SG11201804411TA - Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof - Google Patents

Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof

Info

Publication number
SG11201804411TA
SG11201804411TA SG11201804411TA SG11201804411TA SG11201804411TA SG 11201804411T A SG11201804411T A SG 11201804411TA SG 11201804411T A SG11201804411T A SG 11201804411TA SG 11201804411T A SG11201804411T A SG 11201804411TA SG 11201804411T A SG11201804411T A SG 11201804411TA
Authority
SG
Singapore
Prior art keywords
international
rule
vectors
compositions
immunodeficiency virus
Prior art date
Application number
SG11201804411TA
Inventor
Johannes Langedijk
Original Assignee
Janssen Vaccines & Prevention Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Vaccines & Prevention Bv filed Critical Janssen Vaccines & Prevention Bv
Publication of SG11201804411TA publication Critical patent/SG11201804411TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • C07K14/16—HIV-1 ; HIV-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • C07K14/16—HIV-1 ; HIV-2
    • C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16171—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau rist0) (43) International Publication Date .... ....r .„,„1 22 June 2017(22.06.2017) WIPO I PCT (10) WO International 111111111111311111111111111111111111111111111111111111111111111111111311111111111111111 2017/102929 Publication Al Number (51) International Patent Classification: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, C07K 14/16 (2006.01) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (21) International Application Number: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, PCT/EP2016/081159 RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (22) International Filing Date: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 15 December 2016 (15.12.2016) ZA, ZM, ZW. (25) Filing Language: English (8 4 ) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 15200138.4 15 December 2015 (15.12.2015) EP TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 16194124.0 17 October 2016 (17.10.2016) EP DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) Applicant: JANSSEN VACCINES & PREVENTION SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, B.V. [NL/NL]; Archimedesweg 4, 2333 CN Leiden (NL). GW, KM, ML, MR, NE, SN, TD, TG). (72) Inventor: LANGEDIJK, Johannes, Petrus, Maria; Declarations under Rule 4.17: Archimedesweg 4-6, 2333 CN Leiden (NL). — as to applicant's entitlement to apply for and be granted a (74) Agents: VERHAGE, Richard, A et al.; Archimedesweg patent (Rule 4.170) 4-6, 2333 CN Leiden (NL). — of inventorship (Rule 4.17(iv)) (81) Designated States (unless otherwise indicated, for every Published: kind of national protection available): AE, AG, AL, AM, — with international search report (Art 21(3)) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, _ with sequence listing part of description (Rule 5.2(a)) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, Il .4t C\ N C\ ei O 1-1 it-- 1-1 (54) Title: HUMAN IMMUNODEFICIENCY VIRUS ANTIGENS, VECTORS, COMPOSITIONS, AND METHODS OF USE 0 THEREOF ei Q (57) : Synthetic HIV envelope proteins, vectors and compositions thereof, and methods for inducing protective immunity against human immunodeficiency virus (HIV) infection are described. Viral expression vectors encoding the synthetic HIV envelope proteins can be used in vaccines to provide improved protective immunity against HIV.
SG11201804411TA 2015-12-15 2016-12-15 Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof SG11201804411TA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15200138 2015-12-15
EP16194124 2016-10-17
PCT/EP2016/081159 WO2017102929A1 (en) 2015-12-15 2016-12-15 Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201804411TA true SG11201804411TA (en) 2018-06-28

Family

ID=57737697

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201804411TA SG11201804411TA (en) 2015-12-15 2016-12-15 Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof
SG10202109457R SG10202109457RA (en) 2015-12-15 2016-12-15 Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202109457R SG10202109457RA (en) 2015-12-15 2016-12-15 Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof

Country Status (29)

