SG11201706511TA - Benzoxaborole compounds and uses thereof - Google Patents

Benzoxaborole compounds and uses thereof

Info

Publication number: SG11201706511TA
Authority: SG; Singapore
Prior art keywords: benzoxaborole compounds; benzoxaborole; compounds
Prior art date: 2015-02-12

Application number

SG11201706511TA

Inventor

M R K Alley (Dickon)

David Barros-Aguirre

Ilaria Giordano

Vincent Hernandez

Xianfeng Li

Jacob J Plattner

Original Assignee

Glaxosmithkline Intellectual Property (No 2) Ltd

Anacor Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-02-12

Filing date

2016-02-12

Publication date

2017-09-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55409879&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201706511T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2016-02-12 Application filed by Glaxosmithkline Intellectual Property (No 2) Ltd, Anacor Pharmaceuticals Inc filed Critical Glaxosmithkline Intellectual Property (No 2) Ltd

2017-09-28 Publication of SG11201706511TA publication Critical patent/SG11201706511TA/en

Links

GDMJXXLVTYSBBE-UHFFFAOYSA-N 1,2-benzoxaborole Chemical class C1=CC=C2OB=CC2=C1 GDMJXXLVTYSBBE-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Virology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

SG11201706511TA 2015-02-12 2016-02-12 Benzoxaborole compounds and uses thereof SG11201706511TA (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP15382054		2015-02-12
EP15382056		2015-02-12
EP15382055		2015-02-12
PCT/IB2016/050776 WO2016128949A1 (en)	2015-02-12	2016-02-12	Benzoxaborole compounds and uses thereof

Publications (1)

Publication Number	Publication Date
SG11201706511TA true SG11201706511TA (en)	2017-09-28

Family

ID=55409879

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG11201706510YA SG11201706510YA (en)	2015-02-12	2016-02-12	4 -substituted benzoxaborole compounds and uses thereof
SG11201706511TA SG11201706511TA (en)	2015-02-12	2016-02-12	Benzoxaborole compounds and uses thereof

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SG11201706510YA SG11201706510YA (en)	2015-02-12	2016-02-12	4 -substituted benzoxaborole compounds and uses thereof

Country Status (35)

Country	Link
US (3)	US20180037595A1 (en)
EP (2)	EP3256480A1 (en)
JP (2)	JP6771472B2 (en)
KR (2)	KR20170117156A (en)
CN (2)	CN107531730B (en)
AU (3)	AU2016217507B2 (en)
BR (2)	BR112017017211B1 (en)
CA (2)	CA2976030C (en)
CL (2)	CL2017002059A1 (en)
CO (2)	CO2017008816A2 (en)
CR (2)	CR20170371A (en)
CY (1)	CY1123687T1 (en)
DK (1)	DK3256479T3 (en)
DO (2)	DOP2017000188A (en)
EA (2)	EA201791667A1 (en)
ES (1)	ES2821951T3 (en)
HR (1)	HRP20201597T1 (en)
HU (1)	HUE051113T2 (en)
IL (2)	IL253865A0 (en)
LT (1)	LT3256479T (en)
MA (2)	MA41495A (en)
MX (2)	MX2017010413A (en)
MY (1)	MY194004A (en)
NZ (1)	NZ734379A (en)
PE (2)	PE20171432A1 (en)
PH (2)	PH12017501428A1 (en)
PL (1)	PL3256479T3 (en)
PT (1)	PT3256479T (en)
RS (1)	RS60885B1 (en)
SG (2)	SG11201706510YA (en)
SI (1)	SI3256479T1 (en)
TW (2)	TWI730953B (en)
UA (1)	UA120527C2 (en)
WO (2)	WO2016128948A1 (en)
ZA (1)	ZA201705456B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP2016009046A0 (en) *	2013-08-09	2016-02-29	Anacor Pharmaceuticals Inc	Tricyclic benzoxaborole compounds and uses thereof
PT3621609T (en) *	2017-05-08	2022-08-24	Glaxosmithkline Ip Dev Ltd	Sanfetrinem or a salt or ester thereof for use in treating mycobacterial infection
US11834466B2 (en)	2017-11-30	2023-12-05	5Metis, Inc.	Benzoxaborole compounds and formulations thereof
CA3148168A1 (en)	2018-08-18	2020-02-27	Chun Yu Liu	Solid forms of substituted benzoxaborole and compositions thereof
CN110441344B (en) *	2019-06-25	2020-09-29	北京大学	Method for detecting RNA structure based on solid nuclear magnetic resonance technology
WO2023246841A1 (en) *	2022-06-23	2023-12-28	Shanghai Micurx Pharmaceutical Co., Ltd.	Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
AU2023287063A1 (en) *	2022-06-23	2024-05-30	Shanghai Micurx Pharmaceutical Co., Ltd.	Prodrugs of boron compounds and their use in treating bacterial infections

