SG11201809408SA - Method for reducing the trisulfide level in proteins - Google Patents
Method for reducing the trisulfide level in proteinsInfo
- Publication number
- SG11201809408SA SG11201809408SA SG11201809408SA SG11201809408SA SG11201809408SA SG 11201809408S A SG11201809408S A SG 11201809408SA SG 11201809408S A SG11201809408S A SG 11201809408SA SG 11201809408S A SG11201809408S A SG 11201809408SA SG 11201809408S A SG11201809408S A SG 11201809408SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- proteins
- trisulfide
- english
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 November 2017 (02.11.2017) WIP0 I PCT omit VIII Hot 0 HE VIII Immo oimIE (10) International Publication Number WO 2017/186654 Al (51) International Patent Classification: CO7K 1/113 (2006.01) (21) International Application Number: PCT/EP2017/059691 (22) International Filing Date: 25 April 2017 (25.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16167461.9 28 April 2016 (28.04.2016) EP (71) Applicant: MERCK PATENT GMBH [DE/DE]; Frank- furter Strasse 250, 64293 Darmstadt (DE). (72) Inventor: ZIMMER, Aline; Gruener Weg 12, 64521 Gross-Gerau (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) 11 00 1-1 N 1-1 (54) Title: METHOD FOR REDUCING THE TRISULFIDE LEVEL IN PROTEINS (57) : The present invention relates to the use of sulfocysteine and derivatives thereof as cell culture additives to reduce the 0 trisulfide levels in proteins produced in cell culture.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16167461 | 2016-04-28 | ||
| PCT/EP2017/059691 WO2017186654A1 (en) | 2016-04-28 | 2017-04-25 | Method for reducing the trisulfide level in proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201809408SA true SG11201809408SA (en) | 2018-11-29 |
Family
ID=56008475
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201809408SA SG11201809408SA (en) | 2016-04-28 | 2017-04-25 | Method for reducing the trisulfide level in proteins |
| SG10202010606YA SG10202010606YA (en) | 2016-04-28 | 2017-04-25 | Method for reducing the trisulfide level in proteins |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202010606YA SG10202010606YA (en) | 2016-04-28 | 2017-04-25 | Method for reducing the trisulfide level in proteins |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11220668B2 (en) |
| EP (1) | EP3448871B1 (en) |
| JP (1) | JP7253381B2 (en) |
| KR (1) | KR102425040B1 (en) |
| CN (1) | CN109071595A (en) |
| ES (1) | ES2967868T3 (en) |
| SG (2) | SG11201809408SA (en) |
| WO (1) | WO2017186654A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201708655D0 (en) * | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
| EP3492582A1 (en) | 2017-12-01 | 2019-06-05 | UCB Biopharma SPRL | Cell culture methods |
| CN117534728A (en) * | 2024-01-10 | 2024-02-09 | 哈尔滨吉象隆生物技术有限公司 | Preparation method of octreotide trisulfide bond impurity E |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2483289T3 (en) * | 2009-10-02 | 2019-06-11 | Biogen Ma Inc | PROCEDURES FOR PREVENTION AND REMOVAL OF TRISULATION CONNECTIONS |
| KR20120107793A (en) | 2011-03-22 | 2012-10-04 | 엘지이노텍 주식회사 | Display device and light conversion member |
| EP2707383B1 (en) | 2011-05-13 | 2018-04-18 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
| AR093460A1 (en) * | 2012-11-14 | 2015-06-10 | Merck Patent Ges Mit Beschränkter Haftung | CELL CULTURE MEDIA |
| US10626364B2 (en) | 2015-07-30 | 2020-04-21 | Merck Patent Gmbh | Method for increasing the glutathione level in cells |
-
2017
- 2017-04-25 SG SG11201809408SA patent/SG11201809408SA/en unknown
- 2017-04-25 US US16/096,805 patent/US11220668B2/en active Active
- 2017-04-25 CN CN201780026248.7A patent/CN109071595A/en active Pending
- 2017-04-25 JP JP2018556361A patent/JP7253381B2/en active Active
- 2017-04-25 EP EP17718556.8A patent/EP3448871B1/en active Active
- 2017-04-25 SG SG10202010606YA patent/SG10202010606YA/en unknown
- 2017-04-25 KR KR1020187033842A patent/KR102425040B1/en active IP Right Grant
- 2017-04-25 ES ES17718556T patent/ES2967868T3/en active Active
- 2017-04-25 WO PCT/EP2017/059691 patent/WO2017186654A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| ES2967868T3 (en) | 2024-05-06 |
| CN109071595A (en) | 2018-12-21 |
| WO2017186654A1 (en) | 2017-11-02 |
| EP3448871A1 (en) | 2019-03-06 |
| JP7253381B2 (en) | 2023-04-06 |
| US20200255796A1 (en) | 2020-08-13 |
| US11220668B2 (en) | 2022-01-11 |
| JP2019514918A (en) | 2019-06-06 |
| SG10202010606YA (en) | 2020-11-27 |
| KR20190003603A (en) | 2019-01-09 |
| EP3448871B1 (en) | 2023-10-11 |
| KR102425040B1 (en) | 2022-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201909432SA (en) | Compounds for increasing genome editing efficiency | |
| SG11201909949XA (en) | Targeted immunotolerance | |
| SG11201811432WA (en) | Rna for cancer therapy | |
| SG11201808990QA (en) | Compositions for topical application of compounds | |
| SG11201908820VA (en) | Novel heterocyclic derivatives useful as shp2 inhibitors | |
| SG11201807252QA (en) | Anti-lag-3 antibodies | |
| SG11201811431VA (en) | Multispecific antibodies against cd40 and cd137 | |
| SG11201810003UA (en) | Using programmable dna binding proteins to enhance targeted genome modification | |
| SG11201900163PA (en) | Macrocycle kinase inhibitors | |
| SG11201805044WA (en) | Compounds useful as kinase inhibitors | |
| SG11201805320XA (en) | Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration | |
| SG11201804373VA (en) | Compositions and methods for immunooncology | |
| SG11201907023UA (en) | Method of reducing neutropenia | |
| SG11201909011PA (en) | Niraparib compositions | |
| SG11201908325PA (en) | Process for the preparation of glucuronide drug-linkers and intermediates thereof | |
| SG11201808713YA (en) | Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier | |
| SG11201808222RA (en) | Methods of treatment of cholestatic diseases | |
| SG11201809594WA (en) | Nicotine particles and compositions | |
| SG11201904535VA (en) | Prevention and treatment of bone and cartilage damage or disease | |
| SG11201805149XA (en) | Compositions comprising 15-hepe and methods of using the same | |
| SG11201804704PA (en) | Compositions and methods for decreasing tau expression | |
| SG11201901986SA (en) | Process for the manufacture of a solid pharmaceutical adminstration form | |
| SG11201809882XA (en) | Pharmaceutical combinations for treating cancer | |
| SG11201809534UA (en) | Methods of treating autoimmune disease using allogeneic t cells | |
| SG11201907420VA (en) | Inhibition of smarca2 for treatment of cancer |