Country Link
US (3) US10369214B2 (en)
EP (3) EP3964569A1 (en)
JP (2) JP6510149B2 (en)
KR (1) KR20180086207A (en)
CN (2) CN114686495A (en)
AU (2) AU2016369326B2 (en)
BR (1) BR112018011122A2 (en)
CA (1) CA3008542C (en)
CY (2) CY1122705T1 (en)
DK (2) DK3584252T3 (en)
EA (1) EA038974B1 (en)
ES (2) ES2898271T3 (en)
HR (2) HRP20211566T1 (en)
HU (2) HUE045993T2 (en)
IL (1) IL259942B2 (en)
LT (2) LT3584252T (en)
MA (3) MA44059B1 (en)
MD (2) MD3584252T2 (en)
ME (1) ME03545B (en)
MX (2) MX2018007198A (en)
PH (1) PH12018501047A1 (en)
PL (2) PL3584252T3 (en)
PT (1) PT3390430T (en)
RS (2) RS59447B1 (en)
SG (2) SG11201804411TA (en)
SI (2) SI3584252T1 (en)
TW (2) TWI707039B (en)
WO (1) WO2017102929A1 (en)
ZA (1) ZA201803978B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS61902B1 (en) 2014-09-26 2021-06-30 Beth Israel Deaconess Medical Ct Inc Methods and compositions for inducing protective immunity against human immunodeficiency virus infection
MA40783A (en) 2014-10-03 2017-08-08 Los Alamos Nat Security Llc HIV VACCINES CONTAINING ONE OR MORE POPULATION EPISENSUS ANTIGENS
EP3031923A1 (en) * 2014-12-11 2016-06-15 Institut Pasteur Lentiviral vector-based japanese encephalitis immunogenic composition
AU2016369326B2 (en) 2015-12-15 2019-02-21 Janssen Vaccines & Prevention B.V. Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof
US10273268B2 (en) 2016-06-16 2019-04-30 Janssen Vaccines & Prevention B.V. HIV vaccine formulation
AU2017318689A1 (en) 2016-09-02 2019-04-11 Beth Israel Deaconess Medical Center, Inc. Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
HUE052008T2 (en) 2016-09-15 2021-04-28 Janssen Vaccines & Prevention Bv Trimer stabilizing hiv envelope protein mutations
MA49397A (en) 2017-06-15 2020-04-22 Bavarian Nordic As POXVIRUS VECTORS CODING FOR HIV ANTIGENS, AND METHODS FOR USING THEM
BR112020000867A2 (en) * 2017-07-19 2020-07-21 Janssen Vaccines & Prevention B.V. hiv envelope protein mutations stabilizing the trimer
WO2019055888A1 (en) 2017-09-18 2019-03-21 Janssen Vaccines & Prevention B.V. Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
KR20230019227A (en) * 2017-11-17 2023-02-07 그리폴스 다이어그노스틱 솔루션즈 인크. Novel mammalian expressed human immunodeficiency virus envelope protein antigens
CN114269363A (en) * 2019-04-17 2022-04-01 威斯达研究所 Replication-defective adenovirus vectors for HIV vaccine applications
TW202110476A (en) 2019-05-22 2021-03-16 荷蘭商傑森疫苗防護公司 Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
IL292760A (en) 2019-11-07 2022-07-01 Janssen Vaccines Prevention B V Protein purification
EP4149530A1 (en) 2020-05-12 2023-03-22 Janssen Vaccines & Prevention B.V. Administration of homologous adenoviral vectors
WO2022006095A2 (en) * 2020-06-29 2022-01-06 Duke University Mosaic hiv-1 envelopes to induce adcc responses
US20220118081A1 (en) 2020-10-20 2022-04-21 Janssen Vaccines & Prevention B.V. HIV vaccine regimens
US20220265813A1 (en) 2021-02-23 2022-08-25 Janssen Vaccines & Prevention B.V. Trimer Stabilizing HIV Envelope Protein Mutation
WO2023242155A1 (en) 2022-06-14 2023-12-21 Janssen Vaccines & Prevention B.V. Compositions and methods for the diagnosis of hiv infection

