SG11201808475XA - Method and apparatus for providing a pharmacokinetic drug dosing regiment - Google Patents

Method and apparatus for providing a pharmacokinetic drug dosing regiment

Info

Publication number
SG11201808475XA
SG11201808475XA SG11201808475XA SG11201808475XA SG11201808475XA SG 11201808475X A SG11201808475X A SG 11201808475XA SG 11201808475X A SG11201808475X A SG 11201808475XA SG 11201808475X A SG11201808475X A SG 11201808475XA SG 11201808475X A SG11201808475X A SG 11201808475XA
Authority
SG
Singapore
Prior art keywords
patient
international
pharmacokinetic
weight
cfviii
Prior art date
Application number
SG11201808475XA
Inventor
Kameswara Kuchimanchi
Alexandra Loew-Baselli
Gerald Spotts
Myungshin Oh
Michael Hale
Martin Wolfsegger
Original Assignee
Baxalta Inc
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Inc, Baxalta GmbH filed Critical Baxalta Inc
Publication of SG11201808475XA publication Critical patent/SG11201808475XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/30—Prediction of properties of chemical compounds, compositions or mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N7/00—Computing arrangements based on specific mathematical models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N7/00—Computing arrangements based on specific mathematical models
    • G06N7/01—Probabilistic graphical models, e.g. probabilistic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101111110111111110111011111111101111011111 International Bureau 0.. .... .. ..... ..or::,„,' (10) International Publication Number (43) International Publication Date WO 2017/180807 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: (74) Agents: MEYERS, Thomac, C. et al.; Brown Rudnick A61P 7/04 (2006.01) GOON 7/00 (2006.01) LLP, One Financial Center, Boston, MA 02111 (US). GOOF 19/12 (2011.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2017/027309 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 13 April 2017 (13.04.2017) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 62/323,015 15 April 2016 (15.04.2016) US TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicants: BAXALTA INCORPORATED [US/US]; 1200 Lakeside Drive, Bannockburn, IL 60015 (US). BAX- (84) Designated States (unless otherwise indicated, for every ALTA GMBH [SZ/CH]; Thurgauerstrasse 130, 8152 kind of regional protection available): ARIPO (BW, GH, Glattpark (Opfikon) (CH). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: KUCHIMANCHI, Kameswara, Rao; 10 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Freemont Street, Lexington, MA 02421 (US). LOEW- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, — BASELLI, Alexandra; Veitingergasse 28, 1130 Vienna LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, — (AT). SPOTTS, Gerald; 300 Shire Way, Lexington, MA SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, _ 02421 (US). OH, Myungshin; 1700 Sawtelle Blvd., Suite GW, KM, ML, MR, NE, SN, TD, TG). 221, Los Angeles, CA 90025 (US). HALE, Michael, Don; . Published: 43 Arlingon Street, Winchester, MA 01890 (US). WOLF- — international 21(3)) SEGGER, Martin; Donau-city-strasse 7, 1220 Vienna with search report (Art. (AT). = = = = = = = = = 1-1 IN © C)1: (54) Title: METHOD AND APPARATUS FOR PROVIDING A PHARMACOKINETIC DRUG DOSING REGIMENT 0 *1 : (57) : Systems and methods for providing a clotting factor VIII (CFVIII) dosing regimen include collecting two blood 1-1 ---- samples from a patient after an infusion of CFVIII and determining a CFVIII clearance based on the two blood samples, and determ - fining if a patient has a half-life greater than a predetermined threshold. A pharmacokinetic (PK) profile of the patient is determined 1-1 C using a Bayesian model of pharmacokinetic profiles of sampled patients having similar body weight or age of the patient. A first ei weight is applied to the Bayesian model of pharmacokinetic profiles of sampled patients if the half-life of the patient is greater than O the predetermined threshold, and a second weight, less than the first weight, is applied to the Bayesian model of pharmacokinetic ,-t profiles of sampled patients if the half-life of the patient is less than the predetermined threshold. A dosing regimen is determined for the patient based on the PK profile.
SG11201808475XA 2016-04-15 2017-04-13 Method and apparatus for providing a pharmacokinetic drug dosing regiment SG11201808475XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662323015P 2016-04-15 2016-04-15
PCT/US2017/027309 WO2017180807A1 (en) 2016-04-15 2017-04-13 Method and apparatus for providing a pharmacokinetic drug dosing regiment

Publications (1)

Publication Number Publication Date
SG11201808475XA true SG11201808475XA (en) 2018-10-30

Family

ID=60041975

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201808475XA SG11201808475XA (en) 2016-04-15 2017-04-13 Method and apparatus for providing a pharmacokinetic drug dosing regiment

Country Status (23)

Country Link
US (3) US11670409B2 (en)
EP (2) EP4343774A2 (en)
JP (2) JP6942721B2 (en)
KR (2) KR102468699B1 (en)
CN (1) CN109804432B (en)
AR (1) AR108212A1 (en)
AU (1) AU2017250570A1 (en)
BR (1) BR112018070463A8 (en)
CA (1) CA3020346A1 (en)
CL (1) CL2018002870A1 (en)
CO (1) CO2018012293A2 (en)
EA (1) EA201892347A1 (en)
IL (3) IL288790B2 (en)
MA (1) MA43617A1 (en)
MX (1) MX2018012612A (en)
MY (1) MY197302A (en)
PH (1) PH12018502178A1 (en)
PL (1) PL3442656T3 (en)
SG (1) SG11201808475XA (en)
TW (1) TWI672602B (en)
UA (1) UA126379C2 (en)
WO (1) WO2017180807A1 (en)
ZA (1) ZA201807214B (en)

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US10925565B2 (en) * 2018-04-11 2021-02-23 Siemens Healthcare Gmbh Machine-learning based contrast agent administration
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USD953348S1 (en) * 2020-10-27 2022-05-31 Takeda Pharmaceutical Company Limited Display screen with a transitional graphical user interface
USD1018556S1 (en) * 2021-03-31 2024-03-19 Takeda Pharmaceutical Company Limited Display screen of a mobile phone with graphical user interface
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