SG11201708509YA - Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites - Google Patents
Glucose-responsive insulin delivery system using hyoxia-sensitive nanocompositesInfo
- Publication number
- SG11201708509YA SG11201708509YA SG11201708509YA SG11201708509YA SG11201708509YA SG 11201708509Y A SG11201708509Y A SG 11201708509YA SG 11201708509Y A SG11201708509Y A SG 11201708509YA SG 11201708509Y A SG11201708509Y A SG 11201708509YA SG 11201708509Y A SG11201708509Y A SG 11201708509YA
- Authority
- SG
- Singapore
- Prior art keywords
- hyoxia
- nanocomposites
- glucose
- sensitive
- delivery system
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
- C12Y101/03004—Glucose oxidase (1.1.3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562150622P | 2015-04-21 | 2015-04-21 | |
PCT/US2016/028605 WO2016172320A1 (en) | 2015-04-21 | 2016-04-21 | Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201708509YA true SG11201708509YA (en) | 2017-11-29 |
Family
ID=57144247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201708509YA SG11201708509YA (en) | 2015-04-21 | 2016-04-21 | Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites |
Country Status (23)
Country | Link |
---|---|
US (2) | US11191815B2 (en) |
EP (2) | EP3795143A1 (en) |
JP (1) | JP6856546B2 (en) |
KR (1) | KR102624501B1 (en) |
CN (2) | CN107530296B (en) |
AU (2) | AU2016252738B2 (en) |
BR (1) | BR112017022535A2 (en) |
CA (1) | CA2983289C (en) |
CL (1) | CL2017002652A1 (en) |
CO (1) | CO2017011422A2 (en) |
DO (1) | DOP2017000239A (en) |
EC (1) | ECSP17073558A (en) |
HK (1) | HK1245105A1 (en) |
IL (1) | IL255155A0 (en) |
MA (1) | MA54623A (en) |
MX (1) | MX2017013337A (en) |
NZ (1) | NZ736578A (en) |
PE (1) | PE20180325A1 (en) |
PH (1) | PH12017501910A1 (en) |
RU (1) | RU2719584C2 (en) |
SG (1) | SG11201708509YA (en) |
TN (1) | TN2017000439A1 (en) |
WO (1) | WO2016172320A1 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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MX2017013337A (en) | 2015-04-21 | 2018-04-20 | Univ North Carolina State | Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites. |
WO2017143153A1 (en) | 2016-02-19 | 2017-08-24 | North Carolina State University | Methods and compositions related to physiologically responsive microneedle delivery systems |
WO2018085809A1 (en) * | 2016-11-07 | 2018-05-11 | North Carolina State University | Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery |
US11331277B2 (en) | 2016-12-05 | 2022-05-17 | North Carolina State University | H2O2-responsive nanoparticles and uses thereof |
WO2018106696A1 (en) * | 2016-12-05 | 2018-06-14 | North Carolina State University | Core-shell microneedle devices and uses thereof |
WO2018165294A1 (en) | 2017-03-07 | 2018-09-13 | North Carolina State University | Insulin-responsive glucagon delivery patch |
US11096893B2 (en) | 2017-06-02 | 2021-08-24 | North Carolina State University | Glucose sensitive compositions for drug delivery |
JP6482604B2 (en) * | 2017-06-22 | 2019-03-13 | 教裕 南郷 | Inner skin dissolution type needle and needle device |
WO2019055901A1 (en) * | 2017-09-18 | 2019-03-21 | North Carolina State University | ARTIFICIAL β-CELLS AND METHODS OF USE THEREOF |
KR20200067173A (en) * | 2017-10-10 | 2020-06-11 | 노쓰 캐롤라이나 스테이트 유니버시티 | Glucose transporter inhibitor-regulated insulin for glucose-responsive insulin delivery |
US11813352B2 (en) | 2017-11-21 | 2023-11-14 | North Carolina State University | Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response |
CN108484848A (en) * | 2018-02-27 | 2018-09-04 | 同济大学 | A kind of polymer nano micelle of Anaerobic response and preparation method thereof |
CN108395489A (en) * | 2018-03-22 | 2018-08-14 | 华侨大学 | A kind of 2- nitroimidazoles-cysteine-alginate material and preparation method thereof |