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
CA1341245C (en) 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Recombinant vaccinia virus mva
US5298416A (en) 1989-01-18 1994-03-29 British Technology Group Ltd. Attenuated polioviruses
US5505947A (en) 1994-05-27 1996-04-09 The University Of North Carolina At Chapel Hill Attenuating mutations in Venezuelan Equine Encephalitis virus
UA68327C2 (en) 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
US6479258B1 (en) 1995-12-07 2002-11-12 Diversa Corporation Non-stochastic generation of genetic vaccines
US5741492A (en) * 1996-01-23 1998-04-21 St. Jude Children's Research Hospital Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses
US6083716A (en) 1996-09-06 2000-07-04 The Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
US5761893A (en) 1996-10-22 1998-06-09 Lofquist Welding, Inc. Crop saving attachment for the snouts of combines
ATE519854T1 (en) 1999-05-17 2011-08-15 Crucell Holland Bv RECOMBINANT ADENOVIRUS BASED ON SEROTYPE 48 (AD48).
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6710173B1 (en) 1999-06-25 2004-03-23 Progenics Pharmaceuticals, Inc. Stabilized viral envelope proteins and uses thereof
EP1214333A4 (en) 1999-09-17 2005-01-19 Dana Farber Cancer Inst Inc Stabilized soluble glycoprotein trimers
NZ524661A (en) 2000-11-23 2005-03-24 Bavarian Nordic As Modified vaccinia ankara virus variant
CA2785699A1 (en) * 2001-07-05 2003-01-16 Novartis Vaccines And Diagnostics, Inc. Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
WO2003004657A1 (en) * 2001-07-05 2003-01-16 Chiron Corporation Polynucleotides encoding antigenic hiv type b and/or type c polypeptides, polypeptides and uses thereof
CA2466413C (en) 2001-12-04 2014-11-04 Bavarian Nordic A/S Flavivirus ns1 subunit vaccine
CA2477954C (en) 2002-04-25 2012-07-10 Crucell Holland B.V. Means and methods for the production of adenovirus vectors
CA2478508C (en) 2002-04-25 2013-07-02 Crucell Holland B.V. Stable adenoviral vectors and methods for propagation thereof
AU2003291402A1 (en) 2002-11-07 2004-06-03 Beth Israel Deaconess Medical Center MIP-1Alpha AND GM-CSF AS ADJUVANTS OF IMMUNE RESPONSE
WO2004050856A2 (en) 2002-12-03 2004-06-17 University Of Massachusetts Polyvalent, primary hiv-1 glycoprotein dna vaccines and vaccination methods
EP2359851A3 (en) 2003-03-28 2011-08-31 The Government of the United States of America, represented by The Secretary, Department of Health and Human Services MVA expressing modified hiv envelope, gag, and pol genes
CA2539021A1 (en) 2003-09-15 2005-03-31 Chiron Corporation Combination approaches for generating immune responses
US20070298051A1 (en) 2003-11-19 2007-12-27 Beth Israel Deaconess Medical Center Adjuvants Of Immune Response
CA2553541C (en) 2004-01-23 2015-04-21 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Chimpanzee adenovirus vaccine carriers
EP1737885A2 (en) * 2004-04-12 2007-01-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method of using adenoviral vectors to induce an immune response
US20080274134A1 (en) 2004-06-15 2008-11-06 Norbert Schulke Hiv-1 Neutralizing Antibodies Elicited By Trimeric Hiv-1 Envelope Glycoprotein Complex
JP4772045B2 (en) 2004-07-16 2011-09-14 アメリカ合衆国 Vaccine against AIDS containing CMV / R nucleic acid construct
AU2005279799A1 (en) * 2004-08-27 2006-03-09 Emory University Recombinant MVA viruses expressing Clade A/G, Clade B and Clade C modified HIV ENV, GAG and POL genes
AP2351A (en) 2004-10-13 2012-01-25 Crucell Holland Bv Improved adenoviral vectors and uses thereof.
CN101588813A (en) * 2005-04-12 2009-11-25 杜克大学 Method of inducing neutralizing antibodies to human immunodeficiency virus
WO2007005934A2 (en) 2005-07-06 2007-01-11 University Of Maryland Biotechnology Institute Constrained hiv envelope-based immunogen that simultaneously presents receptor and coreceptor binding sites
EP1917040A4 (en) 2005-08-23 2012-12-12 Univ California Polyvalent vaccine
WO2007104792A2 (en) 2006-03-16 2007-09-20 Crucell Holland B.V. Recombinant adenoviruses based on serotype 26 and 48, and use thereof
EP2040747A4 (en) 2006-06-19 2010-08-25 Progenics Pharm Inc Soluble stabilized trimeric hiv env proteins and uses thereof
CA2667358A1 (en) 2006-10-23 2008-05-29 Progenics Pharmaceuticals, Inc. Modified gp140 envelope polypeptides of hiv-1 isolates, compositions, stabilized trimeric complexes, and uses thereof