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GB9411587D0 (en) *	1994-06-09	1994-08-03	Zeneca Ltd	Compound, composition and use
EP0947498B1 (en)	1996-12-02	2004-09-15	Chisso Corporation	Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same
ES2283867T3 (en)	2002-12-02	2007-11-01	Solvias Ag	CATALYTIC HYDROGENATION OF DOUBLE CARBONOHETEROATOMO LINKS.
NZ560448A (en)	2005-02-16	2009-08-28	Anacor Pharmaceuticals Inc	Boron-containing small molecules
WO2006096131A1 (en)	2005-03-08	2006-09-14	Agency For Science, Technology And Research	Chiral bisoxazoline catalysts
CN106008571A (en)	2005-12-30	2016-10-12	安纳考尔医药公司	Boron-containing small molecules
TWM325238U (en) *	2006-12-29	2008-01-11	Universal Scient Ind Co Ltd	Voltage regulator and voltage regulating system
KR100848491B1 (en)	2007-01-16	2008-07-28	영진약품공업주식회사	2-thiazolidine derivatives having beta;-amino group, pharmaceutical acceptable salts and preparation process thereof
JO3396B1 (en)	2007-06-20	2019-10-20	Anacor Pharmaceuticals Inc	Boron-containing small molecules
EA201190034A1 (en)	2008-12-17	2012-02-28	Анакор Фармасьютикалс, Инк.	(S) -3-Aminomethyl-7- (3-dihydroxypropoxy) -3 H -benzo [c] [1,2] oxaborol-1-
US20110124597A1 (en) *	2009-09-25	2011-05-26	Anacor Pharmaceuticals, Inc.	Boron containing small molecules
KR101508562B1 (en)	2010-04-07	2015-04-07	글락소스미스클라인 엘엘씨	Process for preparing benzoxaboroles
ES2898695T3 (en)	2010-09-07	2022-03-08	Anacor Pharmaceuticals Inc	Benzoxaborole derivatives for the treatment of bacterial infections
CA2858799A1 (en)	2011-12-22	2013-06-27	Micurx Pharmaceuticals, Inc.	Tricyclic boron compounds for antimicrobial therapy
CN102739587B (en)	2012-06-16	2014-05-21	天地融科技股份有限公司	Audio data transmission method
KR101636431B1 (en)	2013-07-30	2016-07-05	동아에스티 주식회사	Tricyclic benzoxaborole compound, process preparing thereof and use thereof
AP2016009046A0 (en) *	2013-08-09	2016-02-29	Anacor Pharmaceuticals Inc	Tricyclic benzoxaborole compounds and uses thereof

