SG11201810360YA - Novel 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one derivative - Google Patents
Novel 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one derivativeInfo
- Publication number
- SG11201810360YA SG11201810360YA SG11201810360YA SG11201810360YA SG11201810360YA SG 11201810360Y A SG11201810360Y A SG 11201810360YA SG 11201810360Y A SG11201810360Y A SG 11201810360YA SG 11201810360Y A SG11201810360Y A SG 11201810360YA SG 11201810360Y A SG11201810360Y A SG 11201810360YA
- Authority
- SG
- Singapore
- Prior art keywords
- kinase
- independently
- hydrogen atom
- broken line
- same
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
㻝㻜 㻌 㻝㻡 㻌 㻞㻜 㻌 㻌 Formula (I) or a salt thereof, which exhibits selected from the group consisting of Akt kinase, R 㻌 proliferation inhibiting disease s represents hetero atoms represents a hydrogen atom 㻌 one another and independently hydrogen atom independently represent different atom or the like; and 㻌 single bond one of X 㻌 The invention Formula (I) or a salt thereof, which exhibits selected from the group consisting of Akt kinase, R proliferation inhibiting s associated with the represents a - to 6 hetero atoms independently represents a hydrogen atom one another and independently hydrogen atom or the like; R independently represent different from each other and independently or the like; and single bond , and represents one of X 1 or X 2 represents N. invention of the present application Formula (I) or a salt thereof, which exhibits selected from the group consisting of Akt kinase, R proliferation inhibiting effect and is useful as a associated with the above to 6 -membered monocyclic unsaturated heterocyclic group independently represents a hydrogen atom or the like; R one another and independently or the like; R 7 independently represent a hydrogen atom from each other and independently or the like; and X3 represents N or CH when represents C when a broken line indicates a double bond, represents N. ] of the present application Formula (I) or a salt thereof, which exhibits selected from the group consisting of Akt kinase, R effect and is useful as a above -mentioned membered monocyclic unsaturated heterocyclic group independently selected from N, S and O or the like; R one another and independently represent a hydrogen atom 7 and R 8, may be the same a hydrogen atom from each other and independently represents N or CH when C when a broken line indicates a double bond, ] 㻝㻜㻤㻌 ABSTRACT of the present application Formula (I) or a salt thereof, which exhibits an inhibitory selected from the group consisting of Akt kinase, Rsk kinase, and S6K kinase effect and is useful as a prophylactic and/or therapeutic mentioned kinase membered monocyclic unsaturated heterocyclic group selected from N, S and O or the like; R 3, R 4, and R represent a hydrogen atom may be the same a hydrogen atom or the like; from each other and independently represent N or represents N or CH when C when a broken line indicates a double bond, ABSTRACT of the present application provides a compound represented by inhibitory activity selected from the group consisting of Akt kinase, Rsk kinase, and S6K kinase prophylactic and/or therapeutic kinase s, particularly membered monocyclic unsaturated heterocyclic group selected from N, S and O and may have a substituent; , and R 5, may be the same represent a hydrogen atom may be the same as or different the like; X1 and represent N or CR represents N or CH when the broken line C when a broken line indicates a double bond, provides a compound represented by activity against sk kinase, and S6K kinase prophylactic and/or therapeutic s, particularly cancer . [In the formula, membered monocyclic unsaturated heterocyclic group and may have a substituent; , may be the same as or the like; R or different from each other and and X2 may be the same CR 9; R 9 represents broken line ( C when a broken line indicates a double bond, provides a compound represented by against at least one kinase sk kinase, and S6K kinase and/or prophylactic and/or therapeutic agent for . [In the formula, membered monocyclic unsaturated heterocyclic group which ha and may have a substituent; as or different or the like; R 6 represents a from each other and may be the same represents a hydrogen ) represents C when a broken line indicates a double bond, wherein provides a compound represented by at least one kinase and/or a cell agent for . [In the formula, R1 ha s 1 to 3 and may have a substituent; R 2 or different from represents a from each other and may be the same as or a hydrogen represents a wherein at least [No Available Figure] NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016101599 | 2016-05-20 | ||