US20080279879A1 (en) 2006-11-17 2008-11-13 New York University INDUCTION OF BROADLY REACTIVE NEUTRALIZING ANTIBODIES BY FOCUSING THE IMMUNE RESPONSE ON V3 EPITOPES OF THE HIV-1 gp120 ENVELOPE
EP2137210B1 (en) 2007-03-02 2016-10-19 GlaxoSmithKline Biologicals SA Novel method and compositions
LT3335728T (en) 2008-10-10 2020-03-10 Children`S Medical Center Corporation Biochemically stabilized hiv-1 env trimer vaccine
WO2010059732A1 (en) * 2008-11-18 2010-05-27 Beth Israel Deaconess Medical Center Antiviral vaccines with improved cellular immunogenicity
JP5882741B2 (en) 2009-02-02 2016-03-09 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Nucleic acid and amino acid sequences of simian adenovirus, vectors containing the same, and uses thereof
WO2010085984A1 (en) 2009-02-02 2010-08-05 Okairos Ag Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
WO2010096561A1 (en) 2009-02-18 2010-08-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Synthetic hiv/siv gag proteins and uses thereof
CN105399833B (en) 2010-01-04 2019-09-06 Kj 生物科学有限公司 Dps fusion protein for vaccine and diagnostics
AU2011209175B2 (en) 2010-01-28 2016-02-04 Bavarian Nordic A/S Vaccinia virus mutants containing the major genomic deletions of MVA
EP3556396B1 (en) 2010-08-31 2022-04-20 Theraclone Sciences, Inc. Human immunodeficiency virus (hiv)-neutralizing antibodies
US9701718B2 (en) 2010-12-14 2017-07-11 Janssen Vaccines & Prevention B.V. Adenovirus serotype 26 and serotype 35 filovirus vaccines
CN103945864A (en) * 2011-04-25 2014-07-23 先进生物学实验室股份有限公司 Truncated HIV envelope proteins (ENV), methods and compositions related thereto
US20140348791A1 (en) 2011-09-09 2014-11-27 Beth Israel Deaconess Medical Center, Inc. Modified adenoviral vectors and methods of treatment using same
US20130189754A1 (en) 2011-09-12 2013-07-25 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
WO2013040766A1 (en) * 2011-09-21 2013-03-28 中国疾病预防控制中心性病艾滋病预防控制中心 Method and vaccine capable of inducing broad spectrum immune response against hiv
EP2766037A4 (en) 2011-10-12 2015-08-05 Scripps Research Inst An hiv-1 gp120 mini v3 loop and uses thereof
US9683268B2 (en) 2012-09-19 2017-06-20 Beth Israel Deaconess Viruses associated with immunodeficiency and enteropathy and methods using same
CA3200425A1 (en) 2012-11-16 2014-05-22 Peter ABBINK Recombinant adenoviruses and use thereof
SG11201505229XA (en) 2013-01-07 2015-08-28 Beth Israel Hospital Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same
WO2014124301A1 (en) 2013-02-07 2014-08-14 University Of Washington Through Its Center For Commercialization Self-assembling protein nanostructures
US9624510B2 (en) * 2013-03-01 2017-04-18 The Wistar Institute Adenoviral vectors comprising partial deletions of E3
WO2015048770A2 (en) 2013-09-30 2015-04-02 Beth Israel Deaconess Medical Center, Inc. Antibody therapies for human immunodeficiency virus (hiv)
WO2015051270A1 (en) * 2013-10-04 2015-04-09 Beth Israel Deaconess Medical Center, Inc. Stabilized human immunodeficiency virus (hiv) clade c envelope (env) trimer vaccines and methods of using same
JP2017507672A (en) * 2014-02-28 2017-03-23 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． Replicative recombinant adenoviral vectors, compositions and methods of use thereof
US10400015B2 (en) 2014-09-04 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant HIV-1 envelope proteins and their use
RS61902B1 (en) 2014-09-26 2021-06-30 Beth Israel Deaconess Medical Ct Inc Methods and compositions for inducing protective immunity against human immunodeficiency virus infection
US9630994B2 (en) 2014-11-03 2017-04-25 University Of Washington Polypeptides for use in self-assembling protein nanostructures
US20180052173A1 (en) * 2015-03-18 2018-02-22 Janssen Vaccines & Prevention B.V. Assays for recombinant expression systems
AU2016369326B2 (en) 2015-12-15 2019-02-21 Janssen Vaccines & Prevention B.V. Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof
US10273268B2 (en) 2016-06-16 2019-04-30 Janssen Vaccines & Prevention B.V. HIV vaccine formulation
AU2017318689A1 (en) 2016-09-02 2019-04-11 Beth Israel Deaconess Medical Center, Inc. Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
HUE052008T2 (en) 2016-09-15 2021-04-28 Janssen Vaccines & Prevention Bv Trimer stabilizing hiv envelope protein mutations
DE102018124348A1 (en) 2018-10-02 2020-04-02 Haver & Boecker Ohg Filling box and method for filling containers