2016
- 2016-02-11 MA MA041495A patent/MA41495A/en unknown
- 2016-02-11 MA MA41494A patent/MA41494B1/en unknown
- 2016-02-12 EP EP16706003.7A patent/EP3256480A1/en not_active Withdrawn
- 2016-02-12 WO PCT/IB2016/050775 patent/WO2016128948A1/en active Application Filing
- 2016-02-12 CR CR20170371A patent/CR20170371A/en unknown
- 2016-02-12 JP JP2017541999A patent/JP6771472B2/en active Active
- 2016-02-12 BR BR112017017211-9A patent/BR112017017211B1/en active IP Right Grant
- 2016-02-12 EA EA201791667A patent/EA201791667A1/en unknown
- 2016-02-12 SI SI201630941T patent/SI3256479T1/en unknown
- 2016-02-12 RS RS20201204A patent/RS60885B1/en unknown
- 2016-02-12 SG SG11201706510YA patent/SG11201706510YA/en unknown
- 2016-02-12 MY MYPI2017702943A patent/MY194004A/en unknown
- 2016-02-12 SG SG11201706511TA patent/SG11201706511TA/en unknown
- 2016-02-12 WO PCT/IB2016/050776 patent/WO2016128949A1/en active Application Filing
- 2016-02-12 US US15/550,658 patent/US20180037595A1/en not_active Abandoned
- 2016-02-12 AU AU2016217507A patent/AU2016217507B2/en active Active
- 2016-02-12 US US15/550,693 patent/US10774096B2/en active Active
- 2016-02-12 UA UAA201708405A patent/UA120527C2/en unknown
- 2016-02-12 KR KR1020177025535A patent/KR20170117156A/en unknown
- 2016-02-12 CA CA2976030A patent/CA2976030C/en active Active
- 2016-02-12 CN CN201680021538.8A patent/CN107531730B/en active Active
- 2016-02-12 MX MX2017010413A patent/MX2017010413A/en unknown
- 2016-02-12 NZ NZ734379A patent/NZ734379A/en unknown
- 2016-02-12 EA EA201791671A patent/EA036516B1/en unknown
- 2016-02-12 JP JP2017542053A patent/JP2018506540A/en active Pending
- 2016-02-12 KR KR1020177025539A patent/KR20170117158A/en not_active Application Discontinuation
- 2016-02-12 MX MX2017010414A patent/MX2017010414A/en unknown
- 2016-02-12 EP EP16706002.9A patent/EP3256479B1/en active Active
- 2016-02-12 CR CR20170372A patent/CR20170372A/en unknown
- 2016-02-12 PL PL16706002T patent/PL3256479T3/en unknown
- 2016-02-12 AU AU2016217508A patent/AU2016217508A1/en not_active Abandoned
- 2016-02-12 BR BR112017017213-5A patent/BR112017017213A2/en not_active Application Discontinuation
- 2016-02-12 PE PE2017001400A patent/PE20171432A1/en not_active Application Discontinuation
- 2016-02-12 LT LTEP16706002.9T patent/LT3256479T/en unknown
- 2016-02-12 DK DK16706002.9T patent/DK3256479T3/en active
- 2016-02-12 PT PT167060029T patent/PT3256479T/en unknown
- 2016-02-12 ES ES16706002T patent/ES2821951T3/en active Active
- 2016-02-12 CN CN201680021488.3A patent/CN107548398A/en active Pending
- 2016-02-12 PE PE2017001401A patent/PE20171348A1/en not_active Application Discontinuation
- 2016-02-12 CA CA2976308A patent/CA2976308A1/en not_active Abandoned
- 2016-02-12 HU HUE16706002A patent/HUE051113T2/en unknown
- 2016-02-15 TW TW105104376A patent/TWI730953B/en not_active IP Right Cessation
- 2016-02-15 TW TW105104422A patent/TW201702250A/en unknown
2017
- 2017-08-07 IL IL253865A patent/IL253865A0/en unknown
- 2017-08-07 IL IL253864A patent/IL253864B/en unknown
- 2017-08-09 PH PH12017501428A patent/PH12017501428A1/en unknown
- 2017-08-09 PH PH12017501427A patent/PH12017501427A1/en unknown
- 2017-08-10 DO DO2017000188A patent/DOP2017000188A/en unknown
- 2017-08-10 DO DO2017000189A patent/DOP2017000189A/en unknown
- 2017-08-11 CL CL2017002059A patent/CL2017002059A1/en unknown
- 2017-08-11 CL CL2017002060A patent/CL2017002060A1/en unknown
- 2017-08-11 ZA ZA201705456A patent/ZA201705456B/en unknown
- 2017-08-29 CO CONC2017/0008816A patent/CO2017008816A2/en unknown
- 2017-08-29 CO CONC2017/0008809A patent/CO2017008809A2/en unknown
2020
- 2020-09-11 US US17/018,301 patent/US11214582B2/en active Active
- 2020-10-07 HR HRP20201597TT patent/HRP20201597T1/en unknown
- 2020-10-14 AU AU2020256369A patent/AU2020256369A1/en not_active Abandoned
- 2020-10-15 CY CY20201100978T patent/CY1123687T1/en unknown

