-10-11
ES2901701T3 (en) 2022-03-23
BR112019027323A2 (en) 2020-07-28
MA49472B1 (en) 2022-01-31
PE20210151A1 (en) 2021-01-26
JP6799178B2 (en) 2020-12-09
HRP20211819T1 (en) 2022-03-04
HUE057666T2 (en) 2022-06-28

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