SG11201908076TA - Cryotherapies - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIPO I PCT omit IIl °nolo Oil 100 mo Imo oimIE (10) International Publication Number WO 2018/160797 Al (51) International Patent Classification: A61F 7/00 (2006.01) A61F 7/10 (2006.01) A61F 7/02 (2006.01) A61F 7/12 (2006.01) (21) International Application Number: PCT/US2018/020387 (22) International Filing Date: 01 March 2018 (01.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/465,336 01 March 2017 (01.03.2017) US (71) Applicant: ARCTIC FOX BIOMEDICAL, INC. [US/US]; 97 Winthrop Street, Harvard Square, Cambridge, MA 02138 (US). (72) Inventors: VELIS, Christopher, J.P.; 97 Winthrop Street, Harvard Square, Cambridge, MA 02138 (US). MILLER, Karen; 97 Winthrop Street, Harvard Square, Cambridge, MA 02138 (US). CHAUDHRY, Tarik, S.; 97 Winthrop Street, Harvard Square, Cambridge, MA 02138 (US). ARIAS, Susan; 97 Winthrop Street, Harvard Square, Cam- bridge, MA 02138 (US). (74) Agent: MEYERS, Thomas, C. et al.; Brown Rudnick LLP, One Financial Center, Boston, MA 02111 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (54) Title: CRYOTHERAPIES 100 1-1 N N O 1-1 00 1-1 O N C FIG. 1 (57) : Delivering cold slurry to internal tissues can be used in therapies for treating a variety or medical diseases and conditions. For example, cold slurry can activate brown adipose tissue to treat obesity. Cold slurry can be delivered to tissue injured by trauma or disease to reduce inflammation, which in turn reduces pain and leads to quicker recovery. Cold slurry therapy can also be used to treat muscular and neurological disorders as well as to manage pain. The cooling effect of cold slurry delivered at or near a nerve reduces innervation that nerve, which in turn reduces spasms or pain. The cooling effect can also cause tissue to undergo the cell death. Advantageously, cold slurry therapies can be used to reduce or remove tissue, for example, to treat fibroadenomas or scar tissue. [Continued on next page] WO 2018/160797 Al MIDEDIMOMOIDEIREEMOMOHINIERDERMS (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))