Also Published As

Publication number	Publication date
ES2821951T3 (en)	2021-04-28
MY194004A (en)	2022-11-07
AU2016217508A1 (en)	2017-09-28
TW201643173A (en)	2016-12-16
EP3256479B1 (en)	2020-07-29
CO2017008809A2 (en)	2017-11-10
CL2017002059A1 (en)	2018-03-16
CN107531730A (en)	2018-01-02
EP3256480A1 (en)	2017-12-20
IL253864B (en)	2021-07-29
CL2017002060A1 (en)	2018-03-16
EA201791667A1 (en)	2018-02-28
CA2976308A1 (en)	2016-08-18
KR20170117158A (en)	2017-10-20
US20180044353A1 (en)	2018-02-15
TW201702250A (en)	2017-01-16
EP3256479A1 (en)	2017-12-20
KR20170117156A (en)	2017-10-20
CO2017008816A2 (en)	2017-11-10
SG11201706510YA (en)	2017-09-28
NZ734379A (en)	2023-06-30
JP2018506538A (en)	2018-03-08
US10774096B2 (en)	2020-09-15
HUE051113T2 (en)	2021-01-28
MX2017010413A (en)	2018-05-11
UA120527C2 (en)	2019-12-26
DK3256479T3 (en)	2020-11-02
PT3256479T (en)	2020-10-22
SI3256479T1 (en)	2020-11-30
CR20170371A (en)	2018-01-22
AU2016217507B2 (en)	2019-03-14
US20180037595A1 (en)	2018-02-08
US20210053996A1 (en)	2021-02-25
DOP2017000188A (en)	2017-09-15
PL3256479T3 (en)	2021-06-14
MA41495A (en)	2017-12-19
CA2976030C (en)	2023-09-26
JP2018506540A (en)	2018-03-08
AU2016217507A1 (en)	2017-09-28
BR112017017211B1 (en)	2023-04-25
PE20171348A1 (en)	2017-09-13
IL253865A0 (en)	2017-10-31
RS60885B1 (en)	2020-11-30
MA41494A (en)	2017-12-19
MX2017010414A (en)	2018-05-11
PH12017501427A1 (en)	2018-01-15
PH12017501428A1 (en)	2018-01-15
LT3256479T (en)	2020-12-28
IL253864A0 (en)	2017-09-28
DOP2017000189A (en)	2018-02-15
WO2016128949A1 (en)	2016-08-18
US11214582B2 (en)	2022-01-04
EA036516B1 (en)	2020-11-18
MA41494B1 (en)	2020-10-28
TWI730953B (en)	2021-06-21
BR112017017213A2 (en)	2018-04-03
PE20171432A1 (en)	2017-09-26
HRP20201597T1 (en)	2020-12-25
AU2020256369A1 (en)	2020-11-12
CN107548398A (en)	2018-01-05
EA201791671A1 (en)	2018-02-28
CA2976030A1 (en)	2016-08-18
CN107531730B (en)	2020-08-07
CR20170372A (en)	2017-10-19
ZA201705456B (en)	2019-10-30
BR112017017211A2 (en)	2018-04-03
JP6771472B2 (en)	2020-10-21
WO2016128948A1 (en)	2016-08-18
CY1123687T1 (en)	2022-03-24

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