| PCT/JP2017/018825 WO2017200087A1 (en) | 2016-05-20 | 2017-05-19 | Novel 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810360YA true SG11201810360YA (en) | 2018-12-28 |
Family
ID=60325930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810360YA SG11201810360YA (en) | 2016-05-20 | 2017-05-19 | Novel 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one derivative |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10538528B2 (en) |
| EP (1) | EP3459953B1 (en) |
| JP (1) | JP6576553B2 (en) |
| KR (1) | KR102149734B1 (en) |
| CN (1) | CN109153681B (en) |
| AU (1) | AU2017265769B9 (en) |
| BR (1) | BR112018073721B1 (en) |
| CA (1) | CA3024831C (en) |
| DK (1) | DK3459953T3 (en) |
| ES (1) | ES2882018T3 (en) |
| HK (1) | HK1259613A1 (en) |
| HU (1) | HUE055846T2 (en) |
| MA (1) | MA45048A (en) |
| MX (1) | MX2018014022A (en) |
| MY (1) | MY185962A (en) |
| PH (1) | PH12018502411A1 (en) |
| PL (1) | PL3459953T3 (en) |
| PT (1) | PT3459953T (en) |
| RU (1) | RU2713181C1 (en) |
| SG (1) | SG11201810360YA (en) |
| TW (2) | TWI679202B (en) |
| WO (1) | WO2017200087A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023063432A1 (en) * | 2021-10-13 | 2023-04-20 | Taiho Pharmaceutical Co., Ltd. | Treatment methods for subjects having cancer with a dysregulated mapk and/or pi3k pathway |
| WO2023143424A1 (en) * | 2022-01-27 | 2023-08-03 | 四川海思科制药有限公司 | Azacyclic derivative and medical application thereof |
| WO2024009977A1 (en) * | 2022-07-05 | 2024-01-11 | 大鵬薬品工業株式会社 | 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one and crystal of salt thereof |
| CN115850244B (en) * | 2023-02-24 | 2023-05-16 | 成都大学 | Preparation method of topiroxostat |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8076338B2 (en) * | 2004-04-23 | 2011-12-13 | Exelixis, Inc. | Kinase modulators and methods of use |
| GB0608184D0 (en) * | 2006-04-25 | 2006-06-07 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| AR064416A1 (en) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | DERIVATIVES OF PURINE, PIRIDINE AND PYRIMIDINE CONDENSED WITH HETEROCICLES, MODULATORS OF PKA AND / OR PKB, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. |
| RU2517804C2 (en) * | 2008-08-08 | 2014-05-27 | Нестек С.А. | Beverage preparation machine equipped with carrying handle, having adaptable appearance and replaceable side panels |
| AR074072A1 (en) * | 2008-11-11 | 2010-12-22 | Lilly Co Eli | COMPOSITE OF IMIDAZOL -PIPERIDIN -PIRROL-PIRIMIDIN-6-ONA, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MULTIFORM GLIOBLASTOMA |
| BR112012011328A2 (en) * | 2009-10-23 | 2016-11-22 | Lilly Co Eli | akt inhibitors |
| WO2014143612A1 (en) * | 2013-03-11 | 2014-09-18 | Merck Patent Gmbh | 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity |
| JP6398659B2 (en) | 2014-11-28 | 2018-10-03 | アイシン・エィ・ダブリュ株式会社 | Tooth profile part manufacturing method and tooth profile part manufacturing apparatus |
-
2017
- 2017-05-19 JP JP2018518384A patent/JP6576553B2/en active Active
- 2017-05-19 BR BR112018073721-6A patent/BR112018073721B1/en active IP Right Grant
- 2017-05-19 WO PCT/JP2017/018825 patent/WO2017200087A1/en active Application Filing
- 2017-05-19 MY MYPI2018704229A patent/MY185962A/en unknown
- 2017-05-19 EP EP17799511.5A patent/EP3459953B1/en active Active
- 2017-05-19 US US16/302,829 patent/US10538528B2/en active Active
- 2017-05-19 PL PL17799511T patent/PL3459953T3/en unknown
- 2017-05-19 MX MX2018014022A patent/MX2018014022A/en active IP Right Grant
- 2017-05-19 PT PT177995115T patent/PT3459953T/en unknown
- 2017-05-19 RU RU2018144542A patent/RU2713181C1/en active
- 2017-05-19 TW TW106116606A patent/TWI679202B/en active
- 2017-05-19 AU AU2017265769A patent/AU2017265769B9/en active Active
- 2017-05-19 CA CA3024831A patent/CA3024831C/en active Active
- 2017-05-19 MA MA045048A patent/MA45048A/en unknown
- 2017-05-19 KR KR1020187030344A patent/KR102149734B1/en active IP Right Grant
- 2017-05-19 DK DK17799511.5T patent/DK3459953T3/en active
- 2017-05-19 CN CN201780030144.3A patent/CN109153681B/en active Active
- 2017-05-19 TW TW108107835A patent/TWI732187B/en active
- 2017-05-19 HU HUE17799511A patent/HUE055846T2/en unknown
- 2017-05-19 SG SG11201810360YA patent/SG11201810360YA/en unknown
- 2017-05-19 ES ES17799511T patent/ES2882018T3/en active Active
-
2018
- 2018-11-15 PH PH12018502411A patent/PH12018502411A1/en unknown
-
2019
- 2019-01-31 HK HK19101800.7A patent/HK1259613A1/en unknown
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