Also Published As

Publication number Publication date
WO2017102929A1 (en) 2017-06-22
TWI792091B (en) 2023-02-11
HRP20211566T1 (en) 2022-03-04
EA201891415A8 (en) 2019-10-31
JP6510149B2 (en) 2019-05-08
JP2019505188A (en) 2019-02-28
ME03545B (en) 2020-07-20
HUE055916T2 (en) 2021-12-28
MA47522B1 (en) 2021-11-30
MA44059A (en) 2018-10-24
EP3390430A1 (en) 2018-10-24
US20170165355A1 (en) 2017-06-15
EP3964569A1 (en) 2022-03-09
US11896663B2 (en) 2024-02-13
CA3008542A1 (en) 2017-06-22
MA55825A (en) 2022-03-09
PT3390430T (en) 2019-11-20
TWI707039B (en) 2020-10-11
ES2753854T3 (en) 2020-04-14
MD3390430T2 (en) 2019-12-31
IL259942B2 (en) 2023-04-01
PL3390430T3 (en) 2020-03-31
MX2018007198A (en) 2018-08-01
SI3390430T1 (en) 2019-12-31
MA44059B1 (en) 2019-11-29
HRP20191902T1 (en) 2020-01-24
LT3390430T (en) 2019-11-25
CN108368157B (en) 2022-04-15
RS62360B1 (en) 2021-10-29
RS59447B1 (en) 2019-11-29
KR20180086207A (en) 2018-07-30
LT3584252T (en) 2021-09-27
EP3390430B1 (en) 2019-08-28
AU2019203468A1 (en) 2019-06-06
SG10202109457RA (en) 2021-10-28
US20190321462A1 (en) 2019-10-24
TW202106701A (en) 2021-02-16
SI3584252T1 (en) 2021-11-30
ZA201803978B (en) 2021-05-26
IL259942B (en) 2022-12-01
JP6959289B2 (en) 2021-11-02
PH12018501047A1 (en) 2018-12-17
CN114686495A (en) 2022-07-01
AU2016369326B2 (en) 2019-02-21
MX2021006931A (en) 2021-07-07
US20210220468A1 (en) 2021-07-22
CN108368157A (en) 2018-08-03
TW201734210A (en) 2017-10-01
MD3584252T2 (en) 2022-01-31
AU2019203468B2 (en) 2020-05-21
DK3584252T3 (en) 2021-11-15
JP2019146574A (en) 2019-09-05
EA038974B1 (en) 2021-11-17
CY1125387T1 (en) 2023-03-24
ES2898271T3 (en) 2022-03-04
CA3008542C (en) 2020-06-02
CY1122705T1 (en) 2021-03-12
US10973907B2 (en) 2021-04-13
BR112018011122A2 (en) 2018-11-21
EA201891415A1 (en) 2018-11-30
AU2016369326A1 (en) 2018-06-07
EP3584252A1 (en) 2019-12-25
PL3584252T3 (en) 2022-01-10
US10369214B2 (en) 2019-08-06
MA47522A (en) 2021-05-05
EP3584252B1 (en) 2021-08-25
HUE045993T2 (en) 2020-01-28
IL259942A (en) 2018-07-31
DK3390430T3 (en) 2019-11-18

Similar Documents

Publication Publication Date Title
SG11201804411TA (en) Human immunodeficiency virus antigens, vectors, compositions, and methods of use thereof
SG11201807912SA (en) Vaccine against rsv
SG11201901206SA (en) Trimer stabilizing hiv envelope protein mutations
SG11201808622SA (en) Chimeric receptors to flt3 and methods of use thereof
SG11201807913XA (en) Stabilized soluble pre-fusion rsv f proteins
SG11201811432WA (en) Rna for cancer therapy
SG11201805229YA (en) Means and methods for treating hbv
SG11201805120YA (en) Zika virus vaccine
SG11201909572QA (en) Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
SG11201810048VA (en) Tri-segmented pichinde viruses as vaccine vectors
SG11201909949XA (en) Targeted immunotolerance
SG11201811442UA (en) Formulation of a peptide vaccine
SG11201810078PA (en) Stabilized pre-fusion rsv f proteins
SG11201806863WA (en) Tetracyclic pyridone compounds as antivirals
SG11201807660QA (en) Cyclic di-nucleotide compounds and methods of use
SG11201903021WA (en) Anti-human 4-1 bb antibodies and use thereof
SG11201809879WA (en) Novel antibodies specifically binding to zika virus epitopes and uses thereof
SG11201807809XA (en) A transient commensal microorganism for improving gut health
SG11201805001UA (en) Method of treating influenza a
SG11201811363YA (en) Anti-zika virus antibodies and methods of use
SG11201810549TA (en) Hiv vaccine formulation
SG11201807051VA (en) Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy
SG11201407586WA (en) Vaccines for hsv-2
SG11201903287PA (en) Anti-respiratory syncytial virus antibodies, and methods of their generation and use
SG11201809908TA (en) Stabilized glycopeptide antibiotic formulations