SG11201909570PA - K-ras modulators - Google Patents

K-ras modulators

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Publication number
SG11201909570PA
SG11201909570PA SG11201909570PA SG11201909570PA SG 11201909570P A SG11201909570P A SG 11201909570PA SG 11201909570P A SG11201909570P A SG 11201909570PA SG 11201909570P A SG11201909570P A SG 11201909570PA
Authority
SG
Singapore
Prior art keywords
co7d
international
frederick
pct
ras
Prior art date
Application number
Inventor
Frank Mccormick
Adam Renslo
David Turner
Anna Maciag
Marcin Dyba
Elizabeth Vo
Joseph Saavedra
Vandana Kumari
Original Assignee
Univ California
Leidos Biomedical Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Leidos Biomedical Research Inc filed Critical Univ California
Publication of SG11201909570PA publication Critical patent/SG11201909570PA/en

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    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/24—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to three ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • C07D487/04—Ortho-condensed systems

Abstract

KrasbH 5C (GppNHp dose response 100 200 300 400 500 Concentration (uM) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIPO I PCT Iiiimmomiolollmonolomomnioomlloonomoun (10) International Publication Number WO 2018/195439 A2 (51) International Patent Classification: CO7D 405/14 (2006.01) CO7D 241/12 A61K 31/4192 (2006.01) CO7C 233/76 (2006.01) (2006.01) C07D 231/56 (2006.01) CO7D 207/40 (2006.01) CO7D 403/06 (2006.01) CO7D 213/40 (2006.01) CO7D 237/08 (2006.01) CO7D 303/36 (2006.01) CO7D 403/14 (2006.01) CO7D 305/06 (2006.01) CO7D 239/26 (2006.01) CO7D 307/28 (2006.01) CO7D 405/12 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/028593 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/487,756 20 April 2017 (20.04.2017) US (71) Applicants: THE REGENTS OF THE UNIVERSI- TY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 (US). LEIDOS BIOMEDICAL RESEARCH, INC. [US/US]; P.O. Box B, 1050 Boyles Street, Frederick, MD 21702 (US). (72) Inventors: MCCORMICK, Frank; 5 Bernice St., San Francisco, CA 94103 (US). RENSLO, Adam; 5359 Shafter Avenue, Oakland, CA 94618 (US). TURNER, David; 501 Prospect Blvd., Apt. 24C, Frederick, MD 21701 (US). MACIAG, Anna, E.; 9214 Charterhouse Rd., Frederick, MD 21704 (US). DYBA, Marcin; 1930 Moran Drive, Frederick, MD 21702-6443 (US). VO, Elizabeth, D.; 391 Valencia St., Apt. 302, San Francisco, CA 94103 (US). SAAVEDRA, Joseph; 7189 Browns Ln, Thurmont, MD 21788 (US). KUMARI, Vandana; 9159 Bealls Farm Road, Frederick, MD 21704 (US). (74) Agent: TERRANOVA, Zachary, L. et al.; Mintz Levin Cohn Ferris Glovsky and Popeo, P.C., One Financial Cen- ter, Boston, MA 02111 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = (54) Title: K-RAS MODULATORS FIG. 2 98e844 966854 917181 917105 960005 917332 916860 916929 917680 917878 957805 © (57) : Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer. C [Continued on next page] WO 2018/195439 A2 IMIOHOIIIMIIMEIHOMOMBREIIIRIONMMIE MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g)) with sequence listing part of description (Rule 5.2(a))
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