SG11201708822PA - Imidazopyrazinones as pde1 inhibitors - Google Patents
Imidazopyrazinones as pde1 inhibitorsInfo
- Publication number
- SG11201708822PA SG11201708822PA SG11201708822PA SG11201708822PA SG11201708822PA SG 11201708822P A SG11201708822P A SG 11201708822PA SG 11201708822P A SG11201708822P A SG 11201708822PA SG 11201708822P A SG11201708822P A SG 11201708822PA SG 11201708822P A SG11201708822P A SG 11201708822PA
- Authority
- SG
- Singapore
- Prior art keywords
- imidazopyrazinones
- pde1 inhibitors
- pde1
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201500261 | 2015-04-30 | ||
DKPA201500666 | 2015-10-29 | ||
DKPA201600202 | 2016-04-04 | ||
PCT/EP2016/059583 WO2016174188A1 (en) | 2015-04-30 | 2016-04-29 | Imidazopyrazinones as pde1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201708822PA true SG11201708822PA (en) | 2017-11-29 |
Family
ID=55910242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201708822PA SG11201708822PA (en) | 2015-04-30 | 2016-04-29 | Imidazopyrazinones as pde1 inhibitors |
Country Status (41)
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201629064A (en) | 2014-10-10 | 2016-08-16 | H 朗德貝克公司 | Triazolopyrainones as PDE1 inhibitors |
JO3627B1 (en) | 2015-04-30 | 2020-08-27 | H Lundbeck As | Imidazopyrazinones as PDE1 inhibitors |
TWI729109B (en) | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 1,5-DIHYDRO-4H-PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES AND 1,5-DIHYDRO-4H-PYRAZOLO[4,3-c]PYRIDIN-4-ONES AS PDE1 INHIBITORS |
ES2967489T3 (en) | 2016-10-18 | 2024-04-30 | H Lundbeck As | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as PDE1 inhibitors |
EP3532053A1 (en) | 2016-10-28 | 2019-09-04 | H. Lundbeck A/S | Combination treatments comprising administration of imidazopyrazinones |
WO2018078038A1 (en) * | 2016-10-28 | 2018-05-03 | H. Lundbeck A/S | Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders |
JOP20190126A1 (en) | 2016-12-22 | 2019-05-28 | H Lundbeck As | Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors |
KR102590848B1 (en) | 2016-12-28 | 2023-10-19 | 다트 뉴로사이언스, 엘엘씨 | Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors |
JP7254078B2 (en) | 2017-11-27 | 2023-04-07 | ダート・ニューロサイエンス・エルエルシー | Substituted furanopyrimidine compounds as PDE1 inhibitors |
AR113926A1 (en) * | 2017-12-14 | 2020-07-01 | H Lundbeck As | DERIVATIVES OF 1H-PYRAZOLE [4,3-B] PYRIDINES |
US11535611B2 (en) | 2017-12-20 | 2022-12-27 | H. Lundbeck A/S | Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors |
Family Cites Families (51)
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GB973361A (en) | 1960-05-11 | 1964-10-28 | Ciba Ltd | Pyrazolo-pyrimidines and process for their manufacture |
DE19709877A1 (en) | 1997-03-11 | 1998-09-17 | Bayer Ag | 1,5-dihydro-pyrazolo [3,4-d] pyrimidinone derivatives |
MY144532A (en) | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
DE10238722A1 (en) | 2002-08-23 | 2004-03-11 | Bayer Ag | Improving attention, concentration, cognition, learning and/or memory performance, using selective phosphodiesterase 9A inhibitors, preferably 4H-pyrazolo-(3,4-d)-pyrimidin-4-one derivatives |
DE10238723A1 (en) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl substituted pyrazolyprimidines |
DE10238724A1 (en) | 2002-08-23 | 2004-03-04 | Bayer Ag | New 6-alkyl-1,5-dihydro-4H-pyrazolo-(3,4-d)-pyrimidin-4-ones useful as selective phosphodiesterase 9A inhibitors for improving attention, concentration, learning and/or memory performance |
JP2006525966A (en) | 2003-05-09 | 2006-11-16 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 6-cyclylmethyl- and 6-alkylmethyl substituted pyrazolopyrimidines |
BRPI0509576A (en) * | 2004-04-02 | 2007-05-29 | Osi Pharm Inc | compound, method of treating a patient having a condition that is mediated by protein kinase activity, and, pharmaceutical composition |
WO2006068978A2 (en) * | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
EP1919287A4 (en) * | 2005-08-23 | 2010-04-28 | Intra Cellular Therapies Inc | Organic compounds for treating reduced dopamine receptor signalling activity |
