SG11201810629QA - New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them - Google Patents
New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- SG11201810629QA SG11201810629QA SG11201810629QA SG11201810629QA SG11201810629QA SG 11201810629Q A SG11201810629Q A SG 11201810629QA SG 11201810629Q A SG11201810629Q A SG 11201810629QA SG 11201810629Q A SG11201810629Q A SG 11201810629QA SG 11201810629Q A SG11201810629Q A SG 11201810629QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- berkshire
- pct
- preparation
- utca
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 December 2017 (14.12.2017) WIP0 I PCT ill~~~~~~~~ 011101tIIl two Hol omoiollm mina mil (10) International Publication Number WO 2017/212012 Al (51) International Patent Classification: CO7D 487/04 (2006.01) A61K 31/519 (2006.01) CO7D 495/04 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2017/064067 (22) International Filing Date: 09 June 2017 (09.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1655392 10 June 2016 (10.06.2016) FR (71) Applicants: LES LABORATOIRES SERVIER [FR/FR]; 35 me de Verdun, 92284 SURESNES (FR). VER- NALIS (R&D) LIMITED [GB/GB]; 100 Berkshire Place, Wharfedale Road, Berkshire, WINNERSH Berkshire RG41 5RD (GB). (72) Inventors: KOTSCHY, Andras; Almos Vezer utca 4, 2045 Torokbalint (HU). WEBER, Csaba; Szentendrei ut- ca 9, 2009 Pilisszentlaszlo (HU). VASAS, Attila; Eori Bar- na u. 65, 2151 Foi (HU). MOLNAR, Balizs; Fenyves ut- ca 3, 2117 Isaszeg (HU). KISS, Arpad; Filst Milan utca 6, 3/10, 1039 Budapest (HU). MACIAS, Alba; 12 Beaulands Close, Cambridge Cambridgeshire CB4 1JA (GB). MUR- RAY, James Brooke; 21 Parsonage Way, LINTON Cam- bridgeshire CB21 4YL (GB). LEWKOWICZ, Elodie; 93 avenue Denfert Rochereau, 75014 Paris (FR). GENESTE, Olivier; Batiment A, 17, me Crevel Duval, 92500 RUEIL MALMAISON (FR). CHANRION, Maya; 14 rue de la Galiote, Apt D441, 92130 ISSY LES MOULINEAUX (FR). DEMARLES, Didier; 21 me du Lievre, 45430 CHECY (FR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: NEW PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COM- POSITIONS CONTAINING THEM (57) : Compounds of formula (I) wherein R1, R2, R3, n and W 1-1 OH are as defined in the description. Medicaments. 1-1 W (RA R , ( 1 ) 1-1 O O 0
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1655392A FR3052452B1 (en) | 2016-06-10 | 2016-06-10 | NOVEL PIPERIDINYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
| PCT/EP2017/064067 WO2017212012A1 (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810629QA true SG11201810629QA (en) | 2018-12-28 |
Family
ID=56943687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810629QA SG11201810629QA (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
Country Status (45)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017155844A1 (en) | 2016-03-07 | 2017-09-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| AU2018254577A1 (en) | 2017-04-21 | 2019-12-05 | Epizyme, Inc. | Combination therapies with EHMT2 inhibitors |
| KR102556744B1 (en) | 2017-08-28 | 2023-07-18 | 이난타 파마슈티칼스, 인코포레이티드 | Hepatitis B antivirals |
| CA3083320C (en) | 2017-11-29 | 2022-08-16 | Les Laboratoires Servier | Piperidinyl derivatives as inhibitors of ubiquitin specific protease 7 |
| GB201801562D0 (en) | 2018-01-31 | 2018-03-14 | Almac Diagnostics Ltd | Pharmaceutical compounds |
| UY38291A (en) * | 2018-07-05 | 2020-06-30 | Servier Lab | NEW AMINO-PYRIMIDONYL DERIVATIVES A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
| US10865211B2 (en) | 2018-09-21 | 2020-12-15 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| UY38423A (en) * | 2018-10-19 | 2021-02-26 | Servier Lab | NEW AMINO-PYRIMIDONIL-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| WO2020106816A1 (en) | 2018-11-21 | 2020-05-28 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| KR20210102285A (en) * | 2018-12-06 | 2021-08-19 | 알막 디스커버리 리미티드 | Use as pharmaceutical compounds and inhibitors of ubiquitin-specific protease 19 (USP19) |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| CN113087718B (en) * | 2020-01-09 | 2024-02-09 | 四川科伦博泰生物医药股份有限公司 | Thienopyrimidinone compounds and medical application thereof |