CN108440684A (en) * | 2018-03-22 | 2018-08-24 | 华侨大学 | A kind of NI-Cys-Alg self-assembled nanometers carrier and its preparation method and application |
US20210161968A1 (en) * | 2018-04-13 | 2021-06-03 | North Carolina State University | Use of microneedle patch to promote hair growth |
WO2019200081A1 (en) * | 2018-04-13 | 2019-10-17 | North Carolina State University | Ros-responsive microneedle patch for acne vulgaris treatment |
CN109464657A (en) * | 2018-11-26 | 2019-03-15 | 常州工程职业技术学院 | A kind of method that block copolymer carries insulin control release |
CN109568567A (en) * | 2019-01-15 | 2019-04-05 | 武汉德丽福生物科技有限公司 | A kind of micropin Dietrine and preparation method thereof |
CN109771659A (en) * | 2019-02-25 | 2019-05-21 | 天津大学 | A kind of weary oxygen responsive nano pharmaceutical carrier and its preparation method and application |
CN110652494B (en) * | 2019-10-21 | 2021-09-28 | 南通大学 | Low-oxygen response polyamino acid-PEG stereo drug-loaded micelle and preparation method thereof |
CN110841065A (en) * | 2019-12-05 | 2020-02-28 | 福州大学 | Nano compound for pH/hypoxia dual-response drug release synergistic photodynamic therapy and preparation method thereof |
CN115317437B (en) * | 2021-05-11 | 2023-09-08 | 中国科学院上海硅酸盐研究所 | Insulin delivery microneedle based on bilirubin nanomaterial and preparation method thereof |
CN114376569B (en) * | 2022-01-19 | 2023-10-13 | 浙江大学 | Glucagon-carrying wearable device for treating hypoglycemia |
CN114432243B (en) * | 2022-01-20 | 2023-08-29 | 华南师范大学 | Nanocarrier responding to pH and glucose and application thereof |
CN115120552A (en) * | 2022-06-22 | 2022-09-30 | 华中科技大学 | Polypeptide drug-loaded microneedle patch capable of releasing drug in microenvironment response manner, preparation and application |
CN115531309B (en) * | 2022-09-29 | 2023-08-22 | 中国药科大学 | Liver targeting polymer micelle drug delivery system and preparation method and application thereof |
Family Cites Families (29)
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GB9415810D0 (en) * | 1994-08-04 | 1994-09-28 | Jerrow Mohammad A Z | Composition |
US8465468B1 (en) * | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
EP1389090A2 (en) * | 2001-04-26 | 2004-02-18 | Board of Regents, The University of Texas System | Diagnostic imaging compositions, their methods of synthesis and use |
GB0116860D0 (en) | 2001-07-10 | 2001-09-05 | Univ Montfort | Gel compositions |
CA2500453A1 (en) * | 2001-09-28 | 2003-04-03 | Biovalve Technologies, Inc. | Microneedle with membrane |
WO2003089506A1 (en) | 2002-04-22 | 2003-10-30 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
JP4185423B2 (en) * | 2003-09-09 | 2008-11-26 | 日本電信電話株式会社 | Method for producing electrochemical biosensor |
WO2006088473A2 (en) * | 2004-04-23 | 2006-08-24 | Panduranga Rao Koritala | Microcapsules and nanocapsules for the transmucosal delivery of therapeutic and diagnostic agents |
JP2009502261A (en) * | 2005-07-25 | 2009-01-29 | ナノテクノロジー ビクトリア ピーティーワイ リミテッド | Microarray device |
WO2007075388A2 (en) * | 2005-12-15 | 2007-07-05 | X-Cell Medical Incorporated | Methods of locally treating and preventing cardiac disorders |
WO2008011625A2 (en) * | 2006-07-21 | 2008-01-24 | Georgia Tech Researh Corporation | Microneedle devices and methods of drug delivery or fluid withdrawal |
CN101125086A (en) * | 2006-08-18 | 2008-02-20 | 刘胜 | Closed-loop automatic controlling insulin-injecting system |
CN101932311B (en) * | 2008-02-22 | 2014-07-16 | 东丽株式会社 | Microparticles and pharmaceutical compositions thereof |
US7775357B2 (en) | 2008-04-14 | 2010-08-17 | Asp Rights Management Pty Limited | Syringe disposal device |