US8012936B2 (en) | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
WO2008070095A1 (en) | 2006-12-05 | 2008-06-12 | Intra-Cellular Therapies, Inc. | Novel uses |
NZ580904A (en) | 2007-05-11 | 2012-02-24 | Pfizer | Amino-heterocyclic compounds for inhibiting pde9 |
EP2227472A1 (en) | 2007-11-30 | 2010-09-15 | Elbion Gmbh | Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10 |
UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
PE20110383A1 (en) * | 2008-09-08 | 2011-07-15 | Boehringer Ingelheim Int | PYRAZOLOPYRIMIDINONES AS INHIBITORS OF PHOSPHODIESTERASE 9A (PDE9A) |
SG171777A1 (en) | 2008-12-06 | 2011-07-28 | Intra Cellular Therapies Inc | Organic compounds |
TWI404721B (en) | 2009-01-26 | 2013-08-11 | Pfizer | Amino-heterocyclic compounds |
CA2765099A1 (en) | 2009-06-10 | 2010-12-16 | New York University | Phosphorylated tau peptide for use in the treatment of tauopathy |
US9434730B2 (en) | 2010-05-31 | 2016-09-06 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
PL3339323T3 (en) | 2010-08-12 | 2020-05-18 | Eli Lilly And Company | Anti-n3pglu amyloid beta peptide antibodies and uses thereof |
CN103313988B (en) * | 2010-09-20 | 2016-06-08 | 论坛医药有限公司 | Imidazo-triazine ketonic compound |
EP2619204A4 (en) | 2010-09-21 | 2014-08-27 | Merck Sharp & Dohme | Triazolopyrazinones as p2x7 receptor antagonists |
JO3089B1 (en) | 2010-11-19 | 2017-03-15 | H Lundbeck As | Imidazole derivatives as PDE10A enzyme inhibitors |
US9499610B2 (en) | 2011-04-08 | 2016-11-22 | H. Lundbeck A/S | Antibodies specific to pyroglutamated Aβ |
US10561656B2 (en) | 2011-06-10 | 2020-02-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
JP2015531401A (en) * | 2011-10-10 | 2015-11-02 | ハー・ルンドベック・アクチエゼルスカベット | PDE9I having imidazopyrazinone skeleton |
US9434733B2 (en) | 2012-01-26 | 2016-09-06 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone |
JP2013166727A (en) | 2012-02-16 | 2013-08-29 | Dainippon Sumitomo Pharma Co Ltd | Dihydroimidazo pyrazinone derivative |
EP2861603B1 (en) | 2012-06-18 | 2018-12-19 | Dart NeuroScience (Cayman) Ltd | 6-Benzyl-6H-pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5-one and 6-benzyl-[1,2,4]triazolo[1,5-c]pteridin-5(6H)-one derivatives as PDE1 inhibitors for treating e.g. neurological disorders |
JP6437519B2 (en) | 2013-03-15 | 2018-12-12 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | Organic compounds |
JP5783297B2 (en) | 2013-08-06 | 2015-09-24 | 株式会社デンソー | Mechanical quantity sensor |
MA39225A1 (en) | 2014-02-19 | 2017-04-28 | H Lundbeck As | 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahydropyridines used as bace1 inhibitors in the treatment of alzheimer's disease |
JP5797815B1 (en) | 2014-06-27 | 2015-10-21 | 細田建設株式会社 | Post-installed anchor and its construction method |
WO2016042775A1 (en) | 2014-09-18 | 2016-03-24 | Sunovion Pharmaceuticals Inc. | Tricyclic derivative |
US20160083391A1 (en) | 2014-09-18 | 2016-03-24 | Sunovion Pharmaceuticals Inc. | Tricyclic piperazine derivative |
US20160083400A1 (en) | 2014-09-18 | 2016-03-24 | Sunovion Pharmaceuticals Inc. | Tricyclic guanidine derivative |
TW201629064A (en) | 2014-10-10 | 2016-08-16 | H 朗德貝克公司 | Triazolopyrainones as PDE1 inhibitors |
MA40941A (en) | 2014-11-10 | 2017-09-19 | H Lundbeck As | 2-AMINO-5,5-DIFLUORO-6- (FLUOROMETHYL) -6-PHENYL-3,4,5,6-TETRAHYDROPYRIDINES AS BACE1 INHIBITORS |
CR20170187A (en) | 2014-11-10 | 2018-02-01 | H Lundbeck As | 2-Amino-3,5-difluoro-6-methyl-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for the treatment of Alzheimer's disease |
JO3458B1 (en) | 2014-11-10 | 2020-07-05 | H Lundbeck As | 2-Amino-6-(difluoromethyl)- 5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors |
JP2018508555A (en) | 2015-03-16 | 2018-03-29 | 大日本住友製薬株式会社 | Bicyclic imidazolo derivatives |
TW201643167A (en) | 2015-04-22 | 2016-12-16 | H 朗德貝克公司 | Imidazotriazinones as PDE1 inhibitors |
JO3627B1 (en) | 2015-04-30 | 2020-08-27 | H Lundbeck As | Imidazopyrazinones as PDE1 inhibitors |
JO3711B1 (en) | 2015-07-13 | 2021-01-31 | H Lundbeck As | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