| CN112608320B (en) * | 2020-01-16 | 2023-03-17 | 中国药科大学 | Piperidine compound and preparation method and medical application thereof |
| GB202001980D0 (en) | 2020-02-13 | 2020-04-01 | Almac Discovery Ltd | Therapeutic mentods |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009521445A (en) * | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | Combination of H3 antagonist / inverse agonist and appetite suppressant |
| CN101674831A (en) * | 2007-03-02 | 2010-03-17 | 先灵公司 | Piperidine derivatives and methods of use thereof |
| EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| TWI698436B (en) * | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors |
| PE20220948A1 (en) * | 2016-06-10 | 2022-05-31 | Servier Lab | NEW PIPERIDINIL DERIVATIVES SUBSTITUTED WITH (HETERO) ARYL, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
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2016
- 2016-06-10 FR FR1655392A patent/FR3052452B1/en not_active Expired - Fee Related
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2017
- 2017-06-09 SG SG11201810629QA patent/SG11201810629QA/en unknown
- 2017-06-09 AU AU2017277734A patent/AU2017277734B2/en active Active
- 2017-06-09 WO PCT/EP2017/064067 patent/WO2017212012A1/en unknown
- 2017-06-09 RU RU2018147430A patent/RU2743163C2/en active
- 2017-06-09 CU CU2018000145A patent/CU20180145A7/en unknown
- 2017-06-09 HU HUE17727927A patent/HUE049507T2/en unknown
- 2017-06-09 CN CN201780035584.8A patent/CN109311888B/en active Active
- 2017-06-09 LT LTEP17727927.0T patent/LT3468974T/en unknown
- 2017-06-09 SI SI201730260T patent/SI3468974T1/en unknown
- 2017-06-09 PT PT177279270T patent/PT3468974T/en unknown
- 2017-06-09 EA EA201892838A patent/EA037211B1/en unknown
- 2017-06-09 MY MYPI2018002416A patent/MY196562A/en unknown
- 2017-06-09 TW TW106119242A patent/TWI620750B/en not_active IP Right Cessation
- 2017-06-09 TN TNP/2018/000410A patent/TN2018000410A1/en unknown
- 2017-06-09 EP EP17727927.0A patent/EP3468974B1/en active Active
- 2017-06-09 MA MA45222A patent/MA45222B1/en unknown
- 2017-06-09 CR CR20180564A patent/CR20180564A/en unknown
- 2017-06-09 DK DK17727927.0T patent/DK3468974T3/en active
- 2017-06-09 PE PE2018003159A patent/PE20220567A1/en unknown
- 2017-06-09 PL PL17727927T patent/PL3468974T3/en unknown
- 2017-06-09 US US16/306,933 patent/US11046681B2/en active Active
- 2017-06-09 UA UAA201900217A patent/UA123794C2/en unknown
- 2017-06-09 AR ARP170101587A patent/AR108706A1/en unknown
- 2017-06-09 CA CA3027014A patent/CA3027014C/en active Active
- 2017-06-09 RS RS20200266A patent/RS60029B1/en unknown
- 2017-06-09 UY UY0001037288A patent/UY37288A/en unknown
- 2017-06-09 ME MEP-2020-47A patent/ME03670B/en unknown
- 2017-06-09 GE GEAP201714978A patent/GEP20207160B/en unknown
- 2017-06-09 KR KR1020197000834A patent/KR20190016106A/en not_active Application Discontinuation
- 2017-06-09 MD MDE20190460T patent/MD3468974T2/en unknown
- 2017-06-09 ES ES17727927T patent/ES2775789T3/en active Active
- 2017-06-09 BR BR112018075433-1A patent/BR112018075433A2/en not_active Application Discontinuation
- 2017-06-09 MX MX2018015216A patent/MX2018015216A/en active IP Right Grant
- 2017-06-09 JP JP2018564356A patent/JP6928005B2/en active Active
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2018
- 2018-11-28 PH PH12018502515A patent/PH12018502515A1/en unknown
- 2018-11-29 SV SV2018005791A patent/SV2018005791A/en unknown
- 2018-12-03 IL IL263463A patent/IL263463B/en active IP Right Grant
- 2018-12-04 EC ECSENADI201890144A patent/ECSP18090144A/en unknown
- 2018-12-04 CL CL2018003474A patent/CL2018003474A1/en unknown
- 2018-12-06 DO DO2018000270A patent/DOP2018000270A/en unknown
- 2018-12-06 CO CONC2018/0013210A patent/CO2018013210A2/en unknown
- 2018-12-07 NI NI201800132A patent/NI201800132A/en unknown
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2020
- 2020-03-04 HR HRP20200361TT patent/HRP20200361T1/en unknown
- 2020-05-06 CY CY20201100414T patent/CY1122870T1/en unknown
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