KR20100037389A (en) * | 2008-10-01 | 2010-04-09 | 연세대학교 산학협력단 | Solid microstructure with multi-controlled release and process for preparing the same |
ES2691388T3 (en) | 2008-10-07 | 2018-11-27 | Tuo Jin | Polymeric phase transition microneedles |
PE20120582A1 (en) | 2009-01-28 | 2012-05-26 | Smartcells Inc | CRYSTALLINE INSULIN CONJUGATES |
WO2010119409A1 (en) | 2009-04-17 | 2010-10-21 | Sensile Pat Ag | Medical device for glucose monitoring or regulation |
CN102039000B (en) * | 2009-10-20 | 2015-08-26 | 苏州纳通生物纳米技术有限公司 | A kind of transdermal administration kit |
TWI545372B (en) | 2010-10-14 | 2016-08-11 | Merck Patent Gmbh | Liquid crystal display device |
GB201101429D0 (en) * | 2011-01-27 | 2011-03-16 | Biocompatibles Uk Ltd | Drug delivery system |
WO2013123492A2 (en) * | 2012-02-17 | 2013-08-22 | Massachusetts Institute Of Technology | Glucose-responsive microgels for closed loop insulin delivery |
BR112015027561A8 (en) * | 2013-04-30 | 2019-12-24 | Massachusetts Inst Technology | formulation of reticulated network by injectable and polymeric nanoparticle, and use of the same |
KR102133889B1 (en) * | 2013-06-28 | 2020-07-14 | 엘지이노텍 주식회사 | Circuit board and lighting device having the circuit board |
CN104353062A (en) * | 2014-11-21 | 2015-02-18 | 中国人民解放军***福州总医院 | Insulin oral nano-preparation and preparation method thereof |
MX2017013337A (en) | 2015-04-21 | 2018-04-20 | Univ North Carolina State | Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites. |
CN108366960B (en) | 2015-10-23 | 2022-04-19 | 国立大学法人东京医科齿科大学 | Drug delivery device |
WO2017143153A1 (en) * | 2016-02-19 | 2017-08-24 | North Carolina State University | Methods and compositions related to physiologically responsive microneedle delivery systems |
WO2018085809A1 (en) | 2016-11-07 | 2018-05-11 | North Carolina State University | Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery |
-
2016
- 2016-04-21 MX MX2017013337A patent/MX2017013337A/en unknown
- 2016-04-21 CA CA2983289A patent/CA2983289C/en active Active
- 2016-04-21 WO PCT/US2016/028605 patent/WO2016172320A1/en active Application Filing
- 2016-04-21 KR KR1020177033592A patent/KR102624501B1/en active IP Right Grant
- 2016-04-21 AU AU2016252738A patent/AU2016252738B2/en active Active
- 2016-04-21 MA MA054623A patent/MA54623A/en unknown
- 2016-04-21 RU RU2017139931A patent/RU2719584C2/en active
- 2016-04-21 CN CN201680023377.6A patent/CN107530296B/en active Active
- 2016-04-21 BR BR112017022535A patent/BR112017022535A2/en not_active IP Right Cessation
- 2016-04-21 TN TNP/2017/000439A patent/TN2017000439A1/en unknown
- 2016-04-21 US US15/567,532 patent/US11191815B2/en active Active
- 2016-04-21 EP EP20202740.5A patent/EP3795143A1/en not_active Withdrawn
- 2016-04-21 NZ NZ736578A patent/NZ736578A/en unknown
- 2016-04-21 EP EP16783841.6A patent/EP3285750B1/en active Active
- 2016-04-21 JP JP2017555709A patent/JP6856546B2/en active Active
- 2016-04-21 PE PE2017002202A patent/PE20180325A1/en not_active Application Discontinuation
- 2016-04-21 CN CN202110614275.4A patent/CN113350489A/en active Pending
- 2016-04-21 SG SG11201708509YA patent/SG11201708509YA/en unknown
-
2017
- 2017-10-17 DO DO2017000239A patent/DOP2017000239A/en unknown
- 2017-10-19 IL IL255155A patent/IL255155A0/en unknown
- 2017-10-19 CL CL2017002652A patent/CL2017002652A1/en unknown
- 2017-10-19 PH PH12017501910A patent/PH12017501910A1/en unknown
- 2017-11-06 EC ECIEPI201773558A patent/ECSP17073558A/en unknown
- 2017-11-07 CO CONC2017/0011422A patent/CO2017011422A2/en unknown
-
2018
- 2018-04-09 HK HK18104568.4A patent/HK1245105A1/en unknown
-
2021
- 2021-06-17 AU AU2021204048A patent/AU2021204048A1/en not_active Abandoned
- 2021-12-03 US US17/542,021 patent/US20220160841A1/en not_active Abandoned
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