MX2018001699A (en) | 2015-08-12 | 2018-05-07 | H Lundbeck As | 2-amino-3-fluoro-3-(fluoromethyl)-6-methyl-6-phenyl-3,4,5,6-tetr ahydropyridins as bace1 inhibitors. |
TWI609870B (en) | 2016-02-12 | 2018-01-01 | 美國禮來大藥廠 | Pde1 inhibitor |
TWI729109B (en) | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 1,5-DIHYDRO-4H-PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES AND 1,5-DIHYDRO-4H-PYRAZOLO[4,3-c]PYRIDIN-4-ONES AS PDE1 INHIBITORS |
ES2967489T3 (en) | 2016-10-18 | 2024-04-30 | H Lundbeck As | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as PDE1 inhibitors |
WO2018078038A1 (en) | 2016-10-28 | 2018-05-03 | H. Lundbeck A/S | Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders |
EP3532053A1 (en) | 2016-10-28 | 2019-09-04 | H. Lundbeck A/S | Combination treatments comprising administration of imidazopyrazinones |
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2016
- 2016-04-26 JO JOP/2016/0081A patent/JO3627B1/en active
- 2016-04-27 TW TW105113074A patent/TWI695838B/en active
- 2016-04-29 LT LTEP16720101.1T patent/LT3288944T/en unknown
- 2016-04-29 SI SI201630319T patent/SI3288944T1/en unknown
- 2016-04-29 EP EP16720101.1A patent/EP3288944B1/en active Active
- 2016-04-29 US US15/142,116 patent/US20160318939A1/en not_active Abandoned
- 2016-04-29 RU RU2017137514A patent/RU2712219C2/en active
- 2016-04-29 ME MEP-2019-186A patent/ME03414B/en unknown
- 2016-04-29 KR KR1020177030665A patent/KR102605759B1/en active IP Right Grant
- 2016-04-29 HU HUE16720101 patent/HUE044244T2/en unknown
- 2016-04-29 MY MYPI2017001597A patent/MY182382A/en unknown
- 2016-04-29 PL PL16720101T patent/PL3288944T3/en unknown
- 2016-04-29 AU AU2016256573A patent/AU2016256573B2/en active Active
- 2016-04-29 JP JP2017556677A patent/JP6663930B2/en active Active
- 2016-04-29 WO PCT/EP2016/059583 patent/WO2016174188A1/en active Application Filing
- 2016-04-29 MX MX2017013785A patent/MX2017013785A/en active IP Right Grant
- 2016-04-29 DK DK16720101.1T patent/DK3288944T3/en active
- 2016-04-29 TN TNP/2017/000428A patent/TN2017000428A1/en unknown
- 2016-04-29 UA UAA201710625A patent/UA123050C2/en unknown
- 2016-04-29 RS RS20190893A patent/RS59051B1/en unknown
- 2016-04-29 MA MA41977A patent/MA41977B1/en unknown
- 2016-04-29 PT PT16720101T patent/PT3288944T/en unknown
- 2016-04-29 BR BR112017023182-4A patent/BR112017023182B1/en active IP Right Grant
- 2016-04-29 SG SG11201708822PA patent/SG11201708822PA/en unknown
- 2016-04-29 ES ES16720101T patent/ES2735422T3/en active Active
- 2016-04-29 PE PE2017002342A patent/PE20180121A1/en unknown
- 2016-04-29 CA CA2983563A patent/CA2983563A1/en active Pending
- 2016-04-29 GE GEAP201614615A patent/GEP20207058B/en unknown
- 2016-04-29 EA EA201792157A patent/EA031946B1/en not_active IP Right Cessation
- 2016-04-29 CN CN201680023903.9A patent/CN107531714B/en active Active
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2017
- 2017-06-06 US US15/615,380 patent/US10011606B2/en active Active
- 2017-10-10 ZA ZA2017/06847A patent/ZA201706847B/en unknown
- 2017-10-12 CO CONC2017/0010399A patent/CO2017010399A2/en unknown
- 2017-10-24 GT GT201700223A patent/GT201700223A/en unknown
- 2017-10-26 CL CL2017002719A patent/CL2017002719A1/en unknown
- 2017-10-27 EC ECIEPI201772228A patent/ECSP17072228A/en unknown
- 2017-10-29 IL IL255316A patent/IL255316B/en unknown
- 2017-10-30 DO DO2017000254A patent/DOP2017000254A/en unknown
- 2017-10-30 PH PH12017501990A patent/PH12017501990B1/en unknown
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2018
- 2018-06-07 US US16/002,116 patent/US10858362B2/en active Active
- 2018-09-05 HK HK18111408.3A patent/HK1252098B/en unknown
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2019
- 2019-07-01 HR HRP20191180TT patent/HRP20191180T1/en unknown
- 2019-07-15 CY CY20191100751T patent/CY1121806T1/en unknown
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2020
- 2020-10-26 US US17/079,951 patent/US11472810B2/en active Active
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