SG11201804223TA - OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF - Google Patents

OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF

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Publication number
SG11201804223TA
SG11201804223TA SG11201804223TA SG11201804223TA SG11201804223TA SG 11201804223T A SG11201804223T A SG 11201804223TA SG 11201804223T A SG11201804223T A SG 11201804223TA SG 11201804223T A SG11201804223T A SG 11201804223TA SG 11201804223T A SG11201804223T A SG 11201804223TA
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SG
Singapore
Prior art keywords
international
guangdong
dongyangguang
dongguan
zhen
Prior art date
Application number
SG11201804223TA
Inventor
Yingjun Zhang
Chuanfei Jin
Ji Zhang
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Sunshine Lake Pharma Co Ltd
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Publication of SG11201804223TA publication Critical patent/SG11201804223TA/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61P3/02—Nutrients, e.g. vitamins, minerals
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau res., 00) (43) International Publication Date ..... ..sr.1 1 June 2017 (01.06.2017) WIPO I PCT ID Hit (10) 1111111111111111111 WO International Ell DION 2017/088759 Publication WHIM 11111 Ill Al Number RIIIIIIIIIIIIIII (51) International Patent Classification: (74) Agent: TSINGYIHUA INTELLECTUAL PROPERTY C07D 487/04 (2006.01) A61P 25/18 (2006.01) LLC; Room 301, Trade Building, Zhaolanyuan, Tsinghua A61K 31/517 (2006.01) A61P 1/00 (2006.01) University, Qinghuayuan, Haidian District, Beijing 100084 A61K 31/423 (2006.01) A61P 29/00 (2006.01) (CN). A61P 25/20 (2006.01) A61P 9/00 (2006.01) A61P 25/24 (2006.01) A61P 3/10 (2006.01) (81) Designated States (unless otherwise indicated, for every A61P 25/22 (2006.01) A61P 37/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/CN2016/106937 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 23 November 2016 (23.11.2016) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 201510823712.8 23 November 2015 (23.11.2015) CN (84) Designated States (unless otherwise indicated, for every (71) Applicant: SUNSHINE LAKE PHARMA CO., LTD. kind of regional protection available): ARIPO (BW, GH, [CN/CN]; Northern Industrial Area, Songshan Lake, Dong- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, guan, Guangdong 523000 (CN). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors . ZHANG, Yingjun; Dongyangguang Hi-tech DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Park, Zhen An Road No.368, Shang Sha, Chang An Town, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Dongguan, Guangdong 523871 (CN). JIN, Chuanfei; SM, TR), OAPI BJ, CF, CG, CI, CM, GA, GN, GQ, (BF, Dongyangguang Hi-tech Park, Zhen An Road No.368, GW, KM, ML, MR, NE, SN, TD, TG). Shang Sha, Chang An Town, Dongguan, Guangdong Published: 523871 (CN) ZHANG, Ti; Dongyangguang Hi-tech Park, Zhen An Road No.368, Shang Sha, Chang An Town, — with international search report (Art 21(3)) Dongguan, Guangdong 523871 (CN). Il .4t C\ In IN GC GC C::: , IN 1-1 (54) Title: OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF 0 N (57) : The invention relates to octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof. Compounds and pharmaceut- ical compositions comprising the compounds provided herein are used for antagonizing orexin receptors. The invention also relates to processes for preparing the compounds and pharmaceutical compositions, and uses thereof in treating or preventing a disease re- lated to orexin receptors.
SG11201804223TA 2015-11-23 2016-11-23 OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF SG11201804223TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510823712 2015-11-23
PCT/CN2016/106937 WO2017088759A1 (en) 2015-11-23 2016-11-23 OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF

Publications (1)

Publication Number Publication Date
SG11201804223TA true SG11201804223TA (en) 2018-06-28

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Family Applications (1)

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SG11201804223TA SG11201804223TA (en) 2015-11-23 2016-11-23 OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF

Country Status (8)

Country Link
US (1) US10370380B2 (en)
EP (1) EP3380475A4 (en)
JP (1) JP6936224B2 (en)
CN (1) CN106749269B (en)
AU (1) AU2016360245B2 (en)
CA (1) CA3005918C (en)
SG (1) SG11201804223TA (en)
WO (1) WO2017088759A1 (en)

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